Lista de obras -

A broader spectrum of tuberculosis

artículo científico publicado en 2016

A genetic strategy to identify targets for the development of drugs that prevent bacterial persistence

artículo científico publicado en 2013

A membrane protein preserves intrabacterial pH in intraphagosomal Mycobacterium tuberculosis

artículo científico publicado en 2008

Acid-susceptible mutants of Mycobacterium tuberculosis share hypersusceptibility to cell wall and oxidative stress and to the host environment

artículo científico publicado en 2008

An NAD Phosphorylase Toxin Triggers Mycobacterium tuberculosis Cell Death

artículo científico publicado en 2019

Ancestral antibiotic resistance in Mycobacterium tuberculosis

scientific journal article

Antitubercular 2-Pyrazolylpyrimidinones: Structure-Activity Relationship and Mode-of-Action Studies

artículo científico publicado en 2021

Avoiding Antibiotic Inactivation in Mycobacterium tuberculosis by Rv3406 through Strategic Nucleoside Modification.

artículo científico publicado en 2018

Biosynthesis and recycling of nicotinamide cofactors in mycobacterium tuberculosis. An essential role for NAD in nonreplicating bacilli

scientific journal article

Bisubstrate Adenylation Inhibitors of Biotin Protein Ligase from Mycobacterium tuberculosis

artículo científico publicado en 2011

Bisubstrate Inhibitors of Biotin Protein Ligase in Mycobacterium tuberculosis Resistant to Cyclonucleoside Formation.

artículo científico publicado en 2013

Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier

artículo científico publicado en 2011

Chemical Genetic Interaction Profiling Reveals Determinants of Intrinsic Antibiotic Resistance in Mycobacterium tuberculosis

artículo científico publicado en 2017

Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis

artículo científico publicado en 2017

Conformational changes necessary for gene regulation by Tet repressor assayed by reversible disulfide bond formation ⬇️

artículo científico publicado el 1 de septiembre de 1998

Conformational changes of the Tet repressor induced by tetracycline trapping

artículo científico publicado en 1998

Conformationally Constrained Cinnolinone Nucleoside Analogues as Siderophore Biosynthesis Inhibitors for Tuberculosis

artículo científico publicado en 2018

Construction of conditional knockdown mutants in mycobacteria

artículo científico publicado en 2015

Controlling gene expression in mycobacteria

artículo científico publicado en 2006

Controlling gene expression in mycobacteria with anhydrotetracycline and Tet repressor

artículo científico publicado en 2005

Critical impact of peptidoglycan precursor amidation on the activity of L,D-transpeptidases from Enterococcus faecium and Mycobacterium tuberculosis

artículo científico publicado en 2018

Crystal structure of the tet repressor in complex with a novel tetracycline, 9-(N,N-dimethylglycylamido)- 6-demethyl-6-deoxy-tetracycline

artículo científico publicado en 1999

Crystallization and preliminary X-ray analysis of the Tet-repressor/operator complex

artículo científico publicado en 1998

Database resources for the tuberculosis community

artículo científico publicado en 2013

Depleting Mycobacterium tuberculosis of the transcription termination factor Rho causes pervasive transcription and rapid death

scientific article published on 28 March 2017

Depletion of antibiotic targets has widely varying effects on growth

artículo científico publicado en 2011

Depletion of the DarG antitoxin in Mycobacterium tuberculosis triggers the DNA-damage response and leads to cell death

scientific article published on 07 July 2020

Detection and treatment of subclinical tuberculosis

article

Determinants of protein-protein recognition by four helix bundles: changing the dimerization specificity of Tet repressor ⬇️

artículo científico publicado el 15 de enero de 1998

Discovery and Structure-Activity-Relationship Study of N-Alkyl-5-hydroxypyrimidinone Carboxamides as Novel Antitubercular Agents Targeting Decaprenylphosphoryl-β-d-ribose 2'-Oxidase.

artículo científico publicado en 2018

Discovery of small molecule probe that shows anti-tubercular activity via Mtb bioA (DAPA synthase) enzyme inhibition

