Lista de obras -

11th IUBMB Focused Meeting on the Aminoacyl-tRNA Synthetases: Sailing a New Sea of Complex Functions in Human Biology and Disease.

artículo científico publicado en 2018

A single Danio rerio hars gene encodes both cytoplasmic and mitochondrial histidyl-tRNA synthetases.

artículo científico publicado en 2017

A substrate-assisted concerted mechanism for aminoacylation by a class II aminoacyl-tRNA synthetase

artículo científico publicado en 2005

A unique hydrophobic cluster near the active site contributes to differences in borrelidin inhibition among threonyl-tRNA synthetases

artículo científico publicado en 2004

Activation of the hetero-octameric ATP phosphoribosyl transferase through subunit interface rearrangement by a tRNA synthetase paralog

artículo científico publicado en 2005

Altered nuclear cofactor switching in retinoic‐resistant variants of the PML‐RARα oncoprotein of acute promyelocytic leukemia ⬇️

artículo científico publicado el 7 de enero de 2012

Aminoacyl transfer rate dictates choice of editing pathway in threonyl-tRNA synthetase

artículo científico publicado en 2010

Aminoacyl-Transfer RNA Synthetases: Connecting Nutrient Status to Angiogenesis Through the Unfolded Protein Response

artículo científico publicado en 2016

Aminoacyl-tRNA synthetase dependent angiogenesis revealed by a bioengineered macrolide inhibitor

artículo científico publicado en 2015

Aminoacyl-tRNA synthetases

artículo científico publicado en 2017

Aminoacyl-tRNA synthetases: versatile players in the changing theater of translation

artículo científico publicado en 2002

Aminoacylating Urzymes Challenge the RNA World Hypothesis ⬇️

artículo científico publicado el 18 de julio de 2013

Analogs of natural aminoacyl-tRNA synthetase inhibitors clear malaria in vivo

artículo científico publicado en 2014

Asymmetric amino acid activation by class II histidyl-tRNA synthetase from Escherichia coli

artículo científico publicado en 2009

Bi-allelic mutations in HARS1 severely impair histidyl-tRNA synthetase expression and enzymatic activity causing a novel multi-system ataxic syndrome

artículo científico publicado en 2020

Biallelic VARS variants cause developmental encephalopathy with microcephaly that is recapitulated in vars knockout zebrafish

artículo científico publicado en 2019

Characterization of aminoacyl-tRNA synthetase stability and substrate interaction by differential scanning fluorimetry.

artículo científico publicado en 2016

Correction: A single Danio rerio hars gene encodes both cytoplasmic and mitochondrial histidyl-tRNA synthetases

artículo científico publicado en 2018

DNA polymerases and aminoacyl-tRNA synthetases: shared mechanisms for ensuring the fidelity of gene expression

artículo científico publicado en 2008

Distinct kinetic mechanisms of the two classes of Aminoacyl-tRNA synthetases

artículo científico publicado en 2006

Evolutionary conservation of a functionally important backbone phosphate group critical for aminoacylation of histidine tRNAs

artículo científico publicado en 2006

Fidelity Escape by the Unnatural Amino Acid β-Hydroxynorvaline: An Efficient Substrate for Escherichia coli Threonyl-tRNA Synthetase with Toxic Effects on Growth ⬇️

artículo científico publicado el 24 de enero de 2011

G-1:C73 recognition by an arginine cluster in the active site of Escherichia coli histidyl-tRNA synthetase

artículo científico publicado en 2004

Genetic Mapping and Exome Sequencing Identify Variants Associated with Five Novel Diseases ⬇️

artículo científico publicado el 17 de enero de 2012

Histidyl-tRNA synthetase urzymes: Class I and II aminoacyl tRNA synthetase urzymes have comparable catalytic activities for cognate amino acid activation ⬇️

artículo científico publicado en 2011

Immunity-Guided Identification of Threonyl-tRNA Synthetase as the Molecular Target of Obafluorin, a β-Lactone Antibiotic

artículo científico publicado en 2019

Induced fit and kinetic mechanism of adenylation catalyzed by Escherichia coli threonyl-tRNA synthetase

artículo científico publicado en 2003

Kinetic discrimination of tRNA identity by the conserved motif 2 loop of a class II aminoacyl-tRNA synthetase

artículo científico publicado en 2007

Knock-Down of Causes Cell Cycle Arrest and Apoptosis of Neuronal Progenitor Cells

