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2-aminoimidazoles collapse mycobacterial proton motive force and block the electron transport chain

artículo científico publicado en 2019

2-aminoimidazoles potentiate ß-lactam antimicrobial activity against Mycobacterium tuberculosis by reducing ß-lactamase secretion and increasing cell envelope permeability.

artículo científico publicado en 2017

A Toll-Like Receptor-2-Directed Fusion Protein Vaccine against Tuberculosis.

artículo científico publicado en 2008

A Toll-like receptor-2-directed fusion protein vaccine against tuberculosis

artículo científico publicado en 2007

A model of type 2 diabetes in the guinea pig using sequential diet-induced glucose intolerance and streptozotocin treatment

artículo científico publicado en 2017

A mouse model of pulmonary Mycobacteroides abscessus infection

scientific article published on 28 February 2020

A mutant of Mycobacterium tuberculosis lacking the 19-kDa lipoprotein Rv3763 is highly attenuated in vivo but retains potent vaccinogenic properties

artículo científico publicado en 2007

Actin enhances the haemolytic activity of Escherichia coli

artículo científico publicado en 1998

Actin polymerization enhances Pasteurella haemolytica leukotoxicity

artículo científico publicado en 1999

Activities of TMC207, rifampin, and pyrazinamide against Mycobacterium tuberculosis infection in guinea pigs

artículo científico publicado en 2010

Alternative BCG delivery strategies improve protection against Mycobacterium tuberculosis in non-human primates: Protection associated with mycobacterial antigen-specific CD4 effector memory T-cell populations

artículo científico publicado en 2016

An aerosol challenge model of tuberculosis in Mauritian cynomolgus macaques

artículo científico publicado en 2017

An ovarian teratoma in a cat

scientific article published on 01 March 1998

Analogue synthesis reveals decoupling of antibiofilm and β-lactam potentiation activities of a lead 2-aminoimidazole adjuvant against Mycobacterium smegmatis.

artículo científico publicado en 2018

Animal model of Mycobacterium abscessus lung infection

artículo científico publicado en 2008

Antitumor activity of novel tricyclic pyrone analogs in murine leukemia cells in vitro

artículo científico publicado el 1 de julio de 1997

Assessment of necropsy findings in sled dogs that died during Iditarod Trail sled dog races: 23 cases (1994-2006)

scientific article published on 01 February 2008

Azithromycin blocks autophagy and may predispose cystic fibrosis patients to mycobacterial infection.

artículo científico publicado en 2011

Beijing sublineages of Mycobacterium tuberculosis differ in pathogenicity in the guinea pig.

artículo científico publicado en 2012

Bilateral Horner's syndrome secondary to metastatic squamous cell carcinoma in a horse

scientific article published on 01 November 1996

Cell-to-cell contact not soluble factors mediate suppression of lymphocyte proliferation by bovine parainfluenza virus type 3.

artículo científico publicado en 1994

Cigarette smoke increases susceptibility to tuberculosis--evidence from in vivo and in vitro models

artículo científico publicado en 2011

Clinical strains of Mycobacterium tuberculosis display a wide range of virulence in guinea pigs

artículo científico publicado en 2009

Comparison of serologic and protective responses induced by two Pasteurella vaccines.

artículo científico publicado en 1998

Copper resistance is essential for virulence of Mycobacterium tuberculosis

artículo científico publicado en 2011

Copper-boosting compounds: a novel concept for antimycobacterial drug discovery

artículo científico publicado en 2012

Correction: Mycobacterium tuberculosis Universal Stress Protein Rv2623 Regulates Bacillary Growth by ATP-Binding: Requirement for Establishing Chronic Persistent Infection

artículo científico publicado en 2009

Cyclin-Dependent Kinases 8 and 19 Regulate Host Cell Metabolism during Dengue Virus Serotype 2 Infection

scientific article published on 17 June 2020

Decreased survival of guinea pigs infected with Mycobacterium tuberculosis after multiple BCG vaccinations

artículo científico publicado en 2005

Defined tuberculosis vaccine, Mtb72F/AS02A, evidence of protection in cynomolgus monkeys

scholarly article

Defining a research agenda to address the converging epidemics of tuberculosis and diabetes. Part 1: Epidemiology and clinical management

artículo científico publicado en 2017

Defining a research agenda to address the converging epidemics of tuberculosis and diabetes. Part 2: Underlying biological mechanisms

artículo científico publicado en 2017

Determination of lesion volume by MRI and stereology in a macaque model of tuberculosis.

