Lista de obras -

A 60 kd cdc2-associated polypeptide complexes with the E1A proteins in adenovirus-infected cells

A mechanism for inhibiting the SUMO pathway

artículo científico publicado en 2004

Accumulation of long-chain fatty acids in the tumor microenvironment drives dysfunction in intrapancreatic CD8+ T cells

scientific article published on 01 August 2020

Allosteric SHP2 inhibitor IACS-13909 overcomes EGFR-dependent and EGFR-independent resistance mechanisms towards osimertinib

scientific article published on 14 September 2020

An inhibitor of oxidative phosphorylation exploits cancer vulnerability

artículo científico publicado en 2018

Apoptosis in T cell acute lymphoblastic leukemia cells after cell cycle arrest induced by pharmacological inhibition of notch signaling.

artículo científico publicado en 2007

Association of High-Intensity Exercise with Renal Medullary Carcinoma in Individuals with Sickle Cell Trait: Clinical Observations and Experimental Animal Studies

artículo científico publicado en 2021

Cancer drug discovery faces the FACT

scientific article published on 01 August 2011

Cdc25A phosphatase: combinatorial phosphorylation, ubiquitylation and proteolysis

artículo científico publicado en 2004

Characterization of the BUD31 gene of Saccharomyces cerevisiae

artículo científico publicado en 2004

Collapsing the Tumor Ecosystem: Preventing Adaptive Response to Treatment by Inhibiting Transcription.

artículo científico publicado en 2018

Commentary on "A new cancer diagnostic system based on a CDK profiling technology" [Biochim. Biophys. Acta Molecular Basis of Disease 1741 (2005) 226-233]

scientific article published on 01 September 2005

Critical questions in ovarian cancer research and treatment: Report of an American Association for Cancer Research Special Conference

article

Current and Future Horizons of Patient-Derived Xenograft Models in Colorectal Cancer Translational Research

scientific article published on 06 September 2019

Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage

artículo científico publicado en 2003

Development of novel cellular histone-binding and chromatin-displacement assays for bromodomain drug discovery

artículo científico publicado en 2015

Discovery of IACS-9439, a potent, exquisitely selective and orally bioavailable inhibitor of CSF1R

artículo científico publicado en 2020

Discovery of IPN60090, a Clinical Stage Selective Glutaminase-1 (GLS-1) Inhibitor with Excellent Pharmacokinetic and Physicochemical Properties

artículo científico publicado en 2020

Downregulation of Notch pathway by a gamma-secretase inhibitor attenuates AKT/mammalian target of rapamycin signaling and glucose uptake in an ERBB2 transgenic breast cancer model.

artículo científico publicado en 2010

Dual mode of degradation of Cdc25 A phosphatase

artículo científico publicado en 2002

EBP1 is a nucleolar growth-regulating protein that is part of pre-ribosomal ribonucleoprotein complexes

artículo científico publicado en 2004

EZH2 Modifies Sunitinib Resistance in Renal Cell Carcinoma by Kinome Reprogramming

artículo científico publicado en 2017

Ebp1 is a dsRNA-binding protein associated with ribosomes that modulates eIF2alpha phosphorylation.

artículo científico publicado en 2006

FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors

artículo científico publicado en 2007

Frequent alterations in the expression of serine/threonine kinases in human cancers

artículo científico publicado en 2006

Functional Genomics Reveals Synthetic Lethality between Phosphogluconate Dehydrogenase and Oxidative Phosphorylation

scientific article published on 01 January 2019

Future cancer research priorities in the USA: a Lancet Oncology Commission

artículo científico publicado en 2017

GE-38IDENTIFYING THE TREATMENT-RESISTANT MESENCHYMAL SIGNATURE BY COMPARATIVE ANALYSES BETWEEN GLIOMA SPHERE-FORMING CELLS AND THEIR GLIOBLASTOMAS OF ORIGIN

artículo científico publicado en 2014

GE-39VALIDATION OF GLIOMA SPHERE-FORMING CELLS AS MODELS OF GLIOBLASTOMA AND IDENTIFICATION OF NOVEL DRIVERS OF TUMORIGENESIS THROUGH COMPREHENSIVE GENOMIC CHARACTERIZATION.

artículo científico publicado en 2014

GENO-36GLIOMA SPHERE-FORMING CELLS REVEAL INTRINSIC GLOBAL HYPERMETHYLATION ASSOCIATED WITH GBM RADIATION RESISTANCE.

