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A biobank of patient-derived pediatric brain tumor models

artículo científico publicado en 2018

A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing.

artículo científico publicado en 2015

A comprehensive multicenter comparison of whole genome sequencing pipelines using a uniform tumor-normal sample pair

A mouse model for embryonal tumors with multilayered rosettes uncovers the therapeutic potential of Sonic-hedgehog inhibitors

artículo científico publicado en 2017

A novel human high-risk ependymoma stem cell model reveals the differentiation-inducing potential of the histone deacetylase inhibitor Vorinostat

artículo científico publicado en 2011

A subset of pediatric-type thalamic gliomas share a distinct DNA methylation profile, H3K27me3 loss and frequent alteration of EGFR

scientific article published on 01 November 2020

AT-03ATYPICAL TERATOID/RHABDOID TUMOUR IS A GENETICALLY HOMOGENEOUS BUT EPIGENETICALLY HETEROGENEOUS DISEASE THAT IS DEFINED BY SUBGROUP SPECIFIC SUPER-ENHANCERS.

artículo científico publicado en 2015

AT-10ATYPICAL TERATOID RHABDOID TUMORS AND POORLY DIFFERENTIATED CHORDOMAS: DISTINCT MOLECULAR ENTITIES WITH SMARCB1/INI1 LOSS AND DISMAL PROGNOSIS.

artículo científico publicado en 2016

ATRX and IDH1-R132H immunohistochemistry with subsequent copy number analysis and IDH sequencing as a basis for an "integrated" diagnostic approach for adult astrocytoma, oligodendroglioma and glioblastoma

artículo científico publicado en 2014

ATRX loss refines the classification of anaplastic gliomas and identifies a subgroup of IDH mutant astrocytic tumors with better prognosis

artículo científico publicado en 2013

Aberrant ERBB4-SRC Signaling as a Hallmark of Group 4 Medulloblastoma Revealed by Integrative Phosphoproteomic Profiling

artículo científico publicado en 2018

Aberrant patterns of H3K4 and H3K27 histone lysine methylation occur across subgroups in medulloblastoma.

artículo científico publicado en 2012

Absence of chromosome 19q13.41 amplification in a case of atypical teratoid/rhabdoid tumor with ependymoblastic differentiation

Abstract 3089: (Epi)genetic profiling enables molecular re-classification of CNS-primitive neuroectodermal tumors

Abstract 3094: Epigenetic classification of ependymal brain tumors across age groups

Abstract LB-198: Epigenomic alterations define lethal CIMP-positive ependymomas of infancy

Accumulation of genomic aberrations during clinical progression of medulloblastoma

artículo científico publicado en 2008

Accurate calling of KIAA1549-BRAF fusions from DNA of human brain tumours using methylation array-based copy number and gene panel sequencing data

artículo científico publicado en 2020

Active medulloblastoma enhancers reveal subgroup-specific cellular origins

artículo científico publicado en 2016

Acyl-CoA-Binding Protein Drives Glioblastoma Tumorigenesis by Sustaining Fatty Acid Oxidation

artículo científico publicado en 2019

Adult IDH wild type astrocytomas biologically and clinically resolve into other tumor entities

artículo científico publicado en 2015

Adult and pediatric medulloblastomas are genetically distinct and require different algorithms for molecular risk stratification

artículo científico publicado en 2010

Adult medulloblastoma comprises three major molecular variants.

artículo científico publicado en 2011

An activated mutant BRAF kinase domain is sufficient to induce pilocytic astrocytoma in mice

artículo científico publicado en 2011

An animal model of MYC-driven medulloblastoma

artículo científico publicado en 2012

An essential role for p38 MAPK in cerebellar granule neuron precursor proliferation

artículo científico publicado en 2012

An optimized workflow to improve reliability of detection of KIAA1549:BRAF fusions from RNA sequencing data

artículo científico publicado en 2020

Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma

artículo científico publicado en 2011

Analysis of the IDH1 codon 132 mutation in brain tumors

artículo científico publicado en 2008

Anaplastic astrocytoma with piloid features, a novel molecular class of IDH wildtype glioma with recurrent MAPK pathway, CDKN2A/B and ATRX alterations.

artículo científico publicado en 2018

Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes

artículo científico publicado en 2016

BAF complexes facilitate decatenation of DNA by topoisomerase IIα

artículo científico publicado en 2013

BRAF gene duplication constitutes a mechanism of MAPK pathway activation in low-grade astrocytomas

artículo científico publicado en 2008

Biological and clinical heterogeneity of MYCN-amplified medulloblastoma.

artículo científico publicado en 2011

CSF1R inhibition depletes tumor-associated macrophages and attenuates tumor progression in a mouse sonic Hedgehog-Medulloblastoma model

artículo científico publicado en 2020

Characterization of R132H mutation-specific IDH1 antibody binding in brain tumors

artículo científico publicado en 2009

Chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programme.

artículo científico publicado en 2017

Chromosomal imbalances in clear cell ependymomas.

artículo científico publicado en 2006

Clinical utility of fluorescence in situ hybridization (FISH) in nonbrainstem glioblastomas of childhood.

artículo científico publicado en 2005

Clonal selection drives genetic divergence of metastatic medulloblastoma

artículo científico publicado en 2012

Combined molecular analysis of BRAF and IDH1 distinguishes pilocytic astrocytoma from diffuse astrocytoma.

