Lista de obras -

A Common Cancer Risk-Associated Allele in the hTERT Locus Encodes a Dominant Negative Inhibitor of Telomerase

artículo científico publicado en 2015

Abstract 5209: Efficacious targeting of TERT oncogene rearrangement with BET bromodomain inhibitor and proteasome inhibitor combination therapy

scholarly article

Age Adjusted Telomere Length Decreases Following Treatment for Pediatric Acute Lymphoblastic Leukemia, but Does Not Predict Toxicity ⬇️

scholarly article

Age-Adjusted Telomere Length May Predict Treatment-Related Mortality in Children Undergoing Hematopoietic Stem Cell Transplantation ⬇️

artículo científico publicado en 2015

Alternative Lengthening of Telomeres: DNA Repair Pathways Converge.

artículo científico publicado en 2017

Alternative lengthening of telomeres in normal mammalian somatic cells

artículo científico publicado en 2013

Alternative lengthening of telomeres: remodeling the telomere architecture

artículo científico publicado en 2013

Amplification of telomerase reverse transcriptase gene in human mammary epithelial cells with limiting telomerase RNA expression levels

artículo científico publicado en 2008

Anti-recombination function of MutSα restricts telomere extension by ALT-associated homology-directed repair

artículo científico publicado en 2021

Aurora Kinase B, a novel regulator of TERF1 binding and telomeric integrity

artículo científico publicado en 2017

Author Correction: The FANCM-BLM-TOP3A-RMI complex suppresses alternative lengthening of telomeres (ALT)

scientific article published on 20 November 2019

BLM and SLX4 play opposing roles in recombination-dependent replication at human telomeres.

artículo científico publicado en 2017

Comparative analysis of whole genome sequencing-based telomere length measurement techniques

artículo científico publicado en 2016

Control of telomere length by a trimming mechanism that involves generation of t-circles

scientific article published on 12 February 2009

Corrigendum: Whole-genome landscape of pancreatic neuroendocrine tumours

artículo científico publicado en 2017

DKC1 is a transcriptional target of GATA1 and drives upregulation of telomerase activity in normal human erythroblasts

artículo científico publicado en 2019

DNA C-circles are specific and quantifiable markers of alternative-lengthening-of-telomeres activity

artículo científico publicado en 2009

Dyskerin Is Upregulated During Erythroid Differentiation of Human Hematopoietic Progenitor Cells and Hyperactivates Telomerase in Erythroid Precursor Cells ⬇️

scholarly article

Efficient in vivo editing of OTC-deficient patient-derived primary human hepatocytes

scientific article published on 27 December 2019

Enhanced cardiac repair by telomerase reverse transcriptase over-expression in human cardiac mesenchymal stromal cells

scientific article published on 22 July 2019

Extensive Proliferation of Human Cancer Cells with Ever-Shorter Telomeres.

artículo científico publicado en 2017

Extreme telomere length dimorphism in the Tasmanian devil and related marsupials suggests parental control of telomere length

artículo científico publicado en 2012

FANCM suppresses DNA replication stress at ALT telomeres by disrupting TERRA R-loops

scientific article published on 13 December 2019

Folate deficiency induces dysfunctional long and short telomeres; both states are associated with hypomethylation and DNA damage in human WIL2-NS cells.

artículo científico publicado en 2013

Functional dissection of breast cancer risk-associated TERT promoter variants

artículo científico publicado en 2017

Functional polymorphisms in the TERT promoter are associated with risk of serious ovarian and breast cancer

Functional polymorphisms in the TERT promoter are associated with risk of serous epithelial ovarian and breast cancers

artículo científico publicado en 2011

Heritable defects in telomere and mitotic function selectively predispose to sarcomas

artículo científico publicado en 2023

Histone variant H3.3 provides the heterochromatic H3 lysine 9 tri-methylation mark at telomeres

artículo científico publicado en 2015

Human telomeres that contain (CTAGGG)n repeats show replication dependent instability in somatic cells and the male germline

artículo científico publicado en 2009

Inherited bone marrow failure associated with germline mutation of ACD, the gene encoding telomere protein TPP1.

artículo científico publicado en 2014

Loss-of-function variants in POT1 predispose to uveal melanoma

scientific article published on 09 September 2020

MYC-Driven Neuroblastomas Are Addicted to a Telomerase-Independent Function of Dyskerin.

