Lista de obras -

2B4 utilizes ITAM-containing receptor complexes to initiate intracellular signaling and cytolysis

artículo científico publicado en 2011

A Dyn2-CIN85 complex mediates degradative traffic of the EGFR by regulation of late endosomal budding

artículo científico publicado en 2010

A FAM21-containing WASH complex regulates retromer-dependent sorting

artículo científico publicado en 2009

A series of potent and selective, triazolylphenyl-based histone deacetylases inhibitors with activity against pancreatic cancer cells and Plasmodium falciparum

artículo científico publicado en 2008

Aberrant nuclear accumulation of glycogen synthase kinase-3beta in human pancreatic cancer: association with kinase activity and tumor dedifferentiation

artículo científico publicado en 2006

Acridine-based agents with topoisomerase II activity inhibit pancreatic cancer cell proliferation and induce apoptosis

artículo científico publicado en 2007

An FGFR/AKT/SOX2 Signaling Axis Controls Pancreatic Cancer Stemness

artículo científico publicado en 2020

Antithetical NFATc1-Sox2 and p53-miR200 signaling networks govern pancreatic cancer cell plasticity

artículo científico publicado en 2015

Asef2 functions as a Cdc42 exchange factor and is stimulated by the release of an autoinhibitory module from a concealed C-terminal activation element

artículo científico publicado en 2007

CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL

scientific journal article

CIN85 phosphorylation is essential for EGFR ubiquitination and sorting into multivesicular bodies

artículo científico publicado en 2012

COMMD Family Regulates Plasma LDL Levels and Attenuates Atherosclerosis Through Stabilizing the CCC Complex in Endosomal LDLR Trafficking.

artículo científico publicado en 2018

COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A

artículo científico publicado en 2015

Cellular functions of WASP family proteins at a glance

artículo científico publicado en 2017

Chemistry, biology, and QSAR studies of substituted biaryl hydroxamates and mercaptoacetamides as HDAC inhibitors-nanomolar-potency inhibitors of pancreatic cancer cell growth

artículo científico publicado en 2008

Coactosin-like 1 antagonizes cofilin to promote lamellipodial protrusion at the immune synapse

artículo científico publicado en 2014

Corrigendum: An FGFR/AKT/SOX2 Signaling Axis Controls Pancreatic Cancer Stemness

artículo científico publicado en 2020

Cutting edge: Rac GTPases sensitize activated T cells to die via Fas

artículo científico publicado en 2007

Dedicator of cytokinesis 8 interacts with talin and Wiskott-Aldrich syndrome protein to regulate NK cell cytotoxicity

artículo científico publicado en 2013

Dendritic cells utilize the evolutionarily conserved WASH and retromer complexes to promote MHCII recycling and helper T cell priming

scientific journal article

Detailed structural-functional analysis of the Krüppel-like factor 16 (KLF16) transcription factor reveals novel mechanisms for silencing Sp/KLF sites involved in metabolism and endocrinology

artículo científico publicado en 2011

Differential activity of GSK-3 isoforms regulates NF-κB and TRAIL- or TNFα induced apoptosis in pancreatic cancer cells

artículo científico publicado en 2014

Differential activity of GSK-3 isoforms regulates NF-κB and TRAIL- or TNFα induced apoptosis in pancreatic cancer cells.

artículo científico publicado en 2014

Differential regulation of TCR-mediated gene transcription by Vav family members

artículo científico publicado en 2004

Dynamic remodeling of the actin cytoskeleton by FMNL1γ is required for structural maintenance of the Golgi complex ⬇️

artículo científico publicado el 24 de agosto de 2011

Dynamin 2 potentiates invasive migration of pancreatic tumor cells through stabilization of the Rac1 GEF Vav1

artículo científico publicado en 2013

Dynamin 2 regulates T cell activation by controlling actin polymerization at the immunological synapse

artículo científico publicado en 2005

Dynamin 2 regulates granule exocytosis during NK cell-mediated cytotoxicity

artículo científico publicado en 2008

Ectopic expression of VAV1 reveals an unexpected role in pancreatic cancer tumorigenesis

artículo científico publicado en 2005

Embryonic stem cell factors and pancreatic cancer

artículo científico publicado en 2014

Endosomal PI(3)P regulation by the COMMD/CCDC22/CCDC93 (CCC) complex controls membrane protein recycling

scientific article published on 19 September 2019

Endosomal Receptor Trafficking: Retromer and Beyond.