artículo científico publicado en 2009

Comparative integrated molecular analysis of intraocular medulloepitheliomas and central nervous system embryonal tumors with multilayered rosettes confirms that they are distinct nosologic entities

artículo científico publicado en 2015

Comprehensive Analysis of Chromatin States in Atypical Teratoid/Rhabdoid Tumor Identifies Diverging Roles for SWI/SNF and Polycomb in Gene Regulation

scientific article published on 27 December 2018

Corrigendum: Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

artículo científico publicado en 2012

Cribriform neuroepithelial tumor: molecular characterization of a SMARCB1-deficient non-rhabdoid tumor with favorable long-term outcome

artículo científico publicado en 2016

Cytogenetic prognostication within medulloblastoma subgroups

artículo científico publicado en 2014

DNA copy number alterations in central primitive neuroectodermal tumors and tumors of the pineal region: an international individual patient data meta-analysis

artículo científico publicado en 2012

DNA methylation profiling is a method of choice for molecular verification of pediatric WNT-activated medulloblastomas

artículo científico publicado en 2019

DNA methylation-based classification of central nervous system tumours.

artículo científico publicado en 2018

DNA topoisomerase II-alpha and cyclin A immunoexpression in meningiomas and its prognostic significance: an analysis of 263 cases

artículo científico publicado en 2002

DNA-methylation profiling discloses significant advantages over NanoString method for molecular classification of medulloblastoma

artículo científico publicado en 2017

Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing

artículo científico publicado en 2014

Deep sequencing of WNT-activated medulloblastomas reveals secondary SHH pathway activation.

artículo científico publicado en 2018

Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors

scientific article published in Nature Communications

Delineation of two clinically and molecularly distinct subgroups of posterior fossa ependymoma

artículo científico publicado en 2011

Desmoplastic Infantile Ganglioglioma/Astrocytoma (DIG/DIA) Are Distinct Entities with Frequent BRAFV600 Mutations

article

Desmoplastic/nodular medulloblastomas (DNMB) and medulloblastomas with extensive nodularity (MBEN) disclose similar epigenetic signatures but different transcriptional profiles

artículo científico publicado en 2019

Differential expression and methylation of brain developmental genes define location-specific subsets of pilocytic astrocytoma

artículo científico

Differential nuclear ATRX expression in sarcomas

artículo científico publicado en 2015

Dissecting the genomic complexity underlying medulloblastoma

artículo científico publicado en 2012

Distinct Histomorphology in Molecular Subgroups of Glioblastomas in Young Patients

artículo científico publicado en 2016

Distribution of TERT promoter mutations in pediatric and adult tumors of the nervous system

artículo científico publicado en 2013

Divergent clonal selection dominates medulloblastoma at recurrence

artículo científico publicado en 2016

Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

artículo científico publicado en 2012

Droplet digital PCR is a powerful technique to demonstrate frequent FGFR1 duplication in dysembryoplastic neuroepithelial tumors

artículo científico publicado en 2016

Duplications of KIAA1549 and BRAF screening by Droplet Digital PCR from formalin-fixed paraffin-embedded DNA is an accurate alternative for KIAA1549-BRAF fusion detection in pilocytic astrocytomas.

artículo científico publicado en 2018

EMBR-10. GENOMIC COMPLEXITY AND EVOLUTION OF EMBRYONAL TUMORS WITH MULTILAYERED ROSETTES (ETMR)

EMBR-12. IMPROVED DIAGNOSTIC ALGORITHM FOR DIFFERENTIAL DIAGNOSTICS OF CNS EMBRYONAL TUMORS (FORMER CNS-PNET) BY NEUROPATHOLOGICAL RE-EVALUATION OF 256 CASES AND CROSSVALIDATION BY METHYLATION CLASSIFICATION

EMBR-15. DIAGNOSTIC RE-EVALUATION AND POOLED CLINICAL DATA ANALYSIS OF PATIENTS WITH PREVIOUS DIAGNOSIS OF CNS-PNET

EP-03MOLECULAR CLASSIFICATION OF EPENDYMAL TUMORS ACROSS ALL CNS COMPARTMENTS, HISTOPATHOLOGICAL GRADES AND AGE GROUPS.

artículo científico publicado en 2015

EPEN-06. YAP1 SUBGROUP SUPRATENTORIAL EPENDYMOMA REQUIRES TEAD AND NUCLEAR FACTOR I-MEDIATED TRANSCRIPTIONAL PROGRAMS FOR TUMORIGENESIS

artículo científico publicado en 2019

EPEN-23. MOLECULAR HETEROGENEITY AMONG PEDIATRIC POSTERIOR FOSSA EPENDYMOMA

EPEN-24. YAP1 FUSION PROTEINS MEDIATE ONCOGENIC ACTIVITY IN EPENDYMOMA VIA INTERACTION WITH TEAD TRANSCRIPTION FACTORS.

artículo científico publicado en 2018

EPEN-28. HETEROGENEITY WITHIN THE PFB EPENDYMOMA SUBGROUP.

artículo científico publicado en 2018

EPIGENOME ALTERATIONS DEFINE LETHAL CIMP POSITIVE EPENDYMOMAS OF INFANCY.