artículo científico publicado en 2009

Dietary retinol inhibits inflammatory responses of rats treated with monocrotaline

artículo científico publicado en 1999

Disseminated disease severity as a measure of virulence of Mycobacterium tuberculosis in the guinea pig model

artículo científico publicado en 2008

Drug treatment combined with BCG vaccination reduces disease reactivation in guinea pigs infected with Mycobacterium tuberculosis

artículo científico publicado en 2012

Early lesions following aerosol infection of rhesus macaques (Macaca mulatta) with Mycobacterium tuberculosis strain H37RV.

artículo científico publicado en 2013

Effect of furosemide on pulmonary blood flow distribution in resting and exercising horses

artículo científico publicado en 1999

Enhanced priming of adaptive immunity by a proapoptotic mutant of Mycobacterium tuberculosis

artículo científico publicado en 2007

Establishment of an aerosol challenge model of tuberculosis in rhesus macaques and an evaluation of endpoints for vaccine testing

artículo científico publicado en 2010

Evaluation of a mouse model of necrotic granuloma formation using C3HeB/FeJ mice for testing of drugs against Mycobacterium tuberculosis

artículo científico publicado en 2012

Evaluation of standard chemotherapy in the guinea pig model of tuberculosis

artículo científico publicado en 2010

Evidence for oxidative stress and defective antioxidant response in guinea pigs with tuberculosis

artículo científico publicado en 2011

Experimental tuberculosis: the role of comparative pathology in the discovery of improved tuberculosis treatment strategies

artículo científico publicado en 2008

Expression of antimicrobial drug tolerance by attached communities of Mycobacterium tuberculosis

artículo científico publicado en 2014

Factors associated with severe granulomatous pneumonia in Mycobacterium tuberculosis-infected mice vaccinated therapeutically with hsp65 DNA.

artículo científico publicado en 2005

Flexible low-cost system for small animal aerosol inhalation exposure to drugs, proteins, inflammatory agents, and infectious agents

artículo científico publicado en 2009

Florid pulmonary inflammatory responses in mice vaccinated with Antigen-85 pulsed dendritic cells and challenged by aerosol with Mycobacterium tuberculosis

artículo científico publicado en 2002

Functional drug screening reveals anticonvulsants as enhancers of mTOR-independent autophagic killing of Mycobacterium tuberculosis through inositol depletion.

artículo científico publicado en 2014

GM-CSF knockout mice for preclinical testing of agents with antimicrobial activity against Mycobacterium abscessus.

artículo científico publicado en 2013

Globoid cell-like leukodystrophy in a domestic longhaired cat.

artículo científico publicado en 2002

Hepatotoxicity of stanozolol in cats

scientific article published on 01 September 2000

High mobility group box 1 acts as an adjuvant for tuberculosis subunit vaccines

artículo científico publicado en 2014

Host-directed therapy targeting the Mycobacterium tuberculosis granuloma: a review

artículo científico publicado en 2015

Human IL-32 expression protects mice against a hypervirulent strain of Mycobacterium tuberculosis

artículo científico publicado en 2015

Hyperpolarized krypton-83 as a contrast agent for magnetic resonance imaging

artículo científico publicado en 2005

Immune Responses of HIV-1 Tat Transgenic Mice to Mycobacterium Tuberculosis W-Beijing SA161.

artículo científico publicado en 2011

Immune response to Mycobacterium tuberculosis and identification of molecular markers of disease.

artículo científico publicado en 2008

Immunopathogenesis of pulmonary granulomas in the guinea pig after infection with Mycobacterium tuberculosis

artículo científico publicado en 2003

Impaired capillary hemodynamics in skeletal muscle of rats in chronic heart failure

artículo científico publicado en 1999

In vivo adaptation of the Wayne model of latent tuberculosis

artículo científico publicado en 2007

Increased Foxp3 expression in guinea pigs infected with W-Beijing strains of M. tuberculosis

artículo científico publicado en 2011

Increased expression of host iron-binding proteins precedes iron accumulation and calcification of primary lung lesions in experimental tuberculosis in the guinea pig

artículo científico publicado en 2008

Increased neutrophil influx but no impairment of protective immunity to tuberculosis in mice lacking the CD44 molecule

artículo científico publicado en 2003

Increased severity of tuberculosis in Guinea pigs with type 2 diabetes: a model of diabetes-tuberculosis comorbidity

artículo científico publicado en 2014

Infectious Bovine Rhinotracheitis, Parainfluenza-3, and Respiratory Coronavirus

artículo científico publicado el 1 de noviembre de 1997

Influence of Mycobacterium bovis BCG vaccination on cellular immune response of guinea pigs challenged with Mycobacterium tuberculosis

artículo científico publicado en 2008

Influence of endurance exercise on serum concentrations of iron and acute phase proteins in racing sled dogs

