Lista de obras - Lorena Sofia Orozco Orozco

A Loss-Of-Function Splice Acceptor Variant in IGF2 is Protective for Type 2 Diabetes

artículo científico publicado en 2017

A homozygous CEP57 c.915_925dupCAATGTTCAGC mutation in a patient with mosaic variegated aneuploidy syndrome with rhizomelic shortening in the upper and lower limbs and a narrow thorax

scientific article published on 17 July 2018

ALOX5, LPA, MMP9 and TPO gene polymorphisms increase atherothrombosis susceptibility in middle-aged Mexicans

artículo científico publicado en 2020

Altered DNA methylation in liver and adipose tissues derived from individuals with obesity and type 2 diabetes

artículo científico publicado en 2018

Analysis of protein-coding genetic variation in 60,706 humans

artículo científico publicado en 2016

Association between APOE polymorphisms and lipid profile in Mexican Amerindian population

artículo científico publicado en 2019

Association between Vitamin D Deficiency and Single Nucleotide Polymorphisms in the Vitamin D Receptor and GC Genes and Analysis of Their Distribution in Mexican Postmenopausal Women

article

Association between vitamin D deficiency and common variants of Vitamin D binding protein gene among Mexican Mestizo and indigenous postmenopausal women

artículo científico publicado en 2020

Association of HMOX1 and NQO1 Polymorphisms with Metabolic Syndrome Components

artículo científico publicado en 2015

Association of PDCD1 polymorphisms with childhood-onset systemic lupus erythematosus

artículo científico publicado en 2007

Association of TLR7 copy number variation with susceptibility to childhood-onset systemic lupus erythematosus in Mexican population

artículo científico publicado en 2010

Association of a low-frequency variant in HNF1A with type 2 diabetes in a Latino population

artículo científico publicado en 2014

Association study of DRD3 gene in schizophrenia in Mexican sib-pairs

artículo científico publicado en 2011

Associations of autozygosity with a broad range of human phenotypes

scientific article published on 31 October 2019

CFTR allelic heterogeneity in Mexican patients with cystic fibrosis: implications for molecular screening

artículo científico publicado el 1 de noviembre de 2010

CHRM2 but not CHRM1 or CHRM3 polymorphisms are associated with asthma susceptibility in Mexican patients

artículo científico publicado en 2014

Catalytically Impaired TYK2 Variants are Protective Against Childhood- and Adult-Onset Systemic Lupus Erythematosus in Mexicans

artículo científico publicado en 2019

Comparing signals of natural selection between three Indigenous North American populations

artículo científico publicado en 2019

Correction to 'ALOX5, LPA, MMP9 and TPO gene polymorphisms increase atherothrombosis susceptibility in middle-aged Mexicans'

scientific article published on 19 February 2020

Curcumin differentially affects cell cycle and cell death in acute and chronic myeloid leukemia cells

artículo científico publicado en 2018

Deep Multi-OMICs and Multi-Tissue Characterization in a Pre- and Postprandial State in Human Volunteers: The GEMM Family Study Research Design

artículo científico publicado en 2018

Demographic history and biologically relevant genetic variation of Native Mexicans inferred from whole-genome sequencing

artículo científico publicado en 2017

Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes

artículo científico publicado en 2020

Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes

ERBIN deficiency links STAT3 and TGF-β pathway defects with atopy in humans.

artículo científico publicado en 2017

Evaluation of imputation-based association in and around the integrin-alpha-M (ITGAM) gene and replication of robust association between a non-synonymous functional variant within ITGAM and systemic lupus erythematosus (SLE).

artículo científico publicado en 2009

Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls

article by Jason Flannick et al published 22 May 2019 in Nature

GSTT1 and GSTM1 null variants in Mestizo and Amerindian populations from northwestern Mexico and a literature review.

artículo científico publicado en 2017

Gender-Dependent Association of FTO Polymorphisms with Body Mass Index in Mexicans

artículo científico publicado en 2016

Gene variants in AKT1, GCKR and SOCS3 are differentially associated with metabolic traits in Mexican Amerindians and Mestizos

scientific article published on 31 August 2018

Genetic Variants Associated With Quantitative Glucose Homeostasis Traits Translate to Type 2 Diabetes in Mexican Americans: The GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium

artículo científico publicado en 2014

Genetic association of IRF5 with SLE in Mexicans: higher frequency of the risk haplotype and its homozygozity than Europeans

