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A Novel Somatostatin-Dopamine Chimera (BIM23B065) Reduced Growth Hormone Secretion In A First-in-human Clinical Trial

scientific article published on 01 March 2019

A Novel Tumor-Specific Agent for Intraoperative Near-Infrared Fluorescence Imaging: A Translational Study in Healthy Volunteers and Patients with Ovarian Cancer.

artículo científico publicado en 2016

A PK-PD model-based assessment of sugammadex effects on coagulation parameters

artículo científico publicado en 2015

A Simplified Oral Flucloxacillin Absorption Test for Patients Requiring Long-Term Treatment ⬇️

artículo científico publicado el 1 de junio de 2012

A novel maturation function for clearance of the cytochrome P450 3A substrate midazolam from preterm neonates to adults

artículo científico publicado en 2013

A novel sustained‐release cysteamine bitartrate formulation for the treatment of cystinosis: Pharmacokinetics and safety in healthy male volunteers

artículo científico publicado en 2021

A phase I dose-escalation and bioequivalence study of a trastuzumab biosimilar in healthy male volunteers

artículo científico publicado en 2014

A phase I study of recombinant human C1 inhibitor in asymptomatic patients with hereditary angioedema

artículo científico publicado en 2005

A phase I, single and fractionated, ascending-dose study evaluating the safety, pharmacokinetics, pharmacodynamics, and immunogenicity of an erythropoietin mimetic antibody fusion protein (CNTO 528) in healthy male subjects

artículo científico publicado en 2008

A randomized controlled proof-of-concept trial of digoxin and furosemide in adults with cutaneous warts

artículo científico publicado en 2019

A randomized controlled trial with a delayed-type hypersensitivity model using keyhole limpet haemocyanin to evaluate adaptive immune responses in man

scientific article published on 06 October 2020

A two-step deconvolution-analysis-informed population pharmacodynamic modeling approach for drugs targeting pulsatile endogenous compounds

artículo científico publicado en 2017

A zwitterionic near-infrared fluorophore for real-time ureter identification during laparoscopic abdominopelvic surgery

scientific article published on 16 July 2019

Abdominal visceral and subcutaneous fat increase, insulin resistance and hyperlipidemia in testicular cancer patients treated with cisplatin-based chemotherapy

artículo científico publicado en 2013

Absence of interaction of fondaparinux sodium with aspirin and piroxicam in healthy male volunteers

artículo científico publicado en 2002

Absence of tolerance and toxicity to high-dose continuous intravenous furosemide in haemodynamically unstable infants after cardiac surgery

artículo científico publicado en 2007

Acute kidney injury during therapy with an antisense oligonucleotide directed against PCSK9.

artículo científico publicado en 2013

Additive effect of erythropoietin use on exercise-induced endothelial activation and hypercoagulability in athletes

artículo científico publicado en 2020

Adverse immunostimulation caused by impurities: The dark side of biopharmaceuticals

artículo científico publicado en 2019

An exploratory study with an adaptive continuous intravenous furosemide regimen in neonates treated with extracorporeal membrane oxygenation

artículo científico publicado en 2007

Antisense-mediated reduction of proprotein convertase subtilisin/kexin type 9 (PCSK9): a first-in-human randomized, placebo-controlled trial

artículo científico publicado en 2015

Assessment of Dermal Absorption of Aluminum from a Representative Antiperspirant Formulation Using a 26 Al Microtracer Approach

scientific article published on 27 July 2018

Autonomic nervous system activity in diabetic and healthy obese female subjects and the effect of distinct weight loss strategies.

artículo científico publicado en 2013

Autonomic nervous system function in chronic exogenous subclinical thyrotoxicosis and the effect of restoring euthyroidism

artículo científico publicado en 2008

Blood pressure-related electrocardiographic findings in healthy young individuals

scientific article published on 12 November 2019

Blunted lipolytic response to fasting in abdominally obese women: evidence for involvement of hyposomatotropism.

artículo científico publicado en 2003

Cardiac age detected by machine learning applied to the surface ECG of healthy subjects: Creation of a benchmark

artículo científico publicado en 2022

Characterization of immune cell, endothelial, and renal responses upon experimental human endotoxemia

artículo científico publicado en 2017

Characterization of inflammation and immune cell modulation induced by low-dose LPS administration to healthy volunteers

