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124 Heterogeneity of Allergen Epitope-specific CD4+ T Cells Responses: Steps Toward Optimal Composition for Peptide-based Immunotherapy

3.2-01 A genetically controlled pairing anomaly between HLA-DQα and HLA-DQβ molecules

6.2-12 Mutagenesis and expression studies of the Dw14 (DR4) epitope

A Comparative Analysis of the Peptide Repertoires of HLA-DR Molecules Differentially Associated With Rheumatoid Arthritis.

artículo científico publicado en 2016

A Novel Approach of Identifying Immunodominant Self and Viral Antigen Cross-Reactive T Cells and Defining the Epitopes They Recognize

article

A disease-associated cellular immune response in type 1 diabetics to an immunodominant epitope of insulin

artículo científico publicado en 2001

A genetically controlled pairing anomaly between HLA-DQ alpha and HLA-DQ beta chains.

artículo científico publicado en 1989

A peptide binding motif for HLA-DQA1*0102/DQB1*0602, the class II MHC molecule associated with dominant protection in insulin-dependent diabetes mellitus ⬇️

artículo científico publicado el 1 de marzo de 1998

A phenotypically and functionally distinct human TH2 cell subpopulation is associated with allergic disorders.

artículo científico publicado en 2017

Acquisition of pneumococci specific effector and regulatory Cd4+ T cells localising within human upper respiratory-tract mucosal lymphoid tissue.

artículo científico publicado en 2011

Activated human epitope-specific T cells identified by class II tetramers reside within a CD4high, proliferating subset

artículo científico publicado en 2001

Allele-specific motifs characterize HLA-DQ interactions with a diabetes-associated peptide derived from glutamic acid decarboxylase.

artículo científico publicado en 1996

Allelic variants of MHC class II Molecules can ACT as partial agonists of antigen-specific T cell responses

article

Allelic variation in key peptide-binding pockets discriminates between closely related diabetes-protective and diabetes-susceptible HLA-DQB1*06 alleles

artículo científico publicado en 2006

Allergen-specific CD4+ T cell responses in peripheral blood do not predict the early onset of clinical efficacy during grass pollen sublingual immunotherapy

artículo científico publicado en 2012

Allergen-specific MHC class II tetramer+ cells are detectable in allergic, but not in nonallergic, individuals

artículo científico publicado en 2006

Allergen-specific naïve and memory CD4+ T cells exhibit functional and phenotypic differences between individuals with or without allergy

artículo científico publicado en 2010

Allergic asthma is distinguished by sensitivity of allergen-specific CD4+ T cells and airway structural cells to type 2 inflammation

artículo científico publicado en 2016

Allorecognition of HLA-DQw8 molecules: Influence of single amino acid substitutions

article

Allospecific epitopes of the DQw3.2 (DQw8) molecule

Amino acids in the peptide-binding groove influence an antibody-defined, disease-associated HLA-DR epitope

artículo científico publicado en 1994

Ana o 1 and Ana o 2 cashew allergens share cross-reactive CD4(+) T cell epitopes with other tree nuts

artículo científico publicado en 2016

Analysis of pancreatic beta cell specific CD4+ T cells reveals a predominance of proinsulin specific cells

scientific article published on 07 November 2018

Antibiotic-refractory Lyme arthritis is associated with HLA-DR molecules that bind a Borrelia burgdorferi peptide

artículo científico publicado en 2006

Antigen-Specific CD4+ T Cells Recognize Epitopes of Protective Antigen following Vaccination with an Anthrax Vaccine.

artículo científico publicado en 2007

Antigen-Specific T Cell Analysis Reveals That Active Immune Responses to β Cell Antigens Are Focused on a Unique Set of Epitopes.

artículo científico publicado en 2017

Antigen-specific CD4+ T cells recognize epitopes of protective antigen following vaccination with an anthrax vaccine.

artículo científico publicado en 2007

Ara h 1-reactive T cells in individuals with peanut allergy

artículo científico publicado en 2011

Arginine kinase Pen m 2 as an important shrimp allergen recognized by TH2 cells.

