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A closed-circuit neonatal xenon delivery system: a technical and practical neuroprotection feasibility study in newborn pigs

artículo científico publicado en 2009

A comparison of cooling methods used in therapeutic hypothermia for perinatal asphyxia

artículo científico publicado en 2010

A neonatal piglet model of intraventricular hemorrhage and posthemorrhagic ventricular dilation

artículo científico publicado en 2007

Adding 5 h delayed xenon to delayed hypothermia treatment improves long-term function in neonatal rats surviving to adulthood

artículo científico publicado en 2015

Amplitude-Integrated Electroencephalography Improves the Identification of Infants with Encephalopathy for Therapeutic Hypothermia and Predicts Neurodevelopmental Outcomes at 2 Years of Age.

artículo científico publicado en 2017

Analysis of neuronal, glial, endothelial, axonal and apoptotic markers following moderate therapeutic hypothermia and anesthesia in the developing piglet brain

artículo científico publicado en 2007

Animal research has been essential to saving babies' lives

artículo científico publicado en 2014

Animal studies of neonatal hypothermic neuroprotection have translated well in to practice

artículo científico

Assessment of brain tissue injury after moderate hypothermia in neonates with hypoxic-ischaemic encephalopathy: a nested substudy of a randomised controlled trial

artículo científico publicado en 2010

Attention and visuo-spatial function in children without cerebral palsy who were cooled for neonatal encephalopathy: a case-control study

artículo científico publicado en 2019

Brain imaging in cooled encephalopathic neonates does not differ between four and 11 days after birth

artículo científico publicado en 2015

Brain wave recovery predicts outcome after cardiac arrest.

artículo científico publicado en 2012

Cerebral Resistance Index is less predictive in hypothermic encephalopathic newborns

artículo científico publicado el 18 de mayo de 2011

Closed circuit xenon delivery for 72h in neonatal piglets following hypoxic insult using an ambient pressure automated control system: Development, technical evaluation and pulmonary effects

artículo científico publicado en 2020

Combined effect of hypothermia and caspase-2 gene deficiency on neonatal hypoxic-ischemic brain injury

artículo científico publicado en 2012

Combined treatment of xenon and hypothermia in newborn rats--additive or synergistic effect?

artículo científico publicado en 2014

Combining two good treatments makes it worse

artículo científico publicado en 2018

Comparison of Bayley‐2 and Bayley‐3 scores at 18 months in term infants following neonatal encephalopathy and therapeutic hypothermia

artículo científico publicado el 9 de agosto de 2013

Cooling combined with immediate or delayed xenon inhalation provides equivalent long-term neuroprotection after neonatal hypoxia-ischemia

artículo científico publicado en 2009

Cooling neonates who do not fulfil the standard cooling criteria - short- and long-term outcomes

artículo científico publicado en 2014

Decorin and colchicine as potential treatments for post-haemorrhagic ventricular dilatation in a neonatal rat model

artículo científico publicado en 2011

Delayed hypothermia as selective head cooling or whole body cooling does not protect brain or body in newborn pig subjected to hypoxia-ischemia

artículo científico publicado en 2008

Determinants of outcomes after head cooling for neonatal encephalopathy.

artículo científico publicado en 2007

Development of amplitude-integrated electroencephalography and interburst interval in the rat.

artículo científico publicado en 2009

Do drugs that block transforming growth factor beta reduce posthaemorrhagic ventricular dilatation in a neonatal rat model?

artículo científico publicado en 2008

Does head cooling with mild systemic hypothermia affect requirement for blood pressure support?

artículo científico publicado en 2009

Early deterioration of cerebrospinal fluid dynamics in a neonatal piglet model of intraventricular hemorrhage and posthemorrhagic ventricular dilation

artículo científico publicado el 28 de septiembre de 2012

Effect of cardiac compressions and hypothermia treatment on cardiac troponin I in newborns with perinatal asphyxia

artículo científico publicado en 2013

Effect of hypothermia on amplitude-integrated electroencephalogram in infants with asphyxia

artículo científico publicado en 2010

Effects of Xenon and Hypothermia on Cerebrovascular Pressure Reactivity in Newborn Global Hypoxic—ischemic Pig Model

artículo científico publicado el 31 de julio de 2013

Effects of hypothermia for perinatal asphyxia on childhood outcomes

artículo científico publicado en 2014

Environmental cooling of the newborn pig brain during whole‐body cooling

artículo científico publicado el 1 de enero de 2011

Equipotent subanesthetic concentrations of sevoflurane and xenon preventing cold-stimulated vocalization of neonatal rats.

artículo científico publicado en 2014

Factors associated with permanent hearing impairment in infants treated with therapeutic hypothermia.

artículo científico publicado en 2013

Fentanyl Induces Cerebellar Internal Granular Cell Layer Apoptosis in Healthy Newborn Pigs.

