Lista de obras -

A 16-residue peptide fragment of macrophage migration inhibitory factor, MIF-(50-65), exhibits redox activity and has MIF-like biological functions

artículo científico publicado en 2003

A Hot-Segment-Based Approach for the Design of Cross-Amyloid Interaction Surface Mimics as Inhibitors of Amyloid Self-Assembly.

artículo científico publicado en 2015

A MIF-derived cyclopeptide that inhibits MIF binding and atherogenic signaling via the chemokine receptor CXCR2

artículo científico publicado en 2020

A novel drug-eluting stent coated with an integrin-binding cyclic Arg-Gly-Asp peptide inhibits neointimal hyperplasia by recruiting endothelial progenitor cells

artículo científico publicado en 2006

Blocking Inflammasome Activation Caused by β-Amyloid Peptide (Aβ) and Islet Amyloid Polypeptide (IAPP) through an IAPP Mimic

scientific article published on 25 July 2019

Conformational restriction via cyclization in beta-amyloid peptide Abeta(1-28) leads to an inhibitor of Abeta(1-28) amyloidogenesis and cytotoxicity

artículo científico publicado en 2003

Conformationally constrained human calcitonin (hCt) analogues reveal a critical role of sequence 17-21 for the oligomerization state and bioactivity of hCt

artículo científico publicado en 2002

Contribution of conformationally constrained calcitonin (Ct) analogs to the understanding of the structural and conformational requirements of calcitonin bioactivity and to the design of potent agonists

artículo científico publicado en 2004

Cross-amyloid interaction of Aβ and IAPP at lipid membranes

artículo científico publicado en 2011

Cross-kingdom mimicry of the receptor signaling and leukocyte recruitment activity of a human cytokine by its plant orthologs

scientific article published on 06 December 2019

Cytotoxicity of insulin within its self-assembly and amyloidogenic pathways

scientific article published on 04 May 2007

Design of a mimic of nonamyloidogenic and bioactive human islet amyloid polypeptide (IAPP) as nanomolar affinity inhibitor of IAPP cytotoxic fibrillogenesis

artículo científico publicado en 2006

Designed CXCR4 mimic acts as a soluble chemokine receptor that blocks atherogenic inflammation by agonist-specific targeting

artículo científico publicado en 2020

Designed Macrocyclic Peptides as Nanomolar Amyloid Inhibitors Based on Minimal Recognition Elements

artículo científico publicado en 2018

Designed hairpin peptides interfere with amyloidogenesis pathways: fibril formation and cytotoxicity inhibition, interception of the preamyloid state

artículo científico

Development of accessible peptidic tool compounds to study the phosphatase PTP1B in intact cells

artículo científico publicado en 2014

Dissecting the role of single regions of an IAPP mimic and IAPP in inhibition of Aβ40 amyloid formation and cytotoxicity.

artículo científico publicado en 2011

Enlightening amyloid fibrils linked to type 2 diabetes and cross-interactions with Aβ

artículo científico publicado en 2020

Exploiting cross-amyloid interactions to inhibit protein aggregation but not function: nanomolar affinity inhibition of insulin aggregation by an IAPP mimic

artículo científico publicado en 2008

IAPP mimic blocks Abeta cytotoxic self-assembly: cross-suppression of amyloid toxicity of Abeta and IAPP suggests a molecular link between Alzheimer's disease and type II diabetes

scientific article published on 01 January 2007

Identification of an Arg-Leu-Arg tripeptide that contributes to the binding interface between the cytokine MIF and the chemokine receptor CXCR4.

artículo científico publicado en 2018

Identification of hot regions of the Abeta-IAPP interaction interface as high-affinity binding sites in both cross- and self-association

artículo científico publicado en 2010

Inhibition of hIAPP amyloid-fibril formation and apoptotic cell death by a designed hIAPP amyloid- core-containing hexapeptide

scientific article published on 01 July 2005

Interaction between amyloid beta peptide and an aggregation blocker peptide mimicking islet amyloid polypeptide

artículo científico publicado en 2011

Key aromatic/hydrophobic amino acids controlling a cross-amyloid peptide interaction versus amyloid self-assembly

artículo científico publicado en 2017

LPS-mediated cell surface expression of CD74 promotes the proliferation of B cells in response to MIF.