artículo científico publicado en 2014

Assessment of CD4+ T cell responses to glutamic acid decarboxylase 65 using DQ8 tetramers reveals a pathogenic role of GAD65 121-140 and GAD65 250-266 in T1D development

artículo científico publicado en 2014

Assessment of seasonal influenza A virus-specific CD4 T-cell responses to 2009 pandemic H1N1 swine-origin influenza A virus

artículo científico publicado en 2010

Autoantigen-specific regulatory T cells, a potential tool for immune-tolerance reconstitution in type-2 autoimmune hepatitis ⬇️

artículo científico publicado el 28 de diciembre de 2010

Autoreactive CD4(+) T cells in patients with atopic dermatitis

artículo científico publicado en 2011

Autoreactive T cells in healthy individuals

artículo científico publicado en 2004

Autoreactive T cells specific for insulin B:11-23 recognize a low-affinity peptide register in human subjects with autoimmune diabetes

artículo científico publicado en 2014

Beta 57-Asp plays an essential role in the unique SDS stability of HLA-DQA1*0102/DQB1*0602 alpha beta protein dimer, the class II MHC allele associated with protection from insulin-dependent diabetes mellitus

artículo científico publicado en 2000

Broadly directed virus-specific CD4+ T cell responses are primed during acute hepatitis C infection, but rapidly disappear from human blood with viral persistence ⬇️

artículo científico publicado el 2 de enero de 2012

C-terminal modification of the insulin B:11-23 peptide creates superagonists in mouse and human type 1 diabetes

artículo científico publicado en 2017

CD4+ T cells from type 1 diabetic and healthy subjects exhibit different thresholds of activation to a naturally processed proinsulin epitope

artículo científico publicado en 2008

CD4+ T cells recognize diverse epitopes within GAD65: implications for repertoire development and diabetes monitoring.

artículo científico publicado en 2013

CD4+ T cells recognize unique and conserved 2009 H1N1 influenza hemagglutinin epitopes after natural infection and vaccination.

artículo científico publicado en 2013

CD8 CTL from genital herpes simplex lesions: recognition of viral tegument and immediate early proteins and lysis of infected cutaneous cells.

artículo científico publicado en 2001

CD8+ suppressor-mediated regulation of human CD4+ T cell responses to glutamic acid decarboxylase 65.

artículo científico publicado en 2007

Canine model for gene therapy: inefficient gene expression in dogs reconstituted with autologous marrow infected with retroviral vectors

artículo científico publicado en 1988

Central T cell tolerance: Identification of tissue-restricted autoantigens in the thymus HLA-DR peptidome.

artículo científico publicado en 2015

Challenges in staining T cells using HLA class II tetramers

artículo científico publicado en 2003

Characterization of CD4+ T cell subsets in allergy ⬇️

artículo científico publicado el 10 de agosto de 2012

Characterization of a Novel Reverse-orientation Model for a Peptide/MHC Complex Putatively Associated with Type I Diabetes Mellitus

article

Chronic cat allergen exposure induces a TH2 cell-dependent IgG4 response related to low sensitization

artículo científico publicado en 2015

Circulating Memory CD4+ T Cells Target Conserved Epitopes of Rhinovirus Capsid Proteins and Respond Rapidly to Experimental Infection in Humans

artículo científico publicado en 2016

Circulating Type-1 Anti-Tumor CD4(+) T Cells are Preferentially Pro-Apoptotic in Cancer Patients.

artículo científico publicado en 2014

Clustering of T cell ligands on artificial APC membranes influences T cell activation and protein kinase C theta translocation to the T cell plasma membrane.

artículo científico publicado en 2005

Comparative study of GAD65-specific CD4+ T cells in healthy and type 1 diabetic subjects

artículo científico publicado en 2005

Comparison between major histocompatibility complex class II tetramer staining and surface expression of activation markers for the detection of allergen‐specific CD4+ T cells ⬇️

artículo científico publicado el 21 de marzo de 2011

Correction: Unsupervised capture and profiling of rare immune cells using multi-directional magnetic ratcheting

scientific article published on 13 November 2018

Critical contribution of beta chain residue 57 in peptide binding ability of both HLA-DR and -DQ molecules

artículo científico publicado en 1996

Cross-reactive and mono-reactive SARS-CoV-2 CD4+ T cells in prepandemic and COVID-19 convalescent individuals

artículo científico publicado en 2021

Cytotoxic herpes simplex type 2-specific, DQ0602-restricted CD4 T+-cell clones show alloreactivity to DQ0601.

artículo científico publicado en 2006

DRB1*12:01 presents a unique subset of epitopes by preferring aromatics in pocket 9

artículo científico publicado en 2011

DRB4*01:01 Has a Distinct Motif and Presents a Proinsulin Epitope That Is Recognized in Subjects with Type 1 Diabetes

artículo científico publicado en 2018

DX and DQ Promoter Regions Contain Homologous Sequences That Differ in Extent of Methylation

