Lista de obras -

A genetics-free method for high-throughput discovery of cryptic microbial metabolites ⬇️

artículo científico publicado en 2019

Acinetodin and Klebsidin, RNA Polymerase Targeting Lasso Peptides Produced by Human Isolates of Acinetobacter gyllenbergii and Klebsiella pneumoniae.

artículo científico publicado en 2017

Algal p-coumaric acid induces oxidative stress and siderophore biosynthesis in the bacterial symbiont Phaeobacter inhibens ⬇️

artículo científico publicado en 2021

Aliphatic Ether Bond Formation Expands the Scope of Radical SAM Enzymes in Natural Product Biosynthesis.

artículo científico publicado en 2019

Bioactivity-HiTES Unveils Cryptic Antibiotics Encoded in Actinomycete Bacteria ⬇️

artículo científico publicado en 2019

CanE, an Iron/2-Oxoglutarate-Dependent Lasso Peptide Hydroxylase from Streptomyces canus

scientific article published on 30 March 2020

Catecholate siderophores protect bacteria from pyochelin toxicity

artículo científico publicado en 2012

Cebulantin, a Cryptic Lanthipeptide Antibiotic Uncovered Using Bioactivity-Coupled HiTES ⬇️

scientific article published on 28 March 2019

Charting an Unexplored Streptococcal Biosynthetic Landscape Reveals a Unique Peptide Cyclization Motif

scientific article published on 05 December 2018

Corrigendum: Discovery of a Cryptic Depsipeptide from Streptomyces ghanaensis via MALDI-MS-Guided High-Throughput Elicitor Screening

artículo científico publicado en 2020

Crochelins: Siderophores with an Unprecedented Iron-Chelating Moiety from the Nitrogen-Fixing Bacterium Azotobacter chroococcum.

artículo científico publicado en 2017

Cytotoxic alkyl-quinolones mediate surface-induced virulence in Pseudomonas aeruginosa

artículo científico publicado en 2020

Direct observation of a transient tyrosine radical competent for initiating turnover in a photochemical ribonucleotide reductase

artículo científico publicado en 2007

Discovery and Biosynthesis of Streptosactin, a Sactipeptide with an Alternative Topology Encoded by Commensal Bacteria in the Human Microbiome

scientific article published on 26 August 2020

Discovery of a Cryptic Antifungal Compound from Streptomyces albus J1074 Using High-Throughput Elicitor Screens ⬇️

artículo científico

Discovery of a Cryptic Depsipeptide from Streptomyces ghanaensis via MALDI-MS-Guided High-Throughput Elicitor Screening

artículo científico publicado en 2020

Discovery of a New Class I Ribonucleotide Reductase with an Essential DOPA Radical and NO Metal as an Initiator of Long-Range Radical Transfer

scientific article published on 26 December 2018

Discovery of scmR as a global regulator of secondary metabolism and virulence in Burkholderia thailandensis E264.

artículo científico

Electron transfer reactions of fluorotyrosyl radicals

artículo científico publicado en 2006

Forward and reverse electron transfer with the Y356DOPA-beta2 heterodimer of E. coli ribonucleotide reductase.

artículo científico publicado en 2007

Function of the diiron cluster of Escherichia coli class Ia ribonucleotide reductase in proton-coupled electron transfer

scientific article published on 31 May 2013

Generation of the R2 subunit of ribonucleotide reductase by intein chemistry: insertion of 3-nitrotyrosine at residue 356 as a probe of the radical initiation process

artículo científico publicado en 2003

Hybrid biosynthesis of roseobacticides from algal and bacterial precursor molecules

artículo científico publicado en 2014

Identification of the Hypertension Drug Guanfacine as an Antivirulence Agent in Pseudomonas aeruginosa

scientific article published on 03 July 2019

In Vitro Reconstitution of OxyA Enzymatic Activity Clarifies Late Steps in Vancomycin Biosynthesis.

artículo científico

In Vitro Reconstitution of OxyC Activity Enables Total Chemo-Enzymatic Syntheses of Vancomycin Aglycone Variants.