artículo científico publicado en 2018

Head cooling with mild systemic hypothermia in anesthetized piglets is neuroprotective

artículo científico publicado en 2003

Heart rate response to therapeutic hypothermia in infants with hypoxic-ischaemic encephalopathy

artículo científico publicado en 2016

Hypothermia Does Not Reverse Cellular Responses Caused by Lipopolysaccharide in Neonatal Hypoxic-Ischaemic Brain Injury.

artículo científico publicado en 2015

Hypothermia Is Neuroprotective after Severe Hypoxic-Ischaemic Brain Injury in Neonatal Rats Pre-Exposed to PAM3CSK4

artículo científico publicado en 2018

Hypothermia and other treatment options for neonatal encephalopathy: an executive summary of the Eunice Kennedy Shriver NICHD workshop

artículo científico publicado en 2011

Hypothermia and perinatal asphyxia: executive summary of the National Institute of Child Health and Human Development workshop

artículo científico publicado en 2006

Hypothermia is not neuroprotective after infection-sensitized neonatal hypoxic-ischemic brain injury.

artículo científico publicado en 2013

Hypothermia: An Evolving Treatment for Neonatal Hypoxic Ischemic Encephalopathy

artículo científico publicado en 2008

Hypothermic Neuronal Rescue from Infection-Sensitised Hypoxic-Ischaemic Brain Injury Is Pathogen Dependent

artículo científico publicado en 2017

Immediate Hypothermia Is Not Neuroprotective After Severe Hypoxia-Ischemia and Is Deleterious When Delayed by 12 Hours in Neonatal Rats

artículo científico publicado el 20 de septiembre de 2012

Immediate Hypothermia Reduces Cardiac Troponin I After Hypoxic-Ischemic Encephalopathy in Newborn Pigs

artículo científico publicado el 1 de octubre de 2011

Increased Inspired Oxygen in the First Hours of Life is Associated with Adverse Outcome in Newborns Treated for Perinatal Asphyxia with Therapeutic Hypothermia

artículo científico publicado el 18 de abril de 2012

Lactate dehydrogenase in hypothermia‐treated newborn infants with hypoxic‐ischaemic encephalopathy

artículo científico publicado el 27 de julio de 2012

Lactate dehydrogenase predicts hypoxic ischaemic encephalopathy in newborn infants: a preliminary study

artículo científico publicado en 2010

Less severe cerebral palsy outcomes in infants treated with therapeutic hypothermia

artículo científico publicado en 2015

Liver enzymes cannot be used to predict liver damage after global hypoxia-ischemia in a neonatal pig model.

artículo científico publicado en 2009

Major concerns about late hypothermia study

scientific article published on 28 November 2018

Mild hypothermia and the distribution of cerebral lesions in neonates with hypoxic-ischemic encephalopathy.

artículo científico publicado en 2005

Minimal systemic hypothermia combined with selective head cooling evaluated in a pig model of hypoxia-ischemia

artículo científico publicado en 2015

Moderate hypothermia to treat perinatal asphyxial encephalopathy

artículo científico publicado en 2009

Monitoring of cerebral blood flow during hypoxia-ischemia and resuscitation in the neonatal rat using laser speckle imaging

artículo científico publicado en 2016

Motor performance and cognitive correlates in children cooled for neonatal encephalopathy without cerebral palsy at school age

scientific article published on 09 April 2019

Neither Xenon nor Fentanyl Induces Neuroapoptosis in the Newborn Pig Brain

artículo científico publicado el 1 de agosto de 2013

Neonatal Systemic Inflammation Induces Inflammatory Reactions and Brain Apoptosis in a Pathogen-Specific Manner.

artículo científico publicado en 2017

Neonatal seizures: magnetic resonance imaging adds value in the diagnosis and prediction of neurodisability

artículo científico publicado en 2014

Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischaemic encephalopathy: synthesis and meta-analysis of trial data

artículo científico publicado en 2010

Neuroprotection after infection-sensitized neonatal hypoxic-ischemic brain injury.

artículo científico publicado en 2015

Phase 1 trial of prevention of hydrocephalus after intraventricular hemorrhage in newborn infants by drainage, irrigation, and fibrinolytic therapy

artículo científico publicado en 2003

Preliminary evaluation of a novel intraparenchymal capacitive intracranial pressure monitor

artículo científico publicado en 2011

Randomized clinical trial of prevention of hydrocephalus after intraventricular hemorrhage in preterm infants: brain-washing versus tapping fluid

artículo científico publicado en 2007

Rectal temperature in the first five hours after hypoxia-ischemia critically affects neuropathological outcomes in neonatal rats

artículo científico publicado en 2017

Reduced infancy and childhood epilepsy following hypothermia-treated neonatal encephalopathy

artículo científico publicado en 2017

Respiratory sinus arrhythmia stabilizes mean arterial blood pressure at high-frequency interval in healthy humans

artículo científico publicado en 2014

Resuscitation with 100% oxygen increases injury and counteracts the neuroprotective effect of therapeutic hypothermia in the neonatal rat.