artículo científico publicado en 2014

EPN-30YAP1-MAMLD1 FUSIONS ALONE ARE SUFFICIENT TO FORM SUPRATENTORIAL EPENDYMOMA-LIKE TUMORS IN MICE.

artículo científico publicado en 2016

EPN-31MOLECULAR REFINEMENT OF PEDIATRIC POSTERIOR FOSSA EPENDYMOMA.

artículo científico publicado en 2016

EPND-07. MOLECULAR HETEROGENEITY AMONG PEDIATRIC POSTERIOR FOSSA EPENDYMOMA.

artículo científico publicado en 2017

EPND-13. YAP1-MAMLD1 FUSIONS ALONE ARE SUFFICIENT TO FORM SUPRATENTORIAL EPENDYMOMA-LIKE TUMORS IN MICE.

artículo científico publicado en 2017

ETMR: a tumor entity in its infancy

scientific article published on 29 June 2020

Embryonal tumor with abundant neuropil and true rosettes (ETANTR) with loss of morphological but retained genetic key features during progression

artículo científico publicado en 2011

Embryonal tumor with abundant neuropil and true rosettes (ETANTR), ependymoblastoma, and medulloepithelioma share molecular similarity and comprise a single clinicopathological entity

artículo científico publicado en 2013

Emerging insights into the ependymoma epigenome

artículo científico publicado en 2013

Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma

artículo científico publicado en 2014

Epithelioid Glioblastomas and Anaplastic Epithelioid Pleomorphic Xanthoastrocytomas--Same Entity or First Cousins?

artículo científico publicado en 2015

Epithelioid glioblastomas stratify into established diagnostic subsets upon integrated molecular analysis.

artículo científico publicado en 2017

Establishment and application of a novel patient-derived KIAA1549:BRAF-driven pediatric pilocytic astrocytoma model for preclinical drug testing

artículo científico publicado en 2016

FBW7 suppression leads to SOX9 stabilization and increased malignancy in medulloblastoma

artículo científico publicado en 2016

FGFR1:TACC1 fusion is a frequent event in molecularly defined extraventricular neurocytoma.

artículo científico publicado en 2018

FORETINIB IS EFFECTIVE THERAPY FOR METASTATIC SONIC HEDGEHOG MEDULLOBLASTOMA.

artículo científico publicado en 2014

FSTL5 is a marker of poor prognosis in non-WNT/non-SHH medulloblastoma

artículo científico publicado en 2011

Focal genomic amplification at 19q13.42 comprises a powerful diagnostic marker for embryonal tumors with ependymoblastic rosettes.

artículo científico publicado en 2010

Foretinib is effective therapy for metastatic sonic hedgehog medulloblastoma.

artículo científico publicado en 2014

Frequent ATRX mutations and loss of expression in adult diffuse astrocytic tumors carrying IDH1/IDH2 and TP53 mutations

artículo científico publicado en 2012

Functional characterization of a BRAF insertion mutant associated with pilocytic astrocytoma

artículo científico publicado en 2011

Functional loss of a noncanonical BCOR-PRC1.1 complex accelerates SHH-driven medulloblastoma formation

artículo científico publicado en 2020

GENE-06. DISTINCT MOLECULAR SUBGROUPS OF TUMORS OF THE PINEAL REGION CORRELATE WITH CLINICAL PARAMETERS AND GENETIC ALTERATIONS

artículo científico publicado en 2019

GENE-12. ANAPLASTIC NEUROEPITHELIAL TUMOR WITH CONDENSED NUCLEI (ANTCON): A NOVEL BRAIN TUMOR ENTITY WITH RECURRENT NTRK FUSION

GENE-13. PEDIATRIC MENINGIOMAS ARE CHARACTERIZED BY DISTINCT METHYLATION PROFILES DIFFERENT FROM ADULT MENINGIOMAS

artículo científico publicado en 2019

Gain of 12p encompassing CCND2 is associated with gemistocytic histology in IDH mutant astrocytomas

artículo científico publicado en 2016

Gains at the 1p36 chromosomal region are associated with symptomatic leptomeningeal dissemination of supratentorial glioblastomas.

artículo científico publicado en 2007

Gene Expression Patterns in Ependymomas Correlate with Tumor Location, Grade, and Patient Age ⬇️

artículo científico publicado el 1 de noviembre de 2003

Genetic aberrations leading to MAPK pathway activation mediate oncogene-induced senescence in sporadic pilocytic astrocytomas

artículo científico publicado en 2011

Genetic confirmation that ependymoma can arise as part of multiple endocrine neoplasia type 1 (MEN1) syndrome.

artículo científico publicado en 2017

Genetically distinct and clinically relevant subtypes of glioblastoma defined by array-based comparative genomic hybridization (array-CGH).

