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(Mu-1,2-peroxo)diiron(III/III) complex as a precursor to the diiron(III/IV) intermediate X in the assembly of the iron-radical cofactor of ribonucleotide reductase from mouse

artículo científico publicado en 2007

2'-Deoxy-2'-methylenecytidine and 2'-deoxy-2',2'-difluorocytidine 5'-diphosphates: potent mechanism-based inhibitors of ribonucleotide reductase

scientific article published on 01 June 1991

A 2.8 Å Fe-Fe separation in the Fe2(III/IV) intermediate, X, from Escherichia coli ribonucleotide reductase

artículo científico publicado en 2013

A New Microbial Pathway for Organophosphonate Degradation Catalyzed by Two Previously Misannotated Non-Heme-Iron Oxygenases

scientific article published on 07 March 2019

A coupled dinuclear iron cluster that is perturbed by substrate binding in myo-inositol oxygenase

artículo científico publicado en 2006

A long-lived, substrate-hydroxylating peroxodiiron(III/III) intermediate in the amine oxygenase, AurF, from Streptomyces thioluteus ⬇️

scientific article published on September 2009

A manganese(IV)/iron(III) cofactor in Chlamydia trachomatis ribonucleotide reductase

artículo científico publicado en 2007

A manganese(IV)/iron(IV) intermediate in assembly of the manganese(IV)/iron(III) cofactor of Chlamydia trachomatis ribonucleotide reductase

artículo científico publicado en 2007

A model for the role of multiple cysteine residues involved in ribonucleotide reduction: amazing and still confusing

artículo científico publicado el 13 de octubre de 1992

A peroxodiiron(III) intermediate mediating both N-hydroxylation steps in biosynthesis of the N-nitrosourea pharmacophore of streptozotocin by SznF

artículo científico publicado en 2020

Addition of oxygen to the diiron(II/II) cluster is the slowest step in formation of the tyrosyl radical in the W103Y variant of ribonucleotide reductase protein R2 from mouse

artículo científico publicado en 2007

Assembly of the unusual oxacycles in the orthosomycin antibiotics

artículo científico publicado en 2015

AurF from Streptomyces thioluteus and a possible new family of manganese/iron oxygenases

artículo científico publicado en 2007

Biochemistry. Electron relay in proteins

artículo científico publicado en 2008

Biochemistry. Remote enzyme microsurgery

artículo científico publicado en 2010

Branched Intermediate Formation Is the Slowest Step in the Protein Splicing Reaction of the Ala1 KlbA Intein from Methanococcus jannaschii ⬇️

artículo científico publicado el 16 de noviembre de 2011

Branched activation- and catalysis-specific pathways for electron relay to the manganese/iron cofactor in ribonucleotide reductase from Chlamydia trachomatis

scientific article published on 26 July 2008

CD and MCD of CytC3 and taurine dioxygenase: role of the facial triad in alpha-KG-dependent oxygenases

artículo científico publicado en 2007

Cation mediation of radical transfer between Trp48 and Tyr356 during O2 activation by protein R2 of Escherichia coli ribonucleotide reductase: relevance to R1-R2 radical transfer in nucleotide reduction?

artículo científico publicado en 2006

Characterization of NO adducts of the diiron center in protein R2 of Escherichia coli ribonucleotide reductase and site-directed variants; implications for the O2 activation mechanism.

artículo científico publicado en 2004

Circular Dichroism and Magnetic Circular Dichroism Studies of the Fully Reduced Binuclear Non-Heme Iron Active Site in the Escherichia coli R2 Subunit of Ribonucleoside Diphosphate Reductase

artículo científico publicado en 1995

Circular dichroism, magnetic circular dichroism, and variable temperature variable field magnetic circular dichroism studies of biferrous and mixed-valent myo-inositol oxygenase: insights into substrate activation of O2 reactivity

artículo científico publicado en 2013

Conversion of fatty aldehydes to alka(e)nes and formate by a cyanobacterial aldehyde decarbonylase: cryptic redox by an unusual dimetal oxygenase

