Lista de obras -

A novel form of integrin dysfunction involving beta1, beta2, and beta3 integrins

artículo científico publicado en 2003

A novel mutation in DDR2 causing spondylo-meta-epiphyseal dysplasia with short limbs and abnormal calcifications (SMED-SL) results in defective intra-cellular trafficking

artículo científico publicado en 2014

A transmembrane leucine zipper is required for activation of the dimeric receptor tyrosine kinase DDR1.

artículo científico publicado en 2006

ADAM10 controls collagen signaling and cell migration on collagen by shedding the ectodomain of discoidin domain receptor 1 (DDR1).

artículo científico publicado en 2014

Cell-collagen interactions: the use of peptide Toolkits to investigate collagen-receptor interactions.

artículo científico publicado en 2008

Chain alignment of collagen I deciphered using computationally designed heterotrimers

scientific article published on 06 January 2020

Characterization of high affinity binding motifs for the discoidin domain receptor DDR2 in collagen

artículo científico publicado en 2008

Collagen binding specificity of the discoidin domain receptors: binding sites on collagens II and III and molecular determinants for collagen IV recognition by DDR1 ⬇️

artículo científico publicado el 28 de octubre de 2010

Collagen induces activation of DDR1 through lateral dimer association and phosphorylation between dimers

artículo científico publicado en 2017

Collective cell migration requires suppression of actomyosin at cell-cell contacts mediated by DDR1 and the cell polarity regulators Par3 and Par6.

artículo científico publicado en 2010

Coupling of a specific photoreactive triple-helical peptide to crosslinked collagen films restores binding and activation of DDR2 and VWF

Crystallographic insight into collagen recognition by discoidin domain receptor 2

artículo científico publicado en 2009

DDR1 autophosphorylation is a result of aggregation into dense clusters

artículo científico publicado en 2019

Discoidin domain receptor 1 controls linear invadosome formation via a Cdc42-Tuba pathway

artículo científico publicado en 2014

Discoidin domain receptor 1 kinase activity is required for regulating collagen IV synthesis

artículo científico publicado en 2016

Discoidin domain receptor functions in physiological and pathological conditions

artículo científico publicado en 2014

Discoidin domain receptor tyrosine kinases: new players in cancer progression ⬇️

artículo científico publicado el 1 de junio de 2012

Discoidin domain receptors promote α1β1- and α2β1-integrin mediated cell adhesion to collagen by enhancing integrin activation

artículo científico publicado en 2012

Discoidin domain receptors: multitaskers for physiological and pathological processes

artículo científico publicado en 2018

Extracellular matrix component signaling in cancer

artículo científico publicado en 2015

Inhibition of collagen receptor discoidin domain receptor-1 (DDR1) reduces cell survival, homing, and colonization in lung cancer bone metastasis.

artículo científico publicado en 2012

Interaction of Discoidin Domain Receptor 1 with a 14-3-3-Beclin-1-Akt1 Complex Modulates Glioblastoma Therapy Sensitivity

artículo científico publicado en 2019

LFA-1-induced T cell migration on ICAM-1 involves regulation of MLCK-mediated attachment and ROCK-dependent detachment

scientific article published on 10 June 2003

Loss of E-cadherin provides tolerance to centrosome amplification in epithelial cancer cells.

artículo científico publicado en 2017

Mammalian collagen receptors

artículo científico publicado en 2006

Mechanisms contributing to the activity of integrins on leukocytes

artículo científico publicado en 2002

Meeting report - first discoidin domain receptors meeting

artículo científico publicado en 2020

Molecular analysis of collagen binding by the human discoidin domain receptors, DDR1 and DDR2. Identification of collagen binding sites in DDR2.

artículo científico publicado en 2003

Multi-organ Site Metastatic Reactivation Mediated by Non-canonical Discoidin Domain Receptor 1 Signaling

artículo científico publicado en 2016

Normal activation of discoidin domain receptor 1 mutants with disulfide cross-links, insertions, or deletions in the extracellular juxtamembrane region: mechanistic implications

artículo científico publicado en 2014

Phosphoproteomics of collagen receptor networks reveals SHP-2 phosphorylation downstream of wild-type DDR2 and its lung cancer mutants

artículo científico publicado en 2013

Recombinant Collagen Engineered to Bind to Discoidin Domain Receptor Functions as a Receptor Inhibitor

artículo científico publicado en 2015

Structure of the Discoidin Domain Receptor 1 Extracellular Region Bound to an Inhibitory Fab Fragment Reveals Features Important for Signaling

artículo científico publicado en 2012

The D2 period of collagen II contains a specific binding site for the human discoidin domain receptor, DDR2

artículo científico publicado en 2004

The binding capacity of α1β1-, α2β1- and α10β1-integrins depends on non-collagenous surface macromolecules rather than the collagens in cartilage fibrils.