artículo científico publicado en 2006

Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition

artículo científico publicado en 2014

Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations

artículo científico publicado en 2012

Genome-wide molecular characterization of central nervous system primitive neuroectodermal tumor and pineoblastoma

artículo científico publicado en 2011

Genomic and expression profiling of glioblastoma stem cell-like spheroid cultures identifies novel tumor-relevant genes associated with survival

artículo científico publicado en 2009

Genomic and protein expression profiling identifies CDK6 as novel independent prognostic marker in medulloblastoma

artículo científico publicado en 2005

Germline Elongator mutations in Sonic Hedgehog medulloblastoma

scientific article published on 01 April 2020

H3-/IDH-wild type pediatric glioblastoma is comprised of molecularly and prognostically distinct subtypes with associated oncogenic drivers

artículo científico publicado en 2017

HD-MB03 is a novel Group 3 medulloblastoma model demonstrating sensitivity to histone deacetylase inhibitor treatment.

artículo científico publicado en 2012

HDAC5 and HDAC9 in medulloblastoma: novel markers for risk stratification and role in tumor cell growth

artículo científico publicado en 2010

HGNET-BCOR Tumors of the Cerebellum: Clinicopathologic and Molecular Characterization of 3 Cases

artículo científico publicado en 2017

Hedgehog-mediated regulation of PPARγ controls metabolic patterns in neural precursors and shh-driven medulloblastoma

artículo científico publicado en 2012

Heterogeneity within the PF-EPN-B ependymoma subgroup

article

Histologically distinct neuroepithelial tumors with histone 3 G34 mutation are molecularly similar and comprise a single nosologic entity

artículo científico publicado en 2015

Histology and molecular pathology of pediatric brain tumors

artículo científico publicado en 2009

Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis

artículo científico publicado en 2020

Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma

artículo científico publicado en 2012

Hypermutation of the inactive X chromosome is a frequent event in cancer

artículo científico publicado en 2013

ICGC PedBrain - dissecting the genomic complexity underlying medulloblastoma using whole-genome sequencing.

artículo científico publicado en 2012

IDH mutant diffuse and anaplastic astrocytomas have similar age at presentation and little difference in survival: a grading problem for WHO.

artículo científico publicado en 2015

Identification and Analyses of Extra-Cranial and Cranial Rhabdoid Tumor Molecular Subgroups Reveal Tumors with Cytotoxic T Cell Infiltration

scientific article published on 07 November 2019

Identification of CD24 as a marker of Patched1 deleted medulloblastoma-initiating neural progenitor cells

artículo científico publicado en 2019

Identification of gains on 1q and epidermal growth factor receptor overexpression as independent prognostic markers in intracranial ependymoma

artículo científico publicado en 2006

Immunohistochemical analysis of H3K27me3 demonstrates global reduction in group-A childhood posterior fossa ependymoma and is a powerful predictor of outcome

artículo científico publicado en 2017

Immunohistochemical analysis of p16INK4a, p14ARF, p18INK4c, p21CIP1, p27KIP1 and p73 expression in 271 meningiomas correlation with tumor grade and clinical outcome

scientific article published on 01 May 2003

Immunohistochemical analysis of p18INK4C and p14ARF protein expression in 117 oligodendrogliomas: correlation with tumor grade and clinical outcome

artículo científico publicado en 2002

Immunohistochemical markers for prognosis of anaplastic astrocytomas.

artículo científico publicado en 2002

Immunohistochemical markers for prognosis of cerebral glioblastomas

artículo científico publicado en 2002

Immunohistochemical markers for prognosis of ependymal neoplasms

artículo científico publicado en 2002

Immunohistochemical markers for prognosis of oligodendroglial neoplasms

artículo científico publicado en 2002

Infant high grade gliomas comprise multiple subgroups characterized by novel targetable gene fusions and favorable outcomes

scientific article published on 01 April 2020

Integrated DNA methylation and copy-number profiling identify three clinically and biologically relevant groups of anaplastic glioma

artículo científico publicado en 2014

Integrated analysis of pediatric glioblastoma reveals a subset of biologically favorable tumors with associated molecular prognostic markers

artículo científico publicado en 2015

Integrating Tenascin-C protein expression and 1q25 copy number status in pediatric intracranial ependymoma prognostication: A new model for risk stratification

artículo científico publicado en 2017

International Society Of Neuropathology--Haarlem consensus guidelines for nervous system tumor classification and grading

artículo científico

International network of cancer genome projects

artículo científico publicado en 2010

Intraocular Medulloepitheliomas and Embryonal Tumors With Multilayered Rosettes of the Brain: Comparative Roles of LIN28A and C19MC.

artículo científico publicado en 2015

Intratumoral platelet aggregate formation in a murine preclinical glioma model depends on podoplanin expression on tumor cells

artículo científico publicado en 2019

Isochromosome breakpoints on 17p in medulloblastoma are flanked by different classes of DNA sequence repeats

artículo científico publicado en 2006

Isomorphic diffuse glioma is a morphologically and molecularly distinct tumour entity with recurrent gene fusions of MYBL1 or MYB and a benign disease course

artículo científico publicado en 2019

K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas

artículo científico publicado en 2012

LGG-04. CHARACTERIZATION OF ONCOGENE-INDUCED SENESCENCE AND THE ROLE OF THE SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE IN PILOCYTIC ASTROCYTOMA.

artículo científico publicado en 2017

LGG-11. REGULATION OF ONCOGENE-INDUCED SENESCENCE IN PILOCYTIC ASTROCYTOMA.

artículo científico publicado en 2018

LGG-20. MOLECULARLY-DEFINED DIFFUSE LEPTOMENINGEAL GLIONEURONAL TUMOR (DLGNT) COMPRISES TWO SUBGROUPS WITH DISTINCT CLINICAL AND GENETIC FEATURES

