Lista de obras -

A network of immediate early gene products propagates subtle differences in mitogen-activated protein kinase signal amplitude and duration.

artículo científico publicado en 2004

AKT Facilitates EGFR Trafficking and Degradation by Phosphorylating and Activating PIKfyve ⬇️

artículo científico publicado el 11 de junio de 2013

ATM: Promoter of metabolic "cost" reduction and "savings" usage during hypoxia through mTORC1 regulation ⬇️

artículo científico publicado el 24 de noviembre de 2010

Adding Polyamine Metabolism to the mTORC1 Toolkit in Cell Growth and Cancer

artículo científico publicado en 2017

Age-induced accumulation of methylmalonic acid promotes tumour progression

artículo científico publicado en 2020

Akt-ivation of RNA splicing

artículo científico publicado en 2014

Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1.

artículo científico publicado en 2005

Appetite for destruction: the inhibition of glycolysis as a therapy for tuberous sclerosis complex-related tumors

artículo científico publicado en 2011

Author Correction: Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis

scientific article published on 01 May 2019

Beyond the Warburg Effect: How Do Cancer Cells Regulate One-Carbon Metabolism?

CELL SIGNALING. Seeing mTORC1 specificity

artículo científico publicado en 2016

Cell signaling in protein synthesis ribosome biogenesis and translation initiation and elongation

artículo científico publicado en 2009

Characterization of a conserved C-terminal motif (RSPRR) in ribosomal protein S6 kinase 1 required for its mammalian target of rapamycin-dependent regulation

artículo científico publicado en 2005

Characterizing the interaction of the mammalian eIF4E-related protein 4EHP with 4E-BP1.

artículo científico publicado en 2004

Deletion of ribosomal S6 kinases does not attenuate pathological, physiological, or insulin-like growth factor 1 receptor-phosphoinositide 3-kinase-induced cardiac hypertrophy

artículo científico publicado en 2004

Down-regulation of CMTM8 Induces Epithelial-to-Mesenchymal Transition-like Changes via c-MET/Extracellular Signal-regulated Kinase (ERK) Signaling ⬇️

artículo científico publicado el 15 de febrero de 2012

Dynamic Incorporation of Histone H3 Variants into Chromatin Is Essential for Acquisition of Aggressive Traits and Metastatic Colonization

scientific article published on 26 September 2019

EIF1AX and RAS mutations cooperate to drive thyroid tumorigenesis through ATF4 and c-MYC

article

ERK reinforces actin polymerization to power persistent edge protrusion during motility.

artículo científico publicado en 2015

ERK-MAP Kinase Signaling in the Cytoplasm ⬇️

artículo científico publicado el 1 de enero de 2010

ERK-MAPK drives lamellipodia protrusion by activating the WAVE2 regulatory complex

artículo científico publicado en 2011

ERK2 Mediates Metabolic Stress Response to Regulate Cell Fate

artículo científico publicado en 2015

ERK2 but not ERK1 induces epithelial-to-mesenchymal transformation via DEF motif-dependent signaling events

artículo científico publicado en 2010

ERK2 regulates epithelial-to-mesenchymal plasticity through DOCK10-dependent Rac1/FoxO1 activation

artículo científico publicado en 2019

Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells

artículo científico publicado en 2014

FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation

artículo científico publicado en 2014

Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition

artículo científico publicado en 2017

Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply

artículo científico publicado en 2010

Glycogen synthase kinase (GSK)-3 promotes p70 ribosomal protein S6 kinase (p70S6K) activity and cell proliferation ⬇️

artículo científico publicado el 7 de noviembre de 2011

Graded mitogen-activated protein kinase activity precedes switch-like c-Fos induction in mammalian cells.

artículo científico publicado en 2005

Grb10 promotes lipolysis and thermogenesis by phosphorylation-dependent feedback inhibition of mTORC1.

artículo científico publicado en 2014

Hippo–YAP and mTOR pathways collaborate to regulate organ size ⬇️

artículo científico publicado el 1 de diciembre de 2012

Histone H3 variants at the root of metastasis

scientific article published on 10 January 2020

Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase

artículo científico publicado en 2005

Identification of a conserved motif required for mTOR signaling

artículo científico publicado en 2002

Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers.

artículo científico publicado en 2016

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

scientific journal article

Inactivation of the tuberous sclerosis complex-1 and -2 gene products occurs by phosphoinositide 3-kinase/Akt-dependent and -independent phosphorylation of tuberin

artículo científico publicado en 2003

Inhibition of ERK-MAP kinase signaling by RSK during Drosophila development

artículo científico publicado en 2006

Integration of mTOR and estrogen-ERK2 signaling in lymphangioleiomyomatosis pathogenesis

artículo científico publicado en 2013

Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex.

artículo científico publicado en 2012

Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism.

