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(-)-Epigallocatechin gallate, a major constituent of green tea, poisons human type II topoisomerases

artículo científico publicado en 2008

1,4-Benzoquinone is a topoisomerase II poison

artículo científico publicado en 2004

A mutant yeast topoisomerase II (top2G437S) with differential sensitivity to anticancer drugs in the presence and absence of ATP.

artículo científico publicado en 1998

A mutation in yeast TOP2 homologous to a quinolone-resistant mutation in bacteria. Mutation of the amino acid homologous to Ser83 of Escherichia coli gyrA alters sensitivity to eukaryotic topoisomerase inhibitors

artículo científico publicado en 1995

A novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases

artículo científico publicado en 2010

A two-drug model for etoposide action against human topoisomerase IIalpha

artículo científico publicado en 2002

A yeast type II topoisomerase selected for resistance to quinolones. Mutation of histidine 1012 to tyrosine confers resistance to nonintercalative drugs but hypersensitivity to ellipticine.

artículo científico publicado en 1995

Ability of viral topoisomerase II to discern the handedness of supercoiled DNA: bimodal recognition of DNA geometry by type II enzymes

artículo científico publicado en 2006

Action of quinolones against Staphylococcus aureus topoisomerase IV: basis for DNA cleavage enhancement.

artículo científico publicado en 2000

Activities of gyrase and topoisomerase IV on positively supercoiled DNA.

artículo científico publicado en 2017

Activity of quinolone CP-115,955 against bacterial and human type II topoisomerases is mediated by different interactions

artículo científico publicado en 2015

Amsacrine as a Topoisomerase II Poison: Importance of Drug–DNA Interactions ⬇️

artículo científico publicado el 10 de febrero de 2012

Apurinic sites are position-specific topoisomerase II poisons

artículo científico publicado en 1997

Azatoxin Is a Mechanistic Hybrid of the Topoisomerase II-Targeted Anticancer Drugs Etoposide and Ellipticine ⬇️

artículo científico publicado el 21 de octubre de 1997

Bacillus anthracis GrlAV96A topoisomerase IV, a quinolone resistance mutation that does not affect the water-metal ion bridge

artículo científico publicado en 2014

Bimodal Actions of a Naphthyridone/Aminopiperidine-Based Antibacterial That Targets Gyrase and Topoisomerase IV

artículo científico publicado en 2019

Bimodal recognition of DNA geometry by human topoisomerase II alpha: preferential relaxation of positively supercoiled DNA requires elements in the C-terminal domain

artículo científico publicado en 2008

Binding of etoposide to topoisomerase II in the absence of DNA: decreased affinity as a mechanism of drug resistance

scientific article published on 01 March 1999

Biochemical mechanism of apoptotic execution.

artículo científico publicado en 2000

Bioflavonoids as poisons of human topoisomerase II alpha and II beta ⬇️

artículo científico publicado en 2007

Catalytic core of human topoisomerase IIα: insights into enzyme-DNA interactions and drug mechanism

artículo científico publicado en 2014

Chiral discrimination and writhe-dependent relaxation mechanism of human topoisomerase IIα.

artículo científico publicado en 2013

Chlorella virus Marburg topoisomerase II: high DNA cleavage activity as a characteristic of Chlorella virus type II enzymes

artículo científico publicado en 2005

Cleavage of plasmid DNA by eukaryotic topoisomerase II.

artículo científico publicado en 2009

Contributions of the D-Ring to the activity of etoposide against human topoisomerase IIα: potential interactions with DNA in the ternary enzyme--drug--DNA complex.

artículo científico publicado en 2011

Coordinating the two protomer active sites of human topoisomerase IIalpha: nicks as topoisomerase II poisons

artículo científico publicado en 2009

Covalent Attachment of Ethidium to DNA Results in Enhanced Topoisomerase II-Mediated DNA Cleavage ⬇️

artículo científico publicado el 16 de diciembre de 1997

DNA abasic lesions in a different light: solution structure of an endogenous topoisomerase II poison.