artículo científico publicado en 2018

Endosomal sorting of Notch receptors through COMMD9-dependent pathways modulates Notch signaling

artículo científico publicado en 2015

Endosome-to-TGN Trafficking: Organelle-Vesicle and Organelle-Organelle Interactions

artículo científico publicado en 2020

Epigenetic regulation of autophagy by the methyltransferase G9a

scientific journal article

Epigenetics of gastrointestinal diseases: notes from a workshop

artículo científico publicado en 2018

Erratum. WASH Regulates Glucose Homeostasis by Facilitating Glut2 Receptor Recycling in Pancreatic β-Cells. Diabetes 2019;68:377-386

artículo científico publicado en 2020

Erratum: The WW domains dictate isoform-specific regulation of YAP1 stability and pancreatic cancer cell malignancy: Erratum

scientific article published on 18 August 2020

Formins regulate the actin-related protein 2/3 complex-independent polarization of the centrosome to the immunological synapse

artículo científico publicado en 2007

From a natural product lead to the identification of potent and selective benzofuran-3-yl-(indol-3-yl)maleimides as glycogen synthase kinase 3beta inhibitors that suppress proliferation and survival of pancreatic cancer cells

artículo científico publicado en 2009

Fructose-1,6-bisphosphatase Inhibits ERK Activation and Bypasses Gemcitabine Resistance in Pancreatic Cancer by Blocking IQGAP1-MAPK Interaction

artículo científico publicado en 2017

GRB2 couples RhoU to epidermal growth factor receptor signaling and cell migration ⬇️

artículo científico publicado el 20 de abril de 2011

GSK-3 inhibition overcomes chemoresistance in human breast cancer

artículo científico publicado en 2016

GSK-3β Governs Inflammation-Induced NFATc2 Signaling Hubs to Promote Pancreatic Cancer Progression

artículo científico publicado en 2016

Glycogen Synthase Kinase-3 Inhibition Sensitizes Pancreatic Cancer Cells to Chemotherapy by Abrogating the TopBP1/ATR-Mediated DNA Damage Response

scientific article published on 18 September 2019

Glycogen synthase kinase-3 (GSK-3) inhibition attenuates hepatocyte lipoapoptosis ⬇️

artículo científico publicado el 23 de noviembre de 2010

Glycogen synthase kinase-3beta participates in nuclear factor kappaB-mediated gene transcription and cell survival in pancreatic cancer cells

artículo científico publicado en 2005

Glycogen synthase kinase-3β ablation limits pancreatitis-induced acinar-to-ductal metaplasia.

artículo científico publicado en 2017

HS1 functions as an essential actin-regulatory adaptor protein at the immune synapse

artículo científico publicado en 2006

Hematopoietic lineage cell-specific protein 1 functions in concert with the Wiskott-Aldrich syndrome protein to promote podosome array organization and chemotaxis in dendritic cells

artículo científico publicado en 2011

Hematopoietic lineage cell-specific protein 1 is recruited to the immunological synapse by IL-2-inducible T cell kinase and regulates phospholipase Cgamma1 Microcluster dynamics during T cell spreading

artículo científico publicado en 2009

High cell surface death receptor expression determines type I versus type II signaling

artículo científico publicado en 2011

HkRP3 is a microtubule-binding protein regulating lytic granule clustering and NK cell killing

artículo científico publicado en 2015

IQGAP1 promotes CXCR4 chemokine receptor function and trafficking via EEA-1+ endosomes

artículo científico publicado en 2015

Identification of HDAC6-Selective Inhibitors of Low Cancer Cell Cytotoxicity

artículo científico publicado en 2015

Inactivation of Rho GTPases by Burkholderia cenocepacia Induces a WASH-Mediated Actin Polymerization that Delays Phagosome Maturation

scientific article published on 01 June 2020

Inflammation-induced NFATc1-STAT3 transcription complex promotes pancreatic cancer initiation by KrasG12D.