Methods for kinetic and thermodynamic analysis of aminoacyl-tRNA synthetases

artículo científico publicado en 2008

Peripheral neuropathy and cognitive impairment associated with a novel monoallelic HARS variant

scientific article published on 24 May 2019

Progress and challenges in aminoacyl-tRNA synthetase-based therapeutics

scientific article published in 2019

RNA-assisted catalysis in a protein enzyme: The 2'-hydroxyl of tRNA(Thr) A76 promotes aminoacylation by threonyl-tRNA synthetase

artículo científico publicado en 2008

Regulation of angiogenesis by aminoacyl-tRNA synthetases

artículo científico publicado en 2014

Secreted Threonyl-tRNA synthetase stimulates endothelial cell migration and angiogenesis

artículo científico publicado en 2013

Standardizing analysis of circulating microRNA: clinical and biological relevance

artículo científico publicado en 2014

Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase

artículo científico publicado en 2015

Substrate interaction defects in histidyl-tRNA synthetase linked to dominant axonal peripheral neuropathy.

artículo científico publicado en 2017

Substrate recognition by the hetero-octameric ATP phosphoribosyltransferase from Lactococcus lactis

artículo científico publicado en 2006

Substrate specificity and catalysis by the editing active site of Alanyl-tRNA synthetase from Escherichia coli

artículo científico publicado en 2011

The Usher Syndrome Type IIIB Histidyl-tRNA Synthetase Mutation Confers Temperature Sensitivity.

artículo científico publicado en 2017

The quaternary structure of the HisZ-HisG N-1-(5'-phosphoribosyl)-ATP transferase from Lactococcus lactis

artículo científico publicado en 2002

The α-Amino Group of the Threonine Substrate as The General Base During tRNA Aminoacylation: A New Version of Substrate-Assisted Catalysis Predicted by Hybrid DFT ⬇️

artículo científico publicado el 26 de septiembre de 2011

Threonyl-tRNA synthetase overexpression correlates with angiogenic markers and progression of human ovarian cancer

artículo científico publicado en 2014

Transfer RNA and human disease

artículo científico publicado en 2014

Turning tRNA upside down: When aminoacylation is not a prerequisite to protein synthesis

artículo científico publicado en 2004

tRNA as an active chemical scaffold for diverse chemical transformations

artículo científico publicado en 2010

tRNA synthetase paralogs: evolutionary links in the transition from tRNA-dependent amino acid biosynthesis to de novo biosynthesis

artículo científico publicado en 2003

Lista de obras de

11th IUBMB Focused Meeting on the Aminoacyl-tRNA Synthetases: Sailing a New Sea of Complex Functions in Human Biology and Disease.

A single Danio rerio hars gene encodes both cytoplasmic and mitochondrial histidyl-tRNA synthetases.

A substrate-assisted concerted mechanism for aminoacylation by a class II aminoacyl-tRNA synthetase

A unique hydrophobic cluster near the active site contributes to differences in borrelidin inhibition among threonyl-tRNA synthetases

Activation of the hetero-octameric ATP phosphoribosyl transferase through subunit interface rearrangement by a tRNA synthetase paralog

Altered nuclear cofactor switching in retinoic‐resistant variants of the PML‐RARα oncoprotein of acute promyelocytic leukemia ⬇️

Aminoacyl transfer rate dictates choice of editing pathway in threonyl-tRNA synthetase

Aminoacyl-Transfer RNA Synthetases: Connecting Nutrient Status to Angiogenesis Through the Unfolded Protein Response

Aminoacyl-tRNA synthetase dependent angiogenesis revealed by a bioengineered macrolide inhibitor

Aminoacyl-tRNA synthetases

Aminoacyl-tRNA synthetases: versatile players in the changing theater of translation

