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A Bounded Integer Model for Rating and Composite Scale Data

scientific article published on 06 June 2019

A Pharmacometric Framework for Axitinib Exposure, Efficacy, and Safety in Metastatic Renal Cell Carcinoma Patients

artículo científico

A Semi-mechanistic Modeling Strategy for Characterization of Regional Absorption Properties and Prospective Prediction of Plasma Concentrations Following Administration of New Modified Release Formulations

artículo científico publicado en 2011

A Semi-mechanistic Modeling Strategy to Link In Vitro and In Vivo Drug Release for Modified Release Formulations

artículo científico publicado en 2011

A Whole-Body Physiologically Based Pharmacokinetic Model for Colistin and Colistin methanesulfonate (CMS) in Rat.

artículo científico publicado en 2018

A diagnostic tool for population models using non-compartmental analysis: The ncappc package for R.

artículo científico publicado en 2016

A fast method for testing covariates in population PK/PD Models

artículo científico

A mechanism-based approach for absorption modeling: the Gastro-Intestinal Transit Time (GITT) model.

artículo científico publicado en 2012

A mechanism-based pharmacokinetic-enzyme model for cyclophosphamide autoinduction in breast cancer patients

artículo científico publicado en 1999

A model based assessment of the CYP2B6 and CYP2C19 inductive properties by artemisinin antimalarials: implications for combination regimens.

artículo científico publicado en 2008

A model of hypertension and proteinuria in cancer patients treated with the anti-angiogenic drug E7080

artículo científico publicado en 2010

A model-based approach to predict longitudinal HbA1c, using early phase glucose data from type 2 diabetes mellitus patients after anti-diabetic treatment.

artículo científico publicado en 2013

A non-linear mixed effect model for innate immune response: In vivo kinetics of endotoxin and its induction of the cytokines tumor necrosis factor alpha and interleukin-6

scientific article published on 21 February 2019

A pharmacodynamic Markov mixed-effects model for determining the effect of exposure to certolizumab pegol on the ACR20 score in patients with rheumatoid arthritis

artículo científico publicado en 2009

A population pharmacokinetic model for cefuroxime using cystatin C as a marker of renal function

artículo científico publicado en 2006

A population pharmacokinetic/pharmacodynamic model of methotrexate and mucositis scores in osteosarcoma

artículo científico publicado en 2011

A positron emission tomography study in healthy volunteers to estimate mGluR5 receptor occupancy of AZD2066 - estimating occupancy in the absence of a reference region

artículo científico publicado en 2013

A rational approach for selection of optimal covariate-based dosing strategies.

artículo científico publicado en 2003

A semi-mechanistic model of CP-690,550-induced reduction in neutrophil counts in patients with rheumatoid arthritis.

artículo científico publicado en 2009

A semi-mechanistic model of the relationship between average glucose and HbA1c in healthy and diabetic subjects

artículo científico publicado en 2013

A semiphysiological pharmacokinetic model for artemisinin in healthy subjects incorporating autoinduction of metabolism and saturable first-pass hepatic extraction

artículo científico publicado en 2005

A simultaneous analysis of the time-course of leukocytes and neutrophils following docetaxel administration using a semi-mechanistic myelosuppression model

artículo científico publicado en 2010

A strategy for residual error modeling incorporating scedasticity of variance and distribution shape.

artículo científico publicado en 2015

A time-to-event model for acute rejections in paediatric renal transplant recipients treated with ciclosporin A.

scientific article published on October 2013

A time-to-event model relating integrated craving to risk of smoking relapse across different nicotine replacement therapy formulations

artículo científico publicado en 2020

A tool for neutrophil guided dose adaptation in chemotherapy

artículo científico publicado en 2008

A two-compartment effect site model describes the bispectral index after different rates of propofol infusion.

artículo científico publicado en 2010

A whole-body physiologically based pharmacokinetic (WB-PBPK) model of ciprofloxacin: a step towards predicting bacterial killing at sites of infection.

scientific article published on 30 August 2016

Accelerating Monte Carlo power studies through parametric power estimation.

artículo científico publicado en 2016

Adjusted adaptive Lasso for covariate model-building in nonlinear mixed-effect pharmacokinetic models.

artículo científico publicado en 2017

An agonist-antagonist interaction model for prolactin release following risperidone and paliperidone treatment

artículo científico publicado en 2008

An automated sampling importance resampling procedure for estimating parameter uncertainty

artículo científico publicado en 2017

An integrated glucose-insulin model to describe oral glucose tolerance test data in healthy volunteers

artículo científico publicado en 2009

An integrated glucose-insulin model to describe oral glucose tolerance test data in type 2 diabetics.