Decline in the Frequencies of Borrelia burgdorferi OspA161-175-Specific T Cells after Antibiotic Therapy in HLA-DRB1*0401-Positive Patients with Antibiotic-Responsive or Antibiotic-Refractory Lyme Arthritis

artículo científico publicado en 2007

Deficient antigen-presenting cell function in multiple genetic complementation groups of type II bare lymphocyte syndrome

artículo científico publicado en 1995

Defining antigen-specific responses with human MHC class II tetramers.

artículo científico publicado en 2002

Definition of the peptide binding motif within DRB1*1401 restricted epitopes by peptide competition and structural modeling

artículo científico publicado en 2008

Der p 1-specific regulatory T-cell response during house dust mite allergen immunotherapy

scientific article published on 13 January 2019

Detection of CD4+ autoreactive T cells in T1D using HLA class II tetramers

artículo científico publicado en 2003

Detection of GAD65-specific T-cells by major histocompatibility complex class II tetramers in type 1 diabetic patients and at-risk subjects

artículo científico publicado en 2002

Detection of low avidity desmoglein 3-reactive T cells in pemphigus vulgaris using HLA-DR beta 1*0402 tetramers

artículo científico publicado en 2006

Differences in self-peptide binding between T1D-related susceptible and protective DR4 subtypes ⬇️

artículo científico publicado el 22 de enero de 2011

Differential CD4+ T-cell responses of allergic and non-allergic subjects to the immunodominant epitope region of the horse major allergen Equ c 1.

artículo científico publicado en 2014

Differential antigen sensitivity and costimulatory requirements in human Th1 and Th2 antigen-specific CD4+ cells with similar TCR avidity

artículo científico publicado en 2003

Differential binding of pyruvate dehydrogenase complex-E2 epitopes by DRB1*08:01 and DRB1*11:01 Is predicted by their structural motifs and correlates with disease risk

artículo científico publicado en 2013

Differential recognition and activation thresholds in human autoreactive GAD-specific T-cells

artículo científico publicado en 2004

Differentiation stage determines pathologic and protective allergen-specific CD4+ T-cell outcomes during specific immunotherapy

artículo científico publicado en 2011

Diminished Proliferation of Human Immunodeficiency Virus-Specific CD4+T Cells Is Associated with Diminished Interleukin-2 (IL-2) Production and Is Recovered by Exogenous IL-2 ⬇️

artículo científico publicado el 1 de octubre de 2003

Direct ex vivo analysis of allergen-specific CD4+ T cells

artículo científico publicado en 2010

Direct killing of Epstein-Barr virus (EBV)-infected B cells by CD4 T cells directed against the EBV lytic protein BHRF1.

artículo científico publicado en 2003

Discriminative T cell recognition of cross-reactive islet-antigens is associated with HLA-DQ8 transdimer-mediated autoimmune diabetes

scientific article published on 21 August 2019

Disease-associated bias in T helper type 1 (Th1)/Th2 CD4(+) T cell responses against MAGE-6 in HLA-DRB10401(+) patients with renal cell carcinoma or melanoma

artículo científico publicado en 2002

Dissecting mechanisms of immunodominance to the common tuberculosis antigens ESAT-6, CFP10, Rv2031c (hspX), Rv2654c (TB7.7), and Rv1038c (EsxJ)

artículo científico publicado en 2012

Distinct T cell interactions with HLA class II tetramers characterize a spectrum of TCR affinities in the human antigen-specific T cell response

artículo científico publicado en 2000

Dominance and diversity in the primary human CD4 T cell response to replication-competent vaccinia virus

artículo científico publicado en 2007

Efficient ex vivo analysis of CD4+ T-cell responses using combinatorial HLA class II tetramer staining

artículo científico publicado en 2016

Eleven Amino Acids of HLA-DRB1 and Fifteen Amino Acids of HLA-DRB3, 4, and 5 Include Potentially Causal Residues Responsible for the Risk of Childhood Type 1 Diabetes

artículo científico publicado en 2019

Epitope Selection for HLA-DQ2 Presentation: Implications for Celiac Disease and Viral Defense

scientific article published on 29 March 2019

Epstein-Barr virus entry utilizing HLA-DP or HLA-DQ as a coreceptor

artículo científico publicado en 2000

Evaluating Responses to Gluten Challenge: A Randomized, Double-Blind, 2-Dose Gluten Challenge Trial

artículo científico publicado en 2020

Exceptional stability of the HLA-DQA1*0102/DQB1*0602 alpha beta protein dimer, the class II MHC molecule associated with protection from insulin-dependent diabetes mellitus.

