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A Phase II Study of Fulvestrant plus Abemaciclib in Hormone Receptor–Positive Advanced or Recurrent Endometrial Cancer

artículo científico publicado en 2024

AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity

artículo científico publicado en 2011

AKT1 E17K inhibits cancer cell migration by abrogating β-catenin signaling

artículo científico publicado en 2020

Abstract PR05: The effect of chemotherapy on HER2+ breast cancer heterogeneity measured by STAR-FISH: Detection of PIK3CA mutation and HER2 amplification at single-cell level in situ

Acquisition of APOBEC Mutagenesis and Microsatellite Instability Signatures in the Development of Brain Metastases in Low-Grade, Early-Stage Endometrioid Endometrial Carcinoma

artículo científico publicado en 2020

Ash1, a Daughter Cell-Specific Protein, Is Required for Pseudohyphal Growth of Saccharomyces cerevisiae ⬇️

artículo científico publicado el 1 de mayo de 1998

Capivasertib, an AKT Kinase Inhibitor, as Monotherapy or in Combination With Fulvestrant in Patients With AKT1 E17K-Mutant, ER-Positive Metastatic Breast Cancer

scientific article published on 20 April 2020

Correlation between PIK3CA mutations in cell-free DNA and everolimus efficacy in HR+, HER2- advanced breast cancer: results from BOLERO-2.

artículo científico

Detection of HER2-Positive Metastases in Patients with HER2-Negative Primary Breast Cancer Using 89Zr-Trastuzumab PET/CT

artículo científico publicado en 2016

Double PIK3CA mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors

scientific article published on 01 November 2019

Efficacy and Determinants of Response to HER Kinase Inhibition in HER2-Mutant Metastatic Breast Cancer

scientific article published on 05 December 2019

Genomic profiling of ER+ breast cancers after short-term estrogen suppression reveals alterations associated with endocrine resistance.

artículo científico

HER2-amplified breast cancer: mechanisms of trastuzumab resistance and novel targeted therapies ⬇️

artículo científico publicado el 1 de febrero de 2011

Identification of HER2-Positive Metastases in Patients with HER2-Negative Primary Breast Cancer by Using HER2-targeted 89Zr-Pertuzumab PET/CT

artículo científico publicado en 2020

In situ single-cell analysis identifies heterogeneity for PIK3CA mutation and HER2 amplification in HER2-positive breast cancer

artículo científico publicado en 2015

KMT2C mediates the estrogen dependence of breast cancer through regulation of ERα enhancer function.

artículo científico publicado en 2018

Neratinib is effective in breast tumors bearing both amplification and mutation of ERBB2 (HER2)

artículo científico publicado en 2018

PI3K pathway activation in high-grade ductal carcinoma in situ--implications for progression to invasive breast carcinoma

artículo científico publicado en 2014

Recurrent hotspot mutations in HRAS Q61 and PI3K-AKT pathway genes as drivers of breast adenomyoepitheliomas.

artículo científico publicado en 2018

Relief of Profound Feedback Inhibition of Mitogenic Signaling by RAF Inhibitors Attenuates Their Activity in BRAFV600E Melanomas ⬇️

artículo científico publicado el 13 de noviembre de 2012

Reversible histone glycation is associated with disease-related changes in chromatin architecture

artículo científico publicado en 2019

Structural underpinnings of oestrogen receptor mutations in endocrine therapy resistance

artículo científico publicado en 2018

TERT promoter hotspot mutations and gene amplification in metaplastic breast cancer

artículo científico publicado en 2021

The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells.

artículo científico publicado en 2018

The genomic landscape of metastatic histologic special types of invasive breast cancer

artículo científico publicado en 2020

Toronto Workshop on Late Recurrence in Estrogen Receptor-Positive Breast Cancer: Part 1: Late Recurrence: Current Understanding, Clinical Considerations

artículo científico publicado en 2019

Toronto Workshop on Late Recurrence in Estrogen Receptor-Positive Breast Cancer: Part 2: Approaches to Predict and Identify Late Recurrence, Research Directions

artículo científico publicado en 2019

mTOR Kinase Inhibition Causes Feedback-Dependent Biphasic Regulation of AKT Signaling ⬇️

artículo científico publicado el 17 de junio de 2011

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