Lista de obras -

A novel and potent brain penetrant inhibitor of extracellular vesicle release

artículo científico publicado en 2019

Bioanalysis of 6-diazo-5-oxo-l-norleucine in plasma and brain by ultra-performance liquid chromatography mass spectrometry

artículo científico publicado en 2015

Cambinol, a novel inhibitor of neutral sphingomyelinase 2 shows neuroprotective properties

artículo científico publicado en 2015

Correction: JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress.

artículo científico publicado en 2019

D-Amino acid oxidase inhibitors based on the 5-hydroxy-1,2,4-triazin-6(1H)-one scaffold.

artículo científico publicado en 2016

DPTIP, a newly identified potent brain penetrant neutral sphingomyelinase 2 inhibitor, regulates astrocyte-peripheral immune communication following brain inflammation

scientific article published in Scientific Reports

Design, synthesis, and pharmacological evaluation of bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide 3 (BPTES) analogs as glutaminase inhibitors.

artículo científico publicado en 2012

Design, synthesis, and pharmacological evaluation of fluorinated tetrahydrouridine derivatives as inhibitors of cytidine deaminase

artículo científico publicado en 2014

Development of a High-Throughput Fluorescence Polarization Assay to Identify Novel Ligands of Glutamate Carboxypeptidase II ⬇️

artículo científico publicado el 29 de junio de 2012

Development of a high-throughput method for the determination of pharmacological levels of plasma D-serine.

artículo científico publicado en 2011

Development of a primary microglia screening assay and its use to characterize inhibition of system xc- by erastin and its analogs

artículo científico publicado en 2017

Discovery of 6-Diazo-5-oxo-l-norleucine (DON) Prodrugs with Enhanced CSF Delivery in Monkeys: A Potential Treatment for Glioblastoma

artículo científico publicado en 2016

Enhanced Brain Delivery of 2-(Phosphonomethyl)pentanedioic Acid Following Intranasal Administration of Its γ-Substituted Ester Prodrugs

artículo científico publicado en 2017

Glutamate carboxypeptidase II is not an amyloid peptide‐degrading enzyme ⬇️

artículo científico publicado el 23 de marzo de 2013

Inhibition of glutamate carboxypeptidase II (GCPII) activity as a treatment for cognitive impairment in multiple sclerosis

artículo científico publicado en 2012

JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress

scientific article published on 13 August 2018

Mutant disrupted-in-schizophrenia 1 in astrocytes: focus on glutamate metabolism

artículo científico publicado en 2014

Neurological sequelae induced by alphavirus infection of the CNS are attenuated by treatment with the glutamine antagonist 6-diazo-5-oxo-l-norleucine

artículo científico publicado en 2015

Oral administration of D-alanine in monkeys robustly increases plasma and cerebrospinal fluid levels but experimental D-amino acid oxidase inhibitors had minimal effect

artículo científico publicado en 2016

Palonosetron exhibits unique molecular interactions with the 5-HT3 receptor

artículo científico publicado en 2008

Palonosetron triggers 5-HT(3) receptor internalization and causes prolonged inhibition of receptor function

artículo científico publicado en 2009

Peptidomimetics of Arg-Phe-NH2 as small molecule agonists of Mas-related gene C (MrgC) receptors.

artículo científico publicado en 2014

Protection against glucose-induced neuronal death by NAAG and GCP II inhibition is regulated by mGluR3

artículo científico publicado en 2004

Reversible Disulfide Formation of the Glutamate Carboxypeptidase II Inhibitor E2072 Results in Prolonged Systemic Exposures In Vivo ⬇️

artículo científico publicado el 4 de septiembre de 2012

Selective CNS Uptake of the GCP-II Inhibitor 2-PMPA following Intranasal Administration

artículo científico publicado en 2015

Synthesis and SAR of 1-hydroxy-1H-benzo[d]imidazol-2(3H)-ones as Inhibitors of D-Amino Acid Oxidase.