artículo científico publicado en 1998

Expression from leukocyte integrin promoters in retroviral vectors

artículo científico publicado en 1994

Expression of HLA-DP0401 molecules for identification of DP0401 restricted antigen specific T cells.

artículo científico publicado en 2005

Expression of cutaneous lymphocyte-associated antigen and E-selectin ligand by circulating human memory CD4+ T lymphocytes specific for herpes simplex virus type 2.

artículo científico publicado en 2004

Extensive replicative capacity of human central memory T cells

artículo científico publicado en 2004

Frequency of Epitope-Specific Naive CD4+ T Cells Correlates with Immunodominance in the Human Memory Repertoire ⬇️

artículo científico publicado el 10 de febrero de 2012

Functional avidity directs T-cell fate in autoreactive CD4+ T cells

artículo científico publicado en 2005

Functional inflammatory profiles distinguish myelin-reactive T cells from patients with multiple sclerosis

artículo científico publicado en 2015

Functional islet-specific Treg can be generated from CD4+CD25- T cells of healthy and type 1 diabetic subjects

artículo científico publicado en 2009

GAD65- and proinsulin-specific CD4+ T-cells detected by MHC class II tetramers in peripheral blood of type 1 diabetes patients and at-risk subjects

article

GAD65-specific CD4+ T-cells with high antigen avidity are prevalent in peripheral blood of patients with type 1 diabetes

artículo científico publicado en 2004

Generation of high quantities of viral and tumor-specific human CD4+ and CD8+ T-cell clones using peptide pulsed mature dendritic cells

artículo científico publicado en 2001

Grass-specific CD4(+) T-cells exhibit varying degrees of cross-reactivity, implications for allergen-specific immunotherapy

artículo científico publicado en 2014

H5N1 strain-specific hemagglutinin CD4+ T cell epitopes restricted by HLA DR4.

artículo científico publicado en 2009

HCV-specific CD4+ T cells of patients with acute and chronic HCV infection display high expression of TIGIT and other co-inhibitory molecules

artículo científico publicado en 2019

HIV controller CD4+ T cells respond to minimal amounts of Gag antigen due to high TCR avidity

artículo científico publicado en 2010

HIV controllers maintain a population of highly efficient Th1 effector cells in contrast to patients treated in the long term.

artículo científico publicado en 2012

HLA class II peptide-binding and autoimmunity

artículo científico publicado en 2002

HLA class II polymorphisms determine responses to bacterial superantigens

artículo científico publicado en 2004

HLA class II tetramers: tools for direct analysis of antigen-specific CD4+ T cells

artículo científico publicado en 2002

HLA class II-restricted CD4+ T cell responses directed against influenza viral antigens postinfluenza vaccination

artículo científico publicado en 2003

HLA tetramer-based artificial antigen-presenting cells for stimulation of CD4+ T cells

article

HLA-DQ allelic polymorphisms constrain patterns of class II heterodimer formation.

artículo científico publicado en 1993

HLA-DQ molecules form alpha-beta heterodimers of mixed allotype.

artículo científico publicado en 1988

HLA-DQ polymorphisms are highly selective for peptide binding interactions ⬇️

artículo científico publicado el 1 de septiembre de 1995

HLA-DQ tetramers identify epitope-specific T cells in peripheral blood of herpes simplex virus type 2-infected individuals: direct detection of immunodominant antigen-responsive cells

artículo científico publicado en 2000

HLA-DQ2 and -DQ8 signatures of gluten T cell epitopes in celiac disease

artículo científico publicado en 2006

HLA-DQB1 codon 57 is critical for peptide binding and recognition.

artículo científico publicado en 1996

HLA-DR-restricted T-cell responses to factor VIII epitopes in a mild haemophilia A family with missense substitution A2201P.

artículo científico publicado en 2010

HLA-DR1001 presents "altered-self" peptides derived from joint-associated proteins by accepting citrulline in three of its binding pockets

artículo científico publicado en 2010

HLA-DR15 Molecules Jointly Shape an Autoreactive T Cell Repertoire in Multiple Sclerosis

artículo científico publicado en 2020

Healthy human subjects have CD4+ T cells directed against H5N1 influenza virus

artículo científico publicado en 2008

Heterogeneity of Ara h Component-Specific CD4 T Cell Responses in Peanut-Allergic Subjects.

