Lista de obras -

5-imino-1,2,4-thiadiazoles: first small molecules as substrate competitive inhibitors of glycogen synthase kinase 3.

artículo científico publicado en 2012

Chameleon-like behavior of indolylpiperidines in complex with cholinesterases targets: Potent butyrylcholinesterase inhibitors

artículo científico publicado en 2018

Computer-aided molecular design of pyrazolotriazines targeting glycogen synthase kinase 3

artículo científico publicado en 2019

Cyclic Nucleotide-Specific Phosphodiesterases as Potential Drug Targets for Anti-Leishmania Therapy

artículo científico publicado en 2018

Deciphering the Inhibition of the Neuronal Calcium Sensor 1 and the Guanine Exchange Factor Ric8a with a Small Phenothiazine Molecule for the Rational Generation of Therapeutic Synapse Function Regulators

article

Deciphering the enzymatic target of a new family of antischistosomal agents bearing a quinazoline scaffold using complementary computational tools

scientific article published on 01 December 2020

Discovery of novel Schistosoma mansoni PDE4A inhibitors as potential agents against schistosomiasis

artículo científico publicado en 2019

Dissimilar interaction of CB1/CB2 with lipid bilayers as revealed by molecular dynamics simulation ⬇️

artículo científico publicado el 21 de diciembre de 2010

Effect of phosphodiesterase 7 (PDE7) inhibitors in experimental autoimmune encephalomyelitis mice. Discovery of a new chemically diverse family of compounds

artículo científico publicado en 2012

From Bitopic Inhibitors to Multitarget Drugs for the Future Treatment of Alzheimer's Disease.

artículo científico

From dual binding site acetylcholinesterase inhibitors to allosteric modulators: A new avenue for disease-modifying drugs in Alzheimer's disease.

artículo científico

Glycogen synthase kinase 3 (GSK-3) inhibitors: a patent update (2016-2019)

scientific article published on 25 August 2020

Identification in silico and experimental validation of novel phosphodiesterase 7 inhibitors with efficacy in experimental autoimmune encephalomyelitis mice

artículo científico publicado en 2012

Identification of new allosteric sites and modulators of AChE through computational and experimental tools.

artículo científico publicado en 2018

Interference of the complex between NCS-1 and Ric8a with phenothiazines regulates synaptic function and is an approach for fragile X syndrome

artículo científico publicado en 2017

Leucine rich repeat kinase 2 (LRRK2) inhibitors based on indolinone scaffold: Potential pro-neurogenic agents

artículo científico publicado en 2017

Medicinal and Biological Chemistry (MBC) Library: An Efficient Source of New Hits.

artículo científico publicado en 2017

Neuroprotective efficacy of quinazoline type phosphodiesterase 7 inhibitors in cellular cultures and experimental stroke model

artículo científico publicado en 2011

New applications for known drugs: Human glycogen synthase kinase 3 inhibitors as modulators of Aspergillus fumigatus growth

artículo científico publicado en 2016

QSAR Modelling to Identify LRRK2 Inhibitors for Parkinson's Disease

scientific article published on 14 February 2019

Subtly Modulating Glycogen Synthase Kinase 3 β: Allosteric Inhibitor Development and Their Potential for the Treatment of Chronic Diseases

artículo científico

Synthesis, Structural Analysis, and Biological Evaluation of Thioxoquinazoline Derivatives as Phosphodiesterase 7 Inhibitors

artículo científico publicado en 2009

Targeting Cannabinoid Receptor Activation and BACE-1 Activity Counteracts TgAPP Mice Memory Impairment and Alzheimer's Disease Lymphoblast Alterations

scientific article published on 03 January 2020

Tau-Centric Multitarget Approach for Alzheimer's Disease: Development of First-in-Class Dual Glycogen Synthase Kinase 3β and Tau-Aggregation Inhibitors

article

Towards discovery of new leishmanicidal scaffolds able to inhibit Leishmania GSK-3

scientific article published on 01 December 2020

Unraveling phosphodiesterase surfaces. Identification of phosphodiesterase 7 allosteric modulation cavities

artículo científico publicado en 2013

Lista de obras de

5-imino-1,2,4-thiadiazoles: first small molecules as substrate competitive inhibitors of glycogen synthase kinase 3.

Chameleon-like behavior of indolylpiperidines in complex with cholinesterases targets: Potent butyrylcholinesterase inhibitors

Computer-aided molecular design of pyrazolotriazines targeting glycogen synthase kinase 3

Cyclic Nucleotide-Specific Phosphodiesterases as Potential Drug Targets for Anti-Leishmania Therapy

Deciphering the Inhibition of the Neuronal Calcium Sensor 1 and the Guanine Exchange Factor Ric8a with a Small Phenothiazine Molecule for the Rational Generation of Therapeutic Synapse Function Regulators

Deciphering the enzymatic target of a new family of antischistosomal agents bearing a quinazoline scaffold using complementary computational tools

Discovery of novel Schistosoma mansoni PDE4A inhibitors as potential agents against schistosomiasis

Dissimilar interaction of CB1/CB2 with lipid bilayers as revealed by molecular dynamics simulation ⬇️

Effect of phosphodiesterase 7 (PDE7) inhibitors in experimental autoimmune encephalomyelitis mice. Discovery of a new chemically diverse family of compounds

From Bitopic Inhibitors to Multitarget Drugs for the Future Treatment of Alzheimer's Disease.

From dual binding site acetylcholinesterase inhibitors to allosteric modulators: A new avenue for disease-modifying drugs in Alzheimer's disease.

Glycogen synthase kinase 3 (GSK-3) inhibitors: a patent update (2016-2019)

Identification in silico and experimental validation of novel phosphodiesterase 7 inhibitors with efficacy in experimental autoimmune encephalomyelitis mice

Identification of new allosteric sites and modulators of AChE through computational and experimental tools.

Interference of the complex between NCS-1 and Ric8a with phenothiazines regulates synaptic function and is an approach for fragile X syndrome

Leucine rich repeat kinase 2 (LRRK2) inhibitors based on indolinone scaffold: Potential pro-neurogenic agents

Medicinal and Biological Chemistry (MBC) Library: An Efficient Source of New Hits.

Neuroprotective efficacy of quinazoline type phosphodiesterase 7 inhibitors in cellular cultures and experimental stroke model

New applications for known drugs: Human glycogen synthase kinase 3 inhibitors as modulators of Aspergillus fumigatus growth

QSAR Modelling to Identify LRRK2 Inhibitors for Parkinson's Disease

Subtly Modulating Glycogen Synthase Kinase 3 β: Allosteric Inhibitor Development and Their Potential for the Treatment of Chronic Diseases

Synthesis, Structural Analysis, and Biological Evaluation of Thioxoquinazoline Derivatives as Phosphodiesterase 7 Inhibitors

Targeting Cannabinoid Receptor Activation and BACE-1 Activity Counteracts TgAPP Mice Memory Impairment and Alzheimer's Disease Lymphoblast Alterations

Tau-Centric Multitarget Approach for Alzheimer's Disease: Development of First-in-Class Dual Glycogen Synthase Kinase 3β and Tau-Aggregation Inhibitors

Towards discovery of new leishmanicidal scaffolds able to inhibit Leishmania GSK-3

Unraveling phosphodiesterase surfaces. Identification of phosphodiesterase 7 allosteric modulation cavities