artículo científico publicado en 2014

Inhibition of GSK-3 induces differentiation and impaired glucose metabolism in renal cancer.

artículo científico publicado en 2013

Inhibition of glycogen synthase kinase-3 activity leads to epigenetic silencing of nuclear factor kappaB target genes and induction of apoptosis in chronic lymphocytic leukemia B cells

artículo científico publicado en 2007

Integrated mate-pair and RNA sequencing identifies novel, targetable gene fusions in peripheral T-cell lymphoma.

artículo científico publicado en 2016

Isoxazole moiety in the linker region of HDAC inhibitors adjacent to the Zn-chelating group: effects on HDAC biology and antiproliferative activity

artículo científico publicado en 2009

Kinase-independent functions for Itk in TCR-induced regulation of Vav and the actin cytoskeleton.

artículo científico publicado en 2005

Loss of MAGEL2 in Prader-Willi syndrome leads to decreased secretory granule and neuropeptide production

scientific article published on 03 September 2020

MMSET is dynamically regulated during cell-cycle progression and promotes normal DNA replication

artículo científico publicado en 2016

Macrogenomic engineering via modulation of the scaling of chromatin packing density

scientific article published on 06 November 2017

Mechanism of cargo recognition by retromer-linked SNX-BAR proteins

artículo científico publicado en 2020

Microbial Sensing by Intestinal Myeloid Cells Controls Carcinogenesis and Epithelial Differentiation

article

Molecular Pathways: Revisiting Glycogen Synthase Kinase-3β as a Target for the Treatment of Cancer

artículo científico publicado en 2017

Molecular regulation of the plasma membrane-proximal cellular steps involved in NK cell cytolytic function

scientific article published on 21 February 2020

Monitoring receptor trafficking following retromer and WASH deregulation

scientific article published on 11 June 2015

Multiple repeat elements within the FAM21 tail link the WASH actin regulatory complex to the retromer ⬇️

artículo científico publicado el 18 de abril de 2012

Mutant K-Ras increases GSK-3β gene expression via an ETS-p300 transcriptional complex in pancreatic cancer ⬇️

artículo científico publicado el 28 de marzo de 2011

NFATc1 Links EGFR Signaling to Induction of Sox9 Transcription and Acinar-Ductal Transdifferentiation in the Pancreas.

artículo científico publicado en 2015

NFATc4 Regulates Sox9 Gene Expression in Acinar Cell Plasticity and Pancreatic Cancer Initiation

artículo científico publicado en 2015

NK cell defects in X-linked pigmentary reticulate disorder

scientific article published on 01 November 2019

NKG2D-DAP10 signaling recruits EVL to the cytotoxic synapse to generate F-actin and promote NK cell cytotoxicity

artículo científico publicado en 2019

NKG2D-DAP10 triggers human NK cell–mediated killing via a Syk-independent regulatory pathway ⬇️

artículo científico publicado el 11 de mayo de 2003

NKG2D-mediated signaling requires a DAP10-bound Grb2-Vav1 intermediate and phosphatidylinositol-3-kinase in human natural killer cells

artículo científico publicado en 2006

NKG7 Is a T-cell-Intrinsic Therapeutic Target for Improving Antitumor Cytotoxicity and Cancer Immunotherapy

artículo científico publicado en 2021

Novel acridine-based compounds that exhibit an anti-pancreatic cancer activity are catalytic inhibitors of human topoisomerase II.