Clinical Evaluation of Humira® Biosimilar ONS-3010 in Healthy Volunteers: Focus on Pharmacokinetics and Pharmacodynamics

artículo científico publicado en 2016

Clinically important interaction between tedisamil and verapamil

artículo científico publicado en 2009

Colistin methanesulfonate infusion solutions are stable over time and suitable for home administration

artículo científico publicado en 2017

Comparative effects of a contraceptive vaginal ring delivering a nonandrogenic progestin and continuous ethinyl estradiol and a combined oral contraceptive containing levonorgestrel on hemostasis variables

artículo científico publicado en 2006

Comparison of body surface area versus weight-based growth hormone dosing for girls with Turner syndrome

artículo científico publicado en 2014

Comparison of the impact of vaginal and oral administration of combined hormonal contraceptives on hepatic proteins sensitive to estrogen

artículo científico publicado en 2007

Comprehensive evaluation of microneedle-based intradermal adalimumab delivery versus subcutaneous administration: results of a randomized controlled trial

scientific article published on 05 January 2021

Comprehensive, Multimodal Characterization of an Imiquimod-Induced Human Skin Inflammation Model for Drug Development

artículo científico publicado en 2018

Creating a culture of thoughtful prescribing

artículo científico publicado en 2009

Detection of colorectal polyps in humans using an intravenously administered fluorescent peptide targeted against c-Met

artículo científico publicado en 2015

Development of an optimal furosemide infusion strategy in infants with modeling and simulation

artículo científico publicado en 2002

Discriminant analysis of the metabolic effects of a new combined contraceptive vaginal ring containing Nestorone/EE vs. a second-generation oral contraceptive containing levonorgestrel/EE ⬇️

artículo científico publicado el 23 de marzo de 2012

Diuretics in pediatrics : current knowledge and future prospects

artículo científico publicado en 2006

Dose escalations in phase I studies: Feasibility of interpreting blinded pharmacodynamic data

artículo científico publicado en 2022

Dose-Finding Study of a CEA-Targeting Agent, SGM-101, for Intraoperative Fluorescence Imaging of Colorectal Cancer

artículo científico publicado en 2020

Effect of Food on the Pharmacokinetics of 2 Formulations of DRL-17822, a Novel Selective Cholesteryl Ester Transfer Protein (CETP) Inhibitor, in Healthy Males

artículo científico publicado en 2019

Effect of an NK1/NK2 receptor antagonist on airway responses and inflammation to allergen in asthma

artículo científico publicado en 2007

Effect of garlic powder on C-reactive protein and plasma lipids in overweight and smoking subjects

scientific article published on 01 December 2006

Effect of short-term fasting on electrocardiographic parameters

scientific article published on 01 April 2019

Effects of a nonpeptide motilin receptor antagonist on proximal gastric motor function

artículo científico publicado en 2004

Effects of erythropoietin on cycling performance of well trained cyclists: a double-blind, randomised, placebo-controlled trial.

artículo científico publicado en 2017

Effects of sugammadex on activated partial thromboplastin time and prothrombin time in healthy subjects.

artículo científico publicado en 2014

Efficacy and safety of RPL554, a dual PDE3 and PDE4 inhibitor, in healthy volunteers and in patients with asthma or chronic obstructive pulmonary disease: findings from four clinical trials

artículo científico publicado en 2013

Endothelial binding of recombinant tissue plasminogen activator: quantification in vivo using a recirculatory model

artículo científico publicado en 2003

Erythropoietin doping in cycling: lack of evidence for efficacy and a negative risk-benefit

artículo científico publicado en 2013

Evaluation of a bedside device to assess the activated partial thromboplastin time for heparin monitoring in infants.