artículo científico publicado en 2007

An integrated model for glucose and insulin regulation in healthy volunteers and type 2 diabetic patients following intravenous glucose provocations.

artículo científico publicado en 2007

An integrated model for the glucose-insulin system

artículo científico publicado en 2009

Analysis of exposure-response of CI-945 in patients with epilepsy: application of novel mixed hidden Markov modeling methodology

artículo científico publicado en 2012

Application of Item Response Theory to Modeling of Expanded Disability Status Scale in Multiple Sclerosis.

artículo científico publicado en 2016

Application of a combined effect compartment and binding model for gastric acid inhibition of AR-HO47108: a potassium competitive acid blocker, and its active metabolite AR-HO47116 in the dog

scientific article published on 09 June 2006

Application of population pharmacokinetics to cladribine

artículo científico publicado en 2005

Application of the Optimal Design Approach to Improve a Pretransplant Drug Dose Finding Design for Ciclosporin

artículo científico publicado en 2011

Approaches for modeling within subject variability in pharmacometric count data analysis: dynamic inter-occasion variability and stochastic differential equations

artículo científico publicado en 2016

Approaches to handling pharmacodynamic baseline responses

artículo científico publicado en 2008

Approaches to simultaneous analysis of frequency and severity of symptoms

artículo científico publicado en 2010

Artemisinin population pharmacokinetics in children and adults with uncomplicated falciparum malaria

artículo científico publicado en 1998

Assessment of actual significance levels for covariate effects in NONMEM.

artículo científico publicado en 2001

Assessment of type I error rates for the statistical sub-model in NONMEM

artículo científico publicado en 2002

Assumption testing in population pharmacokinetic models: illustrated with an analysis of moxonidine data from congestive heart failure patients.

artículo científico publicado en 1998

Automated covariate model building within NONMEM.

artículo científico publicado en 1998

Bayesian Forecasting Utilizing Bleeding Information to Support Dose Individualization of Factor VIII

scientific article published on 30 October 2019

Best practices in population modeling should always be evolving

artículo científico publicado en 2013

CORRIGENDUM: Implementing Pharmacogenomics in Europe: Design and Implementation Strategy of the Ubiquitous Pharmacogenomics Consortium

artículo científico publicado en 2017

Characterization of an in vivo concentration-effect relationship for piperaquine in malaria chemoprevention

artículo científico publicado en 2014

Comment on Jaki et al., A proposal for a new PhD level curriculum on quantitative methods for drug development. Pharmaceutical Statistics 17 (5):593-606, Sep/Oct 2018, DOI: 10.1002/pst.1873

article

Comparing circulating tumor cell counts with dynamic tumor size changes as predictor of overall survival - a quantitative modeling framework

scientific article published on 11 June 2020

Comparison of Dose-Finding Designs for Narrow-Therapeutic-Index Drugs: Concentration-Controlled vs. Dose-Controlled Trials

artículo científico publicado en 2009

Comparison of Power, Prognosis, and Extrapolation Properties of Four Population Pharmacodynamic Models of HbA1c for Type 2 Diabetes.

artículo científico publicado en 2018

Comparison of Precision and Accuracy of Five Methods to Analyse Total Score Data

artículo científico publicado en 2020

Comparison of covariate selection methods with correlated covariates: prior information versus data information, or a mixture of both?

scientific article published on 13 July 2020

Comparison of cytotoxicity of 2-chloro- 2'-arabino-fluoro-2'-deoxyadenosine (clofarabine) with cladribine in mononuclear cells from patients with acute myeloid and chronic lymphocytic leukemia

artículo científico publicado en 2003

Comparison of methods for handling missing covariate data

artículo científico publicado en 2013

Comparison of methods to calculate cyclosporine A bioavailability from consecutive oral and intravenous doses

artículo científico publicado en 1990

Comparison of proportional and differential odds models for mixed-effects analysis of categorical data

artículo científico publicado en 2008

Comparison of some practical sampling strategies for population pharmacokinetic studies.

artículo científico publicado en 1996

Comparison of stepwise covariate model building strategies in population pharmacokinetic-pharmacodynamic analysis

artículo científico publicado en 2002

Comparison of the agonist‐antagonist interaction model and the pool model for the effect of remoxipride on prolactin ⬇️

artículo científico publicado el 1 de diciembre de 2010

Comparisons of Analysis Methods for Proof-of-Concept Trials.