Genetic variability of five ADRB2 polymorphisms among Mexican Amerindian ethnicities and the Mestizo population

scientific article published on 02 December 2019

Genome-Wide Association Study in an Amerindian Ancestry Population Reveals Novel Systemic Lupus Erythematosus Risk Loci and the Role of European Admixture

artículo científico publicado en 2015

Genomewide admixture study in Mexican Mestizos with multiple sclerosis

artículo científico publicado en 2014

HMOX1 promoter (GT)n polymorphim is associated with childhood-onset systemic lupus erythematosus but not with juvenile rheumatoid arthritis in a Mexican population

artículo científico publicado el 1 de marzo de 2012

Heterogenous Distribution of MTHFR Gene Variants among Mestizos and Diverse Amerindian Groups from Mexico

artículo científico publicado en 2016

Impact of genetic ancestry and sociodemographic status on the clinical expression of systemic lupus erythematosus in American Indian-European populations

artículo científico publicado en 2012

Influence of SNPs in Genes that Modulate Lung Disease Severity in a Group of Mexican Patients with Cystic Fibrosis

artículo científico publicado en 2018

Influence of obesity, parental history of diabetes, and genes in type 2 diabetes: A case-control study

article

Metabolic syndrome in indigenous communities in Mexico: a descriptive and cross-sectional study

artículo científico publicado en 2020

MiR‐146a polymorphism is associated with asthma but not with systemic lupus erythematosus and juvenile rheumatoid arthritis in Mexican patients ⬇️

artículo científico publicado el 24 de julio de 2012

Mild cystic fibrosis disease in three Mexican delta‐F508/G551S compound heterozygous siblings ⬇️

artículo científico publicado el 1 de febrero de 1995

Molecular analysis of the PAX6 gene in Mexican patients with congenital aniridia: report of four novel mutations

artículo científico publicado en 2008

Molecular screening of the CFTR gene in Mexican patients with congenital absence of the vas deferens

artículo científico publicado en 2011

NFE2L2 Gene Variants and Arsenic Susceptibility: A Lymphoblastoid Model.

artículo científico publicado en 2015

NFE2L2 gene variants and susceptibility to childhood-onset asthma.

artículo científico publicado en 2011

Next-generation sequencing for identifying a novel/de novo pathogenic variant in a Mexican patient with cystic fibrosis: a case report

scientific article published on 22 May 2019

Nuclear factor erythroid 2-related factor gene variants and susceptibility of arsenic-related skin lesions ⬇️

artículo científico publicado el 9 de octubre de 2013

Polymorphisms in metalloproteinase-9 are associated with the risk for asthma in Mexican pediatric patients.

artículo científico publicado en 2013

Prenatal diagnosis in a cystic fibrosis family: a combined molecular strategy for a precise diagnosis

artículo científico publicado en 2011

Pro-adhesive phenotype of normal endothelial cells responding to metastatic breast cancer cell conditioned medium is linked to NFκB-mediated transcriptomic regulation

artículo científico publicado en 2016

Programa de detecciÃ³n del alelo APOE-E4 en adultos mayores mexicanos con deterioro cognitivo

scientific article published on 01 January 2018

Reconstruction of ancient microbial genomes from the human gut

artículo científico publicado en 2021

STAT4 associates with systemic lupus erythematosus through two independent effects that correlate with gene expression and act additively with IRF5 to increase risk

artículo científico publicado en 2008

Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico

artículo científico publicado en 2014

Small MAF genes variants and chronic myeloid leukemia

artículo científico publicado en 2013

The NRF2-KEAP1 pathway is an early responsive gene network in arsenic exposed lymphoblastoid cells

artículo científico publicado en 2014

The PXR rs7643645 polymorphism is associated with the risk of higher prostate-specific antigen levels in prostate cancer patients

artículo científico publicado en 2014

The genomic landscape of Mexican Indigenous populations brings insights into the peopling of the Americas

artículo científico publicado en 2021

The power of genetic diversity in genome-wide association studies of lipids

The role of oxidant stress and gender in the erythrocyte arginine metabolism and ammonia management in patients with type 2 diabetes

artículo científico publicado en 2019

The rs61764370 Functional Variant in the KRAS Oncogene is Associated with Chronic Myeloid Leukemia Risk in Women

artículo científico publicado en 2016

Towards precision medicine: defining and characterizing adipose tissue dysfunction to identify early immunometabolic risk in symptom-free adults from the GEMM family study

scientific article published on 01 December 2020

Transancestral mapping and genetic load in systemic lupus erythematosus

artículo científico

Transcriptome landmarks of the functional maturity of rat beta-cells, from lactation to adulthood

artículo científico publicado en 2016

Tuberculosis and impaired IL-23-dependent IFN-γ immunity in humans homozygous for a common missense variant

scientific article published on 01 December 2018

Tumor necrosis factor-alpha is a common genetic risk factor for asthma, juvenile rheumatoid arthritis, and systemic lupus erythematosus in a Mexican pediatric population

artículo científico publicado en 2009

Two novel frameshift deletions (1924del7, 2055del9→A) in the CFTR gene in Mexican cystic fibrosis patients

article

Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms

artículo científico publicado en 2017

Variation in Actionable Pharmacogenetic Markers in Natives and Mestizos From Mexico

scientific article published on 10 October 2019

WNT3A gene polymorphisms are associated with bone mineral density variation in postmenopausal mestizo women of an urban Mexican population: findings of a pathway-based high-density single nucleotide screening.

