Lista de obras -

53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

artículo científico publicado en 2010

A RAD51 assay feasible in routine tumor samples calls PARP inhibitor response beyond BRCA mutation

artículo científico publicado en 2018

A high-throughput pharmaceutical screen identifies compounds with specific toxicity against BRCA2-deficient tumors

artículo científico publicado en 2009

A whole-genome mouse BAC microarray with 1-Mb resolution for analysis of DNA copy number changes by array comparative genomic hybridization

artículo científico publicado en 2004

Analysis of tumor heterogeneity and cancer gene networks using deep sequencing of MMTV-induced mouse mammary tumors.

artículo científico publicado en 2013

Aneuploidy arises at early stages of Apc-driven intestinal tumorigenesis and pinpoints conserved chromosomal loci of allelic imbalance between mouse and human

scientific journal article

Atlas of Lobular Breast Cancer Models: Challenges and Strategic Directions

artículo científico publicado en 2021

Author Correction: Landscape of somatic mutations in 560 breast cancer whole-genome sequences

artículo científico publicado en 2019

Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development

artículo científico publicado en 2006

BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity

artículo científico publicado en 2017

BRCA1 deficiency in skin epidermis leads to selective loss of hair follicle stem cells and their progeny

scientific journal article

BRCA1-associated mammary tumorigenesis is dependent on estrogen rather than progesterone signaling

artículo científico publicado en 2018

BRCA1-mutated and basal-like breast cancers have similar aCGH profiles and a high incidence of protein truncating TP53 mutations

artículo científico publicado en 2010

BRCA1185delAG tumors may acquire therapy resistance through expression of RING-less BRCA1

artículo científico publicado en 2016

BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping

scientific journal article

BRCAness, SLFN11, and RB1 loss predict response to topoisomerase I inhibitors in triple-negative breast cancers

artículo científico publicado en 2020

BRD7 is a candidate tumour suppressor gene required for p53 function

artículo científico publicado en 2010

Chemotherapy response of spontaneous mammary tumors is independent of the adaptive immune system ⬇️

artículo científico publicado el 6 de marzo de 2012

Chromosome instability induced by Mps1 and p53 mutation generates aggressive lymphomas exhibiting aneuploidy-induced stress.

artículo científico publicado en 2014

Comparative oncogenomics identifies combinations of driver genes and drug targets in BRCA1-mutated breast cancer

artículo científico publicado en 2019

Computational identification of insertional mutagenesis targets for cancer gene discovery ⬇️

artículo científico publicado el 7 de junio de 2011

Conditional mouse models of sporadic cancer

artículo científico publicado en 2002

Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts

scientific article published on 07 January 2021

CopywriteR: DNA copy number detection from off-target sequence data

artículo científico publicado en 2015

Cross-species comparison of aCGH data from mouse and human BRCA1- and BRCA2-mutated breast cancers

artículo científico publicado en 2010

Cytosolic p120-catenin regulates growth of metastatic lobular carcinoma through Rock1-mediated anoikis resistance ⬇️

artículo científico publicado el 11 de julio de 2011

Deleted in colorectal carcinoma suppresses metastasis in p53-deficient mammary tumours ⬇️

artículo científico publicado el 22 de febrero de 2012

Developmental stage‐specific contribution of LGR5+ cells to basal and luminal epithelial lineages in the postnatal mammary gland ⬇️

artículo científico publicado el 1 de noviembre de 2012

EZH2 Is Overexpressed in -like Breast Tumors and Predictive for Sensitivity to High-Dose Platinum-Based Chemotherapy

artículo científico publicado en 2019

EZN-2208 (PEG-SN38) overcomes ABCG2-mediated topotecan resistance in BRCA1-deficient mouse mammary tumors

artículo científico publicado en 2012

Error-prone translesion replication of damaged DNA suppresses skin carcinogenesis by controlling inflammatory hyperplasia

artículo científico publicado en 2009

Exogenous ERα Expression in the Mammary Epithelium Decreases Over Time and Does Not Contribute to p53-Deficient Mammary Tumor Formation in Mice