artículo científico publicado en 2013

Concordance between criteria for covariate model building

artículo científico publicado en 2014

Conditional weighted residuals (CWRES): a model diagnostic for the FOCE method.

artículo científico publicado en 2007

Confirming model-predicted pharmacokinetic interactions between bedaquiline and lopinavir/ritonavir or nevirapine in patients with HIV and drug-resistant tuberculosis

artículo científico publicado en 2016

Correction to: Model-Based Adaptive Optimal Design (MBAOD) Improves Combination Dose Finding Designs: an Example in Oncology

artículo científico publicado en 2018

Correction to: The Clinical Pharmacology of Cladribine Tablets for the Treatment of Relapsing Multiple Sclerosis

artículo científico publicado en 2019

Current Use and Developments Needed for Optimal Design in Pharmacometrics: A Study Performed Among DDMoRe's European Federation of Pharmaceutical Industries and Associations Members

artículo científico publicado en 2013

Developmental pharmacokinetics of ciclosporin--a population pharmacokinetic study in paediatric renal transplant candidates.

artículo científico publicado en 2007

Discrimination between rival dosing histories.

artículo científico publicado en 1997

Dose dependent absorption and linear disposition of cyclosporin A in rat

scientific article published on 01 January 1994

Dose-Exposure-Response Relationship of the Investigational Anti-Interleukin-13 Monoclonal Antibody Tralokinumab in Patients With Severe, Uncontrolled Asthma

artículo científico publicado en 2017

Drug and disease model resources: a consortium to create standards and tools to enhance model-based drug development.

artículo científico publicado en 2013

Edoxaban Exposure-Response Analysis and Clinical Utility Index Assessment in Patients With Symptomatic Deep-Vein Thrombosis or Pulmonary Embolism.

artículo científico publicado en 2016

Estimating bias in population parameters for some models for repeated measures ordinal data using NONMEM and NLMIXED.

artículo científico publicado en 2004

Estimation of cefuroxime dosage using pharmacodynamic targets, MIC distributions, and minimization of a risk function

artículo científico publicado en 2008

Estimation of dosing strategies aiming at maximizing utility or responder probability, using oxybutynin as an example drug

artículo científico publicado en 2005

Estimation of drug receptor occupancy when non-displaceable binding differs between brain regions – extending the simplified reference tissue model

artículo científico publicado en 2015

Ethically Attractive Dose-Finding Designs for Drugs With a Narrow Therapeutic Index

artículo científico publicado en 2011

Evaluation of IPPSE, an alternative method for sequential population PKPD analysis

artículo científico publicado en 2012

Evaluation of an extended grid method for estimation using nonparametric distributions

artículo científico publicado en 2009

Evaluation of bias, precision, robustness and runtime for estimation methods in NONMEM 7.

artículo científico publicado en 2014

Evaluation of optimized bronchoalveolar lavage sampling designs for characterization of pulmonary drug distribution

artículo científico publicado en 2015

Evaluation of the nonparametric estimation method in NONMEM VI.

artículo científico publicado en 2008

Evaluation of the nonparametric estimation method in NONMEM VI: application to real data

artículo científico publicado en 2009

Evaluation of type I error rates when modeling ordered categorical data in NONMEM.

artículo científico publicado en 2004

Gastric acid secretion in the dog: a mechanism-based pharmacodynamic model for histamine stimulation and irreversible inhibition by omeprazole

artículo científico publicado en 2002

Generating evidence for precision medicine: considerations made by the Ubiquitous Pharmacogenomics Consortium when designing and operationalizing the PREPARE study

scientific article published on 20 April 2020

Handling data below the limit of quantification in mixed effect models

artículo científico publicado en 2009

Handling interoccasion variability in model-based dose individualization using therapeutic drug monitoring data

scientific article published on 29 April 2019

Handling underlying discrete variables with bivariate mixed hidden Markov models in NONMEM

artículo científico publicado en 2019

Identification of the mechanism of action of a glucokinase activator from oral glucose tolerance test data in type 2 diabetic patients based on an integrated glucose-insulin model

artículo científico publicado en 2011

Identification of the primary mechanism of action of an insulin secretagogue from meal test data in healthy volunteers based on an integrated glucose-insulin model.