LIN28A immunoreactivity is a potent diagnostic marker of embryonal tumor with multilayered rosettes (ETMR)

artículo científico publicado en 2012

Lateral cerebellum is preferentially sensitive to high sonic hedgehog signaling and medulloblastoma formation.

artículo científico publicado en 2018

Long-term survival in a case of ETANTR with histological features of neuronal maturation after therapy

artículo científico publicado en 2015

Low-dose Actinomycin-D treatment re-establishes the tumoursuppressive function of P53 in RELA-positive ependymoma

artículo científico publicado en 2016

MB-08MOLECULAR (RE-)CLASSIFICATION OF CNS-PRIMITIVE NEUROECTODERMAL TUMORS.

artículo científico publicado en 2015

MB-18DYSFUNCTION OF THE CHROMATIN REMODELER Chd7 CAUSES ABNORMAL CEREBELLAR DEVELOPMENT AND ACCELERATES MEDULLOBLASTOMA FORMATION.

artículo científico publicado en 2016

MBCL-35. CURRENT PROGNOSTIC FACTORS AND TREATMENT RESULTS IN YOUNG CHILDREN MEDULLOBLASTOMAS

MBCL-44. THE MOLECULAR AND CLINICAL LANDSCAPE OF INFANT MEDULLOBLASTOMA (iMB): RESULTS AND MOLECULAR ANALYSIS FROM A PROSPECTIVE, MULTICENTER PHASE II TRIAL (SJYC07)

MBRS-07. BCOR LOSS IMPACTS SHH MEDULLOBLASTOMA FORMATION VIA TRANSCRIPTIONAL UP-REGULATION OF

MEDU-11. MOLECULAR CHARACTERIZATION OF ETMRs REVEALS A ROLE FOR R-LOOP MEDIATED CHROMOSOMAL INSTABILITY

artículo científico publicado en 2019

MEDU-21. LOSS OF THE TRANSCRIPTIONAL CO-REPRESSOR BCOR LEADS TO OVEREXPRESSION OF THE GROWTH FACTOR IGF2 AND SHH MEDULLOBLASTOMA TUMOR FORMATION

MOLECULAR (RE-)CLASSIFICATION OF CNS-PRIMITIVE NEUROECTODERMAL TUMORS.

artículo científico publicado en 2014

MPTH-15MOLECULAR RECLASSIFICATION OF CNS-PRIMITIVE NEUROECTODERMAL TUMORS INTO WELL-KNOWN AND NOVEL TUMOR ENTITIES.

artículo científico publicado en 2015

MPTH-23DISTINCT MORPHOLOGY IN MOLECULAR SUBGROUPS OF GLIOBLASTOMA IN YOUNG PATIENTS.

artículo científico publicado en 2015

MPTH-26MOLECULAR REFINEMENT OF PEDIATRIC POSTERIOR FOSSA EPENDYMOMA.

artículo científico publicado en 2015

MYC family amplification and clinical risk-factors interact to predict an extremely poor prognosis in childhood medulloblastoma

artículo científico publicado en 2011

MYCN amplification drives an aggressive form of spinal ependymoma

scientific article published on 14 August 2019

Markers of survival and metastatic potential in childhood CNS primitive neuro-ectodermal brain tumours: an integrative genomic analysis

artículo científico publicado en 2012

Medulloblastoma comprises four distinct molecular variants

artículo científico publicado en 2010

Medulloblastoma subgroups remain stable across primary and metastatic compartments

artículo científico publicado en 2015

Medulloblastomics: the end of the beginning

scientific article published on December 2012

Medulloepithelioma with peculiar clinical presentation, stem cell phenotype and aberrant DNA-methylation profile.

artículo científico publicado en 2015

Methylation profiling of choroid plexus tumors reveals 3 clinically distinct subgroups

artículo científico publicado en 2016

MicroRNA-182 promotes leptomeningeal spread of non-sonic hedgehog-medulloblastoma.

artículo científico publicado en 2011

Microarray-based screening for molecular markers in medulloblastoma revealed STK15 as independent predictor for survival.

artículo científico publicado en 2004

Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups

artículo científico publicado en 2015

Molecular analysis of pediatric CNS-PNET revealed nosologic heterogeneity and potent diagnostic markers for CNS neuroblastoma with FOXR2-activation

artículo científico publicado en 2021

Molecular approaches to ependymoma: the next step(s).

artículo científico publicado en 2012

Molecular characterization of medulloblastomas with extensive nodularity (MBEN).

artículo científico publicado en 2018

Molecular diagnostics of CNS embryonal tumors

artículo científico publicado en 2010

Molecular heterogeneity and CXorf67 alterations in posterior fossa group A (PFA) ependymomas

artículo científico publicado en 2018

Molecular profiling of long-term survivors identifies a subgroup of glioblastoma characterized by chromosome 19/20 co-gain

artículo científico publicado en 2015

Molecular progression of SHH-activated medulloblastomas

scientific article published on 27 April 2019

Molecular staging of intracranial ependymoma in children and adults

artículo científico publicado en 2010

Molecular stratification of diagnostically challenging high-grade gliomas composed of small cells: the utility of fluorescence in situ hybridization.