artículo científico publicado en 2015

Genetic events that limit the efficacy of MEK and RTK inhibitor therapies in a mouse model of KRAS-driven pancreatic cancer

artículo científico publicado en 2015

Genetics and biology of pancreatic ductal adenocarcinoma

artículo científico publicado en 2016

Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer

artículo científico publicado en 2017

Hierarchical order of phosphorylation events commits Cdc25A to betaTrCP-dependent degradation

artículo científico publicado en 2004

High-resolution clonal mapping of multi-organ metastasis in triple negative breast cancer

artículo científico publicado en 2018

Histone deacetylase 1 inactivation by an adenovirus early gene product.

artículo científico publicado en 2002

How Much Longer Will We Put Up With $100,000 Cancer Drugs?

artículo científico publicado en 2017

ILF2 Is a Regulator of RNA Splicing and DNA Damage Response in 1q21-Amplified Multiple Myeloma

artículo científico publicado en 2017

Identification of potent and selective MTH1 inhibitors

artículo científico publicado en 2016

In Vivo Genetic Screens of Patient-Derived Tumors Revealed Unexpected Frailty of the Transformed Phenotype.

artículo científico publicado en 2016

Inhibition of NOTCH signaling by gamma secretase inhibitor engages the RB pathway and elicits cell cycle exit in T-cell acute lymphoblastic leukemia cells.

artículo científico publicado en 2009

Lineage-coupled clonal capture identifies clonal evolution mechanisms and vulnerabilities of BRAFV600E inhibition resistance in melanoma

artículo científico publicado en 2022

Loss of ARID1A promotes epithelial-mesenchymal transition and sensitizes pancreatic tumors to proteotoxic stress

artículo científico publicado en 2020

Medium-Chain Acyl-CoA Dehydrogenase Protects Mitochondria from Lipid Peroxidation in Glioblastoma

artículo científico publicado en 2021

Met activation in non-small cell lung cancer is associated with de novo resistance to EGFR inhibitors and the development of brain metastasis

artículo científico publicado en 2010

Metabolic Features of Cancer Treatment Resistance

artículo científico publicado en 2016

Metabolic reprogramming toward oxidative phosphorylation identifies a therapeutic target for mantle cell lymphoma

scientific article published on 01 May 2019

Modulation of p120E4F transcriptional activity by the Gam1 adenoviral early protein ⬇️

artículo científico publicado el 1 de mayo de 2003

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

artículo científico publicado en 2014

Oncology drug discovery: planning a turnaround

artículo científico publicado en 2014

PDK1 attenuation fails to prevent tumor formation in PTEN-deficient transgenic mouse models.

artículo científico publicado en 2011

PRKCI promotes immune suppression in ovarian cancer

artículo científico publicado en 2017

PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma

artículo científico publicado en 2021

Pooled library screening with multiplexed Cpf1 library

artículo científico publicado en 2019

Post-translational Regulation of Cas9 during G1 Enhances Homology-Directed Repair

artículo científico publicado en 2016

Predictive Signatures Inform the Effective Repurposing of Decitabine to Treat KRAS-Dependent Pancreatic Ductal Adenocarcinoma

scientific article published on 05 September 2019

Redox-Mediated Suberoylanilide Hydroxamic Acid Sensitivity in Breast Cancer

artículo científico publicado en 2015

Regulating mammalian checkpoints through Cdc25 inactivation

artículo científico publicado en 2003

Role for histone deacetylase 1 in human tumor cell proliferation

artículo científico publicado en 2007

SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins

artículo científico publicado en 2007

Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor

artículo científico publicado en 2015

Sugar? No Thank You, Just a Deep Breath of Oxygen for Cancer Stem Cells

artículo científico publicado en 2015

Syndecan 1 is a critical mediator of macropinocytosis in pancreatic cancer

scientific article published on 27 March 2019

Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer.

artículo científico publicado en 2017

THE TREATMENT-RESISTANT MESENCHYMAL SIGNATURE IN GLIOBLASTOMA DERIVES FROM TUMOR CELLS INDEPENDENT OF STROMA.

