Lista de obras -

A Randomized, Controlled Trial Validates a Peripheral Supra-Additive Antihyperalgesic Effect of a Paracetamol-Ketorolac Combination ⬇️

artículo científico publicado el 6 de julio de 2011

A cocktail approach for assessing the in vitro activity of human cytochrome P450s: an overview of current methodologies

artículo científico publicado en 2014

A simplified analytical method for a phenotyping cocktail of major CYP450 biotransformation routes

artículo científico publicado en 2004

A simplified method for busulfan monitoring using dried blood spot in combination with liquid chromatography/tandem mass spectrometry

scientific article published on 01 June 2012

An extensive cocktail approach for rapid risk assessment of in vitro CYP450 direct reversible inhibition by xenobiotic exposure.

artículo científico publicado en 2016

Analgesics in patients with hepatic impairment: pharmacology and clinical implications.

artículo científico publicado en 2012

Aspirin response: Differences in serum thromboxane B2 levels between clinical studies.

artículo científico publicado en 2015

Automated system for on-line desorption of dried blood spots applied to LC/MS/MS pharmacokinetic study of flurbiprofen and its metabolite

scientific article published on 01 January 2011

Characterization of oxycodone in vitro metabolism by human cytochromes P450 and UDP-glucuronosyltransferases.

artículo científico publicado en 2016

Codeine intoxication associated with ultrarapid CYP2D6 metabolism

artículo científico publicado en 2004

Comparing Dried Blood Spots and Plasma Concentrations for Busulfan Therapeutic Drug Monitoring in Children

artículo científico publicado en 2020

Complex Drug-Drug-Gene-Disease Interactions Involving Cytochromes P450: Systematic Review of Published Case Reports and Clinical Perspectives.

artículo científico publicado en 2018

Contribution of exome sequencing to the identification of genes involved in the response to clopidogrel in cardiovascular patients

artículo científico publicado en 2020

Cytochrome P450 1A2 activity and incidence of thyroid disease and cancer after chronic or acute exposure to dioxins

artículo científico publicado en 2019

Detection of busulfan adducts on proteins.

artículo científico publicado en 2016

Development of an LC-MS/MS Method for the Assessment of Selected Active Pharmaceuticals and Metabolites in Wastewaters of a Swiss University Hospital

artículo científico publicado en 2015

Dual reuptake inhibitor milnacipran and spinal pain pathways in fibromyalgia patients: a randomized, double-blind, placebo-controlled trial

artículo científico publicado en 2013

Dynamics of active pharmaceutical ingredients loads in a Swiss university hospital wastewaters and prediction of the related environmental risk for the aquatic ecosystems.

artículo científico publicado en 2016

Evaluation of Mutual Drug-Drug Interaction within Geneva Cocktail for Cytochrome P450 Phenotyping using Innovative Dried Blood Sampling Method

artículo científico publicado en 2016

Evaluation of Phenotypic and Genotypic Variations of Drug Metabolising Enzymes and Transporters in Chronic Pain Patients Facing Adverse Drug Reactions or Non-Response to Analgesics: A Retrospective Study

scientific article published on 27 October 2020

Evidence-Based Choice of P2Y12 Inhibitors in End Stage Renal Disease Patients: A Mini-Review

artículo científico

GABAergic modulation of secondary hyperalgesia: A randomized controlled 4-way crossover trial with the α2-subunit preferring GABA positive allosteric modulator, N-desmethyl-clobazam in healthy volunteers

scientific article published on 14 March 2020

Genotype-sensitive reversible and time-dependent CYP2D6 inhibition in human liver microsomes

artículo científico publicado en 2018

Impact of Boosted Antiretroviral Therapy on the Pharmacokinetics and Efficacy of Clopidogrel and Prasugrel Active Metabolites

artículo científico publicado en 2018

Impact of CYP2D6 Functional Allelic Variations on Phenoconversion and Drug-Drug Interactions.

artículo científico publicado en 2017

Impact of acute inflammation on cytochromes P450 activity assessed by the Geneva Cocktail

scientific article published on 20 December 2020

Incorporation of flurbiprofen in a 4-drug cytochrome p450 phenotyping cocktail

artículo científico publicado en 2014

Influence of ABCB1 gene polymorphisms and P-glycoprotein activity on cyclosporine pharmacokinetics in peripheral blood mononuclear cells in healthy volunteers

artículo científico publicado en 2008

Influence of CYP2D6 activity on pre-emptive analgesia by the N-methyl-D-aspartate antagonist dextromethorphan in a randomized controlled trial of acute pain

artículo científico publicado en 2013

Interaction between Fexofenadine and CYP Phenotyping Probe Drugs in Geneva Cocktail

scientific article published on 02 October 2019

Intestinal permeability and P-glycoprotein-mediated efflux transport of ticagrelor in Caco-2 monolayer cells