artículo científico publicado en 2014

Whole genome variation in 27 Mexican indigenous populations, demographic and biomedical insights

artículo científico publicado en 2021

[Cystic fibrosis: molecular update and clinical implications]

artículo científico publicado en 2006

[Genotype-phenotype correlation in a sample of Mexican patients with cystic fibrosis]

scholarly article by Emiy Yokoyama et al published 1 November 2013 in Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion

[Obesity and metabolic syndrome. A challenge for the Mexican Institutes of Health]

artículo científico publicado en 2009

[Obesity and the metabolic syndrome as a public health problem: a reflection]

artículo científico publicado en 2008

Lista de obras de Lorena Sofia Orozco Orozco

A Loss-Of-Function Splice Acceptor Variant in IGF2 is Protective for Type 2 Diabetes

A homozygous CEP57 c.915_925dupCAATGTTCAGC mutation in a patient with mosaic variegated aneuploidy syndrome with rhizomelic shortening in the upper and lower limbs and a narrow thorax

ALOX5, LPA, MMP9 and TPO gene polymorphisms increase atherothrombosis susceptibility in middle-aged Mexicans

Altered DNA methylation in liver and adipose tissues derived from individuals with obesity and type 2 diabetes

Analysis of protein-coding genetic variation in 60,706 humans

Association between APOE polymorphisms and lipid profile in Mexican Amerindian population

Association between Vitamin D Deficiency and Single Nucleotide Polymorphisms in the Vitamin D Receptor and GC Genes and Analysis of Their Distribution in Mexican Postmenopausal Women

Association between vitamin D deficiency and common variants of Vitamin D binding protein gene among Mexican Mestizo and indigenous postmenopausal women

Association of HMOX1 and NQO1 Polymorphisms with Metabolic Syndrome Components

Association of PDCD1 polymorphisms with childhood-onset systemic lupus erythematosus

Association of TLR7 copy number variation with susceptibility to childhood-onset systemic lupus erythematosus in Mexican population

Association of a low-frequency variant in HNF1A with type 2 diabetes in a Latino population

Association study of DRD3 gene in schizophrenia in Mexican sib-pairs

Associations of autozygosity with a broad range of human phenotypes

CFTR allelic heterogeneity in Mexican patients with cystic fibrosis: implications for molecular screening

CHRM2 but not CHRM1 or CHRM3 polymorphisms are associated with asthma susceptibility in Mexican patients

Catalytically Impaired TYK2 Variants are Protective Against Childhood- and Adult-Onset Systemic Lupus Erythematosus in Mexicans

Comparing signals of natural selection between three Indigenous North American populations

Correction to 'ALOX5, LPA, MMP9 and TPO gene polymorphisms increase atherothrombosis susceptibility in middle-aged Mexicans'

Curcumin differentially affects cell cycle and cell death in acute and chronic myeloid leukemia cells

Deep Multi-OMICs and Multi-Tissue Characterization in a Pre- and Postprandial State in Human Volunteers: The GEMM Family Study Research Design

Demographic history and biologically relevant genetic variation of Native Mexicans inferred from whole-genome sequencing

Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes

Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes

ERBIN deficiency links STAT3 and TGF-β pathway defects with atopy in humans.

Evaluation of imputation-based association in and around the integrin-alpha-M (ITGAM) gene and replication of robust association between a non-synonymous functional variant within ITGAM and systemic lupus erythematosus (SLE).

Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls

GSTT1 and GSTM1 null variants in Mestizo and Amerindian populations from northwestern Mexico and a literature review.