Aminoacylating Urzymes Challenge the RNA World Hypothesis ⬇️

Analogs of natural aminoacyl-tRNA synthetase inhibitors clear malaria in vivo

Asymmetric amino acid activation by class II histidyl-tRNA synthetase from Escherichia coli

Bi-allelic mutations in HARS1 severely impair histidyl-tRNA synthetase expression and enzymatic activity causing a novel multi-system ataxic syndrome

Biallelic VARS variants cause developmental encephalopathy with microcephaly that is recapitulated in vars knockout zebrafish

Characterization of aminoacyl-tRNA synthetase stability and substrate interaction by differential scanning fluorimetry.

Correction: A single Danio rerio hars gene encodes both cytoplasmic and mitochondrial histidyl-tRNA synthetases

DNA polymerases and aminoacyl-tRNA synthetases: shared mechanisms for ensuring the fidelity of gene expression

Distinct kinetic mechanisms of the two classes of Aminoacyl-tRNA synthetases

Evolutionary conservation of a functionally important backbone phosphate group critical for aminoacylation of histidine tRNAs

Fidelity Escape by the Unnatural Amino Acid β-Hydroxynorvaline: An Efficient Substrate for Escherichia coli Threonyl-tRNA Synthetase with Toxic Effects on Growth ⬇️

G-1:C73 recognition by an arginine cluster in the active site of Escherichia coli histidyl-tRNA synthetase

Genetic Mapping and Exome Sequencing Identify Variants Associated with Five Novel Diseases ⬇️

Histidyl-tRNA synthetase urzymes: Class I and II aminoacyl tRNA synthetase urzymes have comparable catalytic activities for cognate amino acid activation ⬇️

Immunity-Guided Identification of Threonyl-tRNA Synthetase as the Molecular Target of Obafluorin, a β-Lactone Antibiotic

Induced fit and kinetic mechanism of adenylation catalyzed by Escherichia coli threonyl-tRNA synthetase

Kinetic discrimination of tRNA identity by the conserved motif 2 loop of a class II aminoacyl-tRNA synthetase

Knock-Down of Causes Cell Cycle Arrest and Apoptosis of Neuronal Progenitor Cells

Methods for kinetic and thermodynamic analysis of aminoacyl-tRNA synthetases

Peripheral neuropathy and cognitive impairment associated with a novel monoallelic HARS variant

Progress and challenges in aminoacyl-tRNA synthetase-based therapeutics

RNA-assisted catalysis in a protein enzyme: The 2'-hydroxyl of tRNA(Thr) A76 promotes aminoacylation by threonyl-tRNA synthetase

Regulation of angiogenesis by aminoacyl-tRNA synthetases

Secreted Threonyl-tRNA synthetase stimulates endothelial cell migration and angiogenesis

Standardizing analysis of circulating microRNA: clinical and biological relevance

Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase

Substrate interaction defects in histidyl-tRNA synthetase linked to dominant axonal peripheral neuropathy.

Substrate recognition by the hetero-octameric ATP phosphoribosyltransferase from Lactococcus lactis

Substrate specificity and catalysis by the editing active site of Alanyl-tRNA synthetase from Escherichia coli

The Usher Syndrome Type IIIB Histidyl-tRNA Synthetase Mutation Confers Temperature Sensitivity.

The quaternary structure of the HisZ-HisG N-1-(5'-phosphoribosyl)-ATP transferase from Lactococcus lactis

The α-Amino Group of the Threonine Substrate as The General Base During tRNA Aminoacylation: A New Version of Substrate-Assisted Catalysis Predicted by Hybrid DFT ⬇️

Threonyl-tRNA synthetase overexpression correlates with angiogenic markers and progression of human ovarian cancer

Transfer RNA and human disease

Turning tRNA upside down: When aminoacylation is not a prerequisite to protein synthesis

tRNA as an active chemical scaffold for diverse chemical transformations

tRNA synthetase paralogs: evolutionary links in the transition from tRNA-dependent amino acid biosynthesis to de novo biosynthesis