artículo científico publicado en 2013

Evaluation of furosemide regimens in neonates treated with extracorporeal membrane oxygenation

artículo científico publicado en 2006

Evaluation of lecithinized human recombinant super oxide dismutase as cardioprotectant in anthracycline-treated breast cancer patients

artículo científico publicado en 2014

Evaluation of metabolite profiles as biomarkers for the pharmacological effects of thiazolidinediones in Type 2 diabetes mellitus patients and healthy volunteers

artículo científico publicado en 2007

First Clinical Study with AP30663 - a KCa 2 Channel Inhibitor in Development for Conversion of Atrial Fibrillation

artículo científico publicado en 2020

First proof of pharmacology in humans of a novel glucagon receptor antisense drug

artículo científico publicado en 2014

First-in-Human Assessment of cRGD-ZW800-1, a Zwitterionic, Integrin-Targeted, Near-Infrared Fluorescent Peptide in Colon Carcinoma

artículo científico publicado en 2020

First-in-human administration of a live-attenuated RSV vaccine lacking the G-protein assessing safety, tolerability, shedding and immunogenicity: a randomized controlled trial

scientific article published on 25 July 2020

Fluorescence-guided tumor detection with a novel anti-EpCAM targeted antibody fragment: Preclinical validation

scientific article published on 23 October 2018

Folate receptor-α targeted near-infrared fluorescence imaging in high-risk endometrial cancer patients: a tissue microarray and clinical feasibility study

artículo científico publicado en 2017

Fosfomycin as a potential therapy for the treatment of systemic infections: a population pharmacokinetic model to simulate multiple dosing regimens

artículo científico publicado en 2018

Fosfomycin: Pharmacological, Clinical and Future Perspectives.

artículo científico publicado en 2017

Gender differences in clinical registration trials; is there a real problem?

artículo científico publicado en 2018

Growth hormone blunts protein oxidation and promotes protein turnover to a similar extent in abdominally obese and normal-weight women

artículo científico publicado en 2002

High circulating thyrotropin levels in obese women are reduced after body weight loss induced by caloric restriction

artículo científico publicado en 2005

How are growth hormone and insulin-like growth factor-1 reported as markers for drug effectiveness in clinical acromegaly research? A comprehensive methodologic review.

artículo científico publicado en 2018

Hurdles in modern trial management: as overbureaucracy and commercialization of clinical trials suffocate independent academic research, it's time for a change

scientific article published on 23 June 2009

Hydrolyzed Casein Decreases Postprandial Glucose Concentrations in T2DM Patients Irrespective of Leucine Content ⬇️

artículo científico publicado el 26 de julio de 2011

Hyposomatotropism blunts lipolysis in abdominally obese women

artículo científico publicado en 2002

IMO-8400, a toll-like receptor 7, 8, and 9 antagonist, demonstrates clinical activity in a phase 2a, randomized, placebo-controlled trial in patients with moderate-to-severe plaque psoriasis

artículo científico publicado en 2016

Identifying 24 h variation in the pharmacokinetics of levofloxacin: a population pharmacokinetic approach

artículo científico publicado en 2015

Image-Guided Surgery in Patients with Pancreatic Cancer: First Results of a Clinical Trial Using SGM-101, a Novel Carcinoembryonic Antigen-Targeting, Near-Infrared Fluorescent Agent

scientific article published on 26 July 2018

Immunomonitoring of Tacrolimus in Healthy Volunteers: The First Step from PK- to PD-Based Therapeutic Drug Monitoring?

artículo científico publicado en 2019

In Search for Optimal Targets for Intraoperative Fluorescence Imaging of Peritoneal Metastasis From Colorectal Cancer.

artículo científico publicado en 2017

Increased circadian prolactin release is blunted after body weight loss in obese premenopausal women.

artículo científico publicado en 2005

Increased impact of a contraceptive vaginal ring with ethinyl estradiol and nestorone on C-reactive protein

artículo científico publicado en 2012

Injection site reactions after subcutaneous oligonucleotide therapy

artículo científico publicado en 2016

Inter- and Intra-patient Variability Over Time of Lesional Skin Microbiota in Adult Patients with Atopic Dermatitis

artículo científico publicado en 2020

Intraoperative detection of colorectal and pancreatic liver metastases using SGM-101, a fluorescent antibody targeting CEA

artículo científico publicado en 2020

Intraoperative imaging of folate receptor alpha positive ovarian and breast cancer using the tumor specific agent EC17

artículo científico publicado en 2016

Introduction to haemostasis from a pharmacodynamic perspective ⬇️

artículo científico publicado el 1 de octubre de 2011

Lack of a clinically relevant effect of sugammadex on anti-Xa activity or activated partial thromboplastin time following pretreatment with either unfractionated or low-molecular-weight heparin in healthy subjects