artículo científico publicado en 2018

High Level of PD-1 Expression on Hepatitis C Virus (HCV)-Specific CD8 and CD4 T Cells during Acute HCV Infection, Irrespective of Clinical Outcome

artículo científico publicado en 2011

High Level of PD-1 Expression on Hepatitis C Virus (HCV)-Specific CD8+ and CD4+ T Cells during Acute HCV Infection, Irrespective of Clinical Outcome

artículo científico publicado en 2008

High and Sustained Ex Vivo Frequency but Altered Phenotype of SARS-CoV-2-Specific CD4+ T-Cells in an Anti-CD20-Treated Patient with Prolonged COVID-19

artículo científico publicado en 2022

How C-terminal additions to insulin B-chain fragments create superagonists for T cells in mouse and human type 1 diabetes

scientific article published on 01 April 2019

Human CD4+ T Cells Specific for Merkel Cell Polyomavirus Localize to Merkel Cell Carcinomas and Target a Required Oncogenic Domain

scientific article published on 12 August 2019

Human CD8⁺ and CD4⁺ T cell memory to lymphocytic choriomeningitis virus infection

artículo científico publicado en 2011

Human Th1 and Th2 Cells Targeting Rhinovirus and Allergen Coordinately Promote Allergic Asthma

scientific article published on 19 April 2020

Human class II major histocompatibility complex gene transfer into murine neuroblastoma leads to loss of tumorigenicity, immunity against subsequent tumor challenge, and elimination of microscopic preestablished tumors.

artículo científico publicado en 1995

Human homologues of a Borrelia T cell epitope associated with antibiotic-refractory Lyme arthritis

artículo científico publicado en 2007

Hybrid Insulin Peptides are Recognized by Human T Cells in the Context of DRB1*04:01

scientific article published on 14 April 2020

Identification and In Vitro Expansion of Functional Antigen-Specific CD25+ FoxP3+ Regulatory T Cells in Hepatitis C Virus Infection

artículo científico publicado en 2008

Identification of Human Antigen-Specific CD4+ T-Cells with Peptide-MHC Multimer Technologies

scientific article published on 01 January 2019

Identification of novel Mycobacterium tuberculosis CD4 T-cell antigens via high throughput proteome screening.

artículo científico publicado en 2015

Identification of the amino acid residues contributing to monoclonal antibody-defined DQw1 epitopes

artículo científico publicado en 1991

Identification of two molecular defects in a child with leukocyte adherence deficiency ⬇️

artículo científico publicado el 15 de marzo de 1992

Identification of type II collagen peptide 261-273-specific T cell clones in a patient with relapsing polychondritis

artículo científico publicado en 2002

Immune regulation by intralymphatic immunotherapy with modular allergen translocation MAT vaccine.

artículo científico publicado en 2014

Immunomodulatory potential of heteroclitic analogs of the dominant T-cell epitope of lipocalin allergen Bos d 2 on specific T cells

article

Impaired binding of a DQ2 and DQ8-binding HSV VP16 peptide to a DQA1*0501/DQB1*0302 trans class II heterodimer

artículo científico publicado en 1999

In vivo biotinylation of the major histocompatibility complex (MHC) class II/peptide complex by coexpression of BirA enzyme for the generation of MHC class II/tetramers

artículo científico publicado en 2004

Increased frequencies of myelin oligodendrocyte glycoprotein/MHC class II-binding CD4 cells in patients with multiple sclerosis

artículo científico publicado en 2011

Increased frequency of HLA class II alleles DRB1*0301 and DQB1*0201 in Lambert-Eaton myasthenic syndrome without associated cancer

artículo científico publicado en 2000

Increased islet antigen-specific regulatory and effector CD4+ T cells in healthy individuals with the type 1 diabetes-protective haplotype

artículo científico publicado en 2020

Induction and maintenance of allergen-specific FOXP3+ Treg cells in human tonsils as potential first-line organs of oral tolerance

scientific article published on 03 November 2011

Interactions of peptide side chains with structurally complementary pockets in DQ molecules are critical for allele-specific peptide binding and T cell reactivity

article

Involvement of CD91 and scavenger receptors in Hsp70-facilitated activation of human antigen-specific CD4+ memory T cells

artículo científico publicado en 2010

Islet-Derived CD4 T Cells Targeting Proinsulin in Human Autoimmune Diabetes

artículo científico publicado en 2016

Islet-specific glucose-6-phosphatase catalytic subunit-related protein-reactive CD4+ T cells in human subjects.

