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A Functional Interaction between Herpes Simplex Virus 1 Glycoprotein gH/gL Domains I and II and gD Is Defined by Using Alphaherpesvirus gH and gL Chimeras

artículo científico publicado en 2015

A combination of an anti-SLAMF6 antibody and ibrutinib efficiently abrogates expansion of chronic lymphocytic leukemia cells

artículo científico publicado en 2016

A nonimprinted Prader-Willi Syndrome (PWS)-region gene regulates a different chromosomal domain in trans but the imprinted pws loci do not alter genome-wide mRNA levels

artículo científico publicado en 2005

A shared gene expression signature in mouse models of EBV-associated and non–EBV-associated Burkitt lymphoma

artículo científico publicado el 28 de octubre de 2011

A soluble form of Epstein-Barr virus gH/gL inhibits EBV-induced membrane fusion and does not function in fusion

artículo científico publicado en 2012

Absence of the Epstein-Barr virus genome in breast cancer-derived cell lines.

artículo científico publicado en 2003

An auto-regulatory loop for EBV LMP2A involves activation of Notch

artículo científico publicado en 2007

Analysis of Epstein-Barr virus glycoprotein B functional domains via linker insertion mutagenesis

artículo científico publicado en 2008

Analysis of fusion using a virus-free cell fusion assay.

artículo científico publicado en 2005

Assembly and architecture of the EBV B cell entry triggering complex

artículo científico publicado en 2014

Binding-site interactions between Epstein-Barr virus fusion proteins gp42 and gH/gL reveal a peptide that inhibits both epithelial and B-cell membrane fusion.

artículo científico publicado en 2007

Bruton's tyrosine kinase regulates B cell antigen receptor-mediated JNK1 response through Rac1 and phospholipase C-gamma2 activation

artículo científico publicado en 2002

Cell-surface expression of a mutated Epstein-Barr virus glycoprotein B allows fusion independent of other viral proteins

scholarly article

Characteristics of Epstein-Barr virus envelope protein gp42.

artículo científico publicado en 2010

Characterization of EBV gB indicates properties of both class I and class II viral fusion proteins

artículo científico publicado en 2007

Characterization of Sex Differences in Ocular Herpes Simplex Virus 1 Infection and Herpes Stromal Keratitis Pathogenesis of Wild-Type and Herpesvirus Entry Mediator Knockout Mice

artículo científico publicado en 2019

Cholesterol is critical for Epstein-Barr virus latent membrane protein 2A trafficking and protein stability

artículo científico publicado en 2006

Cholesterol-dependent infection of Burkitt's lymphoma cell lines by Epstein–Barr virus

artículo científico publicado el 1 de noviembre de 2003

Cleavage and secretion of Epstein-Barr virus glycoprotein 42 promote membrane fusion with B lymphocytes

artículo científico publicado en 2009

Cleavage of Epstein-Barr virus glycoprotein B is required for full function in cell-cell fusion with both epithelial and B cells

scientific article published on March 2009

Comparative Mutagenesis of Pseudorabies Virus and Epstein-Barr Virus gH Identifies a Structural Determinant within Domain III of gH Required for Surface Expression and Entry Function

artículo científico publicado en 2015

Crystal structure of the Epstein-Barr virus (EBV) glycoprotein H/glycoprotein L (gH/gL) complex

artículo científico publicado en 2010

Dasatinib therapy results in decreased B cell proliferation, splenomegaly, and tumor growth in a murine model of lymphoma expressing Myc and Epstein-Barr virus LMP2A.

artículo científico publicado en 2012

Differential reliance on autophagy for protection from HSV encephalitis between newborns and adults

artículo científico publicado en 2015

Drosophila Schneider 2 (S2) cells: a novel tool for studying HSV-induced membrane fusion

artículo científico publicado en 2013

EBV LMP-2A employs a novel mechanism to transactivate the HERV-K18 superantigen through its ITAM.

