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Apc deficiency predisposes to renal carcinoma in the mouse

Bcl-2 is a critical mediator of intestinal transformation

artículo científico publicado en 2016

Brca2 deficiency in the murine small intestine sensitizes to p53-dependent apoptosis and leads to the spontaneous deletion of stem cells

scientific journal article

Continuous clonal labeling reveals small numbers of functional stem cells in intestinal crypts and adenomas.

artículo científico publicado en 2013

Cyclin D1 is not an immediate target of beta-catenin following Apc loss in the intestine

artículo científico publicado en 2005

Defining stem cell dynamics in models of intestinal tumor initiation

artículo científico publicado en 2013

Epithelial Pten is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutation

artículo científico publicado en 2008

Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling.

artículo científico publicado en 2010

Heterogeneity in clone dynamics within and adjacent to intestinal tumours identified by Dre-mediated lineage tracing

artículo científico publicado en 2020

Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of beta-catenin

scientific journal article

Intestinal label-retaining cells are secretory precursors expressing Lgr5.

artículo científico publicado en 2013

Itraconazole targets cell cycle heterogeneity in colorectal cancer.

artículo científico publicado en 2018

Lkb1 deficiency alters goblet and paneth cell differentiation in the small intestine

artículo científico publicado en 2009

Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration

scientific journal article

PPARdelta status and Apc-mediated tumourigenesis in the mouse intestine

artículo científico publicado en 2004

Quantifying Microsatellite Mutation Rates from Intestinal Stem Cell Dynamics in Msh2-Deficient Murine Epithelium

artículo científico publicado en 2019