artículo científico publicado en 2013

Mind the GAP: Wnt steps onto the mTORC1 train

artículo científico publicado en 2006

Mitochondrial One-Carbon Pathway Supports Cytosolic Folate Integrity in Cancer Cells

artículo científico publicado en 2018

Molecular interpretation of ERK signal duration by immediate early gene products

artículo científico publicado en 2002

PHLPPing it off: phosphatases get in the Akt

scientific article published on 01 March 2007

PI3-kinase and TOR: PIKTORing cell growth

artículo científico publicado en 2004

Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling

artículo científico publicado en 2011

Phosphoproteomic analysis identifies the tumor suppressor PDCD4 as a RSK substrate negatively regulated by 14-3-3.

artículo científico publicado en 2014

Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity

artículo científico publicado en 2003

Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling.

artículo científico publicado en 2017

Proapoptotic protein Bim attenuates estrogen-enhanced survival in lymphangioleiomyomatosis

artículo científico publicado en 2016

PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex.

artículo científico publicado en 2015

Quantitative phosphoproteomic analysis reveals system-wide signaling pathways downstream of SDF-1/CXCR4 in breast cancer stem cells

artículo científico publicado en 2014

Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors.

artículo científico publicado en 2005

RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation

artículo científico publicado en 2007

Ran-binding protein 3 phosphorylation links the Ras and PI3-kinase pathways to nucleocytoplasmic transport

artículo científico publicado en 2008

Rap1-GTPases control mTORC1 activity by coordinating lysosome organization with amino acid availability

artículo científico publicado en 2020

Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation

artículo científico publicado en 2008

Rapamycin: one drug, many effects

scientific article published on 06 February 2014

Regulation of GSK3 cellular location by FRAT modulates mTORC1-dependent cell growth and sensitivity to rapamycin

scientific article published on 06 September 2019

Ribosomal S6 kinase (RSK) regulates phosphorylation of filamin A on an important regulatory site

artículo científico publicado en 2004

SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism

scientific journal article

SKAR is a specific target of S6 kinase 1 in cell growth control

artículo científico publicado en 2004

SKAR links pre-mRNA splicing to mTOR/S6K1-mediated enhanced translation efficiency of spliced mRNAs

artículo científico publicado en 2008

Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance.

artículo científico publicado en 2005

Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis

artículo científico publicado en 2013

Spatially separate docking sites on ERK2 regulate distinct signaling events in vivo

artículo científico publicado en 2005

Suppression of nuclear GSK3 signaling promotes serine/one-carbon metabolism and confers metabolic vulnerability in lung cancer cells

artículo científico publicado en 2022

Synthetic lethality of combined glutaminase and Hsp90 inhibition in mTORC1-driven tumor cells

artículo científico publicado en 2014

TORgeting oncogene addiction for cancer therapy

artículo científico publicado en 2006

TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function

artículo científico publicado en 2003

TPCK inhibits AGC kinases by direct activation loop adduction at phenylalanine‐directed cysteine residues ⬇️

artículo científico publicado el 10 de agosto de 2012

Targeting the premetastatic niche: epigenetic therapies in the spotlight

artículo científico publicado en 2020

The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation ⬇️

artículo científico publicado el 30 de abril de 2011

The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity

artículo científico publicado en 2006

The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4

scientific journal article

The mTORC1/S6K1 pathway regulates glutamine metabolism through the eIF4B-dependent control of c-Myc translation

artículo científico publicado en 2014

The nuclear translocation of the kinases p38 and JNK promotes inflammation-induced cancer.

artículo científico publicado en 2018

The tumor suppressor DAP kinase is a target of RSK-mediated survival signaling

artículo científico publicado en 2005

The tumor suppressor FLCN mediates an alternate mTOR pathway to regulate browning of adipose tissue

artículo científico publicado en 2016

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

scientific journal article

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

artículo científico publicado en 2002

Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase

artículo científico publicado en 2004

Unique Metabolic Adaptations Dictate Distal Organ-Specific Metastatic Colonization

artículo científico publicado en 2018

mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events

artículo científico publicado en 2005

mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E

artículo científico publicado en 2004

mTOR, translational control and human disease.

artículo científico publicado en 2004

mTORC1 Promotes Metabolic Reprogramming by the Suppression of GSK3-Dependent Foxk1 Phosphorylation

artículo científico publicado en 2018

mTORC1 Signaling Aids in CADalyzing Pyrimidine Biosynthesis ⬇️

artículo científico publicado el 7 de mayo de 2013

mTORC1-Driven Tumor Cells Are Highly Sensitive to Therapeutic Targeting by Antagonists of Oxidative Stress

artículo científico publicado en 2016

p90 ribosomal S6 kinase and p70 ribosomal S6 kinase link phosphorylation of the eukaryotic chaperonin containing TCP-1 to growth factor, insulin, and nutrient signaling

artículo científico publicado en 2009

Lista de obras de

A network of immediate early gene products propagates subtle differences in mitogen-activated protein kinase signal amplitude and duration.

AKT Facilitates EGFR Trafficking and Degradation by Phosphorylating and Activating PIKfyve ⬇️

ATM: Promoter of metabolic "cost" reduction and "savings" usage during hypoxia through mTORC1 regulation ⬇️

Adding Polyamine Metabolism to the mTORC1 Toolkit in Cell Growth and Cancer

Age-induced accumulation of methylmalonic acid promotes tumour progression

Akt-ivation of RNA splicing

Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1.