artículo científico publicado en 2008

EBV LMP2A provides a surrogate pre-B cell receptor signal through constitutive activation of the ERK/MAPK pathway

artículo científico publicado en 2008

EBV gH/gL and KSHV gH/gL bind to different sites on EphA2 to trigger fusion

artículo científico publicado en 2020

EBV germinates lymphoma from the germinal center in a battle with T and NK cells

artículo científico publicado en 2017

EBV latent membrane protein 2A orchestrates p27kip1 degradation via Cks1 to accelerate MYC-driven lymphoma in mice

artículo científico publicado en 2017

Ephrin Receptor A4 is a New Kaposi's Sarcoma-Associated Herpesvirus Virus Entry Receptor

artículo científico publicado en 2019

Ephrin receptor A2 is a functional entry receptor for Epstein-Barr virus.

artículo científico publicado en 2018

Ephrin receptor A4 (EphA4) is a new Kaposi's sarcoma-associated herpesvirus virus entry receptor

Epithelial cell infection by Epstein-Barr virus

artículo científico publicado en 2019

Epstein-Barr Virus (EBV) LMP2A induces alterations in gene transcription similar to those observed in Reed-Sternberg cells of Hodgkin lymphoma

artículo científico publicado en 2003

Epstein-Barr virus (EBV) LMP2A alters normal transcriptional regulation following B-cell receptor activation

artículo científico publicado en 2004

Epstein-Barr virus (EBV) LMP2A mediates B-lymphocyte survival through constitutive activation of the Ras/PI3K/Akt pathway

artículo científico publicado en 2004

Epstein-Barr virus (EBV) latent membrane protein 2A regulates B-cell receptor-induced apoptosis and EBV reactivation through tyrosine phosphorylation

artículo científico publicado en 2005

Epstein-Barr virus LMP2A alters in vivo and in vitro models of B-cell anergy, but not deletion, in response to autoantigen

artículo científico publicado en 2005

Epstein-Barr virus LMP2A bypasses p53 inactivation in a MYC model of lymphomagenesis

artículo científico publicado en 2009

Epstein-Barr virus LMP2A enhances B-cell responses in vivo and in vitro

artículo científico publicado en 2006

Epstein-Barr virus LMP2A imposes sensitivity to apoptosis

artículo científico publicado en 2010

Epstein-Barr virus LMP2A interferes with global transcription factor regulation when expressed during B-lymphocyte development

artículo científico publicado en 2003

Epstein-Barr virus LMP2A reduces hyperactivation induced by LMP1 to restore normal B cell phenotype in transgenic mice

artículo científico publicado en 2012

Epstein-Barr virus LMP2A: regulating cellular ubiquitination processes for maintenance of viral latency?

artículo científico publicado en 2004

Epstein-Barr virus fusion with epithelial cells triggered by gB is restricted by a gL glycosylation site.

artículo científico publicado en 2017

Epstein-Barr virus in Burkitt's lymphoma: a role for latent membrane protein 2A

artículo científico publicado en 2010

Epstein-Barr virus latent membrane protein 2A and autoimmunity

artículo científico publicado en 2007

Epstein-Barr virus latent membrane protein 2A enhances MYC-driven cell cycle progression in a mouse model of B lymphoma

artículo científico publicado en 2013

Epstein-Barr virus latent membrane protein 2A exacerbates experimental autoimmune encephalomyelitis and enhances antigen presentation function

artículo científico publicado en 2012

Epstein-Barr virus latent membrane protein 2A exploits Notch1 to alter B-cell identity in vivo

artículo científico publicado en 2008

Epstein-Barr virus latent membrane protein 2A mediates transformation through constitutive activation of the Ras/PI3-K/Akt Pathway

artículo científico publicado en 2007

Epstein-Barr virus latent membrane protein 2A preferentially signals through the Src family kinase Lyn

artículo científico publicado en 2008

Epstein-barr virus latent membrane protein 2B (LMP2B) modulates LMP2A activity

artículo científico publicado en 2006

Erratum for Riccio et al., "Characterization of Sex Differences in Ocular Herpes Simplex Virus 1 Infection and Herpes Stromal Keratitis Pathogenesis of Wild-Type and Herpesvirus Entry Mediator Knockout Mice"