artículo científico publicado en 2018

Induction of Diverse Cryptic Fungal Metabolites by Steroids and Channel Blockers

Installation of Multiple Aryl Ether Crosslinks onto Non-Native Substrate Peptides by the Vancomycin OxyB

Interspecies modulation of bacterial development through iron competition and siderophore piracy

artículo científico publicado en 2012

Investigation of the Genetics and Biochemistry of Roseobacticide Production in the Roseobacter Clade Bacterium Phaeobacter inhibens ⬇️

artículo científico publicado en 2016

Kinetics of Radical Intermediate Formation and Deoxynucleotide Production in 3-Aminotyrosine-Substituted Escherichia coli Ribonucleotide Reductases ⬇️

artículo científico publicado el 25 de mayo de 2011

Long-range proton-coupled electron transfer in the Escherichia coli class Ia ribonucleotide reductase

artículo científico publicado en 2017

Lysine-Tryptophan-Crosslinked Peptides Produced by Radical SAM Enzymes in Pathogenic Streptococci.

artículo científico publicado en 2017

Macrocyclization via an Arginine-Tyrosine Crosslink Broadens the Reaction Scope of Radical S-Adenosylmethionine Enzymes

artículo científico publicado en 2019

Mapping the Trimethoprim-Induced Secondary Metabolome of Burkholderia thailandensis.

artículo científico publicado en 2016

Mechanistic Investigations of Lysine-Tryptophan Cross-Link Formation Catalyzed by Streptococcal Radical S-Adenosylmethionine Enzymes.

artículo científico publicado en 2018

Mixing and matching siderophore clusters: structure and biosynthesis of serratiochelins from Serratia sp. V4. ⬇️

artículo científico publicado en 2012

Mode of action and resistance studies unveil new roles for tropodithietic acid as an anticancer agent and the γ-glutamyl cycle as a proton sink

artículo científico publicado en 2016

Modulating OxyB-Catalyzed Cross-Coupling Reactions in Vancomycin Biosynthesis by Incorporation of Diverse d-Tyr Analogues

artículo científico publicado en 2018

Momomycin, an Antiproliferative Cryptic Metabolite from the Oxytetracycline Producer Streptomyces rimosus

Mono-, di-, tri-, and tetra-substituted fluorotyrosines: new probes for enzymes that use tyrosyl radicals in catalysis

artículo científico publicado en 2006

Multi-Omic Analyses Provide Links between Low-Dose Antibiotic Treatment and Induction of Secondary Metabolism in Burkholderia thailandensis

artículo científico publicado en 2020

Natural products and synthetic biology

artículo científico publicado en 2014

Nonomuraea sp. ATCC 55076 harbours the largest actinomycete chromosome to date and the kistamicin biosynthetic gene cluster ⬇️

artículo científico

Old meets new: using interspecies interactions to detect secondary metabolite production in actinomycetes

artículo científico publicado en 2012

PELDOR spectroscopy with DOPA-beta2 and NH2Y-alpha2s: distance measurements between residues involved in the radical propagation pathway of E. coli ribonucleotide reductase

artículo científico publicado en 2007

Photoactive peptides for light-initiated tyrosyl radical generation and transport into ribonucleotide reductase.

artículo científico publicado en 2007

Radical Approach to Enzymatic β-Thioether Bond Formation

artículo científico publicado en 2018

Re(bpy)(CO)3CN as a probe of conformational flexibility in a photochemical ribonucleotide reductase

artículo científico publicado en 2009

Recent advances in activating silent biosynthetic gene clusters in bacteria

artículo científico publicado en 2018

Replacement of Y730 and Y731 in the alpha2 subunit of Escherichia coli ribonucleotide reductase with 3-aminotyrosine using an evolved suppressor tRNA/tRNA-synthetase pair

artículo científico publicado en 2009

Reporter-Guided Transposon Mutant Selection for Activation of Silent Gene Clusters in Burkholderia thailandensis

scientific article published on 26 January 2020

Roseobacticides: small molecule modulators of an algal-bacterial symbiosis ⬇️

artículo científico publicado en 2011

Roseochelin B, an Algaecidal Natural Product Synthesized by the Roseobacter Phaeobacter inhibens in Response to Algal Sinapic Acid.