artículo científico publicado en 2008

Nuclear FAM21 participates in NF-κB-dependent gene regulation in pancreatic cancer cells

artículo científico publicado en 2014

PI3K links NKG2D signaling to a CrkL pathway involved in natural killer cell adhesion, polarity, and granule secretion.

artículo científico publicado en 2009

Parkin Regulates Mitosis and Genomic Stability through Cdc20/Cdh1. ⬇️

artículo científico publicado en 2015

Pleiotropic defects in TCR signaling in a Vav-1-null Jurkat T-cell line.

artículo científico publicado en 2002

Poly(ADP-ribose) polymerase inhibitors sensitize cancer cells to death receptor-mediated apoptosis by enhancing death receptor expression.

artículo científico publicado en 2014

Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes

artículo científico publicado en 2003

Protein kinase Cbeta modulates ligand-induced cell surface death receptor accumulation: a mechanistic basis for enzastaurin-death ligand synergy.

artículo científico publicado en 2009

Protein kinase D1 and the beta 1 integrin cytoplasmic domain control beta 1 integrin function via regulation of Rap1 activation.

artículo científico publicado en 2005

ROCK-dependent and ROCK-independent control of cochlear outer hair cell electromotility

artículo científico publicado en 2003

Rab GTPase regulation of retromer-mediated cargo export during endosome maturation

artículo científico publicado en 2012

Regulation of T-cell activation by the cytoskeleton

artículo científico publicado en 2007

Regulation of WASH-dependent actin polymerization and protein trafficking by ubiquitination

artículo científico publicado en 2013

Regulation of copper homeostasis by members of the COMMD protein family

artículo científico publicado en 2020

Regulation of cytoskeletal dynamics at the immune synapse: new stars join the actin troupe

artículo científico publicado en 2006

Regulation of pancreatic tumor cell proliferation and chemoresistance by the histone methyltransferase enhancer of zeste homologue 2.

artículo científico publicado en 2008

Restricted heterochromatin formation links NFATc2 repressor activity with growth promotion in pancreatic cancer

artículo científico publicado en 2011

Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling.

artículo científico publicado en 2017

Retromer Binding to FAM21 and the WASH Complex Is Perturbed by the Parkinson Disease-Linked VPS35(D620N) Mutation.

artículo científico publicado en 2014

Retromer binding to FAM21 and the WASH complex is perturbed by the Parkinson disease-linked VPS35(D620N) mutation

artículo científico publicado en 2014

SIRT1-Activating Compounds (STAC) Negatively Regulate Pancreatic Cancer Cell Growth and Viability Through a SIRT1 Lysosomal-Dependent Pathway

artículo científico publicado en 2015

SLP-76 coordinates Nck-dependent Wiskott-Aldrich syndrome protein recruitment with Vav-1/Cdc42-dependent Wiskott-Aldrich syndrome protein activation at the T cell-APC contact site

artículo científico publicado en 2003

SNX17 affects T cell activation by regulating TCR and integrin recycling

artículo científico publicado en 2015

SOX2 promotes dedifferentiation and imparts stem cell-like features to pancreatic cancer cells

artículo científico publicado en 2013

Structural and Energetic Mechanisms of Cooperative Autoinhibition and Activation of Vav1

artículo científico publicado en 2010

Structural and functional studies of TBC1D23 C-terminal domain provide a link between endosomal trafficking and PCH

scientific article published on 17 October 2019

Structural and mechanistic insights into regulation of the retromer coat by TBC1d5.

artículo científico publicado en 2016

Structure and control of the actin regulatory WAVE complex

artículo científico publicado en 2010

Structure of TBC1D23 N-terminus reveals a novel role for rhodanese domain

scientific article published on 26 May 2020

Synthesis and biological evaluation of triazol-4-ylphenyl-bearing histone deacetylase inhibitors as anticancer agents

artículo científico publicado en 2010

T cell activation and the cytoskeleton: you can't have one without the other

scientific article published on January 2008

TCR/CD28-stimulated actin dynamics are required for NFAT1-mediated transcription of c-rel leading to CD28 response element activation

artículo científico publicado en 2007

Targeting glycogen synthase kinase 3 for therapeutic benefit in lymphoma

scientific article published on 17 May 2019

The Ezh2 methyltransferase complex: actin up in the cytosol

artículo científico publicado en 2005

The WAVE2 complex regulates T cell receptor signaling to integrins via Abl- and CrkL-C3G-mediated activation of Rap1.