scientific article published on 15 May 2019

Expression and characterization of N-terminal domain of Epstein-Barr virus latent membrane protein 2A in Escherichia coli

artículo científico publicado en 2005

Functional analysis of glycoprotein L (gL) from rhesus lymphocryptovirus in Epstein-Barr virus-mediated cell fusion indicates a direct role of gL in gB-induced membrane fusion

artículo científico publicado en 2009

Functional homology of gHs and gLs from EBV-related gamma-herpesviruses for EBV-induced membrane fusion

artículo científico publicado en 2007

Fusing structure and function: a structural view of the herpesvirus entry machinery

artículo científico publicado en 2011

Gammaherpesvirus entry and fusion: A tale how two human pathogenic viruses enter their host cells

scientific article published on 17 July 2019

Genetic mapping of putative Chrna7 and Luzp2 neuronal transcriptional enhancers due to impact of a transgene-insertion and 6.8 Mb deletion in a mouse model of Prader-Willi and Angelman syndromes

artículo científico publicado en 2005

HSV targeting of the host phosphatase PP1α is required for disseminated disease in the neonate and contributes to pathogenesis in the brain.

artículo científico publicado en 2015

Herpes B virus utilizes human nectin-1 but not HVEM or PILRα for cell-cell fusion and virus entry

artículo científico publicado en 2012

Herpesvirus Entry Mediator Binding Partners Mediate Immunopathogenesis of Ocular Herpes Simplex Virus 1 Infection

artículo científico publicado en 2020

Herpesvirus Entry Mediator and Ocular Herpesvirus Infection: More than Meets the Eye.

artículo científico publicado en 2017

Herpesvirus entry mediator and nectin-1 mediate herpes simplex virus 1 infection of the murine cornea.

artículo científico publicado en 2011

Herpesvirus entry mediator is a serotype specific determinant of pathogenesis in ocular herpes.

artículo científico publicado en 2012

Herpesvirus entry mediator on radiation-resistant cell lineages promotes ocular herpes simplex virus 1 pathogenesis in an entry-independent manner

artículo científico publicado en 2015

Herpesvirus entry: an update

artículo científico publicado en 2003

Hydrophobic residues that form putative fusion loops of Epstein-Barr virus glycoprotein B are critical for fusion activity

artículo científico publicado en 2007

Icacinlactone H and Icacintrichantholide from the Tuber of Icacina trichantha

artículo científico publicado en 2015

Identification of latent membrane protein 2A (LMP2A) specific targets for treatment and eradication of Epstein-Barr virus (EBV)-associated diseases

artículo científico publicado en 2003

Inability of simian virus 40 to establish productive infection of lymphoblastic cell lines

artículo científico publicado en 2004

Inhibition of EBV-mediated membrane fusion by anti-gHgL antibodies.

artículo científico publicado en 2017

Inhibition of host kinase activity altered by the LMP2A signalosome-a therapeutic target for Epstein-Barr virus latency and associated disease

artículo científico publicado en 2002

Insertion mutations in herpes simplex virus 1 glycoprotein H reduce cell surface expression, slow the rate of cell fusion, or abrogate functions in cell fusion and viral entry

artículo científico publicado en 2009

Interference with T cell receptor–HLA-DR interactions by Epstein–Barr virus gp42 results in reduced T helper cell recognition

artículo científico publicado el 22 de septiembre de 2003

Introduction to the human γ-herpesviruses

Investigation of the function of the putative self-association site of Epstein-Barr virus (EBV) glycoprotein 42 (gp42).

artículo científico publicado en 2011

Is nectin-1 the "master" receptor for deadly herpes B virus infection?

