Lista de obras -

4-Phenylpyridin-2-one Derivatives: A Novel Class of Positive Allosteric Modulator of the M1 Muscarinic Acetylcholine Receptor.

artículo científico publicado en 2015

6-Phenylpyrimidin-4-ones as Positive Allosteric Modulators at the M1 mAChR: The Determinants of Allosteric Activity

artículo científico publicado en 2018

A Novel Class of N-Sulfonyl and N-Sulfamoyl Noscapine Derivatives that Promote Mitotic Arrest in Cancer Cells

artículo científico publicado en 2019

A Thieno[2,3-d]pyrimidine Scaffold is a Novel Negative Allosteric Modulator of the Dopamine D2 Receptor.

artículo científico publicado en 2018

A new mechanism of allostery in a G protein-coupled receptor dimer

artículo científico publicado en 2014

Assessment of the molecular mechanisms of action of novel 4-phenylpyridine-2-one and 6-phenylpyrimidin-4-one allosteric modulators at the M1 muscarinic acetylcholine receptors

artículo científico publicado en 2018

Development of a photoactivatable allosteric ligand for the m1 muscarinic acetylcholine receptor

artículo científico publicado en 2014

Molecular Determinants of the Intrinsic Efficacy of the Antipsychotic Aripiprazole

artículo científico publicado en 2019

Probing structural requirements of positive allosteric modulators of the M4 muscarinic receptor

artículo científico publicado en 2013

Structure-Kinetic Profiling of Haloperidol Analogues at the Human Dopamine D2 Receptor

scientific article published on 23 October 2019

Subtle Modifications to the Indole-2-carboxamide Motif of the Negative Allosteric Modulator N-(( trans)-4-(2-(7-Cyano-3,4-dihydroisoquinolin-2(1 H)-yl)ethyl)cyclohexyl)-1 H-indole-2-carboxamide (SB269652) Yield Dramatic Changes in Pharmacological Ac

artículo científico publicado en 2018

Synthesis and Pharmacological Evaluation of Noscapine-Inspired 5-Substituted Tetrahydroisoquinolines as Cytotoxic Agents

artículo científico publicado en 2018

Synthesis and pharmacological evaluation of M4 muscarinic receptor positive allosteric modulators derived from VU10004.

artículo científico publicado en 2015

Synthesis and pharmacological evaluation of analogues of benzyl quinolone carboxylic acid (BQCA) designed to bind irreversibly to an allosteric site of the M ₁ muscarinic acetylcholine receptor.

artículo científico publicado en 2014

Synthesis and pharmacological profiling of analogues of benzyl quinolone carboxylic acid (BQCA) as allosteric modulators of the M1 muscarinic receptor.

artículo científico publicado en 2013

The role of kinetic context in apparent biased agonism at GPCRs

artículo científico publicado en 2016

Lista de obras de

4-Phenylpyridin-2-one Derivatives: A Novel Class of Positive Allosteric Modulator of the M1 Muscarinic Acetylcholine Receptor.

6-Phenylpyrimidin-4-ones as Positive Allosteric Modulators at the M1 mAChR: The Determinants of Allosteric Activity

A Novel Class of N-Sulfonyl and N-Sulfamoyl Noscapine Derivatives that Promote Mitotic Arrest in Cancer Cells

A Thieno[2,3-d]pyrimidine Scaffold is a Novel Negative Allosteric Modulator of the Dopamine D2 Receptor.

A new mechanism of allostery in a G protein-coupled receptor dimer

Assessment of the molecular mechanisms of action of novel 4-phenylpyridine-2-one and 6-phenylpyrimidin-4-one allosteric modulators at the M1 muscarinic acetylcholine receptors

Development of a photoactivatable allosteric ligand for the m1 muscarinic acetylcholine receptor

Molecular Determinants of the Intrinsic Efficacy of the Antipsychotic Aripiprazole

Probing structural requirements of positive allosteric modulators of the M4 muscarinic receptor

Structure-Kinetic Profiling of Haloperidol Analogues at the Human Dopamine D2 Receptor

Subtle Modifications to the Indole-2-carboxamide Motif of the Negative Allosteric Modulator N-(( trans)-4-(2-(7-Cyano-3,4-dihydroisoquinolin-2(1 H)-yl)ethyl)cyclohexyl)-1 H-indole-2-carboxamide (SB269652) Yield Dramatic Changes in Pharmacological Ac

Synthesis and Pharmacological Evaluation of Noscapine-Inspired 5-Substituted Tetrahydroisoquinolines as Cytotoxic Agents

Synthesis and pharmacological evaluation of M4 muscarinic receptor positive allosteric modulators derived from VU10004.

Synthesis and pharmacological evaluation of analogues of benzyl quinolone carboxylic acid (BQCA) designed to bind irreversibly to an allosteric site of the M ₁ muscarinic acetylcholine receptor.

Synthesis and pharmacological profiling of analogues of benzyl quinolone carboxylic acid (BQCA) as allosteric modulators of the M1 muscarinic receptor.

The role of kinetic context in apparent biased agonism at GPCRs