artículo científico publicado en 2018

MIF-chemokine receptor interactions in atherogenesis are dependent on an N-loop-based 2-site binding mechanism

artículo científico publicado en 2010

Macrophage Migration Inhibitory Factor (MIF)-Based Therapeutic Concepts in Atherosclerosis and Inflammation

scientific article published on 04 February 2019

Macrophage Migration Inhibitory Factor-CXCR4 Receptor Interactions: EVIDENCE FOR PARTIAL ALLOSTERIC AGONISM IN COMPARISON WITH CXCL12 CHEMOKINE.

artículo científico publicado en 2016

Macrophage migration inhibitory factor increases neuronal delayed rectifier K+ current

scientific journal article

Mif-deficiency favors an atheroprotective autoantibody phenotype in atherosclerosis.

artículo científico publicado en 2018

Molecular characterization of the hetero-assembly of β-amyloid peptide with islet amyloid polypeptide

artículo científico publicado en 2014

Peptide Inhibitors of the amyloidogenesis of IAPP: verification of the hairpin-binding geometry hypothesis

artículo científico publicado en 2016

Peptide-Based Molecular Strategies To Interfere with Protein Misfolding, Aggregation, and Cell Degeneration

artículo científico publicado en 2019

Rapid and transient activation of the ERK MAPK signalling pathway by macrophage migration inhibitory factor (MIF) and dependence on JAB1/CSN5 and Src kinase activity

artículo científico publicado en 2005

Selectively N-methylated soluble IAPP mimics as potent IAPP receptor agonists and nanomolar inhibitors of cytotoxic self-assembly of both IAPP and Aβ40.

artículo científico publicado en 2013

Shedding light on Alzheimer's β-amyloid aggregation with chemical tools

scientific article published on 24 November 2011

Side-chain lactam-bridge conformational constraints differentiate the activities of salmon and human calcitonins and reveal a new design concept for potent calcitonin analogues

artículo científico publicado en 2002

Structural Insight into IAPP-Derived Amyloid Inhibitors and Their Mechanism of Action

artículo científico publicado en 2020

Structural determinants of MIF functions in CXCR2-mediated inflammatory and atherogenic leukocyte recruitment

artículo científico publicado en 2008

Structure-based design and study of non-amyloidogenic, double N-methylated IAPP amyloid core sequences as inhibitors of IAPP amyloid formation and cytotoxicity

artículo científico publicado en 2002

Suppression of IAPP fibrillation at anionic lipid membranes via IAPP-derived amyloid inhibitors and insulin

artículo científico publicado en 2010

Targeting alpha-synuclein in Parkinson's disease

artículo científico publicado en 2004

Terminating the Amyloid Zipper by Design ⬇️

artículo científico publicado el 4 de noviembre de 2011

The Multitasking Potential of Alarmins and Atypical Chemokines

artículo científico publicado en 2019

The backbone dynamics of the amyloid precursor protein transmembrane helix provides a rationale for the sequential cleavage mechanism of γ-secretase

artículo científico publicado en 2013

The human cathelicidin LL-37 is a nanomolar inhibitor of amyloid self-assembly of islet amyloid polypeptide (IAPP)

scientific article published on 30 January 2020

Lista de obras de

A 16-residue peptide fragment of macrophage migration inhibitory factor, MIF-(50-65), exhibits redox activity and has MIF-like biological functions

A Hot-Segment-Based Approach for the Design of Cross-Amyloid Interaction Surface Mimics as Inhibitors of Amyloid Self-Assembly.

A MIF-derived cyclopeptide that inhibits MIF binding and atherogenic signaling via the chemokine receptor CXCR2

A novel drug-eluting stent coated with an integrin-binding cyclic Arg-Gly-Asp peptide inhibits neointimal hyperplasia by recruiting endothelial progenitor cells

Blocking Inflammasome Activation Caused by β-Amyloid Peptide (Aβ) and Islet Amyloid Polypeptide (IAPP) through an IAPP Mimic

Conformational restriction via cyclization in beta-amyloid peptide Abeta(1-28) leads to an inhibitor of Abeta(1-28) amyloidogenesis and cytotoxicity

Conformationally constrained human calcitonin (hCt) analogues reveal a critical role of sequence 17-21 for the oligomerization state and bioactivity of hCt

Contribution of conformationally constrained calcitonin (Ct) analogs to the understanding of the structural and conformational requirements of calcitonin bioactivity and to the design of potent agonists

Cross-amyloid interaction of Aβ and IAPP at lipid membranes

Cross-kingdom mimicry of the receptor signaling and leukocyte recruitment activity of a human cytokine by its plant orthologs