artículo científico publicado en 2004

Molecular subgrouping of primary pineal parenchymal tumors reveals distinct subtypes correlated with clinical parameters and genetic alterations

scientific article published on 25 November 2019

Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas

artículo científico publicado en 2012

Molecular subgroups of medulloblastoma: the current consensus

artículo científico publicado en 2012

Molecularly defined diffuse leptomeningeal glioneuronal tumor (DLGNT) comprises two subgroups with distinct clinical and genetic features.

artículo científico publicado en 2018

Mosaic trisomy of chromosome 1q in human brain tissue associates with unilateral polymicrogyria, very early-onset focal epilepsy, and severe developmental delay

scientific article published on 26 September 2020

Mutations in SETD2 and genes affecting histone H3K36 methylation target hemispheric high-grade gliomas

artículo científico publicado en 2013

Myxoid glioneuronal tumor of the septum pellucidum and lateral ventricle is defined by a recurrent PDGFRA p.K385 mutation and DNT-like methylation profile

artículo científico publicado en 2018

NEXT-GENERATION NEUROPATHOLOGY - IMPROVING DIAGNOSTIC ACCURACY FOR BRAIN TUMORS USING DNA METHYLATION ARRAY-BASED MOLECULAR PROFILING.

artículo científico publicado en 2014

NFM-11. PEDIATRIC MENINGIOMAS ARE MOLECULARLY DISTINCT FROM ADULT COUNTERPARTS

article published in 2018

Nestin Mediates Hedgehog Pathway Tumorigenesis

artículo científico publicado en 2016

Nestin expression identifies ependymoma patients with poor outcome

artículo científico publicado en 2012

New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs

artículo científico publicado en 2016

Next-generation sequencing in routine brain tumor diagnostics enables an integrated diagnosis and identifies actionable targets

artículo científico publicado en 2015

Non-random aneuploidy specifies subgroups of pilocytic astrocytoma and correlates with older age.

artículo científico publicado en 2015

Nonmetastatic Medulloblastoma of Early Childhood: Results From the Prospective Clinical Trial HIT-2000 and An Extended Validation Cohort

scientific article published on 24 April 2020

Novel genomic amplification targeting the microRNA cluster at 19q13.42 in a pediatric embryonal tumor with abundant neuropil and true rosettes.

artículo científico publicado en 2008

Novel oncogene amplifications in tumors from a family with Li-Fraumeni syndrome

artículo científico publicado en 2009

Novel, improved grading system(s) for IDH-mutant astrocytic gliomas.

artículo científico publicado en 2018

Oncogenic FAM131B-BRAF fusion resulting from 7q34 deletion comprises an alternative mechanism of MAPK pathway activation in pilocytic astrocytoma

artículo científico publicado en 2011

Outcome prediction in pediatric medulloblastoma based on DNA copy-number aberrations of chromosomes 6q and 17q and the MYC and MYCN loci

artículo científico publicado en 2009

Overcoming multiple drug resistance mechanisms in medulloblastoma.

artículo científico publicado en 2014

PATH-32. MOLECULAR HETEROGENEITY AMONG PEDIATRIC POSTERIOR FOSSA EPENDYMOMA

PCM-15SOMATIC CRISPR/Cas9-MEDIATED TUMOR SUPPRESSOR DISRUPTION ENABLES VERSATILE BRAIN TUMOR MODELING.

artículo científico publicado en 2016

PCM-20PRE-CLINICAL DRUG SCREEN IN A PDX ETMR MOUSE MODEL.

artículo científico publicado en 2016

PDTM-38. PEDIATRIC MENINGIOMAS ARE CHARACTERIZED BY DISTINCT METHYLATION PROFILES DIFFERENT FROM ADULT MENINGIOMAS

PDTM-47. CHARACTERIZATION OF THE SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE IN PILOCYTIC ASTROCYTOMA AND ITS ROLE IN ONCOGENE-INDUCED SENESCENCE

PDTM-49. GLOBAL REDUCTION IN H3K27me3, SIMILAR TO H3K27M MUTANT GLIOMAS, IS A MOLECULAR SURROGATE FOR PEDIATRIC POSTERIOR FOSSA- GROUP A EPENDYMOMAS

artículo científico publicado en 2017

PNR-12GENOME-WIDE PROFILING OF EMBRYONAL TUMORS WITH MULTILAYERED ROSETTES (ETMR).

artículo científico publicado en 2016

PNR-21FOUR NEW BRAIN TUMOR ENTITIES EMERGE FROM MOLECULAR CLASSIFICATION OF CNS PNETs

artículo científico publicado en 2016

PNR-23SHH AND WNT SIGNALLING ARE UPREGULATED IN HUMAN INTRAOCULAR MEDULLOEPITHELIOMA AND LEAD TO RETINAL TUMOR-LIKE LESIONS IN THE MOUSE.

artículo científico publicado en 2016

PROGNOSTIC AND PREDICTIVE BIOMARKER-BASED SUBGROUPS IN THE NOA-04 TRIAL.

artículo científico publicado en 2014

PROGNOSTIC SIGNIFICANCE OF CLINICAL, HISTOPATHOLOGICAL, AND MOLECULAR CHARACTERISTICS OF MEDULLOBLASTOMAS IN THE PROSPECTIVE HIT2000 MULTICENTER CLINICAL TRIAL COHORT