artículo científico publicado en 2012

Itchy, a Nedd4 Ubiquitin Ligase, Downregulates Latent Membrane Protein 2A Activity in B-Cell Signaling

artículo científico publicado el 1 de mayo de 2003

LMP2A does not require palmitoylation to localize to buoyant complexes or for function

artículo científico publicado en 2004

Latent Membrane Protein 2 (LMP2).

artículo científico

Latent membrane protein 2A inhibits transforming growth factor-beta 1-induced apoptosis through the phosphatidylinositol 3-kinase/Akt pathway

artículo científico publicado en 2004

Latent membrane protein 2A, a viral B cell receptor homologue, induces CD5+ B-1 cell development

artículo científico publicado en 2004

Latent membrane protein 2B regulates susceptibility to induction of lytic Epstein-Barr virus infection

artículo científico publicado en 2007

Lysine-independent ubiquitination of Epstein-Barr virus LMP2A.

artículo científico publicado en 2002

Mapping regions of Epstein-Barr virus (EBV) glycoprotein B (gB) important for fusion function with gH/gL.

artículo científico publicado en 2011

Mapping sites of herpes simplex virus type 1 glycoprotein D that permit insertions and impact gD and gB receptors usage.

artículo científico publicado en 2017

Mapping the N-terminal residues of Epstein-Barr virus gp42 that bind gH/gL by using fluorescence polarization and cell-based fusion assays

artículo científico publicado en 2010

Membrane anchoring of Epstein-Barr virus gp42 inhibits fusion with B cells even with increased flexibility allowed by engineered spacers

artículo científico publicado en 2015

Modulation of Epstein-Barr virus glycoprotein B (gB) fusion activity by the gB cytoplasmic tail domain

artículo científico publicado en 2013

Multipronged attenuation of macrophage-colony stimulating factor signaling by Epstein-Barr virus BARF1

artículo científico publicado en 2012

Murine Corneal Inflammation and Nerve Damage After Infection With HSV-1 Are Promoted by HVEM and Ameliorated by Immune-Modifying Nanoparticle Therapy

artículo científico publicado en 2017

Mutational analyses of Epstein-Barr virus glycoprotein 42 reveal functional domains not involved in receptor binding but required for membrane fusion

artículo científico publicado en 2004

Mutational analysis of the HLA class II interaction with Epstein-Barr virus glycoprotein 42.

artículo científico publicado en 2003

Natural Selection of Glycoprotein B Mutations That Rescue the Small-Plaque Phenotype of a Fusion-Impaired Herpes Simplex Virus Mutant

article

Off-targeting oft-targeted CD20 in cHL

artículo científico publicado en 2012

Pre-B-cell colony formation assay

artículo científico publicado en 2005

Rapamycin Reverses Splenomegaly and Inhibits Tumor Development in a Transgenic Model of Epstein-Barr Virus–Related Burkitt's Lymphoma

artículo científico publicado el 31 de enero de 2011

Rational Targeting of Cellular Cholesterol in Diffuse Large B-Cell Lymphoma (DLBCL) Enabled by Functional Lipoprotein Nanoparticles: A Therapeutic Strategy Dependent on Cell of Origin

artículo científico publicado en 2017

Reevaluating Herpes Simplex Virus Hemifusion

artículo científico publicado el 15 de septiembre de 2010

Residues within the C-terminal arm of the herpes simplex virus 1 glycoprotein B ectodomain contribute to its refolding during the fusion step of virus entry

artículo científico publicado en 2012

Rewiring of B cell receptor signaling by Epstein-Barr virus LMP2A

artículo científico publicado en 2020

Signal transduction through the B cell antigen receptor is normal in ataxia-telangiectasia B lymphocytes

artículo científico publicado en 2001

Soluble Epstein-Barr virus glycoproteins gH, gL, and gp42 form a 1:1:1 stable complex that acts like soluble gp42 in B-cell fusion but not in epithelial cell fusion

artículo científico publicado en 2006

Spleen Tyrosine Kinase Inhibitor TAK-659 Prevents Splenomegaly and Tumor Development in a Murine Model of Epstein-Barr Virus-Associated Lymphoma

article

Structural and Mechanistic Insights into the Tropism of Epstein-Barr Virus

artículo científico publicado en 2016

Structural basis for Epstein-Barr virus host cell tropism mediated by gp42 and gHgL entry glycoproteins.

