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A unique role for striatal serotonergic systems in the withdrawal from adolescent nicotine administration

artículo científico publicado en 2006

Additive and synergistic effects of fetal nicotine and dexamethasone exposure on cholinergic synaptic function in adolescence and adulthood: Implications for the adverse consequences of maternal smoking and pharmacotherapy of preterm delivery

artículo científico publicado en 2009

Administration of nicotine to adolescent rats evokes regionally selective upregulation of CNS alpha 7 nicotinic acetylcholine receptors

artículo científico publicado en 2004

Adolescent nicotine administration changes the responses to nicotine given subsequently in adulthood: adenylyl cyclase cell signaling in brain regions during nicotine administration and withdrawal, and lasting effects

artículo científico publicado en 2008

Adolescent nicotine treatment changes the response of acetylcholine systems to subsequent nicotine administration in adulthood

artículo científico publicado en 2008

Adolescent vs. adult-onset nicotine self-administration in male rats: duration of effect and differential nicotinic receptor correlates

artículo científico publicado en 2007

Adolescents and adults differ in the immediate and long-term impact of nicotine administration and withdrawal on cardiac norepinephrine

artículo científico publicado en 2016

Adverse Benzo[ a ]pyrene Effects on Neurodifferentiation Are Altered by Other Neurotoxicant Coexposures: Interactions with Dexamethasone, Chlorpyrifos, or Nicotine in PC12 Cells ⬇️

artículo científico publicado el 19 de abril de 2013

Adverse neurodevelopmental effects of dexamethasone modeled in PC12 cells: identifying the critical stages and concentration thresholds for the targeting of cell acquisition, differentiation and viability

artículo científico publicado en 2005

Alpha7 nicotinic acetylcholine receptors targeted by cholinergic developmental neurotoxicants: nicotine and chlorpyrifos

artículo científico publicado en 2004

Alterations in central nervous system serotonergic and dopaminergic synaptic activity in adulthood after prenatal or neonatal chlorpyrifos exposure

artículo científico publicado en 2005

Alterations of serotonin synaptic proteins in brain regions of neonatal Rhesus monkeys exposed to perinatal environmental tobacco smoke

artículo científico publicado en 2006

Ameliorating the developmental neurotoxicity of chlorpyrifos: a mechanisms-based approach in PC12 cells

artículo científico publicado en 2007

Amelioration strategies fail to prevent tobacco smoke effects on neurodifferentiation: Nicotinic receptor blockade, antioxidants, methyl donors

artículo científico publicado en 2015

Amyloid precursor protein 96-110 and beta-amyloid 1-42 elicit developmental anomalies in sea urchin embryos and larvae that are alleviated by neurotransmitter analogs for acetylcholine, serotonin and cannabinoids

artículo científico publicado en 2008

Anomalous regulation of beta-adrenoceptor signaling in brain regions of the newborn rat.

artículo científico publicado en 2006

BDE99 (2,2′,4,4′,5-pentabromodiphenyl ether) suppresses differentiation into neurotransmitter phenotypes in PC12 cells ⬇️

artículo científico publicado el 16 de febrero de 2013

Behavioral alterations in adolescent and adult rats caused by a brief subtoxic exposure to chlorpyrifos during neurulation

artículo científico publicado en 2004

Benzo[a]pyrene impairs neurodifferentiation in PC12 cells

artículo científico publicado en 2009

Beta-adrenoceptor modulation of transiently overexpressed alpha 2-adrenoceptors in brain and peripheral tissues: cellular mechanisms underlying the developmental toxicity of terbutaline

artículo científico publicado en 2004

Brominated and organophosphate flame retardants target different neurodevelopmental stages, characterized with embryonic neural stem cells and neuronotypic PC12 cells

artículo científico publicado en 2017

Chlorpyrifos affects phenotypic outcomes in a model of mammalian neurodevelopment: critical stages targeting differentiation in PC12 cells

artículo científico publicado en 2006

Chlorpyrifos developmental neurotoxicity: interaction with glucocorticoids in PC12 cells

artículo científico publicado en 2012

Chlorpyrifos exposure during neurulation: cholinergic synaptic dysfunction and cellular alterations in brain regions at adolescence and adulthood

artículo científico publicado en 2004

Chlorpyrifos targets developing glia: effects on glial fibrillary acidic protein

artículo científico publicado en 2002

Cholinergic receptor subtypes in the olfactory bulbectomy model of depression

artículo científico publicado en 2005

Comparative developmental neurotoxicity of organophosphate insecticides: effects on brain development are separable from systemic toxicity

artículo científico publicado en 2006

Comparative developmental neurotoxicity of organophosphates in vivo: transcriptional responses of pathways for brain cell development, cell signaling, cytotoxicity and neurotransmitter systems

artículo científico publicado en 2007

Consumption of a high-fat diet in adulthood ameliorates the effects of neonatal parathion exposure on acetylcholine systems in rat brain regions

scientific article published on 03 February 2009

Critical periods for chlorpyrifos-induced developmental neurotoxicity: alterations in adenylyl cyclase signaling in adult rat brain regions after gestational or neonatal exposure

artículo científico publicado en 2004

Critical periods for the role of oxidative stress in the developmental neurotoxicity of chlorpyrifos and terbutaline, alone or in combination

artículo científico publicado en 2005

Critical prenatal and postnatal periods for persistent effects of dexamethasone on serotonergic and dopaminergic systems

artículo científico publicado en 2006

Development of glucocorticoid receptor regulation in the rat forebrain: implications for adverse effects of glucocorticoids in preterm infants

artículo científico publicado en 2008

Developmental Neurotoxicity Resulting from Pharmacotherapy of Preterm Labor, Modeled In Vitro: Terbutaline and Dexamethasone, Separately and Together

artículo científico publicado en 2018

Developmental Neurotoxicity of Tobacco Smoke Directed Toward Cholinergic and Serotonergic Systems: More Than Just Nicotine

artículo científico publicado en 2015

Developmental diazinon neurotoxicity in rats: later effects on emotional response

artículo científico publicado en 2007

Developmental effects of chlorpyrifos extend beyond neurotoxicity: critical periods for immediate and delayed-onset effects on cardiac and hepatic cell signaling

artículo científico publicado en 2004

Developmental exposure of rats to chlorpyrifos elicits sex-selective hyperlipidemia and hyperinsulinemia in adulthood

artículo científico publicado en 2005

Developmental exposure of rats to chlorpyrifos leads to behavioral alterations in adulthood, involving serotonergic mechanisms and resembling animal models of depression

artículo científico publicado en 2005

Developmental exposure to chlorpyrifos elicits sex-selective alterations of serotonergic synaptic function in adulthood: critical periods and regional selectivity for effects on the serotonin transporter, receptor subtypes, and cell signaling

artículo científico publicado en 2004

Developmental exposure to organophosphates triggers transcriptional changes in genes associated with Parkinson's disease in vitro and in vivo ⬇️

artículo científico publicado el 28 de septiembre de 2011

Developmental exposure to terbutaline alters cell signaling in mature rat brain regions and augments the effects of subsequent neonatal exposure to the organophosphorus insecticide chlorpyrifos

artículo científico publicado en 2005

Developmental exposure to terbutaline and chlorpyrifos, separately or sequentially, elicits presynaptic serotonergic hyperactivity in juvenile and adolescent rats

artículo científico publicado en 2007

Developmental exposure to terbutaline and chlorpyrifos: pharmacotherapy of preterm labor and an environmental neurotoxicant converge on serotonergic systems in neonatal rat brain regions

artículo científico publicado en 2005

Developmental neurotoxic effects of chlorpyrifos on acetylcholine and serotonin pathways in an avian model

artículo científico publicado en 2008

Developmental neurotoxicants target neurodifferentiation into the serotonin phenotype: Chlorpyrifos, diazinon, dieldrin and divalent nickel

artículo científico publicado en 2008

Developmental neurotoxicity elicited by gestational exposure to chlorpyrifos: when is adenylyl cyclase a target?

artículo científico publicado en 2003

Developmental neurotoxicity elicited by prenatal or postnatal chlorpyrifos exposure: effects on neurospecific proteins indicate changing vulnerabilities

artículo científico publicado en 2003

Developmental neurotoxicity of chlorpyrifos: targeting glial cells ⬇️

artículo científico publicado el 1 de mayo de 2005

Developmental neurotoxicity of chlorpyrifos: what is the vulnerable period?

artículo científico publicado en 2002

Developmental neurotoxicity of low dose diazinon exposure of neonatal rats: effects on serotonin systems in adolescence and adulthood

artículo científico publicado en 2007

Developmental neurotoxicity of organophosphates targets cell cycle and apoptosis, revealed by transcriptional profiles in vivo and in vitro ⬇️

artículo científico publicado el 28 de diciembre de 2011

Developmental neurotoxicity of parathion: progressive effects on serotonergic systems in adolescence and adulthood

artículo científico publicado en 2009

Developmental neurotoxicity of perfluorinated chemicals modeled in vitro

artículo científico publicado en 2008

Developmental neurotoxicity targeting hepatic and cardiac sympathetic innervation: Effects of organophosphates are distinct from those of glucocorticoids ⬇️

artículo científico publicado el 29 de marzo de 2011

Developmental toxicity of terbutaline: critical periods for sex-selective effects on macromolecules and DNA synthesis in rat brain, heart, and liver

artículo científico publicado en 2003

Diazinon and parathion diverge in their effects on development of noradrenergic systems

artículo científico publicado en 2017

Disparate developmental neurotoxicants converge on the cyclic AMP signaling cascade, revealed by transcriptional profiles in vitro and in vivo

artículo científico publicado en 2009

Disruption of rat forebrain development by glucocorticoids: critical perinatal periods for effects on neural cell acquisition and on cell signaling cascades mediating noradrenergic and cholinergic neurotransmitter/neurotrophic responses

artículo científico publicado en 2005

Diverse neurotoxicants converge on gene expression for neuropeptides and their receptors in an in vitro model of neurodifferentiation: Effects of chlorpyrifos, diazinon, dieldrin and divalent nickel in PC12 cells ⬇️

artículo científico publicado el 24 de septiembre de 2010

Diverse neurotoxicants target the differentiation of embryonic neural stem cells into neuronal and glial phenotypes

artículo científico publicado en 2016

Does mechanism matter? Unrelated neurotoxicants converge on cell cycle and apoptosis during neurodifferentiation ⬇️

artículo científico publicado el 24 de abril de 2012

Does pharmacotherapy for preterm labor sensitize the developing brain to environmental neurotoxicants? Cellular and synaptic effects of sequential exposure to terbutaline and chlorpyrifos in neonatal rats

artículo científico publicado en 2004

Does prenatal nicotine exposure sensitize the brain to nicotine-induced neurotoxicity in adolescence?

artículo científico publicado en 2004

Does terbutaline damage the developing heart?

artículo científico publicado en 2003

Does thyroid disruption contribute to the developmental neurotoxicity of chlorpyrifos? ⬇️

artículo científico publicado el 21 de abril de 2013

Early postnatal parathion exposure in rats causes sex-selective cognitive impairment and neurotransmitter defects which emerge in aging

artículo científico publicado en 2009

Effects of prenatal nicotine exposure on primate brain development and attempted amelioration with supplemental choline or vitamin C: neurotransmitter receptors, cell signaling and cell development biomarkers in fetal brain regions of rhesus monkeys

artículo científico publicado en 2005

Effects of tobacco smoke on PC12 cell neurodifferentiation are distinct from those of nicotine or benzo[a]pyrene

artículo científico publicado en 2014

Exposure of developing chicks to perfluorooctanoic acid induces defects in prehatch and early posthatch development

artículo científico publicado en 2008

Exposure of neonatal rats to parathion elicits sex-selective impairment of acetylcholine systems in brain regions during adolescence and adulthood

artículo científico publicado en 2008

Exposure of neonatal rats to parathion elicits sex-selective reprogramming of metabolism and alters the response to a high-fat diet in adulthood

artículo científico publicado en 2008

Exposure to organophosphates reduces the expression of neurotrophic factors in neonatal rat brain regions: similarities and differences in the effects of chlorpyrifos and diazinon on the fibroblast growth factor superfamily

artículo científico publicado en 2007

Fetal chlorpyrifos exposure: adverse effects on brain cell development and cholinergic biomarkers emerge postnatally and continue into adolescence and adulthood

artículo científico publicado en 2003

Gestational dexamethasone treatment elicits sex-dependent alterations in locomotor activity, reward-based memory and hippocampal cholinergic function in adolescent and adult rats

artículo científico publicado en 2005

Heroin neuroteratogenicity: delayed-onset deficits in catecholaminergic synaptic activity

artículo científico publicado en 2003

Imbalances emerge in cardiac autonomic cell signaling after neonatal exposure to terbutaline or chlorpyrifos, alone or in combination

artículo científico publicado en 2005

Impact of adolescent nicotine exposure on adenylyl cyclase-mediated cell signaling: enzyme induction, neurotransmitter-specific effects, regional selectivities, and the role of withdrawal

artículo científico publicado en 2003

In vitro models reveal differences in the developmental neurotoxicity of an environmental polycylic aromatic hydrocarbon mixture compared to benzo[a]pyrene: Neuronotypic PC12 Cells and embryonic neural stem cells

artículo científico publicado en 2016

Increased nicotine self-administration following prenatal exposure in female rats

artículo científico publicado en 2006

Is There a Critical Period for the Developmental Neurotoxicity of Low-Level Tobacco Smoke Exposure?

artículo científico publicado en 2016

Is fipronil safer than chlorpyrifos? Comparative developmental neurotoxicity modeled in PC12 cells

artículo científico publicado en 2008

Is the PentaBDE replacement, tris (1,3-dichloro-2-propyl) phosphate (TDCPP), a developmental neurotoxicant? Studies in PC12 cells.

artículo científico publicado en 2011

Lasting effects of developmental dexamethasone treatment on neural cell number and size, synaptic activity, and cell signaling: critical periods of vulnerability, dose-effect relationships, regional targets, and sex selectivity

artículo científico publicado en 2006

Lasting effects of nicotine treatment and withdrawal on serotonergic systems and cell signaling in rat brain regions: separate or sequential exposure during fetal development and adulthood

artículo científico publicado en 2007

Long-lasting CNS effects of a short-term chemical knockout of ornithine decarboxylase during development: nicotinic cholinergic receptor upregulation and subtle macromolecular changes in adulthood

artículo científico publicado en 2003

Mimicking maternal smoking and pharmacotherapy of preterm labor: fetal nicotine exposure enhances the effect of late gestational dexamethasone treatment on noradrenergic circuits

artículo científico publicado en 2011

Mimicking maternal smoking and pharmacotherapy of preterm labor: interactions of fetal nicotine and dexamethasone on serotonin and dopamine synaptic function in adolescence and adulthood

artículo científico publicado en 2010

Modeling the developmental neurotoxicity of nicotine in vitro: cell acquisition, growth and viability in PC12 cells

artículo científico publicado en 2005

Morphologic effects of subtoxic neonatal chlorpyrifos exposure in developing rat brain: regionally selective alterations in neurons and glia

artículo científico publicado en 2004

Neonatal dexamethasone treatment leads to alterations in cell signaling cascades controlling hepatic and cardiac function in adulthood

artículo científico publicado en 2009

Neonatal exposure to low doses of diazinon: long-term effects on neural cell development and acetylcholine systems

artículo científico publicado en 2008

Neonatal exposure to parathion alters lipid metabolism in adulthood: Interactions with dietary fat intake and implications for neurodevelopmental deficits

artículo científico publicado en 2010

Neonatal organophosphorus pesticide exposure alters the developmental trajectory of cell-signaling cascades controlling metabolism: differential effects of diazinon and parathion

artículo científico publicado en 2010

Neonatal parathion exposure and interactions with a high-fat diet in adulthood: Adenylyl cyclase-mediated cell signaling in heart, liver and cerebellum

artículo científico publicado en 2010

Neonatal parathion exposure disrupts serotonin and dopamine synaptic function in rat brain regions: modulation by a high-fat diet in adulthood

artículo científico publicado en 2009

Neurobehavioral teratogenicity of sarin in an avian model

artículo científico publicado en 2009

Nicotine administration in adolescence reprograms the subsequent response to nicotine treatment and withdrawal in adulthood: sex-selective effects on cerebrocortical serotonergic function

artículo científico publicado en 2014

Nicotine exposure in adolescence alters the response of serotonin systems to nicotine administered subsequently in adulthood

artículo científico publicado en 2009

Nicotine is a developmental neurotoxicant and neuroprotectant: stage-selective inhibition of DNA synthesis coincident with shielding from effects of chlorpyrifos

artículo científico publicado en 2003

Nicotine is a neurotoxin in the adolescent brain: critical periods, patterns of exposure, regional selectivity, and dose thresholds for macromolecular alterations

artículo científico publicado en 2003

Nicotine therapy in adulthood reverses the synaptic and behavioral deficits elicited by prenatal exposure to phenobarbital

artículo científico publicado en 2005

Nonenzymatic functions of acetylcholinesterase splice variants in the developmental neurotoxicity of organophosphates: chlorpyrifos, chlorpyrifos oxon, and diazinon

artículo científico publicado en 2007

Nonenzymatic role of acetylcholinesterase in neuritic sprouting: regional changes in acetylcholinesterase and choline acetyltransferase after neonatal 6-hydroxydopamine lesions

artículo científico publicado en 2009

Ontogenesis of beta-adrenoceptor signaling: implications for perinatal physiology and for fetal effects of tocolytic drugs

artículo científico publicado en 2003

Organophosphate exposure during a critical developmental stage reprograms adenylyl cyclase signaling in PC12 cells

artículo científico publicado en 2010

Organophosphate insecticides target the serotonergic system in developing rat brain regions: disparate effects of diazinon and parathion at doses spanning the threshold for cholinesterase inhibition

artículo científico publicado en 2006

Oxidative and excitatory mechanisms of developmental neurotoxicity: transcriptional profiles for chlorpyrifos, diazinon, dieldrin, and divalent nickel in PC12 cells

artículo científico publicado en 2008

Oxidative mechanisms contributing to the developmental neurotoxicity of nicotine and chlorpyrifos

artículo científico publicado en 2004

Oxidative stress from diverse developmental neurotoxicants: antioxidants protect against lipid peroxidation without preventing cell loss

artículo científico publicado en 2009

Perinatal environmental tobacco smoke exposure in rhesus monkeys: critical periods and regional selectivity for effects on brain cell development and lipid peroxidation

artículo científico publicado en 2006

Permanent, sex-selective effects of prenatal or adolescent nicotine exposure, separately or sequentially, in rat brain regions: indices of cholinergic and serotonergic synaptic function, cell signaling, and neural cell number and size at 6 months of

artículo científico publicado en 2006

Persistent behavioral alterations in rats neonatally exposed to low doses of the organophosphate pesticide, parathion

artículo científico publicado en 2008

Persistent cognitive alterations in rats after early postnatal exposure to low doses of the organophosphate pesticide, diazinon

artículo científico publicado en 2007

Prenatal Nicotine Exposure Evokes Alterations of Cell Structure in Hippocampus and Somatosensory Cortex ⬇️

artículo científico publicado el 1 de enero de 2002

Prenatal chlorpyrifos exposure elicits presynaptic serotonergic and dopaminergic hyperactivity at adolescence: critical periods for regional and sex-selective effects

artículo científico publicado en 2006

Prenatal chlorpyrifos exposure in rats causes persistent behavioral alterations

artículo científico publicado en 2002

Prenatal dexamethasone augments the neurobehavioral teratology of chlorpyrifos: significance for maternal stress and preterm labor

artículo científico publicado en 2014

Prenatal dexamethasone augments the sex-selective developmental neurotoxicity of chlorpyrifos: implications for vulnerability after pharmacotherapy for preterm labor

artículo científico publicado en 2013

Prenatal dexamethasone, as used in preterm labor, worsens the impact of postnatal chlorpyrifos exposure on serotonergic pathways

artículo científico publicado en 2014

Prenatal drug exposures sensitize noradrenergic circuits to subsequent disruption by chlorpyrifos

artículo científico publicado en 2015

Prenatal nicotine alters the developmental neurotoxicity of postnatal chlorpyrifos directed toward cholinergic systems: better, worse, or just "different?"

artículo científico publicado en 2015

Prenatal nicotine changes the response to postnatal chlorpyrifos: Interactions targeting serotonergic synaptic function and cognition

artículo científico publicado en 2015

Prenatal nicotine exposure alters the response to nicotine administration in adolescence: effects on cholinergic systems during exposure and withdrawal

artículo científico publicado en 2004

Prenatal nicotine exposure alters the responses to subsequent nicotine administration and withdrawal in adolescence: Serotonin receptors and cell signaling

artículo científico publicado en 2005

Prenatal nicotine exposure in rhesus monkeys compromises development of brainstem and cardiac monoamine pathways involved in perinatal adaptation and sudden infant death syndrome: Amelioration by Vitamin C ⬇️

artículo científico publicado el 12 de febrero de 2011

Protein kinase C is a target for diverse developmental neurotoxicants: transcriptional responses to chlorpyrifos, diazinon, dieldrin and divalent nickel in PC12 cells

artículo científico publicado en 2009

Quantitative morphological assessment reveals neuronal and glial deficits in hippocampus after a brief subtoxic exposure to chlorpyrifos in neonatal rats

artículo científico publicado en 2005

Screening for developmental neurotoxicity using PC12 cells: comparisons of organophosphates with a carbamate, an organochlorine, and divalent nickel

artículo científico publicado en 2007

Separate or sequential exposure to nicotine prenatally and in adulthood: persistent effects on acetylcholine systems in rat brain regions

artículo científico publicado en 2007

Serotonergic cell signaling in an animal model of aging and depression: olfactory bulbectomy elicits different adaptations in brain regions of young adult vs aging rats

artículo científico publicado en 2005

Serotonergic systems targeted by developmental exposure to chlorpyrifos: effects during different critical periods

artículo científico publicado en 2003

Sex-selective hippocampal alterations after adolescent nicotine administration: effects on neurospecific proteins

artículo científico publicado en 2003

Short-term adolescent nicotine exposure has immediate and persistent effects on cholinergic systems: critical periods, patterns of exposure, dose thresholds

artículo científico publicado en 2003

Short-term adolescent nicotine exposure in rats elicits immediate and delayed deficits in T-lymphocyte function: critical periods, patterns of exposure, dose thresholds

artículo científico publicado en 2003

Silver Nanoparticles Compromise Neurodevelopment in PC12 Cells: Critical Contributions of Silver Ion, Particle Size, Coating, and Composition ⬇️

artículo científico publicado el 14 de septiembre de 2010

Silver exposure in developing zebrafish (Danio rerio): persistent effects on larval behavior and survival

artículo científico publicado en 2010

Silver exposure in developing zebrafish produces persistent synaptic and behavioral changes ⬇️

artículo científico publicado el 28 de octubre de 2010

Silver impairs neurodevelopment: studies in PC12 cells

artículo científico publicado en 2010

Silver nanoparticles alter zebrafish development and larval behavior: distinct roles for particle size, coating and composition.

artículo científico publicado en 2011

Targeting of neurotrophic factors, their receptors, and signaling pathways in the developmental neurotoxicity of organophosphates in vivo and in vitro

artículo científico publicado en 2008

Terbutaline Is a Developmental Neurotoxicant: Effects on Neuroproteins and Morphology in Cerebellum, Hippocampus, and Somatosensory Cortex ⬇️

artículo científico publicado el 10 de noviembre de 2003

Terbutaline impairs the development of peripheral noradrenergic projections: potential implications for autism spectrum disorders and pharmacotherapy of preterm labor

artículo científico publicado en 2012

The alterations in CNS serotonergic mechanisms caused by neonatal chlorpyrifos exposure are permanent

artículo científico publicado en 2005

The sea urchin embryo as a model for mammalian developmental neurotoxicity: ontogenesis of the high-affinity choline transporter and its role in cholinergic trophic activity ⬇️

artículo científico publicado el 1 de noviembre de 2003

Transcriptional biomarkers distinguish between vulnerable periods for developmental neurotoxicity of chlorpyrifos: Implications for toxicogenomics

artículo científico publicado en 2003

Transcriptional profiles for glutamate transporters reveal differences between organophosphates but similarities with unrelated neurotoxicants

artículo científico publicado en 2010

Transcriptional profiles reveal similarities and differences in the effects of developmental neurotoxicants on differentiation into neurotransmitter phenotypes in PC12 cells

artículo científico publicado en 2008

Transiently overexpressed alpha2-adrenoceptors and their control of DNA synthesis in the developing brain

scientific journal article

Ultraviolet photolysis of chlorpyrifos: developmental neurotoxicity modeled in PC12 cells.

artículo científico publicado en 2008

Unrelated developmental neurotoxicants elicit similar transcriptional profiles for effects on neurotrophic factors and their receptors in an in vitro model

artículo científico publicado en 2008

WITHDRAWN: NBTS 2012 abstracts ⬇️

artículo científico publicado el 17 de abril de 2012

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