PTPS-11ATYPICAL TERATOID/RHABDOID TUMOUR IS AN EPIGENETICALLY HETEROGENEOUS DISEASE CHARACTERIZED BY SUBGROUP SPECIFIC SUPER-ENHANCERS.

artículo científico publicado en 2015

Paired box gene 8 (PAX8) expression is associated with sonic hedgehog (SHH)/wingless int (WNT) subtypes, desmoplastic histology and patient survival in human medulloblastomas

artículo científico publicado en 2015

Papillary Tumor of the Pineal Region: A Distinct Molecular Entity

artículo científico publicado en 2015

Papillary glioneuronal tumor (PGNT) exhibits a characteristic methylation profile and fusions involving PRKCA

artículo científico publicado en 2019

Pediatric Targeted Therapy: Clinical Feasibility of Personalized Diagnostics in Children with Relapsed and Progressive Tumors.

artículo científico publicado en 2015

Pediatric and adult sonic hedgehog medulloblastomas are clinically and molecularly distinct

artículo científico publicado en 2011

Phase II study of sorafenib in children with recurrent or progressive low-grade astrocytomas.

artículo científico publicado en 2014

Pilocytic Astrocytoma demethylation and transcriptional landscapes link bZIP transcription factors to immune response

artículo científico publicado en 2020

Poorly differentiated chordoma with SMARCB1/INI1 loss: a distinct molecular entity with dismal prognosis.

artículo científico publicado en 2016

Posterior fossa pilocytic astrocytomas with oligodendroglial features show frequent FGFR1 activation via fusion or mutation

artículo científico publicado en 2019

Practical implementation of DNA methylation and copy-number-based CNS tumor diagnostics: the Heidelberg experience.

artículo científico publicado en 2018

Pre-clinical drug screen reveals topotecan, actinomycin D and volasertib as potential new therapeutic candidates for ETMR brain tumor patients

artículo científico

Primary intracranial sarcomas with DICER1 mutation often contain prominent eosinophilic cytoplasmic globules and can occur in the setting of neurofibromatosis type 1

scientific article published on 16 January 2019

Primary intracranial spindle cell sarcoma with rhabdomyosarcoma-like features share a highly distinct methylation profile and DICER1 mutations.

artículo científico publicado en 2018

Primary mismatch repair deficient IDH-mutant astrocytoma (PMMRDIA) is a distinct type with a poor prognosis

scientific article published on 20 November 2020

Prognostic significance of clinical, histopathological, and molecular characteristics of medulloblastomas in the prospective HIT2000 multicenter clinical trial cohort

artículo científico publicado en 2014

Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis

artículo científico publicado en 2016

Proteomics, Post-translational Modifications, and Integrative Analyses Reveal Molecular Heterogeneity within Medulloblastoma Subgroups

scientific article published on 01 September 2018

Quantification of telomere features in tumor tissue sections by an automated 3D imaging-based workflow

artículo científico publicado en 2016

Quiescent sox2(+) cells drive hierarchical growth and relapse in sonic hedgehog subgroup medulloblastoma

artículo científico publicado en 2014

Radiation-induced gliomas represent H3-/IDH-wild type pediatric gliomas with recurrent PDGFRA amplification and loss of CDKN2A/B

artículo científico publicado en 2021

Rapid, reliable, and reproducible molecular sub-grouping of clinical medulloblastoma samples

artículo científico publicado en 2011

Real-time PCR assay based on the differential expression of microRNAs and protein-coding genes for molecular classification of formalin-fixed paraffin embedded medulloblastomas

artículo científico publicado en 2013

Recurrence patterns across medulloblastoma subgroups: an integrated clinical and molecular analysis

artículo científico publicado en 2013

Recurrent cytogenetic aberrations in central neurocytomas and their biological relevance.

artículo científico publicado en 2006

Recurrent fusions in PLAGL1 define a distinct subset of pediatric-type supratentorial neuroepithelial tumors

artículo científico publicado en 2021

Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma

artículo científico publicado en 2013

Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas

artículo científico publicado en 2013

Reply to J.C. Lindsey et al

Risk-adapted therapy for young children with medulloblastoma (SJYC07): therapeutic and molecular outcomes from a multicentre, phase 2 trial

scientific article published on 16 May 2018

Robust molecular subgrouping and copy-number profiling of medulloblastoma from small amounts of archival tumour material using high-density DNA methylation arrays

artículo científico publicado en 2013

Role of LIM and SH3 protein 1 (LASP1) in the metastatic dissemination of medulloblastoma

artículo científico publicado en 2010

Routine RNA sequencing of formalin-fixed paraffin-embedded specimens in neuropathology diagnostics identifies diagnostically and therapeutically relevant gene fusions

scientific article published on 05 July 2019

Sarcoma classification by DNA methylation profiling

artículo científico publicado en 2021

Second-generation molecular subgrouping of medulloblastoma: an international meta-analysis of Group 3 and Group 4 subtypes

scientific article published on 10 May 2019

Somatic CRISPR/Cas9-mediated tumour suppressor disruption enables versatile brain tumour modelling

artículo científico publicado en 2015

Somatic mutations of DICER1 and KMT2D are frequent in intraocular medulloepitheliomas.