artículo científico publicado en 2006

Jug r 2-reactive CD4(+) T cells have a dominant immune role in walnut allergy

artículo científico publicado en 2015

Lack of allergy to timothy grass pollen is not a passive phenomenon but associated with the allergen-specific modulation of immune reactivity

artículo científico publicado en 2015

Lanthanide-Coordinated Semiconducting Polymer Dots Used for Flow Cytometry and Mass Cytometry

artículo científico publicado en 2017

Lineages of human T-cell clones, including T helper 17/T helper 1 cells, isolated at different stages of anti-factor VIII immune responses.

artículo científico publicado en 2009

Linear B-cell epitopes in Lambert-Eaton myasthenic syndrome defined by cell-free synthetic peptide binding

artículo científico publicado en 2002

Low-affinity major histocompatibility complex-binding peptides in type 1 diabetes.

artículo científico publicado en 2008

Low-avidity recognition by CD4+ T cells directed to self-antigens

artículo científico publicado en 2003

MHC II tetramers visualize human CD4+ T cell responses to Epstein-Barr virus infection and demonstrate atypical kinetics of the nuclear antigen EBNA1 response.

artículo científico publicado en 2013

MHC class II tetramers identify peptide-specific human CD4(+) T cells proliferating in response to influenza A antigen

artículo científico publicado en 1999

MHC-peptide ligand interactions establish a functional threshold for antigen-specific T cell recognition

artículo científico publicado en 1999

Melan-A/MART-1-specific CD4 T cells in melanoma patients: identification of new epitopes and ex vivo visualization of specific T cells by MHC class II tetramers

artículo científico publicado en 2006

Memory T cells in latent Mycobacterium tuberculosis infection are directed against three antigenic islands and largely contained in a CXCR3+CCR6+ Th1 subset

artículo científico publicado en 2013

Memory T cells specific to citrullinated α-enolase are enriched in the rheumatic joint

artículo científico publicado en 2018

Modifying Enzymes are Elicited by ER Stress, Generating Epitopes that are Selectively Recognized by CD4+ T Cells in Patients With Type 1 Diabetes.

artículo científico publicado en 2018

Modulation of CRTh2 expression on allergen-specific T cells following peptide immunotherapy

scientific article published on 07 June 2019

Modulation of HLA-DQ binding properties by differences in class II dimer stability and pH-dependent peptide interactions.

artículo científico publicado en 1996

Modulation of Peanut-specific humoral and cellular responses pre- and post-oral immunotherapy

artículo científico publicado en 2015

Molecular basis for HLA-DQ associations with IDDM

Molecular basis for HLA-DQ associations with IDDM.

artículo científico publicado en 1998

Motifs of Three HLA-DQ Amino Acid Residues (α44, β57, β135) Capture Full Association with the Risk of Type 1 Diabetes in DQ2 and DQ8 Children

scientific article published on 03 April 2020

Multi-HLA class II tetramer analyses of citrulline-reactive T cells and early treatment response in rheumatoid arthritis

artículo científico publicado en 2020

Multiplex mapping of CD4 T cell epitopes using class II tetramers

artículo científico publicado en 2006

Mutational analysis of critical residues determining antigen presentation and activation of HLA-DQ0602 restricted T-cell clones

artículo científico publicado en 2002

Mutational analysis of the HLA-DQ3.2 insulin-dependent diabetes mellitus susceptibility gene

artículo científico publicado en 1989

Nasal allergen challenge and environmental exposure chamber challenge: A randomized trial comparing clinical and biological responses to cat allergen

scientific article published on 10 March 2020

Neuroinvasive West Nile Infection Elicits Elevated and Atypically Polarized T Cell Responses That Promote a Pathogenic Outcome

artículo científico publicado en 2016

Next Generation HLA Sequence Analysis Uncovers Seven HLA-DQ Amino Acid Residues and Six Motifs Resistant to Childhood Type 1 Diabetes

scientific article published on 31 August 2020

Novel glycosylation of HLA-DRalpha disrupts antigen presentation without altering endosomal localization ⬇️

artículo científico publicado el 1 de mayo de 1998

Ontogeny of different subsets of yellow fever virus-specific circulatory CXCR5+ CD4+ T cells after yellow fever vaccination

scientific article published on 24 September 2020

P53(110-124)-specific human CD4+ T-helper cells enhance in vitro generation and antitumor function of tumor-reactive CD8+ T cells

artículo científico publicado en 2003

Papillomavirus-specific CD4+ T cells exhibit reduced STAT-5 signaling and altered cytokine profiles in patients with recurrent respiratory papillomatosis