artículo científico publicado en 1999

DNA cleavage and opening reactions of human topoisomerase IIα are regulated via Mg2+-mediated dynamic bending of gate-DNA

artículo científico publicado en 2012

DNA ligation catalyzed by human topoisomerase II alpha

artículo científico publicado en 2004

DNA methylation impacts the cleavage activity of Chlorella virus topoisomerase II.

artículo científico publicado en 2005

DNA topoisomerase II as the target for the anticancer drug TOP-53: mechanistic basis for drug action

artículo científico publicado en 2001

DNA topoisomerase II in therapy-related acute promyelocytic leukemia.

artículo científico publicado en 2005

DNA topoisomerase IIalpha interacts with CAD nuclease and is involved in chromatin condensation during apoptotic execution

artículo científico publicado en 2000

DNA topoisomerases as targets for the anticancer drug TAS-103: DNA interactions and topoisomerase catalytic inhibition

artículo científico publicado en 1999

DNA topoisomerases as targets for the anticancer drug TAS-103: primary cellular target and DNA cleavage enhancement

artículo científico publicado en 1999

Definitaion of cytochrome c binding domains by chemical modification. Reaction of carboxydinitrophenyl- and trinitrophenyl-cytochromes c with baker's yeast cytochrome c peroxidase ⬇️

artículo científico publicado el 25 de septiembre de 1978

Definition of cytochrome c binding domains by chemical modification. Interaction of horse cytochrome c with beef sulfite oxidase and analysis of steady state kinetics ⬇️

artículo científico publicado el 25 de julio de 1981

Definition of cytochrome c binding domains by chemical modification: Kinetics of reaction with beef mitochondrial reductase and functional organization of the respiratory chain ⬇️

artículo científico publicado el 1 de enero de 1979

Definition of enzymic interaction domains on cytochrome c. Purification and activity of singly substituted carboxydinitrophenyl-lysine 7, 25, 73, 86, and 99 cytochromes c ⬇️

artículo científico publicado el 10 de septiembre de 1980

Dietary polyphenols as topoisomerase II poisons: B ring and C ring substituents determine the mechanism of enzyme-mediated DNA cleavage enhancement

artículo científico publicado en 2008

Direct measurement of DNA bending by type IIA topoisomerases: implications for non-equilibrium topology simplification

artículo científico publicado en 2011

Drug Interactions with Bacillus anthracis Topoisomerase IV: Biochemical Basis for Quinolone Action and Resistance ⬇️

artículo científico publicado el 16 de diciembre de 2011

Drug features that contribute to the activity of quinolones against mammalian topoisomerase II and cultured cells: correlation between enhancement of enzyme-mediated DNA cleavage in vitro and cytotoxic potential

artículo científico publicado en 1993

Effects of Secondary Metabolites from the Fungus Septofusidium berolinense on DNA Cleavage Mediated by Human Topoisomerase IIα.

artículo científico publicado en 2016

Effects of benzene metabolites on DNA cleavage mediated by human topoisomerase II alpha: 1,4-hydroquinone is a topoisomerase II poison

artículo científico publicado en 2005

Effects of novel fluoroquinolones on the catalytic activities of eukaryotic topoisomerase II: Influence of the C-8 fluorine group ⬇️

artículo científico publicado el 1 de abril de 1992

Electrostatic interactions in cytochrome c. The role of interactions between residues 13 and 90 and residues 79 and 47 in stabilizing the heme crevice structure ⬇️

artículo científico publicado el 25 de febrero de 1980

Epimerization of green tea catechins during brewing does not affect the ability to poison human type II topoisomerases

artículo científico publicado en 2013

Etoposide quinone is a covalent poison of human topoisomerase IIβ.

artículo científico publicado en 2014

Etoposide quinone is a redox-dependent topoisomerase II poison

artículo científico publicado en 2011

Evidence for direct involvement of epirubicin in the formation of chromosomal translocations in t(15;17) therapy-related acute promyelocytic leukemia

artículo científico publicado en 2009

Exocyclic DNA lesions stimulate DNA cleavage mediated by human topoisomerase II alpha in vitro and in cultured cells.