artículo científico publicado en 2016

Mechanisms that drive telomere maintenance and recombination in human cancers

artículo científico publicado en 2020

Molecular characterization of inter-telomere and intra-telomere mutations in human ALT cells

artículo científico publicado en 2002

Molecular mechanisms of activity and derepression of alternative lengthening of telomeres

artículo científico publicado en 2015

Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

artículo científico publicado en 2013

Normal mammalian cells negatively regulate telomere length by telomere trimming ⬇️

artículo científico publicado el 8 de septiembre de 2011

NuRD-ZNF827 recruitment to telomeres creates a molecular scaffold for homologous recombination.

artículo científico publicado en 2014

Platelet Derived Growth Factor Receptor-Alpha expressing cardiac progenitor cells can be derived from previously cryopreserved human heart samples.

artículo científico publicado en 2017

Progerin impairs 3D genome organization and induces fragile telomeres by limiting the dNTP pools

artículo científico publicado en 2021

RTEL1 contributes to DNA replication and repair and telomere maintenance.

artículo científico publicado en 2012

Replication stress tolerance and management differs between naïve and primed pluripotent cells

Spontaneous occurrence of telomeric DNA damage response in the absence of chromosome fusions.

artículo científico publicado en 2009

Structural and functional characterization of the RBBP4-ZNF827 interaction and its role in NuRD recruitment to telomeres

scientific article published on 31 August 2018

Targeted therapy of <i>TERT</i>-rearranged neuroblastoma with BET bromodomain inhibitor and proteasome inhibitor combination therapy

artículo científico publicado en 2020

Telomerase activity is associated with an increase in DNA methylation at the proximal subtelomere and a reduction in telomeric transcription

artículo científico publicado en 2009

Telomerase promotes formation of a telomere protective complex in cancer cells

artículo científico publicado en 2019

Telomerase recruitment requires both TCAB1 and Cajal bodies independently

artículo científico publicado en 2012

Telomere Length Measurement by Molecular Combing

artículo científico publicado en 2020

Telomere Loop Dynamics in Chromosome End Protection

scientific article published on 19 July 2018

Telomere extension by telomerase and ALT generates variant repeats by mechanistically distinct processes

artículo científico publicado en 2013

Telomere sequence content can be used to determine ALT activity in tumours.

artículo científico publicado en 2018

The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation

artículo científico publicado en 2024

The FANCM-BLM-TOP3A-RMI complex suppresses alternative lengthening of telomeres (ALT)

scientific article published on 28 May 2019

The Medical Genome Reference Bank contains whole genome and phenotype data of 2570 healthy elderly

artículo científico publicado en 2020

The role of telomere trimming in normal telomere length dynamics

artículo científico

The transcriptional and functional properties of mouse epiblast stem cells resemble the anterior primitive streak.

artículo científico publicado en 2013

Variant repeats are interspersed throughout the telomeres and recruit nuclear receptors in ALT cells.

artículo científico publicado en 2012

Whole-genome landscape of pancreatic neuroendocrine tumours.

artículo científico publicado en 2017

Whole-genome landscapes of major melanoma subtypes.

artículo científico publicado en 2017

Lista de obras de

A Common Cancer Risk-Associated Allele in the hTERT Locus Encodes a Dominant Negative Inhibitor of Telomerase

Abstract 5209: Efficacious targeting of TERT oncogene rearrangement with BET bromodomain inhibitor and proteasome inhibitor combination therapy

Age Adjusted Telomere Length Decreases Following Treatment for Pediatric Acute Lymphoblastic Leukemia, but Does Not Predict Toxicity ⬇️

Age-Adjusted Telomere Length May Predict Treatment-Related Mortality in Children Undergoing Hematopoietic Stem Cell Transplantation ⬇️

Alternative Lengthening of Telomeres: DNA Repair Pathways Converge.

Alternative lengthening of telomeres in normal mammalian somatic cells

Alternative lengthening of telomeres: remodeling the telomere architecture

Amplification of telomerase reverse transcriptase gene in human mammary epithelial cells with limiting telomerase RNA expression levels

Anti-recombination function of MutSα restricts telomere extension by ALT-associated homology-directed repair

Aurora Kinase B, a novel regulator of TERF1 binding and telomeric integrity

Author Correction: The FANCM-BLM-TOP3A-RMI complex suppresses alternative lengthening of telomeres (ALT)

BLM and SLX4 play opposing roles in recombination-dependent replication at human telomeres.