artículo científico publicado en 2016

Intraocular penetration of penciclovir after oral administration of famciclovir: a population pharmacokinetic model

artículo científico publicado en 2013

Is pain temporary and glory for ever? Detection of tramadol using dried blood spot in cycling competitions

artículo científico publicado en 2020

Mixing drugs and genetics: a complex hemorrhagic cocktail

artículo científico publicado en 2020

On-line desorption of dried blood spots coupled to hydrophilic interaction/reversed-phase LC/MS/MS system for the simultaneous analysis of drugs and their polar metabolites

artículo científico publicado en 2010

Optimized low-dose combinatorial drug treatment boosts selectivity and efficacy of colorectal carcinoma treatment

scientific article published on 05 October 2020

P-glycoprotein is not involved in the differential oral potency of naloxone and naltrexone

artículo científico publicado en 2009

Perioperative intravenous low-dose ketamine for neuropathic pain after major lower back surgery: A randomized, placebo-controlled study

scientific article published on 09 December 2019

Pharmacogenomics of Oral Antithrombotic Drugs

artículo científico publicado en 2015

Pharmacokinetic and pharmacodynamic properties of buprenorphine after a single intravenous administration in healthy volunteers: a randomized, double-blind, placebo-controlled, crossover study

artículo científico publicado en 2007

Pharmacokinetic interaction between prasugrel and ritonavir in healthy volunteers

artículo científico publicado en 2012

Pharmacokinetic-pharmacodynamic modelling of opioids in healthy human volunteers. a minireview ⬇️

artículo científico publicado el 9 de noviembre de 2011

Phenotypic Assessment of Drug Metabolic Pathways and P-Glycoprotein in Patients Treated With Antidepressants in an Ambulatory Setting

artículo científico publicado en 2018

Phenotyping of CYP450 in human liver microsomes using the cocktail approach

artículo científico publicado en 2014

Phenotyping of Human CYP450 Enzymes by Endobiotics: Current Knowledge and Methodological Approaches

artículo científico publicado en 2019

Prediction by pharmacogenetics of safety and efficacy of non-steroidal anti- inflammatory drugs: a review

artículo científico publicado en 2014

Prediction of drug-drug interactions using physiologically-based pharmacokinetic models of CYP450 modulators included in Simcyp software.

artículo científico publicado en 2017

Predictive value of CYP3A and ABCB1 phenotyping probes for the pharmacokinetics of sunitinib: the ClearSun study

artículo científico publicado en 2014

Prioritization methodology for the monitoring of active pharmaceutical ingredients in hospital effluents.

artículo científico publicado en 2015

Prioritization of Active Pharmaceutical Ingredients in Hospital Wastewater

artículo científico publicado en 2017

Real-time monitoring of exhaled drugs by mass spectrometry

artículo científico publicado en 2013

Ritonavir inhibits the two main prasugrel bioactivation pathways in vitro: a potential drug-drug interaction in HIV patients.

artículo científico publicado en 2011

Rivaroxaban-Induced Hemorrhage Associated with ABCB1 Genetic Defect.

artículo científico publicado en 2016

Role of P-glycoprotein in the uptake/efflux transport of oral vitamin K antagonists and rivaroxaban through the Caco-2 cell model

artículo científico publicado en 2013

Screening for genotypic and phenotypic variations in CYP450 activity in patients with therapeutic problems in a psychiatric setting, a retrospective study

artículo científico publicado en 2016

Serotonin syndrome following drug-drug interactions and CYP2D6 and CYP2C19 genetic polymorphisms in an HIV-infected patient

artículo científico publicado en 2012

Severe Vincristine-induced Neuropathic Pain in a CYP3A5 Nonexpressor With Reduced CYP3A4/5 Activity: Case Study.

artículo científico publicado en 2015

Severe and persistent morphine-induced respiratory depression associated with ATP-Binding Cassette Subfamily B Member 1 and catechol-O-methyltransferase genetic defects: A case report

artículo científico publicado en 2018

Simultaneous LC-MS/MS quantification of P-glycoprotein and cytochrome P450 probe substrates and their metabolites in DBS and plasma

artículo científico publicado en 2014

The Association of Combined GSTM1 and CYP2C9 Genotype Status with the Occurrence of Hemorrhagic Cystitis in Pediatric Patients Receiving Myeloablative Conditioning Regimen Prior to Allogeneic Hematopoietic Stem Cell Transplantation.

artículo científico publicado en 2017

The tyrosine kinase inhibitor nilotinib inhibits SARS-CoV-2 In Vitro

artículo científico publicado en 2020

Therapeutic Drug Monitoring of Busulfan for the Management of Pediatric Patients: Cross-Validation of Methods and Long-Term Performance.