artículo científico publicado en 2012

Impact of CYP2C8*3 on paclitaxel clearance: a population pharmacokinetic and pharmacogenomic study in 93 patients with ovarian cancer.

artículo científico publicado en 2010

Impact of demographics and disease progression on the relationship between glucose and HbA1c

artículo científico publicado en 2017

Impact of lopinavir-ritonavir or nevirapine on bedaquiline exposures and potential implications for patients with tuberculosis-HIV coinfection

artículo científico publicado en 2014

Implementation of a transit compartment model for describing drug absorption in pharmacokinetic studies.

artículo científico publicado en 2007

Implementing Pharmacogenomics in Europe: Design and Implementation Strategy of the Ubiquitous Pharmacogenomics Consortium.

artículo científico publicado en 2016

Implications for drug characterization in glucose tolerance tests without insulin: Simulation study of power and predictions using model-based analysis

artículo científico publicado en 2017

Importance of shrinkage in empirical bayes estimates for diagnostics: problems and solutions

artículo científico publicado en 2009

Improved precision of exposure-response relationships by optimal dose-selection. Examples from studies of receptor occupancy using PET and dose finding for neuropathic pain treatment

artículo científico publicado en 2015

Improved utilization of ADAS-cog assessment data through item response theory based pharmacometric modeling

artículo científico publicado en 2014

Improving the estimation of parameter uncertainty distributions in nonlinear mixed effects models using sampling importance resampling

artículo científico publicado en 2016

Incorporating physiological and biochemical mechanisms into pharmacokinetic-pharmacodynamic models: a conceptual framework

artículo científico publicado en 2009

Integrated Item Response Theory Modeling of Multiple Patient-Reported Outcomes Assessing Lower Urinary Tract Symptoms Associated with Benign Prostatic Hyperplasia

artículo científico publicado en 2020

Integrated population pharmacokinetic analysis of voriconazole in children, adolescents, and adults

artículo científico publicado en 2012

Integration of data from multiple sources for simultaneous modelling analysis: experience from nevirapine population pharmacokinetics

artículo científico publicado en 2012

Item Response Theory Modeling of the International Prostate Symptom Score in Patients with Lower Urinary Tract Symptoms Associated with Benign Prostatic Hyperplasia

artículo científico publicado en 2020

Item Response Theory to Quantify Longitudinal Placebo and Paliperidone Effects on PANSS Scores in Schizophrenia

artículo científico publicado en 2017

Kinetic Observations in Neonatal Mice Exposed to Lead via Milk

scientific article published on 01 September 1996

Letter to the editor regarding: “A reduction in between subject variability is not mandatory for selecting a new covariate”

artículo científico publicado en 2012

Likelihood-based diagnostics for influential individuals in non-linear mixed effects model selection.

artículo científico publicado en 1999

Likert pain score modeling: a Markov integer model and an autoregressive continuous model

artículo científico publicado en 2012

Limited inter-occasion variability in relation to inter-individual variability in chemotherapy-induced myelosuppression

artículo científico publicado en 2009

Linking preclinical and clinical whole-body physiologically based pharmacokinetic models with prior distributions in NONMEM.

artículo científico publicado en 2007

Long-term changes in cyclosporine pharmacokinetics after renal transplantation in children: evidence for saturable presystemic metabolism and effect of NR1I2 polymorphism

artículo científico publicado en 2010

Longitudinal Modeling of the Relationship Between Mean Plasma Glucose and HbA1c Following Antidiabetic Treatments

artículo científico publicado en 2013

Mathematical beta cell model for insulin secretion following IVGTT and OGTT.

artículo científico publicado en 2006

Mechanism-Based Modeling of Gastric Emptying Rate and Gallbladder Emptying in Response to Caloric Intake

artículo científico publicado en 2016

Mechanism-based pharmacokinetic model for paclitaxel

artículo científico publicado en 2001

Mechanistic modeling of a magnetic marker monitoring study linking gastrointestinal tablet transit, in vivo drug release, and pharmacokinetics.

artículo científico publicado en 2009

Mechanistic models for myelosuppression

artículo científico publicado en 2003

Meta-analysis of Magnetic Marker Monitoring Data to Characterize the Movement of Single Unit Dosage Forms Though the Gastrointestinal Tract Under Fed and Fasting Conditions.