artículo científico publicado en 2017

The discoidin domain receptor DDR2 is a receptor for type X collagen

artículo científico publicado en 2006

The involvement of lipid rafts in the regulation of integrin function

artículo científico publicado en 2002

Trafficking defects and loss of ligand binding are the underlying causes of all reported DDR2 missense mutations found in SMED-SL patients

artículo científico publicado en 2010

Transmembrane Collagen Receptors ⬇️

artículo científico publicado el 13 de mayo de 2011

Two-step release of kinase autoinhibition in discoidin domain receptor 1

scientific article published on 24 August 2020

Lista de obras de

A novel form of integrin dysfunction involving beta1, beta2, and beta3 integrins

A novel mutation in DDR2 causing spondylo-meta-epiphyseal dysplasia with short limbs and abnormal calcifications (SMED-SL) results in defective intra-cellular trafficking

A transmembrane leucine zipper is required for activation of the dimeric receptor tyrosine kinase DDR1.

ADAM10 controls collagen signaling and cell migration on collagen by shedding the ectodomain of discoidin domain receptor 1 (DDR1).

Cell-collagen interactions: the use of peptide Toolkits to investigate collagen-receptor interactions.

Chain alignment of collagen I deciphered using computationally designed heterotrimers

Characterization of high affinity binding motifs for the discoidin domain receptor DDR2 in collagen

Collagen binding specificity of the discoidin domain receptors: binding sites on collagens II and III and molecular determinants for collagen IV recognition by DDR1 ⬇️

Collagen induces activation of DDR1 through lateral dimer association and phosphorylation between dimers

Collective cell migration requires suppression of actomyosin at cell-cell contacts mediated by DDR1 and the cell polarity regulators Par3 and Par6.

Coupling of a specific photoreactive triple-helical peptide to crosslinked collagen films restores binding and activation of DDR2 and VWF

Crystallographic insight into collagen recognition by discoidin domain receptor 2

DDR1 autophosphorylation is a result of aggregation into dense clusters

Discoidin domain receptor 1 controls linear invadosome formation via a Cdc42-Tuba pathway

Discoidin domain receptor 1 kinase activity is required for regulating collagen IV synthesis

Discoidin domain receptor functions in physiological and pathological conditions

Discoidin domain receptor tyrosine kinases: new players in cancer progression ⬇️

Discoidin domain receptors promote α1β1- and α2β1-integrin mediated cell adhesion to collagen by enhancing integrin activation

Discoidin domain receptors: multitaskers for physiological and pathological processes

Extracellular matrix component signaling in cancer

Inhibition of collagen receptor discoidin domain receptor-1 (DDR1) reduces cell survival, homing, and colonization in lung cancer bone metastasis.

Interaction of Discoidin Domain Receptor 1 with a 14-3-3-Beclin-1-Akt1 Complex Modulates Glioblastoma Therapy Sensitivity

LFA-1-induced T cell migration on ICAM-1 involves regulation of MLCK-mediated attachment and ROCK-dependent detachment

Loss of E-cadherin provides tolerance to centrosome amplification in epithelial cancer cells.

Mammalian collagen receptors

Mechanisms contributing to the activity of integrins on leukocytes

Meeting report - first discoidin domain receptors meeting

Molecular analysis of collagen binding by the human discoidin domain receptors, DDR1 and DDR2. Identification of collagen binding sites in DDR2.

Multi-organ Site Metastatic Reactivation Mediated by Non-canonical Discoidin Domain Receptor 1 Signaling

Normal activation of discoidin domain receptor 1 mutants with disulfide cross-links, insertions, or deletions in the extracellular juxtamembrane region: mechanistic implications

Phosphoproteomics of collagen receptor networks reveals SHP-2 phosphorylation downstream of wild-type DDR2 and its lung cancer mutants

Recombinant Collagen Engineered to Bind to Discoidin Domain Receptor Functions as a Receptor Inhibitor

Structure of the Discoidin Domain Receptor 1 Extracellular Region Bound to an Inhibitory Fab Fragment Reveals Features Important for Signaling

The D2 period of collagen II contains a specific binding site for the human discoidin domain receptor, DDR2

The binding capacity of α1β1-, α2β1- and α10β1-integrins depends on non-collagenous surface macromolecules rather than the collagens in cartilage fibrils.

The discoidin domain receptor DDR2 is a receptor for type X collagen

The involvement of lipid rafts in the regulation of integrin function

Trafficking defects and loss of ligand binding are the underlying causes of all reported DDR2 missense mutations found in SMED-SL patients

Transmembrane Collagen Receptors ⬇️

Two-step release of kinase autoinhibition in discoidin domain receptor 1