artículo científico publicado en 2014

TMOD-04. A COMPREHENSIVE GENOMIC LANDSCAPE OF GLIOMA SPHEROID CULTURES RECAPITULATES THE HETEROGENEITY OF GLIOBLASTOMA AND IDENTIFIES DNA METHYLATION PREDICTORS OF RADIOTHERAPY RESPONSE

Targeting mitochondrial respiration and the BCL2 family in high-grade MYC-associated B-cell lymphoma

artículo científico publicado en 2021

The SMARCA2/4 ATPase Domain Surpasses the Bromodomain as a Drug Target in SWI/SNF-Mutant Cancers: Insights from cDNA Rescue and PFI-3 Inhibitor Studies

artículo científico publicado en 2015

The adenovirus protein Gam1 interferes with sumoylation of histone deacetylase 1.

artículo científico publicado en 2002

Transforming growth factor beta facilitates beta-TrCP-mediated degradation of Cdc25A in a Smad3-dependent manner

artículo científico publicado en 2005

YAP1 oncogene is a context-specific driver for pancreatic ductal adenocarcinoma

artículo científico publicado en 2019

Yap1 Activation Enables Bypass of Oncogenic Kras Addiction in Pancreatic Cancer

artículo científico publicado en 2019

Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer

artículo científico publicado en 2014

p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors

scientific article published on 01 February 2019

Lista de obras de

A 60 kd cdc2-associated polypeptide complexes with the E1A proteins in adenovirus-infected cells

A mechanism for inhibiting the SUMO pathway

Accumulation of long-chain fatty acids in the tumor microenvironment drives dysfunction in intrapancreatic CD8+ T cells

Allosteric SHP2 inhibitor IACS-13909 overcomes EGFR-dependent and EGFR-independent resistance mechanisms towards osimertinib

An inhibitor of oxidative phosphorylation exploits cancer vulnerability

Apoptosis in T cell acute lymphoblastic leukemia cells after cell cycle arrest induced by pharmacological inhibition of notch signaling.

Association of High-Intensity Exercise with Renal Medullary Carcinoma in Individuals with Sickle Cell Trait: Clinical Observations and Experimental Animal Studies

Cancer drug discovery faces the FACT

Cdc25A phosphatase: combinatorial phosphorylation, ubiquitylation and proteolysis

Characterization of the BUD31 gene of Saccharomyces cerevisiae

Collapsing the Tumor Ecosystem: Preventing Adaptive Response to Treatment by Inhibiting Transcription.

Commentary on "A new cancer diagnostic system based on a CDK profiling technology" [Biochim. Biophys. Acta Molecular Basis of Disease 1741 (2005) 226-233]

Critical questions in ovarian cancer research and treatment: Report of an American Association for Cancer Research Special Conference

Current and Future Horizons of Patient-Derived Xenograft Models in Colorectal Cancer Translational Research

Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage

Development of novel cellular histone-binding and chromatin-displacement assays for bromodomain drug discovery

Discovery of IACS-9439, a potent, exquisitely selective and orally bioavailable inhibitor of CSF1R

Discovery of IPN60090, a Clinical Stage Selective Glutaminase-1 (GLS-1) Inhibitor with Excellent Pharmacokinetic and Physicochemical Properties

Downregulation of Notch pathway by a gamma-secretase inhibitor attenuates AKT/mammalian target of rapamycin signaling and glucose uptake in an ERBB2 transgenic breast cancer model.

Dual mode of degradation of Cdc25 A phosphatase

EBP1 is a nucleolar growth-regulating protein that is part of pre-ribosomal ribonucleoprotein complexes

EZH2 Modifies Sunitinib Resistance in Renal Cell Carcinoma by Kinome Reprogramming

Ebp1 is a dsRNA-binding protein associated with ribosomes that modulates eIF2alpha phosphorylation.

FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors

Frequent alterations in the expression of serine/threonine kinases in human cancers

Functional Genomics Reveals Synthetic Lethality between Phosphogluconate Dehydrogenase and Oxidative Phosphorylation

Future cancer research priorities in the USA: a Lancet Oncology Commission

GE-38IDENTIFYING THE TREATMENT-RESISTANT MESENCHYMAL SIGNATURE BY COMPARATIVE ANALYSES BETWEEN GLIOMA SPHERE-FORMING CELLS AND THEIR GLIOBLASTOMAS OF ORIGIN

GE-39VALIDATION OF GLIOMA SPHERE-FORMING CELLS AS MODELS OF GLIOBLASTOMA AND IDENTIFICATION OF NOVEL DRIVERS OF TUMORIGENESIS THROUGH COMPREHENSIVE GENOMIC CHARACTERIZATION.