artículo científico publicado en 2019

Exosome transfer from stromal to breast cancer cells regulates therapy resistance pathways

artículo científico publicado en 2014

Feasibility of Phosphoproteomics on Leftover Samples After RNA Extraction With Guanidinium Thiocyanate

artículo científico publicado en 2021

Fgf10 is an oncogene activated by MMTV insertional mutagenesis in mouse mammary tumors and overexpressed in a subset of human breast carcinomas

artículo científico publicado en 2004

Frat is dispensable for canonical Wnt signaling in mammals

scientific journal article

Functional categorization of BRCA1 variants of uncertain clinical significance in homologous recombination repair complementation assays

artículo científico publicado en 2020

GATA3 Truncating Mutations Promote Cistromic Re-Programming In Vitro, but Not Mammary Tumor Formation in Mice

scientific article published on 19 June 2019

Genetically engineered mouse models in oncology research and cancer medicine

artículo científico publicado en 2016

Genetically engineered mouse models of PI3K signaling in breast cancer

artículo científico publicado en 2013

Genomic instability in breast and ovarian cancers: translation into clinical predictive biomarkers ⬇️

artículo científico publicado el 16 de septiembre de 2011

Genomic patterns resembling BRCA1- and BRCA2-mutated breast cancers predict benefit of intensified carboplatin-based chemotherapy

artículo científico publicado en 2014

Glucocorticoid receptor triggers a reversible drug-tolerant dormancy state with acquired therapeutic vulnerabilities in lung cancer

artículo científico publicado en 2021

HELB Is a Feedback Inhibitor of DNA End Resection

scientific journal article

High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs

artículo científico publicado en 2008

Human and mouse oligonucleotide-based array CGH.

artículo científico publicado en 2005

Identification of cancer genes using a statistical framework for multiexperiment analysis of nondiscretized array CGH data

artículo científico publicado en 2008

Identification of networks of co-occurring, tumor-related DNA copy number changes using a genome-wide scoring approach

artículo científico publicado en 2010

Impact of intertumoral heterogeneity on predicting chemotherapy response of BRCA1-deficient mammary tumors

artículo científico publicado en 2012

In situ CRISPR-Cas9 base editing for the development of genetically engineered mouse models of breast cancer

artículo científico publicado en 2020

Insertional mutagenesis identifies drivers of a novel oncogenic pathway in invasive lobular breast carcinoma

artículo científico publicado en 2017

Insertional mutagenesis in mice deficient for p15Ink4b, p16Ink4a, p21Cip1, and p27Kip1 reveals cancer gene interactions and correlations with tumor phenotypes

artículo científico publicado en 2010

KC-SMARTR: An R package for detection of statistically significant aberrations in multi-experiment aCGH data.

artículo científico publicado en 2010

Lack of genomic heterogeneity at high-resolution aCGH between primary breast cancers and their paired lymph node metastases

artículo científico publicado en 2014

Landscape of somatic mutations in 560 breast cancer whole-genome sequences

artículo científico publicado en 2016

Long-term expanding human airway organoids for disease modeling

scientific article published on 14 January 2019

Loss of p120-Catenin Induces Metastatic Progression of Breast Cancer by Inducing Anoikis Resistance and Augmenting Growth Factor Receptor Signaling ⬇️

artículo científico publicado el 3 de junio de 2013

Loss of p53 partially rescues embryonic development of Palb2 knockout mice but does not foster haploinsufficiency of Palb2 in tumour suppression

scientific journal article

MEK inhibition as a strategy for targeting residual breast cancer cells with low DUSP4 expression ⬇️

artículo científico publicado el 5 de noviembre de 2012

MYC promotes immune-suppression in triple-negative breast cancer via inhibition of interferon signaling

scientific article published in 2022

Mammary-specific inactivation of E-cadherin and p53 impairs functional gland development and leads to pleomorphic invasive lobular carcinoma in mice

artículo científico publicado en 2011

Mechanisms of Therapy Resistance in Patient-Derived Xenograft Models of BRCA1-Deficient Breast Cancer

artículo científico publicado en 2016

Mice deficient for all PIM kinases display reduced body size and impaired responses to hematopoietic growth factors

artículo científico publicado en 2004

Mouse Model Systems to Study Multistep Tumorigenesis ⬇️

artículo científico publicado el 1 de enero de 1994

Mutagenic insertion and chromosome engineering resource (MICER).