artículo científico publicado en 2005

Fluoroquinolone interactions with Mycobacterium tuberculosis gyrase: Enhancing drug activity against wild-type and resistant gyrase

artículo científico publicado en 2016

From Theory to Practice: Utilizing Competency-based Milestones to Assess Professional Growth and Development in the Foundational Science Blocks of a Pre-Clerkship Medical School Curriculum

artículo científico publicado en 2016

Genome-wide TOP2A DNA cleavage is biased toward translocated and highly transcribed loci

artículo científico publicado en 2017

Human topoisomerase IIalpha possesses an intrinsic nucleic acid specificity for DNA ligation. Use of 5' covalently activated oligonucleotide substrates to study enzyme mechanism

artículo científico publicado en 2002

Human topoisomerase IIalpha uses a two-metal-ion mechanism for DNA cleavage

artículo científico publicado en 2008

Impact of the C-terminal domain of topoisomerase IIalpha on the DNA cleavage activity of the human enzyme

artículo científico publicado en 2005

In vitro evolution of preferred topoisomerase II DNA cleavage sites

artículo científico publicado en 1999

Increased drug affinity as the mechanistic basis for drug hypersensitivity of a mutant type II topoisomerase

artículo científico publicado en 1995

Inhibition of human DNA topoisomerase IIα by two novel ellipticine derivatives

artículo científico publicado en 2016

Integrating Foundational Sciences in a Clinical Context in the Post-Clerkship Curriculum

artículo científico publicado en 2018

Interactions between Quinolones and Bacillus anthracis Gyrase and the Basis of Drug Resistance

artículo científico publicado en 2017

Interactions between the Etoposide Derivative F14512 and Human Type II Topoisomerases: Implications for the C4 Spermine Moiety in Promoting Enzyme-Mediated DNA Cleavage ⬇️

artículo científico publicado el 28 de marzo de 2011

Interlinked DNA nano-circles for measuring topoisomerase II activity at the level of single decatenation events

artículo científico publicado en 2017

Intrinsic intermolecular DNA ligation activity of eukaryotic topoisomerase II. Potential roles in recombination ⬇️

artículo científico publicado el 15 de junio de 1992

Lactoperoxidase-catalyzed iodination of horse cytochrome c:monoiodotyrosyl 74 cytochrome c ⬇️

artículo científico publicado el 10 de noviembre de 1977

MLL-SEPTIN6 fusion recurs in novel translocation of chromosomes 3, X, and 11 in infant acute myelomonocytic leukaemia and in t(X;11) in infant acute myeloid leukaemia, and MLL genomic breakpoint in complex MLL-SEPTIN6 rearrangement is a DNA topoisom

artículo científico publicado en 2002

Mapping of anion binding sites on cytochrome c by differential chemical modification of lysine residues ⬇️

artículo científico publicado el 1 de agosto de 1980

Mapping of the interaction domain for purified cytochromec1on cytochromec ⬇️

artículo científico publicado el 10 de marzo de 1980

Mechanism of Action of Mycobacterium tuberculosis Gyrase Inhibitors: A Novel Class of Gyrase Poisons

scientific article published on 17 May 2018

Mechanism of quinolone action and resistance

scientific article published on 07 March 2014

Mechanistic and Structural Basis for the Actions of the Antibacterial Gepotidacin against Staphylococcus aureus Gyrase

artículo científico publicado en 2019

Merbarone Inhibits the Catalytic Activity of Human Topoisomerase IIα by Blocking DNA Cleavage ⬇️

artículo científico publicado el 10 de julio de 1998

Metal ion interactions in the DNA cleavage/ligation active site of human topoisomerase IIalpha

artículo científico publicado en 2009

Metnase promotes restart and repair of stalled and collapsed replication forks

artículo científico publicado en 2010

Molecular analysis of t(15;17) genomic breakpoints in secondary acute promyelocytic leukemia arising after treatment of multiple sclerosis

artículo científico publicado en 2008

Molecular basis of the targeting of topoisomerase II-mediated DNA cleavage by VP16 derivatives conjugated to triplex-forming oligonucleotides

artículo científico publicado en 2006

N-acetyl-p-benzoquinone imine, the toxic metabolite of acetaminophen, is a topoisomerase II poison

artículo científico publicado en 2004

Natural products as topoisomerase II poisons: effects of thymoquinone on DNA cleavage mediated by human topoisomerase IIα

artículo científico publicado en 2014

Novel 1-8-bridged chiral quinolones with activity against topoisomerase II: stereospecificity of the eukaryotic enzyme

artículo científico publicado en 1993

Novel xanthone-polyamine conjugates as catalytic inhibitors of human topoisomerase IIα.