artículo científico publicado en 2014

Local tissue factor pathway inhibitor release in the human forearm

scientific article published on 01 March 2003

Measurement of collagen- and serotonin-induced platelet aggregation in whole blood

artículo científico publicado en 2010

Metabolic profile of a continuous versus a cyclic low-dose combined oral contraceptive after one year of use ⬇️

artículo científico publicado el 1 de abril de 2011

Midazolam pharmacokinetics in morbidly obese patients following semi-simultaneous oral and intravenous administration: a comparison with healthy volunteers

artículo científico publicado en 2014

Model informed quantification of the feed-forward stimulation of growth hormone by growth hormone-releasing hormone

artículo científico publicado en 2020

Modeling the influence of growth hormone on lipolysis.

artículo científico publicado en 2002

Modulation of Vasoactivity and Platelet Aggregation by Selective 5-HT Receptor Antagonism in Humans ⬇️

artículo científico publicado el 1 de diciembre de 2011

Motilin effects on the proximal stomach in patients with functional dyspepsia and healthy volunteers

artículo científico publicado en 2003

Multi-parameter comparison of a standardized mixed meal tolerance test in healthy and type 2 diabetic subjects: the PhenFlex challenge

artículo científico publicado en 2017

Near-infrared fluorescence imaging compared to standard sentinel lymph node detection with blue dye in patients with vulvar cancer - a randomized controlled trial

artículo científico publicado en 2020

No clinically relevant interaction between sugammadex and aspirin on platelet aggregation and coagulation parameters

artículo científico

Novel SGLT2 inhibitor: first-in-man studies of antisense compound is associated with unexpected renal effects.

artículo científico publicado en 2017

Omiganan Enhances Imiquimod-Induced Inflammatory Responses in Skin of Healthy Volunteers

scientific article published on 10 February 2020

PK/PD modeling of 5-hydroxytryptophan (5-HTP) challenge test with cortisol measurement in serum and saliva

artículo científico publicado en 2020

Pharmacodynamic effects of topical omiganan in patients with mild to moderate atopic dermatitis in a randomized placebo-controlled phase II trial

artículo científico publicado en 2020

Pharmacokinetics and central nervous system effects of the novel dopamine D2 receptor antagonist JNJ-37822681 ⬇️

artículo científico publicado el 2 de septiembre de 2011

Pharmacokinetics and pharmacodynamics of the erythropoietin Mimetibody construct CNTO 528 in healthy subjects

artículo científico publicado en 2009

Pharmacokinetics of PC-SOD, a lecithinized recombinant superoxide dismutase, after single- and multiple-dose administration to healthy Japanese and Caucasian volunteers

artículo científico publicado en 2007

Pharmacokinetics of fosfomycin in patients with prophylactic treatment for recurrent Escherichia coli urinary tract infection

artículo científico publicado en 2020

Pharmacokinetics of oral fumarates in healthy subjects.

artículo científico publicado en 2004

Physiological thyroid hormone levels regulate numerous skeletal muscle transcripts.

artículo científico publicado en 2009

Potential Influence of Endothelial Adsorption on the Delayed Time to Maximum Concentration of Biopharmaceuticals

artículo científico publicado en 2017

Prevalent levels of RSV serum neutralizing antibodies in healthy adults outside the RSV-season

scientific article published on 20 December 2019

Proof of Pharmacology of Org 48775-0, a p38 MAP kinase inhibitor, in Healthy Volunteers

artículo científico publicado en 2020

Quantification of heparin-induced TFPI release: a maximum release at low heparin dose

artículo científico publicado en 2002

Quantification of the endogenous growth hormone and prolactin lowering effects of a somatostatin-dopamine chimera using population PK/PD modeling

scientific article published on 04 April 2020

Real-time near-infrared fluorescence imaging using cRGD-ZW800-1 for intraoperative visualization of multiple cancer types

artículo científico publicado en 2017

Recombinant human erythropoietin does not affect several microvascular parameters in well-trained cyclists

artículo científico publicado en 2018

Recombinant human pentraxin-2 therapy in patients with idiopathic pulmonary fibrosis: safety, pharmacokinetics and exploratory efficacy.