Appetite for destruction: the inhibition of glycolysis as a therapy for tuberous sclerosis complex-related tumors

Author Correction: Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis

Beyond the Warburg Effect: How Do Cancer Cells Regulate One-Carbon Metabolism?

CELL SIGNALING. Seeing mTORC1 specificity

Cell signaling in protein synthesis ribosome biogenesis and translation initiation and elongation

Characterization of a conserved C-terminal motif (RSPRR) in ribosomal protein S6 kinase 1 required for its mammalian target of rapamycin-dependent regulation

Characterizing the interaction of the mammalian eIF4E-related protein 4EHP with 4E-BP1.

Deletion of ribosomal S6 kinases does not attenuate pathological, physiological, or insulin-like growth factor 1 receptor-phosphoinositide 3-kinase-induced cardiac hypertrophy

Down-regulation of CMTM8 Induces Epithelial-to-Mesenchymal Transition-like Changes via c-MET/Extracellular Signal-regulated Kinase (ERK) Signaling ⬇️

Dynamic Incorporation of Histone H3 Variants into Chromatin Is Essential for Acquisition of Aggressive Traits and Metastatic Colonization

EIF1AX and RAS mutations cooperate to drive thyroid tumorigenesis through ATF4 and c-MYC

ERK reinforces actin polymerization to power persistent edge protrusion during motility.

ERK-MAP Kinase Signaling in the Cytoplasm ⬇️

ERK-MAPK drives lamellipodia protrusion by activating the WAVE2 regulatory complex

ERK2 Mediates Metabolic Stress Response to Regulate Cell Fate

ERK2 but not ERK1 induces epithelial-to-mesenchymal transformation via DEF motif-dependent signaling events

ERK2 regulates epithelial-to-mesenchymal plasticity through DOCK10-dependent Rac1/FoxO1 activation

Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells

FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation

Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition

Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply

Glycogen synthase kinase (GSK)-3 promotes p70 ribosomal protein S6 kinase (p70S6K) activity and cell proliferation ⬇️

Graded mitogen-activated protein kinase activity precedes switch-like c-Fos induction in mammalian cells.

Grb10 promotes lipolysis and thermogenesis by phosphorylation-dependent feedback inhibition of mTORC1.

Hippo–YAP and mTOR pathways collaborate to regulate organ size ⬇️

Histone H3 variants at the root of metastasis

Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase

Identification of a conserved motif required for mTOR signaling

Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers.

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

Inactivation of the tuberous sclerosis complex-1 and -2 gene products occurs by phosphoinositide 3-kinase/Akt-dependent and -independent phosphorylation of tuberin

Inhibition of ERK-MAP kinase signaling by RSK during Drosophila development

Integration of mTOR and estrogen-ERK2 signaling in lymphangioleiomyomatosis pathogenesis

Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex.

Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism.

Mind the GAP: Wnt steps onto the mTORC1 train

Mitochondrial One-Carbon Pathway Supports Cytosolic Folate Integrity in Cancer Cells

Molecular interpretation of ERK signal duration by immediate early gene products

PHLPPing it off: phosphatases get in the Akt

PI3-kinase and TOR: PIKTORing cell growth

Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling

Phosphoproteomic analysis identifies the tumor suppressor PDCD4 as a RSK substrate negatively regulated by 14-3-3.

Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity

Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling.

Proapoptotic protein Bim attenuates estrogen-enhanced survival in lymphangioleiomyomatosis

PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex.

Quantitative phosphoproteomic analysis reveals system-wide signaling pathways downstream of SDF-1/CXCR4 in breast cancer stem cells

Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors.

RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation

Ran-binding protein 3 phosphorylation links the Ras and PI3-kinase pathways to nucleocytoplasmic transport

Rap1-GTPases control mTORC1 activity by coordinating lysosome organization with amino acid availability

Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation

Rapamycin: one drug, many effects

Regulation of GSK3 cellular location by FRAT modulates mTORC1-dependent cell growth and sensitivity to rapamycin

Ribosomal S6 kinase (RSK) regulates phosphorylation of filamin A on an important regulatory site

SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism

SKAR is a specific target of S6 kinase 1 in cell growth control

SKAR links pre-mRNA splicing to mTOR/S6K1-mediated enhanced translation efficiency of spliced mRNAs

Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance.

Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis

Spatially separate docking sites on ERK2 regulate distinct signaling events in vivo

Suppression of nuclear GSK3 signaling promotes serine/one-carbon metabolism and confers metabolic vulnerability in lung cancer cells

Synthetic lethality of combined glutaminase and Hsp90 inhibition in mTORC1-driven tumor cells

TORgeting oncogene addiction for cancer therapy

TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function

TPCK inhibits AGC kinases by direct activation loop adduction at phenylalanine‐directed cysteine residues ⬇️

Targeting the premetastatic niche: epigenetic therapies in the spotlight

The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation ⬇️

The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity

The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4

The mTORC1/S6K1 pathway regulates glutamine metabolism through the eIF4B-dependent control of c-Myc translation

The nuclear translocation of the kinases p38 and JNK promotes inflammation-induced cancer.