artículo científico publicado en 2017

Site-specific incorporation of fluorotyrosines into the R2 subunit of E. coli ribonucleotide reductase by expressed protein ligation

artículo científico publicado en 2007

Site-specific insertion of 3-aminotyrosine into subunit alpha2 of E. coli ribonucleotide reductase: direct evidence for involvement of Y730 and Y731 in radical propagation

artículo científico publicado en 2007

Site-specific replacement of Y356 with 3,4-dihydroxyphenylalanine in the beta2 subunit of E. coli ribonucleotide reductase

artículo científico publicado en 2006

Special Issue in Honor of Professor Jon Clardy

artículo científico publicado en 2020

Structural Elucidation of Cryptic Algaecides in Marine Algal‐Bacterial Symbioses by NMR Spectroscopy and MicroED

Structural examination of the transient 3-aminotyrosyl radical on the PCET pathway of E. coli ribonucleotide reductase by multifrequency EPR spectroscopy

artículo científico publicado en 2009

Structure and biosynthesis of amychelin, an unusual mixed-ligand siderophore from Amycolatopsis sp. AA4. ⬇️

artículo científico publicado en 2011

Synergy and Target Promiscuity Drive Structural Divergence in Bacterial Alkylquinolone Biosynthesis.

artículo científico publicado en 2017

Targeted Discovery of Cryptic Metabolites with Antiproliferative Activity

Thailandenes, Cryptic Polyene Natural Products Isolated from Burkholderia thailandensis Using Phenotype-Guided Transposon Mutagenesis

artículo científico publicado en 2020

The Chemistry and Biology of Bactobolin: A 10-Year Collaboration with Natural Product Chemist Extraordinaire Jon Clardy

artículo científico publicado en 2020

The Jekyll-and-Hyde chemistry of Phaeobacter gallaeciensis ⬇️

artículo científico publicado el 27 de febrero de 2011

The Polyene Natural Product Thailandamide A Inhibits Fatty Acid Biosynthesis in Gram-Positive and Gram-Negative Bacteria

artículo científico publicado en 2018

Total Synthesis and Stereochemical Assignment of Streptide

scientific article published on 17 October 2019

Toward a global picture of bacterial secondary metabolism

scientific article published on 25 January 2019

Unlocking Cryptic Metabolites with Mass Spectrometry-Guided Transposon Mutant Selection

artículo científico publicado en 2020

Use of 2,3,5-F(3)Y-β2 and 3-NH(2)Y-α2 to study proton-coupled electron transfer in Escherichia coli ribonucleotide reductase

artículo científico publicado en 2011

Use of 3-aminotyrosine to examine the pathway dependence of radical propagation in Escherichia coli ribonucleotide reductase

artículo científico publicado en 2009

pH Rate profiles of FnY356-R2s (n = 2, 3, 4) in Escherichia coli ribonucleotide reductase: evidence that Y356 is a redox-active amino acid along the radical propagation pathway

artículo científico publicado en 2006

Lista de obras de

A genetics-free method for high-throughput discovery of cryptic microbial metabolites ⬇️

Acinetodin and Klebsidin, RNA Polymerase Targeting Lasso Peptides Produced by Human Isolates of Acinetobacter gyllenbergii and Klebsiella pneumoniae.

Algal p-coumaric acid induces oxidative stress and siderophore biosynthesis in the bacterial symbiont Phaeobacter inhibens ⬇️

Aliphatic Ether Bond Formation Expands the Scope of Radical SAM Enzymes in Natural Product Biosynthesis.