GENO-36GLIOMA SPHERE-FORMING CELLS REVEAL INTRINSIC GLOBAL HYPERMETHYLATION ASSOCIATED WITH GBM RADIATION RESISTANCE.

Genetic events that limit the efficacy of MEK and RTK inhibitor therapies in a mouse model of KRAS-driven pancreatic cancer

Genetics and biology of pancreatic ductal adenocarcinoma

Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer

Hierarchical order of phosphorylation events commits Cdc25A to betaTrCP-dependent degradation

High-resolution clonal mapping of multi-organ metastasis in triple negative breast cancer

Histone deacetylase 1 inactivation by an adenovirus early gene product.

How Much Longer Will We Put Up With $100,000 Cancer Drugs?

ILF2 Is a Regulator of RNA Splicing and DNA Damage Response in 1q21-Amplified Multiple Myeloma

Identification of potent and selective MTH1 inhibitors

In Vivo Genetic Screens of Patient-Derived Tumors Revealed Unexpected Frailty of the Transformed Phenotype.

Inhibition of NOTCH signaling by gamma secretase inhibitor engages the RB pathway and elicits cell cycle exit in T-cell acute lymphoblastic leukemia cells.

Lineage-coupled clonal capture identifies clonal evolution mechanisms and vulnerabilities of BRAFV600E inhibition resistance in melanoma

Loss of ARID1A promotes epithelial-mesenchymal transition and sensitizes pancreatic tumors to proteotoxic stress

Medium-Chain Acyl-CoA Dehydrogenase Protects Mitochondria from Lipid Peroxidation in Glioblastoma

Met activation in non-small cell lung cancer is associated with de novo resistance to EGFR inhibitors and the development of brain metastasis

Metabolic Features of Cancer Treatment Resistance

Metabolic reprogramming toward oxidative phosphorylation identifies a therapeutic target for mantle cell lymphoma

Modulation of p120E4F transcriptional activity by the Gam1 adenoviral early protein ⬇️

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

Oncology drug discovery: planning a turnaround

PDK1 attenuation fails to prevent tumor formation in PTEN-deficient transgenic mouse models.

PRKCI promotes immune suppression in ovarian cancer

PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma

Pooled library screening with multiplexed Cpf1 library

Post-translational Regulation of Cas9 during G1 Enhances Homology-Directed Repair

Predictive Signatures Inform the Effective Repurposing of Decitabine to Treat KRAS-Dependent Pancreatic Ductal Adenocarcinoma

Redox-Mediated Suberoylanilide Hydroxamic Acid Sensitivity in Breast Cancer

Regulating mammalian checkpoints through Cdc25 inactivation

Role for histone deacetylase 1 in human tumor cell proliferation

SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins

Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor

Sugar? No Thank You, Just a Deep Breath of Oxygen for Cancer Stem Cells

Syndecan 1 is a critical mediator of macropinocytosis in pancreatic cancer

Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer.

THE TREATMENT-RESISTANT MESENCHYMAL SIGNATURE IN GLIOBLASTOMA DERIVES FROM TUMOR CELLS INDEPENDENT OF STROMA.

TMOD-04. A COMPREHENSIVE GENOMIC LANDSCAPE OF GLIOMA SPHEROID CULTURES RECAPITULATES THE HETEROGENEITY OF GLIOBLASTOMA AND IDENTIFIES DNA METHYLATION PREDICTORS OF RADIOTHERAPY RESPONSE

Targeting mitochondrial respiration and the BCL2 family in high-grade MYC-associated B-cell lymphoma

The SMARCA2/4 ATPase Domain Surpasses the Bromodomain as a Drug Target in SWI/SNF-Mutant Cancers: Insights from cDNA Rescue and PFI-3 Inhibitor Studies

The adenovirus protein Gam1 interferes with sumoylation of histone deacetylase 1.

Transforming growth factor beta facilitates beta-TrCP-mediated degradation of Cdc25A in a Smad3-dependent manner

YAP1 oncogene is a context-specific driver for pancreatic ductal adenocarcinoma

Yap1 Activation Enables Bypass of Oncogenic Kras Addiction in Pancreatic Cancer

Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer

p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors