Lista de obras -

3-(2-Benzyloxyphenyl)isoxazoles and isoxazolines: synthesis and evaluation as CFTR activators

artículo científico publicado en 2003

4,8-Dimethylcoumarin Inhibitors of Intestinal Anion Exchanger slc26a3 (Downregulated in Adenoma) for Anti-Absorptive Therapy of Constipation

artículo científico publicado en 2019

A simple method to generate human airway epithelial organoids with externally orientated apical membranes

artículo científico publicado en 2022

Aggregation state determines the localization and function of M1- and M23-aquaporin-4 in astrocytes

artículo científico publicado en 2014

Alpha-aminoazaheterocyclic-methylglyoxal adducts do not inhibit cystic fibrosis transmembrane conductance regulator chloride channel activity.

artículo científico publicado en 2008

Altered channel gating mechanism for CFTR inhibition by a high-affinity thiazolidinone blocker

artículo científico publicado en 2004

Anchored PDE4 regulates chloride conductance in wild-type and ΔF508-CFTR human airway epithelia

artículo científico publicado en 2013

Antidiarrheal efficacy and cellular mechanisms of a Thai herbal remedy

artículo científico publicado en 2014

Aquaporin water channels in the nervous system.

artículo científico publicado en 2013

Aquaporin-1 Expression in Herniated Human Lumbar Intervertebral Discs

artículo científico publicado en 2017

Aquaporin-3 mediates hydrogen peroxide-dependent responses to environmental stress in colonic epithelia

artículo científico publicado en 2017

Aquaporin-4 and brain edema.

artículo científico publicado en 2007

Aquaporin-4: orthogonal array assembly, CNS functions, and role in neuromyelitis optica.

artículo científico publicado en 2011

Aquaporins: important but elusive drug targets.

artículo científico publicado en 2014

Benzoflavone activators of the cystic fibrosis transmembrane conductance regulator: towards a pharmacophore model for the nucleotide-binding domain

artículo científico publicado en 2003

Bioactive Thymosin Alpha-1 Does Not Influence F508del-CFTR Maturation and Activity

scientific article published on 16 July 2019

CFTR activation in human bronchial epithelial cells by novel benzoflavone and benzimidazolone compounds

artículo científico publicado en 2003

CFTR chloride channel drug discovery--inhibitors as antidiarrheals and activators for therapy of cystic fibrosis

artículo científico publicado en 2006

CFTR inhibitors

artículo científico publicado en 2013

Chemokine-dependent T cell migration requires aquaporin-3-mediated hydrogen peroxide uptake

artículo científico publicado en 2012

Chloride channels as drug targets

artículo científico publicado en 2008

Complement-independent retinal pathology produced by intravitreal injection of neuromyelitis optica immunoglobulin G.

artículo científico publicado en 2016

Contribution of CFTR to apical-basolateral fluid transport in cultured human alveolar epithelial type II cells

artículo científico publicado en 2005

Correctors and Potentiators Rescue Function of the Truncated W1282X-Cystic Fibrosis Transmembrane Regulator (CFTR) Translation Product

artículo científico publicado en 2016

Determinants of aquaporin-4 assembly in orthogonal arrays revealed by live-cell single-molecule fluorescence imaging

artículo científico publicado en 2009

Discovery of glycine hydrazide pore-occluding CFTR inhibitors: mechanism, structure-activity analysis, and in vivo efficacy

artículo científico publicado en 2004

Disruption of aquaporin-11 produces polycystic kidneys following vacuolization of the proximal tubule

artículo científico publicado en 2005

Drug discovery and epithelial physiology

artículo científico publicado en 2004

Evidence for direct CFTR inhibition by CFTR(inh)-172 based on Arg347 mutagenesis.

artículo científico publicado en 2008

Experimental animal models of aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders: progress and shortcomings

scientific article published on 21 October 2019

Experimental mouse model of optic neuritis with inflammatory demyelination produced by passive transfer of neuromyelitis optica-immunoglobulin G.

artículo científico publicado en 2014

Function-Oriented Synthesis of a Didesmethyl Triazacryptand Analogue for Fluorescent Potassium Ion Sensing

artículo científico publicado en 2011

High-affinity activators of cystic fibrosis transmembrane conductance regulator (CFTR) chloride conductance identified by high-throughput screening

artículo científico publicado en 2002

Hollow Micropillar Array Method for High-Capacity Drug Screening on Filter-Grown Epithelial Cells

artículo científico publicado en 2018

Imaging Renal Urea Handling in Rats at Millimeter Resolution using Hyperpolarized Magnetic Resonance Relaxometry.

artículo científico publicado en 2016

Improved long-term outcome after transient cerebral ischemia in aquaporin-4 knockout mice

artículo científico publicado en 2016

Knock-out models reveal new aquaporin functions

artículo científico publicado en 2009

Lectin conjugates as potent, nonabsorbable CFTR inhibitors for reducing intestinal fluid secretion in cholera.

artículo científico publicado en 2007

Marked central nervous system pathology in CD59 knockout rats following passive transfer of Neuromyelitis optica immunoglobulin G.

artículo científico publicado en 2017

Mechanism-based corrector combination restores ΔF508-CFTR folding and function

artículo científico publicado en 2013

Mechanisms of Autoantibody-Induced Pathology.

artículo científico publicado en 2017

Microfluidics platform for measurement of volume changes in immobilized intestinal enteroids

artículo científico publicado en 2014

Mildly Reduced Brain Swelling and Improved Neurological Outcome in Aquaporin-4 Knockout Mice following Controlled Cortical Impact Brain Injury.

artículo científico publicado en 2015

Mutagenesis of the aquaporin 4 extracellular domains defines restricted binding patterns of pathogenic neuromyelitis optica IgG.

artículo científico publicado en 2015

Nanomolar CFTR inhibition by pore-occluding divalent polyethylene glycol-malonic acid hydrazides

artículo científico publicado en 2008

Nanomolar-Potency Aminophenyl-1,3,5-triazine Activators of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Chloride Channel for Prosecretory Therapy of Dry Eye Diseases

artículo científico publicado en 2017

Phenylglycine and sulfonamide correctors of defective delta F508 and G551D cystic fibrosis transmembrane conductance regulator chloride-channel gating

artículo científico publicado en 2005

Phenylquinoxalinone CFTR activator as potential prosecretory therapy for constipation

artículo científico publicado en 2016

Proinflammatory cytokine secretion is suppressed by TMEM16A or CFTR channel activity in human cystic fibrosis bronchial epithelia

artículo científico publicado en 2012

Reduced PDZ interactions of rescued ΔF508CFTR increases its cell surface mobility.

artículo científico publicado en 2012

Salt-sparing diuretic action of a water-soluble urea analog inhibitor of urea transporters UT-A and UT-B in rats

artículo científico publicado en 2015

Secretory diarrhoea: mechanisms and emerging therapies

artículo científico publicado en 2015

Small-molecule correctors of defective DeltaF508-CFTR cellular processing identified by high-throughput screening.

artículo científico publicado en 2005

Small-molecule inhibitors of urea transporters

artículo científico publicado en 2014

Solute and macromolecule diffusion in cellular aqueous compartments

artículo científico publicado en 2002

Some gating potentiators, including VX-770, diminish ΔF508-CFTR functional expression.

artículo científico publicado en 2014

Spatial model of convective solute transport in brain extracellular space does not support a "glymphatic" mechanism.

artículo científico publicado en 2016

Superresolution Imaging of Aquaporin-4 Cluster Size in Antibody-Stained Paraffin Brain Sections

artículo científico publicado en 2015

Synthesis and evaluation of 5,6-disubstituted thiopyrimidine aryl aminothiazoles as inhibitors of the calcium-activated chloride channel TMEM16A/Ano1.

artículo científico publicado en 2016

TRPV4 and AQP4 Channels Synergistically Regulate Cell Volume and Calcium Homeostasis in Retinal Müller Glia

artículo científico publicado en 2015

Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion.

artículo científico publicado en 2002

Tolerance checkpoint bypass permits emergence of pathogenic T cells to neuromyelitis optica autoantigen aquaporin-4.

artículo científico publicado en 2016

Transient hyperckemia in the setting of neuromyelitis optica (NMO).

artículo científico publicado en 2014

Treatment of neuromyelitis optica: state-of-the-art and emerging therapies

artículo científico publicado en 2014

Unimpaired osmotic water permeability and fluid secretion in bile duct epithelia of AQP1 null mice

scientific journal article

Urea transporter proteins as targets for small-molecule diuretics

artículo científico publicado en 2014

ΔF508-CFTR Modulator Screen Based on Cell Surface Targeting of a Chimeric Nucleotide Binding Domain 1 Reporter

artículo científico publicado en 2018

Lista de obras de

3-(2-Benzyloxyphenyl)isoxazoles and isoxazolines: synthesis and evaluation as CFTR activators

4,8-Dimethylcoumarin Inhibitors of Intestinal Anion Exchanger slc26a3 (Downregulated in Adenoma) for Anti-Absorptive Therapy of Constipation

A simple method to generate human airway epithelial organoids with externally orientated apical membranes

Aggregation state determines the localization and function of M1- and M23-aquaporin-4 in astrocytes

Alpha-aminoazaheterocyclic-methylglyoxal adducts do not inhibit cystic fibrosis transmembrane conductance regulator chloride channel activity.

Altered channel gating mechanism for CFTR inhibition by a high-affinity thiazolidinone blocker

Anchored PDE4 regulates chloride conductance in wild-type and ΔF508-CFTR human airway epithelia

Antidiarrheal efficacy and cellular mechanisms of a Thai herbal remedy

Aquaporin water channels in the nervous system.

Aquaporin-1 Expression in Herniated Human Lumbar Intervertebral Discs

Aquaporin-3 mediates hydrogen peroxide-dependent responses to environmental stress in colonic epithelia

Aquaporin-4 and brain edema.

Aquaporin-4: orthogonal array assembly, CNS functions, and role in neuromyelitis optica.

Aquaporins: important but elusive drug targets.

Benzoflavone activators of the cystic fibrosis transmembrane conductance regulator: towards a pharmacophore model for the nucleotide-binding domain

Bioactive Thymosin Alpha-1 Does Not Influence F508del-CFTR Maturation and Activity

CFTR activation in human bronchial epithelial cells by novel benzoflavone and benzimidazolone compounds

CFTR chloride channel drug discovery--inhibitors as antidiarrheals and activators for therapy of cystic fibrosis

CFTR inhibitors

Chemokine-dependent T cell migration requires aquaporin-3-mediated hydrogen peroxide uptake

Chloride channels as drug targets

Complement-independent retinal pathology produced by intravitreal injection of neuromyelitis optica immunoglobulin G.

Contribution of CFTR to apical-basolateral fluid transport in cultured human alveolar epithelial type II cells

Correctors and Potentiators Rescue Function of the Truncated W1282X-Cystic Fibrosis Transmembrane Regulator (CFTR) Translation Product

Determinants of aquaporin-4 assembly in orthogonal arrays revealed by live-cell single-molecule fluorescence imaging

Discovery of glycine hydrazide pore-occluding CFTR inhibitors: mechanism, structure-activity analysis, and in vivo efficacy

Disruption of aquaporin-11 produces polycystic kidneys following vacuolization of the proximal tubule

Drug discovery and epithelial physiology

Evidence for direct CFTR inhibition by CFTR(inh)-172 based on Arg347 mutagenesis.

Experimental animal models of aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders: progress and shortcomings

Experimental mouse model of optic neuritis with inflammatory demyelination produced by passive transfer of neuromyelitis optica-immunoglobulin G.

Function-Oriented Synthesis of a Didesmethyl Triazacryptand Analogue for Fluorescent Potassium Ion Sensing

High-affinity activators of cystic fibrosis transmembrane conductance regulator (CFTR) chloride conductance identified by high-throughput screening

Hollow Micropillar Array Method for High-Capacity Drug Screening on Filter-Grown Epithelial Cells

Imaging Renal Urea Handling in Rats at Millimeter Resolution using Hyperpolarized Magnetic Resonance Relaxometry.

Improved long-term outcome after transient cerebral ischemia in aquaporin-4 knockout mice

Knock-out models reveal new aquaporin functions

Lectin conjugates as potent, nonabsorbable CFTR inhibitors for reducing intestinal fluid secretion in cholera.

Marked central nervous system pathology in CD59 knockout rats following passive transfer of Neuromyelitis optica immunoglobulin G.

Mechanism-based corrector combination restores ΔF508-CFTR folding and function

Mechanisms of Autoantibody-Induced Pathology.

Microfluidics platform for measurement of volume changes in immobilized intestinal enteroids

Mildly Reduced Brain Swelling and Improved Neurological Outcome in Aquaporin-4 Knockout Mice following Controlled Cortical Impact Brain Injury.

Mutagenesis of the aquaporin 4 extracellular domains defines restricted binding patterns of pathogenic neuromyelitis optica IgG.

Nanomolar CFTR inhibition by pore-occluding divalent polyethylene glycol-malonic acid hydrazides

Nanomolar-Potency Aminophenyl-1,3,5-triazine Activators of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Chloride Channel for Prosecretory Therapy of Dry Eye Diseases

Phenylglycine and sulfonamide correctors of defective delta F508 and G551D cystic fibrosis transmembrane conductance regulator chloride-channel gating

Phenylquinoxalinone CFTR activator as potential prosecretory therapy for constipation

Proinflammatory cytokine secretion is suppressed by TMEM16A or CFTR channel activity in human cystic fibrosis bronchial epithelia

Reduced PDZ interactions of rescued ΔF508CFTR increases its cell surface mobility.

Salt-sparing diuretic action of a water-soluble urea analog inhibitor of urea transporters UT-A and UT-B in rats

Secretory diarrhoea: mechanisms and emerging therapies

Small-molecule correctors of defective DeltaF508-CFTR cellular processing identified by high-throughput screening.

Small-molecule inhibitors of urea transporters

Solute and macromolecule diffusion in cellular aqueous compartments

Some gating potentiators, including VX-770, diminish ΔF508-CFTR functional expression.

Spatial model of convective solute transport in brain extracellular space does not support a "glymphatic" mechanism.

Superresolution Imaging of Aquaporin-4 Cluster Size in Antibody-Stained Paraffin Brain Sections

Synthesis and evaluation of 5,6-disubstituted thiopyrimidine aryl aminothiazoles as inhibitors of the calcium-activated chloride channel TMEM16A/Ano1.

TRPV4 and AQP4 Channels Synergistically Regulate Cell Volume and Calcium Homeostasis in Retinal Müller Glia

Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion.

Tolerance checkpoint bypass permits emergence of pathogenic T cells to neuromyelitis optica autoantigen aquaporin-4.

Transient hyperckemia in the setting of neuromyelitis optica (NMO).

Treatment of neuromyelitis optica: state-of-the-art and emerging therapies

Unimpaired osmotic water permeability and fluid secretion in bile duct epithelia of AQP1 null mice

Urea transporter proteins as targets for small-molecule diuretics

ΔF508-CFTR Modulator Screen Based on Cell Surface Targeting of a Chimeric Nucleotide Binding Domain 1 Reporter