artículo científico publicado en 2011

Pathogenic Autoreactive T and B Cells Cross-React with Mimotopes Expressed by a Common Human Gut Commensal to Trigger Autoimmunity

scientific article published on 18 June 2019

Peanut-specific T cell responses in patients with different clinical reactivity

scientific article published in PLoS ONE

Peptide binding affinity and pH variation establish functional thresholds for activation of HLA-DQ-restricted T cell recognition

artículo científico publicado en 1999

Peptide-MHC cellular microarray with innovative data analysis system for simultaneously detecting multiple CD4 T-cell responses

artículo científico publicado en 2010

Peptide-induced immune regulation by a promiscuous and immunodominant CD4T-cell epitope of Timothy grass pollen: a role of Cbl-b and Itch in regulation

artículo científico publicado en 2013

Persistence of herpes simplex virus type 2 VP16-specific CD4+ T cells

artículo científico publicado en 2005

Polymorphic DQ alpha and DQ beta interactions dictate HLA class II determinants of allo-recognition

artículo científico publicado en 1990

Potential of an altered peptide ligand of lipocalin allergen Bos d 2 for peptide immunotherapy

artículo científico publicado en 2007

Preferential presentation of herpes simplex virus T-cell antigen by HLA DQA1*0501/DQB1*0201 in comparison to HLA DQA1*0201/DQB1*0201.

artículo científico publicado en 1997

Proliferative T lymphocyte clones identify multiple recognition sites on DQw3 molecules

Rapid epitope identification from complex class-II-restricted T-cell antigens.

artículo científico publicado en 2001

Ratiometric Barcoding for Mass Cytometry

scientific article published on 05 September 2018

Reassessing the role of HLA-DRB3 T-cell responses: evidence for significant expression and complementary antigen presentation.

artículo científico publicado en 2010

Recognition of Herpes Simplex Virus Type 2 Tegument Proteins by CD4 T Cells Infiltrating Human Genital Herpes Lesions ⬇️

artículo científico publicado el 1 de septiembre de 1998

Recognition of major histocompatibility complex class II antigens by two anti-HLA-DR monoclonal antibodies on canine marrow cells correlates with effects on in vitro and in vivo hematopoiesis

artículo científico publicado en 1999

Recognition of posttranslationally modified GAD65 epitopes in subjects with type 1 diabetes.

artículo científico publicado en 2014

Recurrent Clostridioides difficile infection is associated with impaired Th17 immunity to TcdB

artículo científico publicado en 2020

Regulatory CD4+ T Cells Recognize MHC-II-Restricted Peptide Epitopes of Apolipoprotein B.

artículo científico publicado en 2018

Reply

artículo científico publicado en 2016

Restricted myeloperoxidase epitopes drive the adaptive immune response in MPO-ANCA vasculitis

artículo científico publicado en 2019

Retroviral transfer of genes into canine hematopoietic progenitor cells

artículo científico publicado en 1988

Retroviral transfer of genes into canine hemopoietic progenitor cells in culture: a model for human gene therapy

artículo científico publicado en 1986

Retroviral-mediated gene transfer of the leukocyte integrin CD18 subunit

artículo científico publicado en 1990

SV-BR-1-GM, a Clinically Effective GM-CSF-Secreting Breast Cancer Cell Line, Expresses an Immune Signature and Directly Activates CD4+ T Lymphocytes

artículo científico publicado en 2018

Searching for borrelial T cell epitopes associated with antibiotic-refractory Lyme arthritis

artículo científico publicado en 2008

Searching immunodominant epitopes prior to epidemic: HLA class II-restricted SARS-CoV spike protein epitopes in unexposed individuals.

artículo científico publicado en 2008

Selective T-cell-receptor gene usage in allorecognition and graft-versus-host disease ⬇️

artículo científico publicado el 1 de mayo de 1993

Single-Cell RNA Sequencing Reveals Expanded Clones of Islet Antigen-Reactive CD4+ T Cells in Peripheral Blood of Subjects with Type 1 Diabetes.

artículo científico publicado en 2017

Single-Cell Tracking Reveals a Role for Pre-Existing CCR5+ Memory Th1 Cells in the Control of Rhinovirus-A39 After Experimental Challenge in Humans

artículo científico publicado en 2017

Specific immunotherapy modifies allergen-specific CD4(+) T-cell responses in an epitope-dependent manner.