artículo científico publicado en 2004

Novel candidate cancer genes identified by a large-scale cross-species comparative oncogenomics approach

artículo científico publicado en 2010

Opportunities and hurdles in the treatment of BRCA1-related breast cancer ⬇️

artículo científico publicado el 19 de agosto de 2013

PARP Inhibitor Efficacy Depends on CD8+ T-cell Recruitment via Intratumoral STING Pathway Activation in BRCA-Deficient Models of Triple-Negative Breast Cancer

scientific article published on 23 April 2019

PTEN Loss in E-Cadherin-Deficient Mouse Mammary Epithelial Cells Rescues Apoptosis and Results in Development of Classical Invasive Lobular Carcinoma

artículo científico publicado en 2016

Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer

scientific journal article

Patient-derived xenograft models: an emerging platform for translational cancer research

artículo científico publicado en 2014

Prophylactic window therapy with the clinical poly(ADP-ribose) polymerase inhibitor olaparib delays BRCA1-deficient mammary tumour formation in mice

artículo científico publicado en 2016

Proteomics of genetically engineered mouse mammary tumors identifies fatty acid metabolism members as potential predictive markers for cisplatin resistance

artículo científico publicado en 2013

Proteomics of mouse BRCA1-deficient mammary tumors identifies DNA repair proteins with potential diagnostic and prognostic value in human breast cancer

artículo científico publicado en 2012

Publisher Correction: Truncated FGFR2 is a clinically actionable oncogene in multiple cancers

artículo científico publicado en 2022

Radiosensitivity Is an Acquired Vulnerability of PARPi-Resistant BRCA1-Deficient Tumors

artículo científico publicado en 2018

Rapid validation of cancer genes in chimeras derived from established genetically engineered mouse models ⬇️

artículo científico publicado el 7 de julio de 2011

Rebalancing of actomyosin contractility enables mammary tumor formation upon loss of E-cadherin

scientific article published on 23 August 2019

Response of metastatic mouse invasive lobular carcinoma to mTOR inhibition is partly mediated by the adaptive immune system

artículo científico publicado en 2020

Secretome proteomics reveals candidate non-invasive biomarkers of BRCA1 deficiency in breast cancer

scientific article published on 23 August 2016

Selective inhibition of BRCA2-deficient mammary tumor cell growth by AZD2281 and cisplatin.

artículo científico publicado en 2008

Sensitivity and acquired resistance of BRCA1;p53-deficient mouse mammary tumors to the topoisomerase I inhibitor topotecan

artículo científico publicado en 2010

Somatic structural rearrangements in genetically engineered mouse mammary tumors

artículo científico publicado en 2010

Sorafenib synergizes with metformin in NSCLC through AMPK pathway activation

artículo científico publicado en 2014

Studying Therapy Response and Resistance in Mouse Models for BRCA1-Deficient Breast Cancer ⬇️

artículo científico publicado el 18 de febrero de 2011

Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer ⬇️

artículo científico publicado el 1 de diciembre de 2001

TRPS1 acts as a context-dependent regulator of mammary epithelial cell growth/differentiation and breast cancer development

artículo científico publicado en 2019

The effects of deregulated DNA damage signalling on cancer chemotherapy response and resistance ⬇️

artículo científico publicado el 1 de septiembre de 2012

Tracking Evolution of BRCA1-Associated Breast Cancer ⬇️

artículo científico publicado el 1 de junio de 2012

Transcriptomics and Transposon Mutagenesis Identify Multiple Mechanisms of Resistance to the FGFR Inhibitor AZD4547

artículo científico publicado en 2018

Truncated ASPP2 Drives Initiation and Progression of Invasive Lobular Carcinoma via Distinct Mechanisms

artículo científico publicado en 2020

Truncated FGFR2 is a clinically actionable oncogene in multiple cancers

artículo científico publicado en 2022

Tumor-initiating cells are not enriched in cisplatin-surviving BRCA1;p53-deficient mammary tumor cells in vivo

artículo científico publicado en 2010

Use of a single hybrid imaging agent for integration of target validation with in vivo and ex vivo imaging of mouse tumor lesions resembling human DCIS

artículo científico publicado en 2013

αE-catenin is a candidate tumor suppressor for the development of E-cadherin-expressing lobular-type breast cancer

scientific article published on 20 June 2018

Lista de obras de

53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

A RAD51 assay feasible in routine tumor samples calls PARP inhibitor response beyond BRCA mutation