artículo científico publicado en 2015

Methodological comparison of in vitro binding parameter estimation: sequential vs. simultaneous non-linear regression

artículo científico publicado en 2010

Methods and strategies for assessing uncontrolled drug-drug interactions in population pharmacokinetic analyses: results from the International Society of Pharmacometrics (ISOP) Working Group

artículo científico publicado en 2016

Methods for Predicting Diabetes Phase III Efficacy Outcome From Early Data: Superior Performance Obtained Using Longitudinal Approaches

artículo científico publicado en 2016

Methods for Predicting Diabetes Phase III Efficacy Outcome From Early Data: Superior Performance Obtained Using Longitudinal Approaches

artículo científico publicado en 2014

Model Description Language (MDL): A Standard for Modeling and Simulation

artículo científico publicado en 2017

Model Evaluation of Continuous Data Pharmacometric Models: Metrics and Graphics

artículo científico publicado en 2016

Model averaging for robust assessment of QT prolongation by concentration-response analysis.

artículo científico

Model of chemotherapy-induced myelosuppression with parameter consistency across drugs

artículo científico publicado en 2002

Model-Based Adaptive Optimal Design (MBAOD) Improves Combination Dose Finding Designs: an Example in Oncology.

artículo científico publicado en 2018

Model-Based Conditional Weighted Residuals Analysis for Structural Model Assessment

article

Model-Based Interspecies Scaling of Glucose Homeostasis

artículo científico publicado en 2017

Model-based estimates of the effects of efavirenz on bedaquiline pharmacokinetics and suggested dose adjustments for patients coinfected with HIV and tuberculosis ⬇️

artículo científico publicado en 2013

Model-based neutrophil-guided dose adaptation in chemotherapy: evaluation of predicted outcome with different types and amounts of information

artículo científico publicado en 2009

Model-based prediction of myelosuppression and recovery based on frequent neutrophil monitoring

artículo científico publicado en 2017

Modeling Disease Progression in Acute Stroke Using Clinical Assessment Scales ⬇️

artículo científico publicado el 21 de septiembre de 2010

Modeling Exposure-Driven Adverse Event Time Courses in Oncology Exemplified by Afatinib

Modeling a Composite Score in Parkinson's Disease Using Item Response Theory

artículo científico publicado en 2017

Modeling and Simulation Workbench for NONMEM: Tutorial on Pirana, PsN, and Xpose

artículo científico publicado en 2013

Modeling and simulation of the time course of asenapine exposure response and dropout patterns in acute schizophrenia.

artículo científico publicado en 2009

Modeling and simulation to optimize the design and analysis of confirmatory trials, characterize risk-benefit, and support label claims

artículo científico publicado en 2013

Modeling longitudinal daily seizure frequency data from pregabalin add-on treatment

artículo científico publicado en 2011

Modeling of 24-hour glucose and insulin profiles of patients with type 2 diabetes

artículo científico publicado en 2010

Modeling of red blood cell life-spans in hematologically normal populations

artículo científico publicado en 2012

Modeling sleep data for a new drug in development using markov mixed-effects models

artículo científico publicado en 2011

Modeling the Disease Progression from Healthy to Overt Diabetes in ZDSD Rats

artículo científico publicado en 2016

Modelling a spontaneously reported side effect by use of a Markov mixed-effects model

artículo científico publicado en 2005

Modelling and simulation in the development and use of anti-cancer agents: an underused tool?

artículo científico publicado en 2004

Modelling overdispersion and Markovian features in count data

artículo científico publicado en 2009

Modelling the genesis and treatment of cancer: the potential role of physiologically based pharmacodynamics.

artículo científico publicado en 2010

Models for time-varying covariates in population pharmacokinetic-pharmacodynamic analysis

artículo científico publicado en 2004

Multinomial logistic estimation of Markov-chain models for modeling sleep architecture in primary insomnia patients.

artículo científico publicado en 2010

Multinomial logistic functions in markov chain models of sleep architecture: internal and external validation and covariate analysis.

artículo científico publicado en 2011

Multiple imputation of missing covariates in NONMEM and evaluation of the method's sensitivity to η-shrinkage

scientific article published on 19 July 2013

Non-linear mixed effects modelling of positron emission tomography data for simultaneous estimation of radioligand kinetics and occupancy in healthy volunteers.

artículo científico publicado en 2012

Open Systems Pharmacology Community-An Open Access, Open Source, Open Science Approach to Modeling and Simulation in Pharmaceutical Sciences

scientific article published on 12 November 2019

Open innovation: Towards sharing of data, models and workflows.