artículo científico publicado en 2012

School-age outcomes of children without cerebral palsy cooled for neonatal hypoxic-ischaemic encephalopathy in 2008-2010

artículo científico publicado en 2019

Secretions from placenta, after hypoxia/reoxygenation, can damage developing neurones of brain under experimental conditions.

artículo científico publicado en 2014

Sedation management during therapeutic hypothermia for neonatal encephalopathy: atropine premedication for endotracheal intubation causes a prolonged increase in heart rate.

artículo científico publicado en 2014

Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial

artículo científico publicado en 2005

Serum gentamicin concentrations in encephalopathic infants are not affected by therapeutic hypothermia.

artículo científico publicado en 2009

Seven- to eight-year follow-up of the CoolCap trial of head cooling for neonatal encephalopathy

artículo científico publicado el 21 de diciembre de 2011

Should therapeutic hypothermia be offered to babies with mild neonatal encephalopathy in the first 6 h after birth?

artículo científico publicado en 2019

Significant selective head cooling can be maintained long-term after global hypoxia ischemia in newborn piglets

artículo científico publicado en 2002

Start cooling as soon as possible.

artículo científico publicado en 2019

The Effects of Xenon Gas Inhalation on Neuropathology in a Placental-Induced Brain Injury Model in Neonates: A Pilot Study

artículo científico publicado en 2020

The TOBY Study. Whole body hypothermia for the treatment of perinatal asphyxial encephalopathy: a randomised controlled trial

artículo científico publicado en 2008

The effect of resuscitation in 100% oxygen on brain injury in a newborn rat model of severe hypoxic-ischaemic encephalopathy

artículo científico publicado en 2015

The feasibility of using a portable xenon delivery device to permit earlier xenon ventilation with therapeutic cooling of neonates during ambulance retrieval.

artículo científico publicado en 2015

The pathogenesis of neonatal post-hemorrhagic hydrocephalus

artículo científico publicado en 2004

Therapeutic Hypothermia Changes the Prognostic Value of Clinical Evaluation of Neonatal Encephalopathy

scientific article published on 24 October 2007

Therapeutic Hypothermia in Neonatal Hypoxic-Ischemic Encephalopathy

scientific article published on 14 January 2019

Therapeutic hypothermia delays the C-reactive protein response and suppresses white blood cell and platelet count in infants with neonatal encephalopathy

artículo científico publicado en 2014

Therapeutic hypothermia for hypoxic-ischaemic encephalopathy in the newborn infant

artículo científico publicado en 2005

Therapeutic hypothermia in neonates. Review of current clinical data, ILCOR recommendations and suggestions for implementation in neonatal intensive care units

artículo científico publicado en 2008

Therapeutic hypothermia translates from ancient history in to practice.

artículo científico publicado en 2017

Time is brain: starting therapeutic hypothermia within three hours after birth improves motor outcome in asphyxiated newborns

artículo científico publicado en 2013

Treatment temperature and insult severity influence the neuroprotective effects of therapeutic hypothermia.

artículo científico publicado en 2016

Validation of a neuropathology score using quantitative methods to evaluate brain injury in a pig model of hypoxia ischaemia

artículo científico publicado en 2014

Variability and sex-dependence of hypothermic neuroprotection in a rat model of neonatal hypoxic-ischaemic brain injury: a single laboratory meta-analysis

artículo científico publicado en 2020

Why results from Bayesian statistical analyses of clinical trials with a strong prior and small sample sizes may be misleading The case of the NICHD Neonatal Research Network Late Hypothermia Trial

artículo científico publicado en 2019

Xenon Combined with Therapeutic Hypothermia Is Not Neuroprotective after Severe Hypoxia-Ischemia in Neonatal Rats

artículo científico publicado en 2016

Xenon and hypothermia combine additively, offering long-term functional and histopathologic neuroprotection after neonatal hypoxia/ischemia

artículo científico publicado en 2008

Xenon depresses aEEG background voltage activity whilst maintaining cardiovascular stability in sedated healthy newborn pigs.

artículo científico publicado en 2016

Xenon enhances hypothermic neuroprotection in asphyxiated newborn pigs

artículo científico publicado en 2010

Xenon offers stable haemodynamics independent of induced hypothermia after hypoxia–ischaemia in newborn pigs

artículo científico publicado el 13 de diciembre de 2011

Xenon provides short-term neuroprotection in neonatal rats when administered after hypoxia-ischemia

artículo científico publicado en 2005

Xenon ventilation during therapeutic hypothermia in neonatal encephalopathy: a feasibility study

artículo científico publicado en 2014

Xenon/hypothermia neuroprotection regimes in spontaneously breathing neonatal rats after hypoxic-ischemic insult: the respiratory and sedative effects

artículo científico publicado en 2008