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AWZ1066S, a highly specific anti- drug candidate for a short-course treatment of filariasis

article published in the Proceedings of the National Academy of Sciences of the United States of America

Apparent activation energies of protein-protein complex dissociation in the gas-phase determined by electrospray mass spectrometry. ⬇️

artículo científico publicado en 2017

Boron-Pleuromutilins as Anti- Wolbachia Agents with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis

artículo científico publicado en 2019

Corallopyronin A for short-course anti-wolbachial, macrofilaricidal treatment of filarial infections

artículo científico publicado en 2020

Discovery of ABBV-4083, a novel analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity

scientific article published on 28 February 2019

Discovery of short-course antiwolbachial quinazolines for elimination of filarial worm infections

scientific article published on 01 May 2019

Filarial nematode phenotypic screening cascade to identify compounds with anti-parasitic activity for drug discovery optimization

artículo científico publicado en 2022

In vivo efficacy of the boron-pleuromutilin AN11251 against Wolbachia of the rodent filarial nematode Litomosoides sigmodontis

scientific article published on 27 January 2020

In vivo kinetics of Wolbachia depletion by ABBV-4083 in L. sigmodontis adult worms and microfilariae

artículo científico publicado en 2019

Macrofilaricidal efficacy of single and repeated oral and subcutaneous doses of flubendazole in Litomosoides sigmodontis infected jirds

artículo científico publicado en 2019

Preclinical development of an oral anti-Wolbachia macrolide drug for the treatment of lymphatic filariasis and onchocerciasis

artículo científico publicado en 2019

Short-course quinazoline drug treatments are effective in the Litomosoides sigmodontis and Brugia pahangi jird models

artículo científico publicado en 2019

Susceptibility to L. sigmodontis infection is highest in animals lacking IL-4R/IL-5 compared to single knockouts of IL-4R, IL-5 or eosinophils

scientific article published on 20 May 2019

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