Disruption of an M. tuberculosis membrane protein causes a magnesium-dependent cell division defect and failure to persist in mice

artículo científico publicado en 2015

Dual inhibition of the terminal oxidases eradicates antibiotic-tolerant Mycobacterium tuberculosis

artículo científico publicado en 2020

Energy transfer between fluorescent proteins using a co-expression system in Mycobacterium smegmatis

artículo científico publicado en 2001

Evaluating the sensitivity of Mycobacterium tuberculosis to biotin deprivation using regulated gene expression

artículo científico publicado en 2011

Expression profiling of host pathogen interactions: how Mycobacterium tuberculosis and the macrophage adapt to one another

artículo científico publicado en 2006

Fast large-scale purification of tetracycline repressor variants from overproducing Escherichia coli strains

artículo científico publicado en 1996

Fragment-based exploration of binding site flexibility in Mycobacterium tuberculosis BioA.

artículo científico publicado en 2015

Generation of conditional mutants in higher eukaryotes by switching between the expression of two genes

artículo científico publicado en 1999

Genetic Approaches to Facilitate Antibacterial Drug Development

artículo científico publicado en 2015

Genome-Wide Screen for Mycobacterium tuberculosis Genes That Regulate Host Immunity ⬇️

artículo científico publicado el 10 de diciembre de 2010

Genomics of host-pathogen interactions.

artículo científico publicado en 2007

Gluconeogenic carbon flow of tricarboxylic acid cycle intermediates is critical for Mycobacterium tuberculosis to establish and maintain infection

artículo científico publicado en 2010

Glycolytic and Non-glycolytic Functions of Mycobacterium tuberculosis Fructose-1,6-bisphosphate Aldolase, an Essential Enzyme Produced by Replicating and Non-replicating Bacilli

artículo científico publicado en 2011

Glyoxylate detoxification is an essential function of malate synthase required for carbon assimilation in Mycobacterium tuberculosis

artículo científico publicado en 2017

Identification of Enolase as the Target of 2-Aminothiazoles in

artículo científico publicado en 2018

Identification of a stability determinant on the edge of the Tet repressor four-helix bundle dimerization motif

artículo científico publicado en 2001

Improved tetracycline repressors for gene silencing in mycobacteria

artículo científico publicado en 2009

In vivo gene silencing identifies the Mycobacterium tuberculosis proteasome as essential for the bacteria to persist in mice

scientific journal article

Inactivation of fructose-1,6-bisphosphate aldolase prevents optimal co-catabolism of glycolytic and gluconeogenic carbon substrates in Mycobacterium tuberculosis

artículo científico publicado en 2014

Introduction: genomic approaches in infectious diseases

scientific article published on 27 January 2006

Investigation of ( S)-(-)-Acidomycin: A Selective Antimycobacterial Natural Product That Inhibits Biotin Synthase

scientific article published on 04 February 2019

Isolation of plasmids from E. coli by alkaline lysis

artículo científico publicado en 2003

Isolation of plasmids from E. coli by boiling lysis

artículo científico publicado en 2003

Large-scale chemical-genetics yields new M. tuberculosis inhibitor classes

scientific article published on 19 June 2019

Mechanism-based Inactivation by Aromatization of the Transaminase BioA Involved in Biotin Biosynthesis in Mycobaterium tuberculosis

artículo científico publicado en 2011

Metabolic principles of persistence and pathogenicity in Mycobacterium tuberculosis

artículo científico publicado en 2018

MyD88 primes macrophages for full-scale activation by interferon-gamma yet mediates few responses to Mycobacterium tuberculosis

artículo científico publicado en 2003

Mycobacterial genes essential for the pathogen's survival in the host

artículo científico publicado en 2015

Mycobacterial nonhomologous end joining mediates mutagenic repair of chromosomal double-strand DNA breaks

artículo científico publicado en 2007

Mycobacterial survival strategies in the phagosome: defence against host stresses

artículo científico publicado en 2009

Mycobacterium tuberculosis Thioredoxin Reductase Is Essential for Thiol Redox Homeostasis but Plays a Minor Role in Antioxidant Defense

artículo científico publicado en 2016

Mycobacterium tuberculosis exploits asparagine to assimilate nitrogen and resist acid stress during infection