Comparative analysis of whole genome sequencing-based telomere length measurement techniques

Control of telomere length by a trimming mechanism that involves generation of t-circles

Corrigendum: Whole-genome landscape of pancreatic neuroendocrine tumours

DKC1 is a transcriptional target of GATA1 and drives upregulation of telomerase activity in normal human erythroblasts

DNA C-circles are specific and quantifiable markers of alternative-lengthening-of-telomeres activity

Dyskerin Is Upregulated During Erythroid Differentiation of Human Hematopoietic Progenitor Cells and Hyperactivates Telomerase in Erythroid Precursor Cells ⬇️

Efficient in vivo editing of OTC-deficient patient-derived primary human hepatocytes

Enhanced cardiac repair by telomerase reverse transcriptase over-expression in human cardiac mesenchymal stromal cells

Extensive Proliferation of Human Cancer Cells with Ever-Shorter Telomeres.

Extreme telomere length dimorphism in the Tasmanian devil and related marsupials suggests parental control of telomere length

FANCM suppresses DNA replication stress at ALT telomeres by disrupting TERRA R-loops

Folate deficiency induces dysfunctional long and short telomeres; both states are associated with hypomethylation and DNA damage in human WIL2-NS cells.

Functional dissection of breast cancer risk-associated TERT promoter variants

Functional polymorphisms in the TERT promoter are associated with risk of serious ovarian and breast cancer

Functional polymorphisms in the TERT promoter are associated with risk of serous epithelial ovarian and breast cancers

Heritable defects in telomere and mitotic function selectively predispose to sarcomas

Histone variant H3.3 provides the heterochromatic H3 lysine 9 tri-methylation mark at telomeres

Human telomeres that contain (CTAGGG)n repeats show replication dependent instability in somatic cells and the male germline

Inherited bone marrow failure associated with germline mutation of ACD, the gene encoding telomere protein TPP1.

Loss-of-function variants in POT1 predispose to uveal melanoma

MYC-Driven Neuroblastomas Are Addicted to a Telomerase-Independent Function of Dyskerin.

Mechanisms that drive telomere maintenance and recombination in human cancers

Molecular characterization of inter-telomere and intra-telomere mutations in human ALT cells

Molecular mechanisms of activity and derepression of alternative lengthening of telomeres

Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

Normal mammalian cells negatively regulate telomere length by telomere trimming ⬇️

NuRD-ZNF827 recruitment to telomeres creates a molecular scaffold for homologous recombination.

Platelet Derived Growth Factor Receptor-Alpha expressing cardiac progenitor cells can be derived from previously cryopreserved human heart samples.

Progerin impairs 3D genome organization and induces fragile telomeres by limiting the dNTP pools

RTEL1 contributes to DNA replication and repair and telomere maintenance.

Replication stress tolerance and management differs between naïve and primed pluripotent cells

Spontaneous occurrence of telomeric DNA damage response in the absence of chromosome fusions.

Structural and functional characterization of the RBBP4-ZNF827 interaction and its role in NuRD recruitment to telomeres

Targeted therapy of <i>TERT</i>-rearranged neuroblastoma with BET bromodomain inhibitor and proteasome inhibitor combination therapy

Telomerase activity is associated with an increase in DNA methylation at the proximal subtelomere and a reduction in telomeric transcription

Telomerase promotes formation of a telomere protective complex in cancer cells

Telomerase recruitment requires both TCAB1 and Cajal bodies independently

Telomere Length Measurement by Molecular Combing

Telomere Loop Dynamics in Chromosome End Protection

Telomere extension by telomerase and ALT generates variant repeats by mechanistically distinct processes

Telomere sequence content can be used to determine ALT activity in tumours.

The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation

The FANCM-BLM-TOP3A-RMI complex suppresses alternative lengthening of telomeres (ALT)

The Medical Genome Reference Bank contains whole genome and phenotype data of 2570 healthy elderly

The role of telomere trimming in normal telomere length dynamics

The transcriptional and functional properties of mouse epiblast stem cells resemble the anterior primitive streak.

Variant repeats are interspersed throughout the telomeres and recruit nuclear receptors in ALT cells.

Whole-genome landscape of pancreatic neuroendocrine tumours.

Whole-genome landscapes of major melanoma subtypes.