artículo científico publicado en 2017

Optimal adaptive design in clinical drug development: a simulation example

artículo científico publicado en 2007

Optimal clinical trial design based on a dichotomous Markov-chain mixed-effect sleep model

artículo científico publicado en 2014

Optimization of the intravenous glucose tolerance test in T2DM patients using optimal experimental design.

artículo científico publicado en 2009

Optimizing disease progression study designs for drug effect discrimination.

artículo científico publicado en 2013

PK-PD modeling of individual lesion FDG-PET response to predict overall survival in patients with sunitinib-treated gastrointestinal stromal tumor

artículo científico publicado en 2016

PKPD Modeling of Predictors for Adverse Effects and Overall Survival in Sunitinib-Treated Patients With GIST.

artículo científico publicado en 2013

PKPD Modeling of VEGF, sVEGFR-2, sVEGFR-3, and sKIT as Predictors of Tumor Dynamics and Overall Survival Following Sunitinib Treatment in GIST

artículo científico publicado en 2013

Performance comparison of various maximum likelihood nonlinear mixed-effects estimation methods for dose-response models

artículo científico publicado en 2012

Performance in population models for count data, part I: maximum likelihood approximations

artículo científico publicado en 2009

Performance of Three Estimation Methods in Repeated Time-to-Event Modeling ⬇️

artículo científico publicado el 13 de enero de 2011

Performance of longitudinal item response theory models in shortened or partial assessments

artículo científico publicado en 2020

Pharmacodynamic model of interleukin-21 effects on red blood cells in cynomolgus monkeys

artículo científico publicado en 2007

Pharmacodynamic models for the cardiovascular effects of moxonidine in patients with congestive heart failure

artículo científico publicado en 2001

Pharmacogenetics of cyclosporine in children suggests an age-dependent influence of ABCB1 polymorphisms

artículo científico publicado en 2008

Pharmacokinetic Interactions for Drugs with a Long Half-Life—Evidence for the Need of Model-Based Analysis

artículo científico publicado en 2015

Pharmacokinetic/pharmacodynamic modelling in oncological drug development

artículo científico publicado en 2005

Pharmacokinetic/pharmacodynamic models for the depletion of Vbeta5.2/5.3 T cells by the monoclonal antibody ATM-027 in patients with multiple sclerosis, as measured by FACS

artículo científico publicado en 2004

Pharmacokinetics and renal excretion of desmopressin after intravenous administration to healthy subjects and renally impaired patients

artículo científico publicado en 2004

Pharmacokinetics of desmopressin administrated as an oral lyophilisate dosage form in children with primary nocturnal enuresis and healthy adults.

artículo científico publicado en 2006

Pharmacokinetics of melagatran and the effect on ex vivo coagulation time in orthopaedic surgery patients receiving subcutaneous melagatran and oral ximelagatran: a population model analysis

artículo científico publicado en 2003

Pharmacokinetics of oral noscapine

artículo científico publicado en 1990

Pharmacokinetics of ximelagatran and relationship to clinical response in acute deep vein thrombosis

artículo científico publicado en 2005

Pharmacometric Analysis of the Relationship Between Absolute Lymphocyte Count and Expanded Disability Status Scale and Relapse Rate, Efficacy End Points, in Multiple Sclerosis Trials

artículo científico publicado en 2018

Pharmacometrics Markup Language (PharmML): Opening New Perspectives for Model Exchange in Drug Development.

artículo científico publicado en 2015

PopED: an extended, parallelized, nonlinear mixed effects models optimal design tool.

artículo científico publicado en 2012

Population Pharmacokinetic and Pharmacodynamic Modeling of Artemisinin Resistance in Southeast Asia

artículo científico publicado en 2017

Population Pharmacokinetics of Cladribine in Patients with Multiple Sclerosis

artículo científico publicado en 2017

Population Pharmacokinetics of Edoxaban in Patients with Non-Valvular Atrial Fibrillation in the ENGAGE AF-TIMI 48 Study, a Phase III Clinical Trial.

artículo científico publicado en 2016

Population Pharmacokinetics to Model the Time-Varying Clearance of the PEGylated Asparaginase Oncaspar® in Children with Acute Lymphoblastic Leukemia

artículo científico publicado en 2017

Population pharmacokinetic and pharmacodynamic modelling of artemisinin and mefloquine enantiomers in patients with falciparum malaria

artículo científico publicado en 2002

Population pharmacokinetic and pharmacodynamic properties of artesunate in patients with artemisinin sensitive and resistant infections in Southern Myanmar.