artículo científico publicado en 2014

Mycobacterium tuberculosis virulence: lipids inside and out

scientific article published on 01 March 2007

Nitrate respiration protects hypoxic Mycobacterium tuberculosis against acid- and reactive nitrogen species stresses

scientific journal article

Opposing reactions in coenzyme A metabolism sensitize Mycobacterium tuberculosis to enzyme inhibition

artículo científico publicado en 2019

Persistent infection in mice requires PerM for successful cell division

scientific article published on 21 November 2019

Plasticity of the Mycobacterium tuberculosis respiratory chain and its impact on tuberculosis drug development

scientific article published on 31 October 2019

Post-translational regulation via Clp protease is critical for survival of Mycobacterium tuberculosis.

artículo científico publicado en 2014

Programmable transcriptional repression in mycobacteria using an orthogonal CRISPR interference platform

artículo científico publicado en 2017

Protein inactivation in mycobacteria by controlled proteolysis and its application to deplete the beta subunit of RNA polymerase.

artículo científico publicado en 2010

Re-discovery of PF-3845 as a new chemical scaffold inhibiting phenylalanyl-tRNA synthetase in <i>Mycobacterium tuberculosis</i>

scientific article published on 04 January 2021

Reconstruction and topological characterization of the sigma factor regulatory network of Mycobacterium tuberculosis

artículo científico publicado en 2016

Regulated Expression Systems for Mycobacteria and Their Applications

artículo científico publicado en 2014

Reprogramming of the macrophage transcriptome in response to interferon-gamma and Mycobacterium tuberculosis: signaling roles of nitric oxide synthase-2 and phagocyte oxidase

artículo científico publicado en 2001

Silencing Mycobacterium smegmatis by using tetracycline repressors

artículo científico publicado en 2007

Simultaneous analysis of multiple Mycobacterium tuberculosis knockdown mutants in vitro and in vivo

artículo científico publicado en 2010

Single-chain Tet transregulators

artículo científico publicado en 2003

Solvent-exposed residues in the Tet repressor (TetR) four-helix bundle contribute to subunit recognition and dimer stability

artículo científico publicado en 1999

Spectrum of latent tuberculosis — existing tests cannot resolve the underlying phenotypes: author's reply

scientific article published in 2010

Statistical analysis of variability in TnSeq data across conditions using zero-inflated negative binomial regression

scientific article published on 21 November 2019

Stressed mycobacteria use the chaperone ClpB to sequester irreversibly oxidized proteins asymmetrically within and between cells

artículo científico publicado en 2015

Structural basis of gene regulation by the tetracycline inducible Tet repressor-operator system

artículo científico publicado en 2000

Structure-Based Optimization of Pyridoxal 5'-Phosphate-Dependent Transaminase Enzyme (BioA) Inhibitors that Target Biotin Biosynthesis in Mycobacterium tuberculosis.

artículo científico publicado en 2017

Target-based identification of whole-cell active inhibitors of biotin biosynthesis in Mycobacterium tuberculosis

artículo científico publicado en 2014

Targeting Mycobacterium tuberculosis Biotin Protein Ligase (MtBPL) with Nucleoside-Based Bisubstrate Adenylation Inhibitors.

artículo científico publicado en 2015

Targeting protein biotinylation enhances tuberculosis chemotherapy.

artículo científico publicado en 2018

Tetracyclines: antibiotic action, uptake, and resistance mechanisms

artículo científico publicado en 1996

The Mycobacterium tuberculosis β-oxidation genes echA5 and fadB3 are dispensable for growth in vitro and in vivo

artículo científico publicado en 2011

The role of the variable region in Tet repressor for inducibility by tetracycline

artículo científico publicado en 1997

The spectrum of latent tuberculosis: rethinking the biology and intervention strategies

artículo científico publicado en 2009

Therapeutic Potential of the Mycobacterium tuberculosis Mycolic Acid Transporter, MmpL3

artículo científico publicado en 2016

Tissue distribution of doxycycline in animal models of tuberculosis

scientific article published on 10 February 2020

Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages: Insights into the Phagosomal Environment

scientific journal article

Triosephosphate isomerase is dispensable in vitro yet essential for Mycobacterium tuberculosis to establish infection