artículo científico publicado el 1 de noviembre de 2011

Inhibition and breaking of advanced glycation end-products (AGEs) with bis-2-aminoimidazole derivatives

artículo científico publicado en 2015

Interleukin-10 production by lung macrophages in CBA xid mutant mice infected with Mycobacterium tuberculosis

artículo científico publicado en 2005

Interstitial nephritis in cats inoculated with Crandell Rees feline kidney cell lysates

artículo científico publicado en 2006

Investigation of the induction of antibodies against Crandell-Rees feline kidney cell lysates and feline renal cell lysates after parenteral administration of vaccines against feline viral rhinotracheitis, calicivirus, and panleukopenia in cats

artículo científico publicado en 2005

Limited tuberculosis progression in guinea pigs naturally exposed to human multidrug resistant strains

abstract published in 2009

Localized immunosuppressive environment in the foreign body response to implanted biomaterials

artículo científico publicado en 2009

Location of Intra- and Extracellular M. tuberculosis Populations in Lungs of Mice and Guinea Pigs during Disease Progression and after Drug Treatment

artículo científico publicado el 21 de marzo de 2011

Location of persisting mycobacteria in a Guinea pig model of tuberculosis revealed by r207910.

artículo científico publicado en 2007

Lymphadenitis as a major element of disease in the guinea pig model of tuberculosis

scientific article published on 10 February 2006

Magnetic resonance imaging of pulmonary lesions in guinea pigs infected with Mycobacterium tuberculosis

scientific article published on October 2004

Mast cell tumors in three ferrets.

artículo científico publicado en 1990

Maxillary lymphosarcoma in a cow.

artículo científico publicado en 1994

Memory T lymphocytes generated by Mycobacterium bovis BCG vaccination reside within a CD4 CD44lo CD62 ligand(hi) population

artículo científico publicado en 2005

Metabolic Profiling of Lung Granuloma in Mycobacterium tuberculosis Infected Guinea Pigs: Ex vivo 1H Magic Angle Spinning NMR Studies

artículo científico publicado el 26 de julio de 2011

Metabolomic signatures in guinea pigs infected with epidemic-associated W-Beijing strains of Mycobacterium tuberculosis

artículo científico publicado en 2012

Metformin enhances anti-mycobacterial responses by educating CD8+ T-cell immunometabolic circuits

artículo científico publicado en 2020

Metformin enhances protection in guinea pigs chronically infected with Mycobacterium tuberculosis

scientific article published on 01 October 2020

Metronidazole lacks antibacterial activity in guinea pigs infected with Mycobacterium tuberculosis

artículo científico publicado en 2008

Microhemorrhage is an early event in the pulmonary fibrotic disease of PECAM-1 deficient FVB/n mice

artículo científico publicado en 2014

Minimal redistribution of pulmonary blood flow with exercise in racehorses

scientific article published on 01 September 1996

Mucosal expression of aquaporin 5 and epithelial barrier proteins in chronic rhinosinusitis with and without nasal polyps.

artículo científico publicado en 2013

Multimodality topical therapy for refractory chronic rhinosinusitis: our experience in thirteen patients with and twelve patients without nasal polyps

artículo científico publicado en 2013

Multiple M. tuberculosis phenotypes in mouse and guinea pig lung tissue revealed by a dual-staining approach

artículo científico publicado en 2010

Mycobacteria lacking the RD1 region do not induce necrosis in the lungs of mice lacking interferon-gamma.

artículo científico publicado en 2006

Mycobacterial Biofilms: Revisiting Tuberculosis Bacilli in Extracellular Necrotizing Lesions.

artículo científico publicado en 2017

Mycobacterium bovis BCG-mediated protection against W-Beijing strains of Mycobacterium tuberculosis is diminished concomitant with the emergence of regulatory T cells

artículo científico publicado en 2011

Mycobacterium tuberculosis Lsr2 is a global transcriptional regulator required for adaptation to changing oxygen levels and virulence

scientific journal article

Mycobacterium tuberculosis pellicles express unique proteins recognized by the host humoral response

artículo científico publicado en 2014

Mycobacterium tuberculosis universal stress protein Rv2623 regulates bacillary growth by ATP-Binding: requirement for establishing chronic persistent infection

artículo científico publicado en 2009

Natural infection of guinea pigs exposed to patients with highly drug-resistant tuberculosis

artículo científico publicado el 7 de abril de 2011

Non-clinical efficacy and safety of HyVac4:IC31 vaccine administered in a BCG prime-boost regimen

article published in 2010

Non-diabetic hyperglycemia exacerbates disease severity in Mycobacterium tuberculosis infected guinea pigs

artículo científico publicado en 2012

Norepinephrine stimulates in vitro growth but does not increase pathogenicity of Salmonella choleraesuis in an in vivo model

artículo científico publicado en 1999

Opposing biological functions of tryptophan catabolizing enzymes during intracellular infection

artículo científico publicado en 2011

Oral therapy using nanoparticle-encapsulated antituberculosis drugs in guinea pigs infected with Mycobacterium tuberculosis

artículo científico publicado en 2005

Pathology of Tuberculosis: How the Pathology of Human Tuberculosis Informs and Directs Animal Models

artículo científico publicado en 2017

Phosphatidylinositol di-mannoside and derivates modulate the immune response to and efficacy of a tuberculosis protein vaccine against Mycobacterium bovis infection.