artículo científico publicado en 2018

Population pharmacokinetic drug-drug interaction pooled analysis of existing data for rifabutin and HIV PIs

artículo científico publicado en 2016

Population pharmacokinetic model for docetaxel in patients with varying degrees of liver function: incorporating cytochrome P4503A activity measurements

artículo científico publicado en 2008

Population pharmacokinetic modelling and estimation of dosing strategy for NXY-059, a nitrone being developed for stroke

artículo científico publicado en 2005

Population pharmacokinetic modelling of darifenacin and its hydroxylated metabolite using pooled data, incorporating saturable first‐pass metabolism, CYP2D6 genotype and formulation‐dependent bioavailability ⬇️

artículo científico publicado el 1 de diciembre de 2003

Population pharmacokinetic-pharmacodynamic model for neutropenia with patient subgroup identification: comparison across anticancer drugs.

artículo científico publicado en 2006

Population pharmacokinetic/pharmacodynamic (PK/PD) modelling of the hypothalamic-pituitary-gonadal axis following treatment with GnRH analogues

artículo científico publicado en 2006

Population pharmacokinetics and pharmacodynamics of doxorubicin and cyclophosphamide in breast cancer patients: a study by the EORTC-PAMM-NDDG.

artículo científico publicado en 2007

Population pharmacokinetics and pharmacodynamics of paclitaxel and carboplatin in ovarian cancer patients: a study by the European organization for research and treatment of cancer-pharmacology and molecular mechanisms group and new drug development

artículo científico publicado en 2007

Population pharmacokinetics of artemether, dihydroartemisinin and lumefantrine in Rwandese pregnant women treated for uncomplicated malaria

artículo científico publicado en 2018

Population pharmacokinetics of busulfan in children: increased evidence for body surface area and allometric body weight dosing of busulfan in children

artículo científico publicado en 2011

Population pharmacokinetics of clomethiazole and its effect on the natural course of sedation in acute stroke patients

artículo científico publicado en 2003

Population pharmacokinetics of colistin and the relation to survival in critically ill patients infected with colistin susceptible and carbapenem-resistant bacteria

artículo científico publicado en 2020

Population pharmacokinetics of daptomycin in patients affected by severe Gram-positive infections.

artículo científico publicado en 2013

Population pharmacokinetics of edoxaban and its main metabolite in a dedicated renal impairment study.

artículo científico publicado en 2015

Population pharmacokinetics of edoxaban in patients with symptomatic deep-vein thrombosis and/or pulmonary embolism--the Hokusai-VTE phase 3 study

artículo científico publicado en 2015

Population pharmacokinetics of ethambutol in South African tuberculosis patients.

artículo científico publicado en 2011

Population pharmacokinetics of levosimendan in patients with congestive heart failure

artículo científico publicado en 2003

Population pharmacokinetics of melagatran, the active form of the oral direct thrombin inhibitor ximelagatran, in atrial fibrillation patients receiving long-term anticoagulation therapy

artículo científico publicado en 2006

Population pharmacokinetics of rifampin in pulmonary tuberculosis patients, including a semimechanistic model to describe variable absorption

artículo científico publicado en 2008

Population pharmacokinetics of sibrotuzumab, a novel therapeutic monoclonal antibody, in cancer patients

artículo científico publicado en 2004

Population pharmacokinetics of tacrolimus in pediatric liver transplantation: early posttransplantation clearance

artículo científico publicado en 2011

Prediction of Improved Antimalarial Chemoprevention with Weekly Dosing of Dihydroartemisinin-Piperaquine

artículo científico publicado en 2017

Prediction-corrected visual predictive checks for diagnosing nonlinear mixed-effects models

artículo científico publicado en 2011

Predictive ability of a semi-mechanistic model for neutropenia in the development of novel anti-cancer agents: two case studies.

artículo científico publicado en 2010

Randomized exposure-controlled trials; impact of randomization and analysis strategies

artículo científico publicado en 2007

Rapid sample size calculations for a defined likelihood ratio test-based power in mixed-effects models

artículo científico publicado en 2012

Reduced and optimized trial designs for drugs described by a target mediated drug disposition model.