artículo científico publicado en 2008

The WAVE2 complex regulates actin cytoskeletal reorganization and CRAC-mediated calcium entry during T cell activation

artículo científico publicado en 2006

The WW domains dictate isoform-specific regulation of YAP1 stability and pancreatic cancer cell malignancy

artículo científico publicado en 2020

The cytoskeletal adaptor protein IQGAP1 regulates TCR-mediated signaling and filamentous actin dynamics.

artículo científico publicado en 2012

The hepatic WASH complex is required for efficient plasma LDL and HDL cholesterol clearance

scientific article published on 06 June 2019

The isoforms of phospholipase C-gamma are differentially used by distinct human NK activating receptors

artículo científico publicado en 2005

The septin cytoskeleton regulates natural killer cell lytic granule release

scientific article published on 01 November 2020

Trafficking defects in WASH-knockout fibroblasts originate from collapsed endosomal and lysosomal networks

artículo científico publicado en 2012

Trans-endocytosis elicited by nectins transfers cytoplasmic cargo, including infectious material, between cells

artículo científico publicado en 2019

Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: a new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6.

artículo científico publicado en 2008

VASP Regulates NK Cell Lytic Granule Convergence

artículo científico publicado en 2018

Vav links the T cell antigen receptor to the actin cytoskeleton and T cell activation independently of intrinsic Guanine nucleotide exchange activity

artículo científico publicado en 2009

Vav1 acidic region tyrosine 174 is required for the formation of T cell receptor-induced microclusters and is essential in T cell development and activation

artículo científico publicado en 2006

Vav1 as a central regulator of invadopodia assembly

artículo científico publicado en 2013

Vav1 dephosphorylation by the tyrosine phosphatase SHP-1 as a mechanism for inhibition of cellular cytotoxicity

artículo científico publicado en 2003

WASH Regulates Glucose Homeostasis by Facilitating Glut2 Receptor Recycling in Pancreatic β-Cells

artículo científico publicado en 2018

WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexes

artículo científico publicado en 2010

WASH knockout T cells demonstrate defective receptor trafficking, proliferation, and effector function

scientific journal article

WASH phosphorylation balances endosomal versus cortical actin network integrities during epithelial morphogenesis

artículo científico publicado en 2019

WAVE2 regulates high-affinity integrin binding by recruiting vinculin and talin to the immunological synapse.

artículo científico publicado en 2007

Lista de obras de

2B4 utilizes ITAM-containing receptor complexes to initiate intracellular signaling and cytolysis

A Dyn2-CIN85 complex mediates degradative traffic of the EGFR by regulation of late endosomal budding

A FAM21-containing WASH complex regulates retromer-dependent sorting

A series of potent and selective, triazolylphenyl-based histone deacetylases inhibitors with activity against pancreatic cancer cells and Plasmodium falciparum

Aberrant nuclear accumulation of glycogen synthase kinase-3beta in human pancreatic cancer: association with kinase activity and tumor dedifferentiation

Acridine-based agents with topoisomerase II activity inhibit pancreatic cancer cell proliferation and induce apoptosis

An FGFR/AKT/SOX2 Signaling Axis Controls Pancreatic Cancer Stemness

Antithetical NFATc1-Sox2 and p53-miR200 signaling networks govern pancreatic cancer cell plasticity

Asef2 functions as a Cdc42 exchange factor and is stimulated by the release of an autoinhibitory module from a concealed C-terminal activation element

CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL

CIN85 phosphorylation is essential for EGFR ubiquitination and sorting into multivesicular bodies

COMMD Family Regulates Plasma LDL Levels and Attenuates Atherosclerosis Through Stabilizing the CCC Complex in Endosomal LDLR Trafficking.

COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A

Cellular functions of WASP family proteins at a glance

Chemistry, biology, and QSAR studies of substituted biaryl hydroxamates and mercaptoacetamides as HDAC inhibitors-nanomolar-potency inhibitors of pancreatic cancer cell growth

Coactosin-like 1 antagonizes cofilin to promote lamellipodial protrusion at the immune synapse

Corrigendum: An FGFR/AKT/SOX2 Signaling Axis Controls Pancreatic Cancer Stemness

Cutting edge: Rac GTPases sensitize activated T cells to die via Fas

Dedicator of cytokinesis 8 interacts with talin and Wiskott-Aldrich syndrome protein to regulate NK cell cytotoxicity

Dendritic cells utilize the evolutionarily conserved WASH and retromer complexes to promote MHCII recycling and helper T cell priming

Detailed structural-functional analysis of the Krüppel-like factor 16 (KLF16) transcription factor reveals novel mechanisms for silencing Sp/KLF sites involved in metabolism and endocrinology

Differential activity of GSK-3 isoforms regulates NF-κB and TRAIL- or TNFα induced apoptosis in pancreatic cancer cells

Differential activity of GSK-3 isoforms regulates NF-κB and TRAIL- or TNFα induced apoptosis in pancreatic cancer cells.

Differential regulation of TCR-mediated gene transcription by Vav family members

Dynamic remodeling of the actin cytoskeleton by FMNL1γ is required for structural maintenance of the Golgi complex ⬇️

Dynamin 2 potentiates invasive migration of pancreatic tumor cells through stabilization of the Rac1 GEF Vav1

Dynamin 2 regulates T cell activation by controlling actin polymerization at the immunological synapse

Dynamin 2 regulates granule exocytosis during NK cell-mediated cytotoxicity

Ectopic expression of VAV1 reveals an unexpected role in pancreatic cancer tumorigenesis

Embryonic stem cell factors and pancreatic cancer

Endosomal PI(3)P regulation by the COMMD/CCDC22/CCDC93 (CCC) complex controls membrane protein recycling

Endosomal Receptor Trafficking: Retromer and Beyond.

Endosomal sorting of Notch receptors through COMMD9-dependent pathways modulates Notch signaling

Endosome-to-TGN Trafficking: Organelle-Vesicle and Organelle-Organelle Interactions

Epigenetic regulation of autophagy by the methyltransferase G9a

Epigenetics of gastrointestinal diseases: notes from a workshop

Erratum. WASH Regulates Glucose Homeostasis by Facilitating Glut2 Receptor Recycling in Pancreatic β-Cells. Diabetes 2019;68:377-386

Erratum: The WW domains dictate isoform-specific regulation of YAP1 stability and pancreatic cancer cell malignancy: Erratum

Formins regulate the actin-related protein 2/3 complex-independent polarization of the centrosome to the immunological synapse

From a natural product lead to the identification of potent and selective benzofuran-3-yl-(indol-3-yl)maleimides as glycogen synthase kinase 3beta inhibitors that suppress proliferation and survival of pancreatic cancer cells

Fructose-1,6-bisphosphatase Inhibits ERK Activation and Bypasses Gemcitabine Resistance in Pancreatic Cancer by Blocking IQGAP1-MAPK Interaction

GRB2 couples RhoU to epidermal growth factor receptor signaling and cell migration ⬇️

GSK-3 inhibition overcomes chemoresistance in human breast cancer

GSK-3β Governs Inflammation-Induced NFATc2 Signaling Hubs to Promote Pancreatic Cancer Progression

Glycogen Synthase Kinase-3 Inhibition Sensitizes Pancreatic Cancer Cells to Chemotherapy by Abrogating the TopBP1/ATR-Mediated DNA Damage Response

Glycogen synthase kinase-3 (GSK-3) inhibition attenuates hepatocyte lipoapoptosis ⬇️

Glycogen synthase kinase-3beta participates in nuclear factor kappaB-mediated gene transcription and cell survival in pancreatic cancer cells

Glycogen synthase kinase-3β ablation limits pancreatitis-induced acinar-to-ductal metaplasia.