artículo científico publicado en 2016

Relationship between airway responsiveness to neurokinin A and methacholine in asthma.

artículo científico publicado en 2005

Remarkable Pharmacokinetics of Monoclonal Antibodies: A Quest for an Explanation

artículo científico publicado en 2016

Renal Effects of Antisense-Mediated Inhibition of SGLT2.

artículo científico publicado en 2016

Reproducibility of biomarkers in induced sputum and in serum from chronic smokers

artículo científico publicado en 2015

Results of phase 2 trials exploring the safety and efficacy of omiganan in patients with human papillomavirus-induced genital lesions

scientific article published on 22 November 2019

Safety and effectiveness of SGM-101, a fluorescent antibody targeting carcinoembryonic antigen, for intraoperative detection of colorectal cancer: a dose-escalation pilot study

artículo científico publicado en 2018

Sensitivity and specificity of detection methods for erythropoietin doping in cyclists

artículo científico publicado en 2019

Setting Standards for Reporting and Quantification in Fluorescence-Guided Surgery

artículo científico publicado en 2019

Short-term overt hypothyroidism induces sympathovagal imbalance in thyroidectomized differentiated thyroid carcinoma patients.

artículo científico publicado en 2009

Sputum RNA signature in allergic asthmatics following allergen bronchoprovocation test

artículo científico publicado en 2016

Stimulation programs for pediatric drug research--do children really benefit?

artículo científico publicado en 2007

Synergy of therapeutic vaccination against HPV16 oncogenic proteins and standard chemotherapeutics.

artículo científico publicado en 2014

Tasquinimod: a novel drug in advanced prostate cancer

artículo científico publicado en 2013

The Effect of a 13-Valent Conjugate Pneumococcal Vaccine on Circulating Antibodies Against Oxidized LDL and Phosphorylcholine in Man, A Randomized Placebo-Controlled Clinical Trial

scientific article published on 22 October 2020

The Oral Pheneticillin Absorption Test: An Accurate Method to Identify Patients with Inadequate Oral Pheneticillin Absorption

artículo científico publicado en 2019

The Pharmacodynamic Effects of a Dopamine-Somatostatin Chimera Agonist on the Cardiovascular System

artículo científico publicado en 2019

The association between body temperature and electrocardiographic parameters in normothermic healthy volunteers

scientific article published on 12 November 2020

The effect of food and formulation on the population pharmacokinetics of CETP inhibitor DRL-17822 in healthy male volunteers

scientific article published on 06 April 2020

The effect of repeated methotrexate injections on the quality of life of children with rheumatic diseases

scientific article published on 17 November 2018

The mode of action of sugammadex on coagulation

artículo científico publicado en 2020

The need for improvement of the treatment of advanced and metastatic cervical cancer, the rationale for combined chemo-immunotherapy

artículo científico

The optimal imaging window for dysplastic colorectal polyp detection using c-Met targeted fluorescence molecular endoscopy

artículo científico publicado en 2020

The synthetic pentasaccharide fondaparinux sodium does not interact with oral warfarin

artículo científico publicado en 2002

Topical anti-microbial peptide omiganan recovers cutaneous dysbiosis but does not improve clinical symptoms in patients with mild-to-moderate atopic dermatitis in a phase 2 randomized controlled trial

scientific article published on 30 September 2020

Trastuzumab Induces an Immediate, Transient Volume Increase in Humans: A Randomised Placebo-Controlled Trial

artículo científico publicado en 2015

Type 2 iodothyronine deiodinase in skeletal muscle: effects of hypothyroidism and fasting.

artículo científico publicado en 2009

Under-representation of elderly in clinical trials: An analysis of the initial approval documents in the Food and Drug Administration database

artículo científico publicado en 2019

Unfavorable metabolic changes are accompanied by impaired myocardial function shortly after chemotherapy.

artículo científico publicado en 2013

Urinary kidney biomarkers for early detection of nephrotoxicity in clinical drug development

artículo científico publicado en 2014

Vaccination during myeloid cell depletion by cancer chemotherapy fosters robust T cell responses

artículo científico publicado en 2016

Whole blood assay as a model for in vitro evaluation of inflammasome activation and subsequent caspase-mediated interleukin-1 beta release

artículo científico publicado en 2019

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