artículo científico publicado en 2011

Post-exposure vaccination against Mycobacterium tuberculosis

artículo científico publicado en 2009

Presence of multiple lesion types with vastly different microenvironments in C3HeB/FeJ mice following aerosol infection with Mycobacterium tuberculosis.

artículo científico publicado en 2015

Pulmonary lymphatics are primary sites of Mycobacterium tuberculosis infection in guinea pigs infected by aerosol

artículo científico publicado en 2006

Pulmonary necrosis resulting from DNA vaccination against tuberculosis

artículo científico publicado en 2003

Reply to Schroecksnadel, et al

scientific article published in 2012

Reversal of Mycobacterium tuberculosis phenotypic drug resistance by 2-aminoimidazole-based small molecules

artículo científico publicado en 2014

Role for matrix metalloproteinase 9 in granuloma formation during pulmonary Mycobacterium tuberculosis infection

artículo científico publicado en 2006

Role of chemokine ligand 2 in the protective response to early murine pulmonary tuberculosis

artículo científico publicado en 2003

Salmonella Shedding in Racing Sled Dogs

artículo científico publicado el 1 de octubre de 1997

Second generation 2-aminoimidazole based advanced glycation end product inhibitors and breakers

artículo científico publicado en 2015

Suppression of lymphocyte proliferation by parainfluenza virus type 3-infected bovine alveolar macrophages

artículo científico publicado en 1993

The Discovery of 2-Aminobenzimidazoles That Sensitize Mycobacterium smegmatis and M. tuberculosis to β-Lactam Antibiotics in a Pattern Distinct from β-Lactamase Inhibitors.

artículo científico publicado en 2017

The cellular immune response to Mycobacterium tuberculosis infection in the guinea pig.

artículo científico publicado en 2007

The formation of the granuloma in tuberculosis infection

artículo científico publicado en 2014

The hypervirulent Mycobacterium tuberculosis strain HN878 induces a potent TH1 response followed by rapid down-regulation

scientific article published on 01 July 2007

The principal sigma factor sigA mediates enhanced growth of Mycobacterium tuberculosis in vivo

scientific journal article

The protective effect of the Mycobacterium bovis BCG vaccine is increased by coadministration with the Mycobacterium tuberculosis 72-kilodalton fusion polyprotein Mtb72F in M. tuberculosis-infected guinea pigs

artículo científico publicado en 2004

Therapeutic vaccination against relevant high virulence clinical isolates of Mycobacterium tuberculosis

artículo científico publicado en 2013

Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens

artículo científico publicado en 2008

Topical gel therapy for sinonasal polyposis in Samter's triad: preliminary report

artículo científico publicado en 2012

Topical therapy for refractory rhinosinusitis caused by methicillin-resistant Staphylococcus aureus: First report in a prospective series

artículo científico publicado en 2018

Toxicosis in cattle from concurrent feeding of monensin and dried distiller's grains contaminated with macrolide antibiotics

scientific article published on 01 January 1999

Tricyclic pyrone analogs: a new class of microtubule-disrupting anticancer drugs effective against murine leukemia cells in vitro

artículo científico publicado el 1 de febrero de 1998

Truncated gamma-glutamyl carboxylase in rambouillet sheep.

artículo científico publicado en 2006

Uptake and accumulation of oxidized low-density lipoprotein during Mycobacterium tuberculosis infection in guinea pigs

artículo científico publicado en 2012

Use of specific rRNA oligonucleotide probes for microscopic detection of Mycobacterium tuberculosis in culture and tissue specimens

artículo científico publicado en 2005

Vaccination of guinea pigs using mce operon mutants of Mycobacterium tuberculosis

artículo científico publicado el 22 de abril de 2011

Vaccines displaying mycobacterial proteins on biopolyester beads stimulate cellular immunity and induce protection against tuberculosis

artículo científico publicado en 2011

What is your diagnosis? Cortical lysis, medullary sclerosis, and periosteal bony proliferation of the distal portion of the metacarpus

scientific article published on 01 March 2003