artículo científico publicado en 2013

Structural and functional constraints on HLA class II dimers implicated in susceptibility to insulin dependent diabetes mellitus

artículo científico publicado en 1991

Structural basis of specificity and degeneracy of T cell recognition: pluriallelic restriction of T cell responses to a peptide antigen involves both specific and promiscuous interactions between the T cell receptor, peptide, and HLA-DR.

artículo científico publicado en 1998

Structural requirements for recognition of the HLA-Dw14 class II epitope: a key HLA determinant associated with rheumatoid arthritis

artículo científico publicado en 1990

Synchronous Immune Alterations Mirror Clinical Response During Allergen Immunotherapy.

artículo científico publicado en 2017

Systematic Assessment of Immune Marker Variation in Type 1 Diabetes: A Prospective Longitudinal Study

artículo científico publicado en 2019

T cell receptor heterogeneity in the clonal recognition of HLA Dw14

T cell selection and differential activation on structurally related HLA-DR4 ligands

artículo científico publicado en 2001

T-cell receptor V beta selectivity in T-cell clones alloreactive to HLA-Dw14.

artículo científico publicado en 1992

T-cell responses in two unrelated hemophilia A inhibitor subjects include an epitope at the factor VIII R593C missense site.

artículo científico publicado en 2011

T-cell responses over time in a mild hemophilia A inhibitor subject: epitope identification and transient immunogenicity of the corresponding self-peptide

artículo científico publicado en 2007

Targeting CD4(+) T-helper cells improves the induction of antitumor responses in dendritic cell-based vaccination

artículo científico publicado en 2012

Tegument-specific, virus-reactive CD4 T cells localize to the cornea in herpes simplex virus interstitial keratitis in humans.

artículo científico publicado en 2000

Tetramer-Guided Epitope Mapping: A Rapid Approach to Identify HLA-Restricted T-Cell Epitopes from Composite Allergens

artículo científico publicado en 2017

Tetramer-guided epitope mapping reveals broad, individualized repertoires of tetanus toxin-specific CD4+ T cells and suggests HLA-based differences in epitope recognition

artículo científico publicado en 2007

Tetramer-guided epitope mapping: rapid identification and characterization of immunodominant CD4+ T cell epitopes from complex antigens

artículo científico publicado en 2001

The anthrax vaccine adsorbed vaccine generates protective antigen (PA)-Specific CD4+ T cells with a phenotype distinct from that of naive PA T cells

artículo científico publicado en 2008

The binding of antigenic peptides to HLA-DR is influenced by interactions between pocket 6 and pocket 9.

artículo científico publicado en 2009

The heat shock protein Hsp70 enhances antigen-specific proliferation of human CD4+ memory T cells

artículo científico publicado en 2005

Tracking antigen specific CD4+ T-cells with soluble MHC molecules

artículo científico publicado en 2007

Transfer and Expression of an IDDM Susceptibility Gene into Lymphoblastoid Cell Lines by Retroviral Vectors

article

Tumor antigen-specific FOXP3+ CD4 T cells identified in human metastatic melanoma: peptide vaccination results in selective expansion of Th1-like counterparts

scientific article published on 06 October 2009

Tumor-infiltrating BRAFV600E-specific CD4+ T cells correlated with complete clinical response in melanoma

artículo científico publicado en 2018

Unsupervised capture and profiling of rare immune cells using multi-directional magnetic ratcheting

artículo científico publicado en 2018

Unsupervised machine learning reveals key immune cell subsets in COVID-19, rhinovirus infection, and cancer therapy

scientific article published on 01 August 2020

Unusual plasmid DNA organization in an octopine crown gall tumor

artículo científico publicado en 1985

Use of HLA class II tetramers in tracking antigen-specific T cells and mapping T-cell epitopes ⬇️

artículo científico publicado el 1 de marzo de 2003

Use of class II tetramers for identification of CD4+ T cells

artículo científico publicado en 2002

Uveitis-associated epitopes of retinal antigens are pathogenic in the humanized mouse model of uveitis and identify autoaggressive T cells

artículo científico publicado en 2011

Virologic and immunologic evidence of multifocal genital herpes simplex virus 2 infection

artículo científico publicado en 2014

Visualizing antigen specific CD4+ T cells using MHC class II tetramers

artículo científico publicado en 2009

Yellow fever vaccination elicits broad functional CD4+ T cell responses that recognize structural and nonstructural proteins

artículo científico publicado en 2013

αS1-Casein elucidate major T-cell responses in cow's milk allergy

artículo científico publicado en 2017

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