artículo científico publicado en 2017

Therapeutic drug monitoring of voriconazole: a case report of multiple drug interactions in a patient with an increased CYP2C19 activity

artículo científico publicado en 2014

Toward precision medicine in pediatric population using cytochrome P450 phenotyping approaches and physiologically based pharmacokinetic modeling

artículo científico publicado en 2019

Towards Personalized Antithrombotic Treatments: Focus on P2Y12 Inhibitors and Direct Oral Anticoagulants

artículo científico publicado en 2019

Transcriptional regulation of CYP2C19 and its role in altered enzyme activity

artículo científico publicado en 2012

Two-dimensional liquid chromatography-ion trap mass spectrometry for the simultaneous determination of ketorolac enantiomers and paracetamol in human plasma: application to a pharmacokinetic study

artículo científico publicado en 2009

Uptake/efflux transport of tramadol enantiomers and O-desmethyl-tramadol: focus on P-glycoprotein

artículo científico publicado en 2009

Usefulness of PBPK Modeling in Incorporation of Clinical Conditions in Personalized Medicine

artículo científico publicado en 2017

Validation of the simplified UVB model to assess the pharmacodynamics of analgesics in healthy human volunteers

artículo científico publicado en 2012

Lista de obras de

A Randomized, Controlled Trial Validates a Peripheral Supra-Additive Antihyperalgesic Effect of a Paracetamol-Ketorolac Combination ⬇️

A cocktail approach for assessing the in vitro activity of human cytochrome P450s: an overview of current methodologies

A simplified analytical method for a phenotyping cocktail of major CYP450 biotransformation routes

A simplified method for busulfan monitoring using dried blood spot in combination with liquid chromatography/tandem mass spectrometry

An extensive cocktail approach for rapid risk assessment of in vitro CYP450 direct reversible inhibition by xenobiotic exposure.

Analgesics in patients with hepatic impairment: pharmacology and clinical implications.

Aspirin response: Differences in serum thromboxane B2 levels between clinical studies.

Automated system for on-line desorption of dried blood spots applied to LC/MS/MS pharmacokinetic study of flurbiprofen and its metabolite

Characterization of oxycodone in vitro metabolism by human cytochromes P450 and UDP-glucuronosyltransferases.

Codeine intoxication associated with ultrarapid CYP2D6 metabolism

Comparing Dried Blood Spots and Plasma Concentrations for Busulfan Therapeutic Drug Monitoring in Children

Complex Drug-Drug-Gene-Disease Interactions Involving Cytochromes P450: Systematic Review of Published Case Reports and Clinical Perspectives.

Contribution of exome sequencing to the identification of genes involved in the response to clopidogrel in cardiovascular patients

Cytochrome P450 1A2 activity and incidence of thyroid disease and cancer after chronic or acute exposure to dioxins

Detection of busulfan adducts on proteins.

Development of an LC-MS/MS Method for the Assessment of Selected Active Pharmaceuticals and Metabolites in Wastewaters of a Swiss University Hospital

Dual reuptake inhibitor milnacipran and spinal pain pathways in fibromyalgia patients: a randomized, double-blind, placebo-controlled trial

Dynamics of active pharmaceutical ingredients loads in a Swiss university hospital wastewaters and prediction of the related environmental risk for the aquatic ecosystems.

Evaluation of Mutual Drug-Drug Interaction within Geneva Cocktail for Cytochrome P450 Phenotyping using Innovative Dried Blood Sampling Method

Evaluation of Phenotypic and Genotypic Variations of Drug Metabolising Enzymes and Transporters in Chronic Pain Patients Facing Adverse Drug Reactions or Non-Response to Analgesics: A Retrospective Study

Evidence-Based Choice of P2Y12 Inhibitors in End Stage Renal Disease Patients: A Mini-Review

GABAergic modulation of secondary hyperalgesia: A randomized controlled 4-way crossover trial with the α2-subunit preferring GABA positive allosteric modulator, N-desmethyl-clobazam in healthy volunteers

Genotype-sensitive reversible and time-dependent CYP2D6 inhibition in human liver microsomes

Impact of Boosted Antiretroviral Therapy on the Pharmacokinetics and Efficacy of Clopidogrel and Prasugrel Active Metabolites

Impact of CYP2D6 Functional Allelic Variations on Phenoconversion and Drug-Drug Interactions.