Cytotoxicity of insulin within its self-assembly and amyloidogenic pathways

Design of a mimic of nonamyloidogenic and bioactive human islet amyloid polypeptide (IAPP) as nanomolar affinity inhibitor of IAPP cytotoxic fibrillogenesis

Designed CXCR4 mimic acts as a soluble chemokine receptor that blocks atherogenic inflammation by agonist-specific targeting

Designed Macrocyclic Peptides as Nanomolar Amyloid Inhibitors Based on Minimal Recognition Elements

Designed hairpin peptides interfere with amyloidogenesis pathways: fibril formation and cytotoxicity inhibition, interception of the preamyloid state

Development of accessible peptidic tool compounds to study the phosphatase PTP1B in intact cells

Dissecting the role of single regions of an IAPP mimic and IAPP in inhibition of Aβ40 amyloid formation and cytotoxicity.

Enlightening amyloid fibrils linked to type 2 diabetes and cross-interactions with Aβ

Exploiting cross-amyloid interactions to inhibit protein aggregation but not function: nanomolar affinity inhibition of insulin aggregation by an IAPP mimic

IAPP mimic blocks Abeta cytotoxic self-assembly: cross-suppression of amyloid toxicity of Abeta and IAPP suggests a molecular link between Alzheimer's disease and type II diabetes

Identification of an Arg-Leu-Arg tripeptide that contributes to the binding interface between the cytokine MIF and the chemokine receptor CXCR4.

Identification of hot regions of the Abeta-IAPP interaction interface as high-affinity binding sites in both cross- and self-association

Inhibition of hIAPP amyloid-fibril formation and apoptotic cell death by a designed hIAPP amyloid- core-containing hexapeptide

Interaction between amyloid beta peptide and an aggregation blocker peptide mimicking islet amyloid polypeptide

Key aromatic/hydrophobic amino acids controlling a cross-amyloid peptide interaction versus amyloid self-assembly

LPS-mediated cell surface expression of CD74 promotes the proliferation of B cells in response to MIF.

MIF-chemokine receptor interactions in atherogenesis are dependent on an N-loop-based 2-site binding mechanism

Macrophage Migration Inhibitory Factor (MIF)-Based Therapeutic Concepts in Atherosclerosis and Inflammation

Macrophage Migration Inhibitory Factor-CXCR4 Receptor Interactions: EVIDENCE FOR PARTIAL ALLOSTERIC AGONISM IN COMPARISON WITH CXCL12 CHEMOKINE.

Macrophage migration inhibitory factor increases neuronal delayed rectifier K+ current

Mif-deficiency favors an atheroprotective autoantibody phenotype in atherosclerosis.

Molecular characterization of the hetero-assembly of β-amyloid peptide with islet amyloid polypeptide

Peptide Inhibitors of the amyloidogenesis of IAPP: verification of the hairpin-binding geometry hypothesis

Peptide-Based Molecular Strategies To Interfere with Protein Misfolding, Aggregation, and Cell Degeneration

Rapid and transient activation of the ERK MAPK signalling pathway by macrophage migration inhibitory factor (MIF) and dependence on JAB1/CSN5 and Src kinase activity

Selectively N-methylated soluble IAPP mimics as potent IAPP receptor agonists and nanomolar inhibitors of cytotoxic self-assembly of both IAPP and Aβ40.

Shedding light on Alzheimer's β-amyloid aggregation with chemical tools

Side-chain lactam-bridge conformational constraints differentiate the activities of salmon and human calcitonins and reveal a new design concept for potent calcitonin analogues

Structural Insight into IAPP-Derived Amyloid Inhibitors and Their Mechanism of Action

Structural determinants of MIF functions in CXCR2-mediated inflammatory and atherogenic leukocyte recruitment

Structure-based design and study of non-amyloidogenic, double N-methylated IAPP amyloid core sequences as inhibitors of IAPP amyloid formation and cytotoxicity

Suppression of IAPP fibrillation at anionic lipid membranes via IAPP-derived amyloid inhibitors and insulin

Targeting alpha-synuclein in Parkinson's disease

Terminating the Amyloid Zipper by Design ⬇️

The Multitasking Potential of Alarmins and Atypical Chemokines

The backbone dynamics of the amyloid precursor protein transmembrane helix provides a rationale for the sequential cleavage mechanism of γ-secretase

The human cathelicidin LL-37 is a nanomolar inhibitor of amyloid self-assembly of islet amyloid polypeptide (IAPP)