artículo científico publicado en 2016

Somatostatin receptor subtype 2 (sst₂) is a potential prognostic marker and a therapeutic target in medulloblastoma

artículo científico publicado en 2013

Sorafenib plus valproic acid for infant spinal glioblastoma

artículo científico publicado en 2010

Spatial heterogeneity in medulloblastoma

artículo científico publicado en 2017

Specific detection of methionine 27 mutation in histone 3 variants (H3K27M) in fixed tissue from high-grade astrocytomas

artículo científico publicado en 2014

Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort.

artículo científico publicado en 2018

Spinal Myxopapillary Ependymomas Demonstrate a Warburg Phenotype.

artículo científico publicado en 2015

Spinal metastasis of gliosarcoma: array-based comparative genomic hybridization for confirmation of metastatic spread

artículo científico publicado en 2014

Stepwise accumulation of distinct genomic aberrations in a patient with progressively metastasizing ependymoma

artículo científico publicado en 2009

Subgroup-specific prognostic implications of TP53 mutation in medulloblastoma

artículo científico publicado en 2013

Subgroup-specific structural variation across 1,000 medulloblastoma genomes

artículo científico publicado en 2012

Supratentorial primitive neuroectodermal tumors of the central nervous system frequently harbor deletions of the CDKN2A locus and other genomic aberrations distinct from medulloblastomas.

artículo científico publicado en 2007

TBIO-10. PEDIATRIC TARGETED THERAPY 2.0: DEVELOPMENT OF PERSONALIZED PEDIATRIC ONCOLOGY

TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma

artículo científico publicado en 2013

TP53 mutation is frequently associated with CTNNB1 mutation or MYCN amplification and is compatible with long-term survival in medulloblastoma.

artículo científico publicado en 2010

TRTH-09. PTT2.0: DEVELOPING PERSONALIZED PEDIATRIC ONCOLOGY.

artículo científico publicado en 2017

Targeting class I histone deacetylase 2 in MYC amplified group 3 medulloblastoma

artículo científico publicado en 2015

Targeting self-renewal in high-grade brain tumors leads to loss of brain tumor stem cells and prolonged survival

artículo científico publicado en 2014

Telomerase activation in posterior fossa group A ependymomas is associated with dismal prognosis and chromosome 1q gain

artículo científico publicado en 2017

Telomere dysfunction and chromothripsis

artículo científico publicado en 2016

The RNA-binding protein Musashi1 affects medulloblastoma growth via a network of cancer-related genes and is an indicator of poor prognosis

artículo científico publicado en 2012

The Senescence-associated Secretory Phenotype Mediates Oncogene-induced Senescence in Pediatric Pilocytic Astrocytoma

artículo científico publicado en 2018

The Shh receptor Boc promotes progression of early medulloblastoma to advanced tumors

artículo científico publicado en 2014

The clinical implications of medulloblastoma subgroups

artículo científico publicado en 2012

The current consensus on the clinical management of intracranial ependymoma and its distinct molecular variants

artículo científico publicado en 2016

The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation

artículo científico publicado en 2013

The histologic grade is a main prognostic factor for patients with intracranial ependymomas treated in the microneurosurgical era: an analysis of 258 patients.

artículo científico publicado en 2004

The molecular landscape of ETMR at diagnosis and relapse

scientific article published on 04 December 2019

The next generation of glioma biomarkers: MGMT methylation, BRAF fusions and IDH1 mutations

artículo científico publicado en 2011

The prognostic relevance of molecular alterations in glioblastomas for patients age < 50 years

artículo científico publicado en 2005

The transcription factor evi-1 is overexpressed, promotes proliferation, and is prognostically unfavorable in infratentorial ependymomas

artículo científico publicado en 2011

The whole-genome landscape of medulloblastoma subtypes

artículo científico publicado en 2017

Therapeutic Impact of Cytoreductive Surgery and Irradiation of Posterior Fossa Ependymoma in the Molecular Era: A Retrospective Multicohort Analysis

artículo científico publicado en 2016

Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling

artículo científico publicado en 2017

Tissue Factor Regulation by miR-520g in Primitive Neuronal Brain Tumor Cells: A Possible Link between Oncomirs and the Vascular Tumor Microenvironment

artículo científico publicado en 2015

Transcriptional profiling of medulloblastoma with extensive nodularity (MBEN) reveals two clinically relevant tumor subsets with VSNL1 as potent prognostic marker

scientific article published on 28 November 2019

Tumors diagnosed as cerebellar glioblastoma comprise distinct molecular entities

artículo científico publicado en 2019

Ultra high-risk PFA ependymoma is characterized by loss of chromosome 6q

artículo científico publicado en 2021

Update on molecular and genetic alterations in adult medulloblastoma

artículo científico publicado en 2012

WNT activation by lithium abrogates TP53 mutation associated radiation resistance in medulloblastoma

artículo científico publicado en 2014

YAP1 subgroup supratentorial ependymoma requires TEAD and nuclear factor I-mediated transcriptional programmes for tumorigenesis

scientific article published on 02 September 2019

YAP1-fusions in pediatric NF2-wildtype meningioma

artículo científico publicado en 2019

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