Gender-Dependent Association of FTO Polymorphisms with Body Mass Index in Mexicans

Gene variants in AKT1, GCKR and SOCS3 are differentially associated with metabolic traits in Mexican Amerindians and Mestizos

Genetic Variants Associated With Quantitative Glucose Homeostasis Traits Translate to Type 2 Diabetes in Mexican Americans: The GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium

Genetic association of IRF5 with SLE in Mexicans: higher frequency of the risk haplotype and its homozygozity than Europeans

Genetic variability of five ADRB2 polymorphisms among Mexican Amerindian ethnicities and the Mestizo population

Genome-Wide Association Study in an Amerindian Ancestry Population Reveals Novel Systemic Lupus Erythematosus Risk Loci and the Role of European Admixture

Genomewide admixture study in Mexican Mestizos with multiple sclerosis

HMOX1 promoter (GT)n polymorphim is associated with childhood-onset systemic lupus erythematosus but not with juvenile rheumatoid arthritis in a Mexican population

Heterogenous Distribution of MTHFR Gene Variants among Mestizos and Diverse Amerindian Groups from Mexico

Impact of genetic ancestry and sociodemographic status on the clinical expression of systemic lupus erythematosus in American Indian-European populations

Influence of SNPs in Genes that Modulate Lung Disease Severity in a Group of Mexican Patients with Cystic Fibrosis

Influence of obesity, parental history of diabetes, and genes in type 2 diabetes: A case-control study

Metabolic syndrome in indigenous communities in Mexico: a descriptive and cross-sectional study

MiR‐146a polymorphism is associated with asthma but not with systemic lupus erythematosus and juvenile rheumatoid arthritis in Mexican patients ⬇️

Mild cystic fibrosis disease in three Mexican delta‐F508/G551S compound heterozygous siblings ⬇️

Molecular analysis of the PAX6 gene in Mexican patients with congenital aniridia: report of four novel mutations

Molecular screening of the CFTR gene in Mexican patients with congenital absence of the vas deferens

NFE2L2 Gene Variants and Arsenic Susceptibility: A Lymphoblastoid Model.

NFE2L2 gene variants and susceptibility to childhood-onset asthma.

Next-generation sequencing for identifying a novel/de novo pathogenic variant in a Mexican patient with cystic fibrosis: a case report

Nuclear factor erythroid 2-related factor gene variants and susceptibility of arsenic-related skin lesions ⬇️

Polymorphisms in metalloproteinase-9 are associated with the risk for asthma in Mexican pediatric patients.

Prenatal diagnosis in a cystic fibrosis family: a combined molecular strategy for a precise diagnosis

Pro-adhesive phenotype of normal endothelial cells responding to metastatic breast cancer cell conditioned medium is linked to NFκB-mediated transcriptomic regulation

Programa de detecciÃ³n del alelo APOE-E4 en adultos mayores mexicanos con deterioro cognitivo

Reconstruction of ancient microbial genomes from the human gut

STAT4 associates with systemic lupus erythematosus through two independent effects that correlate with gene expression and act additively with IRF5 to increase risk

Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico

Small MAF genes variants and chronic myeloid leukemia

The NRF2-KEAP1 pathway is an early responsive gene network in arsenic exposed lymphoblastoid cells

The PXR rs7643645 polymorphism is associated with the risk of higher prostate-specific antigen levels in prostate cancer patients

The genomic landscape of Mexican Indigenous populations brings insights into the peopling of the Americas

The power of genetic diversity in genome-wide association studies of lipids

The role of oxidant stress and gender in the erythrocyte arginine metabolism and ammonia management in patients with type 2 diabetes

The rs61764370 Functional Variant in the KRAS Oncogene is Associated with Chronic Myeloid Leukemia Risk in Women

Towards precision medicine: defining and characterizing adipose tissue dysfunction to identify early immunometabolic risk in symptom-free adults from the GEMM family study

Transancestral mapping and genetic load in systemic lupus erythematosus

Transcriptome landmarks of the functional maturity of rat beta-cells, from lactation to adulthood

Tuberculosis and impaired IL-23-dependent IFN-γ immunity in humans homozygous for a common missense variant

Tumor necrosis factor-alpha is a common genetic risk factor for asthma, juvenile rheumatoid arthritis, and systemic lupus erythematosus in a Mexican pediatric population

Two novel frameshift deletions (1924del7, 2055del9→A) in the CFTR gene in Mexican cystic fibrosis patients

Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms

Variation in Actionable Pharmacogenetic Markers in Natives and Mestizos From Mexico

WNT3A gene polymorphisms are associated with bone mineral density variation in postmenopausal mestizo women of an urban Mexican population: findings of a pathway-based high-density single nucleotide screening.

Whole genome variation in 27 Mexican indigenous populations, demographic and biomedical insights

[Cystic fibrosis: molecular update and clinical implications]

[Genotype-phenotype correlation in a sample of Mexican patients with cystic fibrosis]

[Obesity and metabolic syndrome. A challenge for the Mexican Institutes of Health]

[Obesity and the metabolic syndrome as a public health problem: a reflection]