artículo científico publicado en 2018

Relating nicotine plasma concentration to momentary craving across four nicotine replacement therapy formulations

artículo científico publicado en 2019

Relationship between factor VIII activity, bleeds and individual characteristics in severe hemophilia A patients

artículo científico publicado en 2019

Rifampicin and rifapentine significantly reduce concentrations of bedaquiline, a new anti-TB drug

artículo científico publicado en 2014

Scaling the time-course of myelosuppression from rats to patients with a semi-physiological model

artículo científico publicado en 2009

Semi-physiological model describing the hematological toxicity of the anti-cancer agent indisulam

artículo científico publicado en 2005

Semimechanistic pharmacokinetic/pharmacodynamic model for assessment of activity of antibacterial agents from time-kill curve experiments

artículo científico publicado en 2006

Semiparametric distributions with estimated shape parameters

artículo científico publicado en 2009

Serial correlation in optimal design for nonlinear mixed effects models

artículo científico publicado en 2012

Simultaneous optimal experimental design for in vitro binding parameter estimation

artículo científico publicado en 2013

Simultaneous optimal experimental design on dose and sample times

artículo científico publicado en 2009

Suboptimal Antituberculosis Drug Concentrations and Outcomes in Small and HIV-Coinfected Children in India: Recommendations for Dose Modifications

artículo científico publicado en 2017

The Clinical Pharmacology of Cladribine Tablets for the Treatment of Relapsing Multiple Sclerosis.

artículo científico publicado en 2019

The Role of Modeling and Simulation in Development and Registration of Medicinal Products: Output From the EFPIA/EMA Modeling and Simulation Workshop

artículo científico publicado en 2013

The back-step method--method for obtaining unbiased population parameter estimates for ordered categorical data

artículo científico publicado en 2004

The dosing solution influence on the pharmacokinetics of degarelix, a new GnRH antagonist, after s.c. administration to beagle dogs ⬇️

artículo científico publicado el 1 de noviembre de 2003

The impact of misspecification of residual error or correlation structure on the type I error rate for covariate inclusion.

artículo científico publicado en 2009

The influence of underlying assumptions on evaluating the relative merits of concentration-controlled and dose-controlled trials.

artículo científico publicado en 2009

The integrated glucose insulin minimal model: An improved version

scientific article published on 09 April 2019

The pharmacokinetic modelling of GI198745 (dutasteride), a compound with parallel linear and nonlinear elimination

artículo científico publicado en 1999

The population pharmacokinetics of recombinant- and urinary-human follicle stimulating hormone in women.

artículo científico publicado en 1998

The risk of febrile neutropenia in breast cancer patients following adjuvant chemotherapy is predicted by the time course of interleukin-6 and C-reactive protein by modelling

artículo científico publicado en 2017

The time course of body temperature, serum amyloid A protein, C-reactive protein and interleukin-6 in patients with bacterial infection during the initial 3 days of antibiotic therapy

artículo científico publicado en 2009

The use of clinical irrelevance criteria in covariate model building with application to dofetilide pharmacokinetic data

artículo científico publicado en 2008

Transforming parts of a differential equations system to difference equations as a method for run-time savings in NONMEM ⬇️

artículo científico publicado el 29 de septiembre de 2010

Transient lower esophageal sphincter relaxation pharmacokinetic-pharmacodynamic modeling: count model and repeated time-to-event model

artículo científico publicado en 2011

Translation Between Two Models; Application with Integrated Glucose Homeostasis Models

artículo científico publicado en 2019

Trial Treatment Length Optimization With an Emphasis on Disease Progression Studies

artículo científico publicado en 2009

Two bootstrapping routines for obtaining imprecision estimates for nonparametric parameter distributions in nonlinear mixed effects models ⬇️

artículo científico publicado el 13 de noviembre de 2010

Two-stage model-based clinical trial design to optimize phase I development of novel anticancer agents

artículo científico publicado en 2009

Use of a linearization approximation facilitating stochastic model building

artículo científico

Validation of a population pharmacokinetic/pharmacodynamic model for 5 alpha-reductase inhibitors.

artículo científico publicado en 1999

Variability Attribution for Automated Model Building

Visceral leishmaniasis relapse hazard is linked to reduced miltefosine exposure in patients from Eastern Africa: a population pharmacokinetic/pharmacodynamic study.

artículo científico publicado en 2017

Weight-HbA1c-insulin-glucose model for describing disease progression of type 2 diabetes

artículo científico publicado en 2015

Xpose--an S-PLUS based population pharmacokinetic/pharmacodynamic model building aid for NONMEM

artículo científico publicado en 1999

dOFV distributions: a new diagnostic for the adequacy of parameter uncertainty in nonlinear mixed-effects models applied to the bootstrap

artículo científico publicado en 2016

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