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A Chemical Biology Toolbox for the Study of Protein Methyltransferases and Epigenetic Signaling

scholarly article

A Systematic Analysis of Atomic Protein-Ligand Interactions in the PDB

preprint

A chemical biology toolbox to study protein methyltransferases and epigenetic signaling

artículo científico publicado en 2019

A systematic analysis of atomic protein-ligand interactions in the PDB.

artículo científico publicado en 2017

Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3).

artículo científico publicado en 2017

Discovery of Small Molecule Antagonists of the USP5 Zinc Finger Ubiquitin-Binding Domain

artículo científico publicado en 2019

Discovery of a chemical probe for PRDM9

scientific article published on 17 December 2019

Disease Association and Druggability of WD40 Repeat Proteins.

artículo científico publicado en 2017

HAP40 orchestrates huntingtin structure for differential interaction with polyglutamine expanded exon 1

preprint

Huntingtin structure is orchestrated by HAP40 and shows a polyglutamine expansion-specific interaction with exon 1

artículo científico publicado en 2021

Identification and Structure-Activity Relationship of HDAC6 Zinc-finger Ubiquitin Binding Domain Inhibitors

Identification and Structure–Activity Relationship of HDAC6 Zinc-Finger Ubiquitin Binding Domain Inhibitors

scientific article published on 09 May 2018

Methyltransferase Inhibitors: Competing with, or Exploiting the Bound Cofactor

scientific article published on 08 December 2019

Open laboratory notebooks: good for science, good for society, good for scientists

artículo científico publicado en 2019

Selective, Small-Molecule Co-Factor Binding Site Inhibition of a Su(var)3-9, Enhancer of Zeste, Trithorax Domain Containing Lysine Methyltransferase

artículo científico publicado en 2019

Small Molecule Antagonists of the Interaction between the Histone Deacetylase 6 Zinc-Finger Domain and Ubiquitin

artículo científico publicado en 2017

Targeted protein degradation: expanding the toolbox

scientific article published on 30 October 2019

Targeting non-bromodomain chromatin readers

artículo científico publicado en 2019

Ten simple rules for open human health research

artículo científico publicado en 2020