Bioactivity-HiTES Unveils Cryptic Antibiotics Encoded in Actinomycete Bacteria ⬇️

CanE, an Iron/2-Oxoglutarate-Dependent Lasso Peptide Hydroxylase from Streptomyces canus

Catecholate siderophores protect bacteria from pyochelin toxicity

Cebulantin, a Cryptic Lanthipeptide Antibiotic Uncovered Using Bioactivity-Coupled HiTES ⬇️

Charting an Unexplored Streptococcal Biosynthetic Landscape Reveals a Unique Peptide Cyclization Motif

Corrigendum: Discovery of a Cryptic Depsipeptide from Streptomyces ghanaensis via MALDI-MS-Guided High-Throughput Elicitor Screening

Crochelins: Siderophores with an Unprecedented Iron-Chelating Moiety from the Nitrogen-Fixing Bacterium Azotobacter chroococcum.

Cytotoxic alkyl-quinolones mediate surface-induced virulence in Pseudomonas aeruginosa

Direct observation of a transient tyrosine radical competent for initiating turnover in a photochemical ribonucleotide reductase

Discovery and Biosynthesis of Streptosactin, a Sactipeptide with an Alternative Topology Encoded by Commensal Bacteria in the Human Microbiome

Discovery of a Cryptic Antifungal Compound from Streptomyces albus J1074 Using High-Throughput Elicitor Screens ⬇️

Discovery of a Cryptic Depsipeptide from Streptomyces ghanaensis via MALDI-MS-Guided High-Throughput Elicitor Screening

Discovery of a New Class I Ribonucleotide Reductase with an Essential DOPA Radical and NO Metal as an Initiator of Long-Range Radical Transfer

Discovery of scmR as a global regulator of secondary metabolism and virulence in Burkholderia thailandensis E264.

Electron transfer reactions of fluorotyrosyl radicals

Forward and reverse electron transfer with the Y356DOPA-beta2 heterodimer of E. coli ribonucleotide reductase.

Function of the diiron cluster of Escherichia coli class Ia ribonucleotide reductase in proton-coupled electron transfer

Generation of the R2 subunit of ribonucleotide reductase by intein chemistry: insertion of 3-nitrotyrosine at residue 356 as a probe of the radical initiation process

Hybrid biosynthesis of roseobacticides from algal and bacterial precursor molecules

Identification of the Hypertension Drug Guanfacine as an Antivirulence Agent in Pseudomonas aeruginosa

In Vitro Reconstitution of OxyA Enzymatic Activity Clarifies Late Steps in Vancomycin Biosynthesis.

In Vitro Reconstitution of OxyC Activity Enables Total Chemo-Enzymatic Syntheses of Vancomycin Aglycone Variants.

Induction of Diverse Cryptic Fungal Metabolites by Steroids and Channel Blockers

Installation of Multiple Aryl Ether Crosslinks onto Non-Native Substrate Peptides by the Vancomycin OxyB

Interspecies modulation of bacterial development through iron competition and siderophore piracy

Investigation of the Genetics and Biochemistry of Roseobacticide Production in the Roseobacter Clade Bacterium Phaeobacter inhibens ⬇️

Kinetics of Radical Intermediate Formation and Deoxynucleotide Production in 3-Aminotyrosine-Substituted Escherichia coli Ribonucleotide Reductases ⬇️

Long-range proton-coupled electron transfer in the Escherichia coli class Ia ribonucleotide reductase

Lysine-Tryptophan-Crosslinked Peptides Produced by Radical SAM Enzymes in Pathogenic Streptococci.

Macrocyclization via an Arginine-Tyrosine Crosslink Broadens the Reaction Scope of Radical S-Adenosylmethionine Enzymes

Mapping the Trimethoprim-Induced Secondary Metabolome of Burkholderia thailandensis.

Mechanistic Investigations of Lysine-Tryptophan Cross-Link Formation Catalyzed by Streptococcal Radical S-Adenosylmethionine Enzymes.