scientific article published on 22 April 2014

Two-Way Regulation of MmpL3 Expression Identifies and Validates Inhibitors of MmpL3 Function in <i>Mycobacterium tuberculosis</i>

scientific article published on 15 December 2020

Validation of CoaBC as a Bactericidal Target in the Coenzyme A Pathway of Mycobacterium tuberculosis

artículo científico publicado en 2016

Virulence of Mycobacterium tuberculosis depends on lipoamide dehydrogenase, a member of three multienzyme complexes

artículo científico publicado en 2011

Lista de obras de

A broader spectrum of tuberculosis

A genetic strategy to identify targets for the development of drugs that prevent bacterial persistence

A membrane protein preserves intrabacterial pH in intraphagosomal Mycobacterium tuberculosis

Acid-susceptible mutants of Mycobacterium tuberculosis share hypersusceptibility to cell wall and oxidative stress and to the host environment

An NAD Phosphorylase Toxin Triggers Mycobacterium tuberculosis Cell Death

Ancestral antibiotic resistance in Mycobacterium tuberculosis

Antitubercular 2-Pyrazolylpyrimidinones: Structure-Activity Relationship and Mode-of-Action Studies

Avoiding Antibiotic Inactivation in Mycobacterium tuberculosis by Rv3406 through Strategic Nucleoside Modification.

Biosynthesis and recycling of nicotinamide cofactors in mycobacterium tuberculosis. An essential role for NAD in nonreplicating bacilli

Bisubstrate Adenylation Inhibitors of Biotin Protein Ligase from Mycobacterium tuberculosis

Bisubstrate Inhibitors of Biotin Protein Ligase in Mycobacterium tuberculosis Resistant to Cyclonucleoside Formation.

Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier

Chemical Genetic Interaction Profiling Reveals Determinants of Intrinsic Antibiotic Resistance in Mycobacterium tuberculosis

Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis

Conformational changes necessary for gene regulation by Tet repressor assayed by reversible disulfide bond formation ⬇️

Conformational changes of the Tet repressor induced by tetracycline trapping

Conformationally Constrained Cinnolinone Nucleoside Analogues as Siderophore Biosynthesis Inhibitors for Tuberculosis

Construction of conditional knockdown mutants in mycobacteria

Controlling gene expression in mycobacteria

Controlling gene expression in mycobacteria with anhydrotetracycline and Tet repressor

Critical impact of peptidoglycan precursor amidation on the activity of L,D-transpeptidases from Enterococcus faecium and Mycobacterium tuberculosis

Crystal structure of the tet repressor in complex with a novel tetracycline, 9-(N,N-dimethylglycylamido)- 6-demethyl-6-deoxy-tetracycline

Crystallization and preliminary X-ray analysis of the Tet-repressor/operator complex

Database resources for the tuberculosis community

Depleting Mycobacterium tuberculosis of the transcription termination factor Rho causes pervasive transcription and rapid death

Depletion of antibiotic targets has widely varying effects on growth

Depletion of the DarG antitoxin in Mycobacterium tuberculosis triggers the DNA-damage response and leads to cell death

Detection and treatment of subclinical tuberculosis

Determinants of protein-protein recognition by four helix bundles: changing the dimerization specificity of Tet repressor ⬇️

Discovery and Structure-Activity-Relationship Study of N-Alkyl-5-hydroxypyrimidinone Carboxamides as Novel Antitubercular Agents Targeting Decaprenylphosphoryl-β-d-ribose 2'-Oxidase.

Discovery of small molecule probe that shows anti-tubercular activity via Mtb bioA (DAPA synthase) enzyme inhibition

Disruption of an M. tuberculosis membrane protein causes a magnesium-dependent cell division defect and failure to persist in mice

Dual inhibition of the terminal oxidases eradicates antibiotic-tolerant Mycobacterium tuberculosis

Energy transfer between fluorescent proteins using a co-expression system in Mycobacterium smegmatis

Evaluating the sensitivity of Mycobacterium tuberculosis to biotin deprivation using regulated gene expression

Expression profiling of host pathogen interactions: how Mycobacterium tuberculosis and the macrophage adapt to one another

Fast large-scale purification of tetracycline repressor variants from overproducing Escherichia coli strains

Fragment-based exploration of binding site flexibility in Mycobacterium tuberculosis BioA.