A high-throughput pharmaceutical screen identifies compounds with specific toxicity against BRCA2-deficient tumors

A whole-genome mouse BAC microarray with 1-Mb resolution for analysis of DNA copy number changes by array comparative genomic hybridization

Analysis of tumor heterogeneity and cancer gene networks using deep sequencing of MMTV-induced mouse mammary tumors.

Aneuploidy arises at early stages of Apc-driven intestinal tumorigenesis and pinpoints conserved chromosomal loci of allelic imbalance between mouse and human

Atlas of Lobular Breast Cancer Models: Challenges and Strategic Directions

Author Correction: Landscape of somatic mutations in 560 breast cancer whole-genome sequences

Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development

BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity

BRCA1 deficiency in skin epidermis leads to selective loss of hair follicle stem cells and their progeny

BRCA1-associated mammary tumorigenesis is dependent on estrogen rather than progesterone signaling

BRCA1-mutated and basal-like breast cancers have similar aCGH profiles and a high incidence of protein truncating TP53 mutations

BRCA1185delAG tumors may acquire therapy resistance through expression of RING-less BRCA1

BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping

BRCAness, SLFN11, and RB1 loss predict response to topoisomerase I inhibitors in triple-negative breast cancers

BRD7 is a candidate tumour suppressor gene required for p53 function

Chemotherapy response of spontaneous mammary tumors is independent of the adaptive immune system ⬇️

Chromosome instability induced by Mps1 and p53 mutation generates aggressive lymphomas exhibiting aneuploidy-induced stress.

Comparative oncogenomics identifies combinations of driver genes and drug targets in BRCA1-mutated breast cancer

Computational identification of insertional mutagenesis targets for cancer gene discovery ⬇️

Conditional mouse models of sporadic cancer

Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts

CopywriteR: DNA copy number detection from off-target sequence data

Cross-species comparison of aCGH data from mouse and human BRCA1- and BRCA2-mutated breast cancers

Cytosolic p120-catenin regulates growth of metastatic lobular carcinoma through Rock1-mediated anoikis resistance ⬇️

Deleted in colorectal carcinoma suppresses metastasis in p53-deficient mammary tumours ⬇️

Developmental stage‐specific contribution of LGR5+ cells to basal and luminal epithelial lineages in the postnatal mammary gland ⬇️

EZH2 Is Overexpressed in -like Breast Tumors and Predictive for Sensitivity to High-Dose Platinum-Based Chemotherapy

EZN-2208 (PEG-SN38) overcomes ABCG2-mediated topotecan resistance in BRCA1-deficient mouse mammary tumors

Error-prone translesion replication of damaged DNA suppresses skin carcinogenesis by controlling inflammatory hyperplasia

Exogenous ERα Expression in the Mammary Epithelium Decreases Over Time and Does Not Contribute to p53-Deficient Mammary Tumor Formation in Mice

Exosome transfer from stromal to breast cancer cells regulates therapy resistance pathways

Feasibility of Phosphoproteomics on Leftover Samples After RNA Extraction With Guanidinium Thiocyanate

Fgf10 is an oncogene activated by MMTV insertional mutagenesis in mouse mammary tumors and overexpressed in a subset of human breast carcinomas

Frat is dispensable for canonical Wnt signaling in mammals

Functional categorization of BRCA1 variants of uncertain clinical significance in homologous recombination repair complementation assays

GATA3 Truncating Mutations Promote Cistromic Re-Programming In Vitro, but Not Mammary Tumor Formation in Mice

Genetically engineered mouse models in oncology research and cancer medicine

Genetically engineered mouse models of PI3K signaling in breast cancer

Genomic instability in breast and ovarian cancers: translation into clinical predictive biomarkers ⬇️

Genomic patterns resembling BRCA1- and BRCA2-mutated breast cancers predict benefit of intensified carboplatin-based chemotherapy

Glucocorticoid receptor triggers a reversible drug-tolerant dormancy state with acquired therapeutic vulnerabilities in lung cancer

HELB Is a Feedback Inhibitor of DNA End Resection

High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs

Human and mouse oligonucleotide-based array CGH.