Mixing and matching siderophore clusters: structure and biosynthesis of serratiochelins from Serratia sp. V4. ⬇️

Mode of action and resistance studies unveil new roles for tropodithietic acid as an anticancer agent and the γ-glutamyl cycle as a proton sink

Modulating OxyB-Catalyzed Cross-Coupling Reactions in Vancomycin Biosynthesis by Incorporation of Diverse d-Tyr Analogues

Momomycin, an Antiproliferative Cryptic Metabolite from the Oxytetracycline Producer Streptomyces rimosus

Mono-, di-, tri-, and tetra-substituted fluorotyrosines: new probes for enzymes that use tyrosyl radicals in catalysis

Multi-Omic Analyses Provide Links between Low-Dose Antibiotic Treatment and Induction of Secondary Metabolism in Burkholderia thailandensis

Natural products and synthetic biology

Nonomuraea sp. ATCC 55076 harbours the largest actinomycete chromosome to date and the kistamicin biosynthetic gene cluster ⬇️

Old meets new: using interspecies interactions to detect secondary metabolite production in actinomycetes

PELDOR spectroscopy with DOPA-beta2 and NH2Y-alpha2s: distance measurements between residues involved in the radical propagation pathway of E. coli ribonucleotide reductase

Photoactive peptides for light-initiated tyrosyl radical generation and transport into ribonucleotide reductase.

Radical Approach to Enzymatic β-Thioether Bond Formation

Re(bpy)(CO)3CN as a probe of conformational flexibility in a photochemical ribonucleotide reductase

Recent advances in activating silent biosynthetic gene clusters in bacteria

Replacement of Y730 and Y731 in the alpha2 subunit of Escherichia coli ribonucleotide reductase with 3-aminotyrosine using an evolved suppressor tRNA/tRNA-synthetase pair

Reporter-Guided Transposon Mutant Selection for Activation of Silent Gene Clusters in Burkholderia thailandensis

Roseobacticides: small molecule modulators of an algal-bacterial symbiosis ⬇️

Roseochelin B, an Algaecidal Natural Product Synthesized by the Roseobacter Phaeobacter inhibens in Response to Algal Sinapic Acid.

Site-specific incorporation of fluorotyrosines into the R2 subunit of E. coli ribonucleotide reductase by expressed protein ligation

Site-specific insertion of 3-aminotyrosine into subunit alpha2 of E. coli ribonucleotide reductase: direct evidence for involvement of Y730 and Y731 in radical propagation

Site-specific replacement of Y356 with 3,4-dihydroxyphenylalanine in the beta2 subunit of E. coli ribonucleotide reductase

Special Issue in Honor of Professor Jon Clardy

Structural Elucidation of Cryptic Algaecides in Marine Algal‐Bacterial Symbioses by NMR Spectroscopy and MicroED

Structural examination of the transient 3-aminotyrosyl radical on the PCET pathway of E. coli ribonucleotide reductase by multifrequency EPR spectroscopy

Structure and biosynthesis of amychelin, an unusual mixed-ligand siderophore from Amycolatopsis sp. AA4. ⬇️

Synergy and Target Promiscuity Drive Structural Divergence in Bacterial Alkylquinolone Biosynthesis.

Targeted Discovery of Cryptic Metabolites with Antiproliferative Activity

Thailandenes, Cryptic Polyene Natural Products Isolated from Burkholderia thailandensis Using Phenotype-Guided Transposon Mutagenesis

The Chemistry and Biology of Bactobolin: A 10-Year Collaboration with Natural Product Chemist Extraordinaire Jon Clardy

The Jekyll-and-Hyde chemistry of Phaeobacter gallaeciensis ⬇️

The Polyene Natural Product Thailandamide A Inhibits Fatty Acid Biosynthesis in Gram-Positive and Gram-Negative Bacteria

Total Synthesis and Stereochemical Assignment of Streptide

Toward a global picture of bacterial secondary metabolism

Unlocking Cryptic Metabolites with Mass Spectrometry-Guided Transposon Mutant Selection

Use of 2,3,5-F(3)Y-β2 and 3-NH(2)Y-α2 to study proton-coupled electron transfer in Escherichia coli ribonucleotide reductase

Use of 3-aminotyrosine to examine the pathway dependence of radical propagation in Escherichia coli ribonucleotide reductase

pH Rate profiles of FnY356-R2s (n = 2, 3, 4) in Escherichia coli ribonucleotide reductase: evidence that Y356 is a redox-active amino acid along the radical propagation pathway