Generation of conditional mutants in higher eukaryotes by switching between the expression of two genes

Genetic Approaches to Facilitate Antibacterial Drug Development

Genome-Wide Screen for Mycobacterium tuberculosis Genes That Regulate Host Immunity ⬇️

Genomics of host-pathogen interactions.

Gluconeogenic carbon flow of tricarboxylic acid cycle intermediates is critical for Mycobacterium tuberculosis to establish and maintain infection

Glycolytic and Non-glycolytic Functions of Mycobacterium tuberculosis Fructose-1,6-bisphosphate Aldolase, an Essential Enzyme Produced by Replicating and Non-replicating Bacilli

Glyoxylate detoxification is an essential function of malate synthase required for carbon assimilation in Mycobacterium tuberculosis

Identification of Enolase as the Target of 2-Aminothiazoles in

Identification of a stability determinant on the edge of the Tet repressor four-helix bundle dimerization motif

Improved tetracycline repressors for gene silencing in mycobacteria

In vivo gene silencing identifies the Mycobacterium tuberculosis proteasome as essential for the bacteria to persist in mice

Inactivation of fructose-1,6-bisphosphate aldolase prevents optimal co-catabolism of glycolytic and gluconeogenic carbon substrates in Mycobacterium tuberculosis

Introduction: genomic approaches in infectious diseases

Investigation of ( S)-(-)-Acidomycin: A Selective Antimycobacterial Natural Product That Inhibits Biotin Synthase

Isolation of plasmids from E. coli by alkaline lysis

Isolation of plasmids from E. coli by boiling lysis

Large-scale chemical-genetics yields new M. tuberculosis inhibitor classes

Mechanism-based Inactivation by Aromatization of the Transaminase BioA Involved in Biotin Biosynthesis in Mycobaterium tuberculosis

Metabolic principles of persistence and pathogenicity in Mycobacterium tuberculosis

MyD88 primes macrophages for full-scale activation by interferon-gamma yet mediates few responses to Mycobacterium tuberculosis

Mycobacterial genes essential for the pathogen's survival in the host

Mycobacterial nonhomologous end joining mediates mutagenic repair of chromosomal double-strand DNA breaks

Mycobacterial survival strategies in the phagosome: defence against host stresses

Mycobacterium tuberculosis Thioredoxin Reductase Is Essential for Thiol Redox Homeostasis but Plays a Minor Role in Antioxidant Defense

Mycobacterium tuberculosis exploits asparagine to assimilate nitrogen and resist acid stress during infection

Mycobacterium tuberculosis virulence: lipids inside and out

Nitrate respiration protects hypoxic Mycobacterium tuberculosis against acid- and reactive nitrogen species stresses

Opposing reactions in coenzyme A metabolism sensitize Mycobacterium tuberculosis to enzyme inhibition

Persistent infection in mice requires PerM for successful cell division

Plasticity of the Mycobacterium tuberculosis respiratory chain and its impact on tuberculosis drug development

Post-translational regulation via Clp protease is critical for survival of Mycobacterium tuberculosis.

Programmable transcriptional repression in mycobacteria using an orthogonal CRISPR interference platform

Protein inactivation in mycobacteria by controlled proteolysis and its application to deplete the beta subunit of RNA polymerase.

Re-discovery of PF-3845 as a new chemical scaffold inhibiting phenylalanyl-tRNA synthetase in <i>Mycobacterium tuberculosis</i>

Reconstruction and topological characterization of the sigma factor regulatory network of Mycobacterium tuberculosis

Regulated Expression Systems for Mycobacteria and Their Applications

Reprogramming of the macrophage transcriptome in response to interferon-gamma and Mycobacterium tuberculosis: signaling roles of nitric oxide synthase-2 and phagocyte oxidase

Silencing Mycobacterium smegmatis by using tetracycline repressors

Simultaneous analysis of multiple Mycobacterium tuberculosis knockdown mutants in vitro and in vivo

Single-chain Tet transregulators

Solvent-exposed residues in the Tet repressor (TetR) four-helix bundle contribute to subunit recognition and dimer stability