HS1 functions as an essential actin-regulatory adaptor protein at the immune synapse

Hematopoietic lineage cell-specific protein 1 functions in concert with the Wiskott-Aldrich syndrome protein to promote podosome array organization and chemotaxis in dendritic cells

Hematopoietic lineage cell-specific protein 1 is recruited to the immunological synapse by IL-2-inducible T cell kinase and regulates phospholipase Cgamma1 Microcluster dynamics during T cell spreading

High cell surface death receptor expression determines type I versus type II signaling

HkRP3 is a microtubule-binding protein regulating lytic granule clustering and NK cell killing

IQGAP1 promotes CXCR4 chemokine receptor function and trafficking via EEA-1+ endosomes

Identification of HDAC6-Selective Inhibitors of Low Cancer Cell Cytotoxicity

Inactivation of Rho GTPases by Burkholderia cenocepacia Induces a WASH-Mediated Actin Polymerization that Delays Phagosome Maturation

Inflammation-induced NFATc1-STAT3 transcription complex promotes pancreatic cancer initiation by KrasG12D.

Inhibition of GSK-3 induces differentiation and impaired glucose metabolism in renal cancer.

Inhibition of glycogen synthase kinase-3 activity leads to epigenetic silencing of nuclear factor kappaB target genes and induction of apoptosis in chronic lymphocytic leukemia B cells

Integrated mate-pair and RNA sequencing identifies novel, targetable gene fusions in peripheral T-cell lymphoma.

Isoxazole moiety in the linker region of HDAC inhibitors adjacent to the Zn-chelating group: effects on HDAC biology and antiproliferative activity

Kinase-independent functions for Itk in TCR-induced regulation of Vav and the actin cytoskeleton.

Loss of MAGEL2 in Prader-Willi syndrome leads to decreased secretory granule and neuropeptide production

MMSET is dynamically regulated during cell-cycle progression and promotes normal DNA replication

Macrogenomic engineering via modulation of the scaling of chromatin packing density

Mechanism of cargo recognition by retromer-linked SNX-BAR proteins

Microbial Sensing by Intestinal Myeloid Cells Controls Carcinogenesis and Epithelial Differentiation

Molecular Pathways: Revisiting Glycogen Synthase Kinase-3β as a Target for the Treatment of Cancer

Molecular regulation of the plasma membrane-proximal cellular steps involved in NK cell cytolytic function

Monitoring receptor trafficking following retromer and WASH deregulation

Multiple repeat elements within the FAM21 tail link the WASH actin regulatory complex to the retromer ⬇️

Mutant K-Ras increases GSK-3β gene expression via an ETS-p300 transcriptional complex in pancreatic cancer ⬇️

NFATc1 Links EGFR Signaling to Induction of Sox9 Transcription and Acinar-Ductal Transdifferentiation in the Pancreas.

NFATc4 Regulates Sox9 Gene Expression in Acinar Cell Plasticity and Pancreatic Cancer Initiation

NK cell defects in X-linked pigmentary reticulate disorder

NKG2D-DAP10 signaling recruits EVL to the cytotoxic synapse to generate F-actin and promote NK cell cytotoxicity

NKG2D-DAP10 triggers human NK cell–mediated killing via a Syk-independent regulatory pathway ⬇️

NKG2D-mediated signaling requires a DAP10-bound Grb2-Vav1 intermediate and phosphatidylinositol-3-kinase in human natural killer cells

NKG7 Is a T-cell-Intrinsic Therapeutic Target for Improving Antitumor Cytotoxicity and Cancer Immunotherapy