artículo científico publicado en 2012

Synthesis of kojic acid derivatives as secondary binding site probes of D-amino acid oxidase

artículo científico publicado en 2013

Targeting the Glutamatergic System for the Treatment of HIV-Associated Neurocognitive Disorders ⬇️

artículo científico publicado el 4 de abril de 2013

The Antiemetic 5-HT3 Receptor Antagonist Palonosetron Inhibits Substance P-Mediated Responses In Vitro and In Vivo ⬇️

artículo científico publicado el 19 de agosto de 2010

The Low-Affinity Binding of Second Generation Radiotracers Targeting TSPO is Associated with a Unique Allosteric Binding Site.

artículo científico publicado en 2017

δ-Thiolactones as prodrugs of thiol-based glutamate carboxypeptidase II (GCPII) inhibitors

artículo científico publicado en 2013

Lista de obras de

A novel and potent brain penetrant inhibitor of extracellular vesicle release

Bioanalysis of 6-diazo-5-oxo-l-norleucine in plasma and brain by ultra-performance liquid chromatography mass spectrometry

Cambinol, a novel inhibitor of neutral sphingomyelinase 2 shows neuroprotective properties

Correction: JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress.

D-Amino acid oxidase inhibitors based on the 5-hydroxy-1,2,4-triazin-6(1H)-one scaffold.

DPTIP, a newly identified potent brain penetrant neutral sphingomyelinase 2 inhibitor, regulates astrocyte-peripheral immune communication following brain inflammation

Design, synthesis, and pharmacological evaluation of bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide 3 (BPTES) analogs as glutaminase inhibitors.

Design, synthesis, and pharmacological evaluation of fluorinated tetrahydrouridine derivatives as inhibitors of cytidine deaminase

Development of a High-Throughput Fluorescence Polarization Assay to Identify Novel Ligands of Glutamate Carboxypeptidase II ⬇️

Development of a high-throughput method for the determination of pharmacological levels of plasma D-serine.

Development of a primary microglia screening assay and its use to characterize inhibition of system xc- by erastin and its analogs

Discovery of 6-Diazo-5-oxo-l-norleucine (DON) Prodrugs with Enhanced CSF Delivery in Monkeys: A Potential Treatment for Glioblastoma

Enhanced Brain Delivery of 2-(Phosphonomethyl)pentanedioic Acid Following Intranasal Administration of Its γ-Substituted Ester Prodrugs

Glutamate carboxypeptidase II is not an amyloid peptide‐degrading enzyme ⬇️

Inhibition of glutamate carboxypeptidase II (GCPII) activity as a treatment for cognitive impairment in multiple sclerosis

JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress

Mutant disrupted-in-schizophrenia 1 in astrocytes: focus on glutamate metabolism

Neurological sequelae induced by alphavirus infection of the CNS are attenuated by treatment with the glutamine antagonist 6-diazo-5-oxo-l-norleucine

Oral administration of D-alanine in monkeys robustly increases plasma and cerebrospinal fluid levels but experimental D-amino acid oxidase inhibitors had minimal effect

Palonosetron exhibits unique molecular interactions with the 5-HT3 receptor

Palonosetron triggers 5-HT(3) receptor internalization and causes prolonged inhibition of receptor function

Peptidomimetics of Arg-Phe-NH2 as small molecule agonists of Mas-related gene C (MrgC) receptors.

Protection against glucose-induced neuronal death by NAAG and GCP II inhibition is regulated by mGluR3

Reversible Disulfide Formation of the Glutamate Carboxypeptidase II Inhibitor E2072 Results in Prolonged Systemic Exposures In Vivo ⬇️

Selective CNS Uptake of the GCP-II Inhibitor 2-PMPA following Intranasal Administration

Synthesis and SAR of 1-hydroxy-1H-benzo[d]imidazol-2(3H)-ones as Inhibitors of D-Amino Acid Oxidase.

Synthesis of kojic acid derivatives as secondary binding site probes of D-amino acid oxidase

Targeting the Glutamatergic System for the Treatment of HIV-Associated Neurocognitive Disorders ⬇️

The Antiemetic 5-HT3 Receptor Antagonist Palonosetron Inhibits Substance P-Mediated Responses In Vitro and In Vivo ⬇️

The Low-Affinity Binding of Second Generation Radiotracers Targeting TSPO is Associated with a Unique Allosteric Binding Site.

δ-Thiolactones as prodrugs of thiol-based glutamate carboxypeptidase II (GCPII) inhibitors