artículo científico publicado en 2016

Structure of Epstein-Barr Virus Glycoprotein 42 Suggests a Mechanism for Triggering Receptor-Activated Virus Entry

artículo científico publicado en 2009

Structure of a trimeric variant of the Epstein-Barr virus glycoprotein B

artículo científico publicado en 2009

Structure of the Epstein-Barr virus gp42 protein bound to the MHC class II receptor HLA-DR1

artículo científico publicado en 2002

Structure-Based Mutations in the Herpes Simplex Virus 1 Glycoprotein B Ectodomain Arm Impart a Slow-Entry Phenotype.

artículo científico publicado en 2017

Substitution of herpes simplex virus 1 entry glycoproteins with those of saimiriine herpesvirus 1 reveals a gD-gH/gL functional interaction and a region within the gD profusion domain that is critical for fusion

artículo científico publicado en 2014

Syk tyrosine kinase mediates Epstein-Barr virus latent membrane protein 2A-induced cell migration in epithelial cells

artículo científico publicado en 2006

The COMPLEXity in herpesvirus entry

artículo científico publicado en 2017

The Cytoplasmic Tail Domain of Epstein-Barr Virus gH Regulates Membrane Fusion Activity through Altering gH Binding to gp42 and Epithelial Cell Attachment

artículo científico publicado en 2016

The Epstein-Barr virus (EBV) glycoprotein B cytoplasmic C-terminal tail domain regulates the energy requirement for EBV-induced membrane fusion

artículo científico publicado en 2014

The Herpes Simplex Virus Neurovirulence Factor γ34.5: Revealing Virus-Host Interactions

artículo científico publicado en 2016

The Ig-like v-type domain of paired Ig-like type 2 receptor alpha is critical for herpes simplex virus type 1-mediated membrane fusion

artículo científico publicado en 2010

The Innate Immune Response to Herpes Simplex Virus 1 Infection Is Dampened in the Newborn Brain and Can Be Modulated by Exogenous Interferon Beta To Improve Survival

scientific article published on 26 May 2020

The KGD motif of Epstein-Barr virus gH/gL is bifunctional, orchestrating infection of B cells and epithelial cells

artículo científico publicado en 2012

The LMP2A signalosome--a therapeutic target for Epstein-Barr virus latency and associated disease

artículo científico publicado en 2002

The Type I Interferon Response Determines Differences in Choroid Plexus Susceptibility between Newborns and Adults in Herpes Simplex Virus Encephalitis

scientific article published on 12 April 2016

The Type I Interferon Response and Age-Dependent Susceptibility to Herpes Simplex Virus Infection

artículo científico publicado en 2017

The amino terminus of Epstein-Barr virus glycoprotein gH is important for fusion with epithelial and B cells

artículo científico publicado en 2005

The c-Cbl proto-oncoprotein downregulates EBV LMP2A signaling

scientific article published on 10 December 2008

The conserved disulfide bond within domain II of Epstein-Barr virus gH has divergent roles in membrane fusion with epithelial cells and B cells

artículo científico publicado en 2014

The fusion loops and membrane proximal region of Epstein-Barr virus glycoprotein B (gB) can function in the context of herpes simplex virus 1 gB when substituted individually but not in combination

artículo científico publicado en 2012

The large groove found in the gH/gL structure is an important functional domain for Epstein-Barr virus fusion

artículo científico publicado en 2013

The structural basis of herpesvirus entry

artículo científico publicado en 2020

Two Pathways of p27 Degradation Are Required for Murine Lymphoma Driven by Myc and EBV Latent Membrane Protein 2A

artículo científico publicado en 2019

Ubiquitinylation of Ig beta dictates the endocytic fate of the B cell antigen receptor

artículo científico publicado en 2007