artículo científico publicado en 2017

Novel, Potent, and Druglike Tetrahydroquinazoline Inhibitor That Is Highly Selective for Human Topoisomerase II α over β

artículo científico publicado en 2020

Overcoming target-mediated quinolone resistance in topoisomerase IV by introducing metal-ion-independent drug-enzyme interactions.

scientific article published on 30 September 2013

Oxidative Transformation of Demethoxy- and Bisdemethoxycurcumin: Products, Mechanism of Formation, and Poisoning of Human Topoisomerase IIα

artículo científico publicado en 2015

Oxidative metabolites of curcumin poison human type II topoisomerases

artículo científico publicado en 2012

Polyamine-containing etoposide derivatives as poisons of human type II topoisomerases: Differential effects on topoisomerase IIα and IIβ

scholarly article by Alexandria A Oviatt published in September 2018

Polychlorinated biphenyl quinone metabolites poison human topoisomerase IIalpha: altering enzyme function by blocking the N-terminal protein gate

artículo científico publicado en 2006

Preferred sites for electron transfer between cytochrome c and iron and cobalt complexes ⬇️

artículo científico publicado el 25 de mayo de 1983

Preferred sites on cytochrome c for electron transfer with two positively charged blue copper proteins, Anabaena variabilis plastocyanin and stellacyanin

artículo científico publicado en 1986

Prospective tracing of MLL-FRYL clone with low MEIS1 expression from emergence during neuroblastoma treatment to diagnosis of myelodysplastic syndrome

artículo científico publicado en 2008

Proteomic analysis of human metaphase chromosomes reveals topoisomerase II alpha as an Aurora B substrate

artículo científico publicado en 2002

Purification of DNA topoisomerase II from Drosophila melanogaster

artículo científico publicado en 1999

Quinolone action against human topoisomerase IIalpha: stimulation of enzyme-mediated double-stranded DNA cleavage

artículo científico publicado en 2003

Quinolones inhibit DNA religation mediated by Staphylococcus aureus topoisomerase IV. Changes in drug mechanism across evolutionary boundaries

artículo científico publicado en 1999

Quinolones share a common interaction domain on topoisomerase II with other DNA cleavage-enhancing antineoplastic drugs

artículo científico publicado en 1997

Quinone-induced enhancement of DNA cleavage by human topoisomerase IIalpha: adduction of cysteine residues 392 and 405.

artículo científico publicado en 2007

Reciprocal DNA topoisomerase II cleavage events at 5'-TATTA-3' sequences in MLL and AF-9 create homologous single-stranded overhangs that anneal to form der(11) and der(9) genomic breakpoint junctions in treatment-related AML without further process

artículo científico publicado en 2003

Recognition of DNA Supercoil Geometry by Mycobacterium tuberculosis Gyrase.

artículo científico publicado en 2017

Role of the water-metal ion bridge in mediating interactions between quinolones and Escherichia coli topoisomerase IV.

artículo científico publicado en 2014

Selection of DNA Cleavage Sites by Topoisomerase II Results from Enzyme-Induced Flexibility of DNA

scientific article published on 31 January 2019

Site-specific DNA cleavage by Chlorella virus topoisomerase II.

artículo científico publicado en 2002

Site-specific anti-cytochrome c antibodies. Inhibition of the reactions between cytochrome c and its respiratory chain electron exchange partners ⬇️

artículo científico publicado el 25 de diciembre de 1979

Site-specific cleavage of a DNA hairpin by topoisomerase II. DNA secondary structure as a determinant of enzyme recognition/cleavage.