Impact of acute inflammation on cytochromes P450 activity assessed by the Geneva Cocktail

Incorporation of flurbiprofen in a 4-drug cytochrome p450 phenotyping cocktail

Influence of ABCB1 gene polymorphisms and P-glycoprotein activity on cyclosporine pharmacokinetics in peripheral blood mononuclear cells in healthy volunteers

Influence of CYP2D6 activity on pre-emptive analgesia by the N-methyl-D-aspartate antagonist dextromethorphan in a randomized controlled trial of acute pain

Interaction between Fexofenadine and CYP Phenotyping Probe Drugs in Geneva Cocktail

Intestinal permeability and P-glycoprotein-mediated efflux transport of ticagrelor in Caco-2 monolayer cells

Intraocular penetration of penciclovir after oral administration of famciclovir: a population pharmacokinetic model

Is pain temporary and glory for ever? Detection of tramadol using dried blood spot in cycling competitions

Mixing drugs and genetics: a complex hemorrhagic cocktail

On-line desorption of dried blood spots coupled to hydrophilic interaction/reversed-phase LC/MS/MS system for the simultaneous analysis of drugs and their polar metabolites

Optimized low-dose combinatorial drug treatment boosts selectivity and efficacy of colorectal carcinoma treatment

P-glycoprotein is not involved in the differential oral potency of naloxone and naltrexone

Perioperative intravenous low-dose ketamine for neuropathic pain after major lower back surgery: A randomized, placebo-controlled study

Pharmacogenomics of Oral Antithrombotic Drugs

Pharmacokinetic and pharmacodynamic properties of buprenorphine after a single intravenous administration in healthy volunteers: a randomized, double-blind, placebo-controlled, crossover study

Pharmacokinetic interaction between prasugrel and ritonavir in healthy volunteers

Pharmacokinetic-pharmacodynamic modelling of opioids in healthy human volunteers. a minireview ⬇️

Phenotypic Assessment of Drug Metabolic Pathways and P-Glycoprotein in Patients Treated With Antidepressants in an Ambulatory Setting

Phenotyping of CYP450 in human liver microsomes using the cocktail approach

Phenotyping of Human CYP450 Enzymes by Endobiotics: Current Knowledge and Methodological Approaches

Prediction by pharmacogenetics of safety and efficacy of non-steroidal anti- inflammatory drugs: a review

Prediction of drug-drug interactions using physiologically-based pharmacokinetic models of CYP450 modulators included in Simcyp software.

Predictive value of CYP3A and ABCB1 phenotyping probes for the pharmacokinetics of sunitinib: the ClearSun study

Prioritization methodology for the monitoring of active pharmaceutical ingredients in hospital effluents.

Prioritization of Active Pharmaceutical Ingredients in Hospital Wastewater

Real-time monitoring of exhaled drugs by mass spectrometry

Ritonavir inhibits the two main prasugrel bioactivation pathways in vitro: a potential drug-drug interaction in HIV patients.

Rivaroxaban-Induced Hemorrhage Associated with ABCB1 Genetic Defect.

Role of P-glycoprotein in the uptake/efflux transport of oral vitamin K antagonists and rivaroxaban through the Caco-2 cell model

Screening for genotypic and phenotypic variations in CYP450 activity in patients with therapeutic problems in a psychiatric setting, a retrospective study

Serotonin syndrome following drug-drug interactions and CYP2D6 and CYP2C19 genetic polymorphisms in an HIV-infected patient

Severe Vincristine-induced Neuropathic Pain in a CYP3A5 Nonexpressor With Reduced CYP3A4/5 Activity: Case Study.

Severe and persistent morphine-induced respiratory depression associated with ATP-Binding Cassette Subfamily B Member 1 and catechol-O-methyltransferase genetic defects: A case report

Simultaneous LC-MS/MS quantification of P-glycoprotein and cytochrome P450 probe substrates and their metabolites in DBS and plasma

The Association of Combined GSTM1 and CYP2C9 Genotype Status with the Occurrence of Hemorrhagic Cystitis in Pediatric Patients Receiving Myeloablative Conditioning Regimen Prior to Allogeneic Hematopoietic Stem Cell Transplantation.

The tyrosine kinase inhibitor nilotinib inhibits SARS-CoV-2 In Vitro

Therapeutic Drug Monitoring of Busulfan for the Management of Pediatric Patients: Cross-Validation of Methods and Long-Term Performance.

Therapeutic drug monitoring of voriconazole: a case report of multiple drug interactions in a patient with an increased CYP2C19 activity

Toward precision medicine in pediatric population using cytochrome P450 phenotyping approaches and physiologically based pharmacokinetic modeling

Towards Personalized Antithrombotic Treatments: Focus on P2Y12 Inhibitors and Direct Oral Anticoagulants

Transcriptional regulation of CYP2C19 and its role in altered enzyme activity

Two-dimensional liquid chromatography-ion trap mass spectrometry for the simultaneous determination of ketorolac enantiomers and paracetamol in human plasma: application to a pharmacokinetic study

Uptake/efflux transport of tramadol enantiomers and O-desmethyl-tramadol: focus on P-glycoprotein

Usefulness of PBPK Modeling in Incorporation of Clinical Conditions in Personalized Medicine

Validation of the simplified UVB model to assess the pharmacodynamics of analgesics in healthy human volunteers