Identification of cancer genes using a statistical framework for multiexperiment analysis of nondiscretized array CGH data

Identification of networks of co-occurring, tumor-related DNA copy number changes using a genome-wide scoring approach

Impact of intertumoral heterogeneity on predicting chemotherapy response of BRCA1-deficient mammary tumors

In situ CRISPR-Cas9 base editing for the development of genetically engineered mouse models of breast cancer

Insertional mutagenesis identifies drivers of a novel oncogenic pathway in invasive lobular breast carcinoma

Insertional mutagenesis in mice deficient for p15Ink4b, p16Ink4a, p21Cip1, and p27Kip1 reveals cancer gene interactions and correlations with tumor phenotypes

KC-SMARTR: An R package for detection of statistically significant aberrations in multi-experiment aCGH data.

Lack of genomic heterogeneity at high-resolution aCGH between primary breast cancers and their paired lymph node metastases

Landscape of somatic mutations in 560 breast cancer whole-genome sequences

Long-term expanding human airway organoids for disease modeling

Loss of p120-Catenin Induces Metastatic Progression of Breast Cancer by Inducing Anoikis Resistance and Augmenting Growth Factor Receptor Signaling ⬇️

Loss of p53 partially rescues embryonic development of Palb2 knockout mice but does not foster haploinsufficiency of Palb2 in tumour suppression

MEK inhibition as a strategy for targeting residual breast cancer cells with low DUSP4 expression ⬇️

MYC promotes immune-suppression in triple-negative breast cancer via inhibition of interferon signaling

Mammary-specific inactivation of E-cadherin and p53 impairs functional gland development and leads to pleomorphic invasive lobular carcinoma in mice

Mechanisms of Therapy Resistance in Patient-Derived Xenograft Models of BRCA1-Deficient Breast Cancer

Mice deficient for all PIM kinases display reduced body size and impaired responses to hematopoietic growth factors

Mouse Model Systems to Study Multistep Tumorigenesis ⬇️

Mutagenic insertion and chromosome engineering resource (MICER).

Novel candidate cancer genes identified by a large-scale cross-species comparative oncogenomics approach

Opportunities and hurdles in the treatment of BRCA1-related breast cancer ⬇️

PARP Inhibitor Efficacy Depends on CD8+ T-cell Recruitment via Intratumoral STING Pathway Activation in BRCA-Deficient Models of Triple-Negative Breast Cancer

PTEN Loss in E-Cadherin-Deficient Mouse Mammary Epithelial Cells Rescues Apoptosis and Results in Development of Classical Invasive Lobular Carcinoma

Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer

Patient-derived xenograft models: an emerging platform for translational cancer research

Prophylactic window therapy with the clinical poly(ADP-ribose) polymerase inhibitor olaparib delays BRCA1-deficient mammary tumour formation in mice

Proteomics of genetically engineered mouse mammary tumors identifies fatty acid metabolism members as potential predictive markers for cisplatin resistance

Proteomics of mouse BRCA1-deficient mammary tumors identifies DNA repair proteins with potential diagnostic and prognostic value in human breast cancer

Publisher Correction: Truncated FGFR2 is a clinically actionable oncogene in multiple cancers

Radiosensitivity Is an Acquired Vulnerability of PARPi-Resistant BRCA1-Deficient Tumors

Rapid validation of cancer genes in chimeras derived from established genetically engineered mouse models ⬇️

Rebalancing of actomyosin contractility enables mammary tumor formation upon loss of E-cadherin

Response of metastatic mouse invasive lobular carcinoma to mTOR inhibition is partly mediated by the adaptive immune system