artículo científico publicado en 1994

Smoothed Potential MD Simulations for Dissociation Kinetics of Etoposide To Unravel Isoform Specificity in Targeting Human Topoisomerase II

scientific article published on 09 September 2019

Spontaneous DNA lesions poison human topoisomerase IIalpha and stimulate cleavage proximal to leukemic 11q23 chromosomal breakpoints

scientific article published on 01 May 1997

Stimulation of topoisomerase II-mediated DNA cleavage by benzene metabolites

artículo científico publicado en 2005

Structure of a topoisomerase II–DNA–nucleotide complex reveals a new control mechanism for ATPase activity ⬇️

artículo científico publicado el 30 de septiembre de 2012

Substituents on etoposide that interact with human topoisomerase IIalpha in the binary enzyme-drug complex: contributions to etoposide binding and activity.

artículo científico publicado en 2008

Synthesis and evaluation of ether-linked demethylepipodophyllotoxin dimers

artículo científico publicado en 2014

The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing

artículo científico publicado en 2008

The bis(naphthalimide) DMP-840 causes cytotoxicity by its action against eukaryotic topoisomerase II.

artículo científico publicado en 1998

The efficacy of topoisomerase II-targeted anticancer agents reflects the persistence of drug-induced cleavage complexes in cells

artículo científico publicado en 2008

The geometry of DNA supercoils modulates the DNA cleavage activity of human topoisomerase I ⬇️

artículo científico publicado el 19 de septiembre de 2010

The geometry of DNA supercoils modulates topoisomerase-mediated DNA cleavage and enzyme response to anticancer drugs

artículo científico publicado en 2006

The presteady state reaction of chemically modified cytochromes c with cytochrome oxidase ⬇️

artículo científico publicado el 10 de mayo de 1983

The reaction of primate cytochromes c with cytochrome c oxidase. Analysis of the polarographic assay ⬇️

artículo científico publicado el 10 de mayo de 1983

The use of divalent metal ions by type II topoisomerases.

artículo científico publicado en 2010

Topoisomerase II - drug interaction domains: identification of substituents on etoposide that interact with the enzyme.

artículo científico publicado en 2007

Topoisomerase II and leukemia

scientific article published on 03 February 2014

Topoisomerase II and the etiology of chromosomal translocations

artículo científico publicado en 2006

Topoisomerase II from Chlorella virus PBCV-1 has an exceptionally high DNA cleavage activity

artículo científico publicado en 2001

Topoisomerase II from Chlorella virus PBCV-1. Characterization of the smallest known type II topoisomerase

artículo científico publicado en 2000

Topoisomerase II-catalyzed relaxation and catenation of plasmid DNA.

artículo científico publicado en 2001

Topoisomerase II-mediated cleavage of plasmid DNA.

artículo científico publicado en 2001

Topoisomerase II.etoposide interactions direct the formation of drug-induced enzyme-DNA cleavage complexes

artículo científico publicado en 1996

Topoisomerase IV Catalysis and the Mechanism of Quinolone Action ⬇️

artículo científico publicado el 10 de julio de 1998

Topoisomerase IV-quinolone interactions are mediated through a water-metal ion bridge: mechanistic basis of quinolone resistance ⬇️

artículo científico publicado el 4 de marzo de 2013

Tryptophane-205 of human topoisomerase I is essential for camptothecin inhibition of negative but not positive supercoil removal

artículo científico publicado en 2007

Type II topoisomerases as targets for quinolone antibacterials: turning Dr. Jekyll into Mr. Hyde

artículo científico publicado en 2001

Uncoupling the DNA cleavage and religation activities of topoisomerase II with a single-stranded nucleic acid substrate: evidence for an active enzyme-cleaved DNA intermediate

artículo científico publicado en 1990

Use of divalent metal ions in the DNA cleavage reaction of topoisomerase IV ⬇️

artículo científico publicado el 7 de febrero de 2011

Use of divalent metal ions in the dna cleavage reaction of human type II topoisomerases.

artículo científico publicado en 2009

Using 3'-bridging phosphorothiolates to isolate the forward DNA cleavage reaction of human topoisomerase IIalpha

scientific article published on 05 March 2008

Using Small Case-Based Learning Groups as a Setting for Teaching Medical Students How to Provide and Receive Peer Feedback

artículo científico publicado en 2017

Voreloxin is an anticancer quinolone derivative that intercalates DNA and poisons topoisomerase II

artículo científico publicado en 2010

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