artículo científico publicado en 2011

Cryoreduction of the NO-adduct of taurine:alpha-ketoglutarate dioxygenase (TauD) yields an elusive {FeNO}(8) species

artículo científico publicado en 2010

Cyanobacterial alkane biosynthesis further expands the catalytic repertoire of the ferritin-like 'di-iron-carboxylate' proteins

artículo científico publicado en 2011

Demonstration by 2H ENDOR spectroscopy that myo-inositol binds via an alkoxide bridge to the mixed-valent diiron center of myo-inositol oxygenase

artículo científico publicado en 2006

Detection of formate, rather than carbon monoxide, as the stoichiometric coproduct in conversion of fatty aldehydes to alkanes by a cyanobacterial aldehyde decarbonylase

artículo científico publicado en 2011

Direct Measurement of the Radical Translocation Distance in the Class I Ribonucleotide Reductase from Chlamydia trachomatis.

artículo científico publicado en 2015

Direct nitration and azidation of aliphatic carbons by an iron-dependent halogenase

artículo científico publicado en 2014

Direct spectroscopic detection of a C-H-cleaving high-spin Fe(IV) complex in a prolyl-4-hydroxylase

artículo científico publicado en 2006

Direct spectroscopic evidence for a high-spin Fe(IV) intermediate in tyrosine hydroxylase

artículo científico publicado en 2007

EXAFS spectroscopic evidence for an Fe=O unit in the Fe(IV) intermediate observed during oxygen activation by taurine:alpha-ketoglutarate dioxygenase

artículo científico publicado en 2004

Efficient delivery of long-chain fatty aldehydes from the Nostoc punctiforme acyl-acyl carrier protein reductase to its cognate aldehyde-deformylating oxygenase

artículo científico publicado en 2015

Electronic Structure of the Ferryl Intermediate in the α-Ketoglutarate Dependent Non-Heme Iron Halogenase SyrB2: Contributions to H Atom Abstraction Reactivity

artículo científico publicado en 2016

Electronic and spectroscopic studies of the non-heme reduced binuclear iron sites of two ribonucleotide reductase variants: comparison to reduced methane monooxygenase and contributions to O2 reactivity

artículo científico publicado en 2004

Electronic structure analysis of the oxygen-activation mechanism by Fe(II)- and α-ketoglutarate (αKG)-dependent dioxygenases

artículo científico publicado en 2012

Elucidation of the Fe(IV)=O intermediate in the catalytic cycle of the halogenase SyrB2.

artículo científico publicado en 2013

Enzymatic C–H activation by metal–superoxo intermediates

Evidence That the β Subunit of Chlamydia trachomatis Ribonucleotide Reductase Is Active with the Manganese Ion of Its Manganese(IV)/Iron(III) Cofactor in Site 1

artículo científico publicado en 2012

Evidence for C-H cleavage by an iron-superoxide complex in the glycol cleavage reaction catalyzed by myo-inositol oxygenase

artículo científico publicado en 2006

Evidence for Modulation of Oxygen Rebound Rate in Control of Outcome by Iron(II)- and 2-Oxoglutarate-Dependent Oxygenases

scientific article published on 16 September 2019

Evidence for a Di-μ-oxo Diamond Core in the Mn(IV)/Fe(IV) Activation Intermediate of Ribonucleotide Reductase from Chlamydia trachomatis.

artículo científico publicado en 2017

Evidence for a high-spin Fe(IV) species in the catalytic cycle of a bacterial phenylalanine hydroxylase

artículo científico publicado en 2011

Evidence for hydrogen abstraction from C1 of taurine by the high-spin Fe(IV) intermediate detected during oxygen activation by taurine:alpha-ketoglutarate dioxygenase (TauD).

artículo científico publicado en 2003

Evidence for only oxygenative cleavage of aldehydes to alk(a/e)nes and formate by cyanobacterial aldehyde decarbonylases

artículo científico publicado en 2012

Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen

artículo científico publicado en 2010

Evidence that the fosfomycin-producing epoxidase, HppE, is a non-heme-iron peroxidase

artículo científico publicado en 2013

Exchange coupling constant J of peroxodiferric reaction intermediates determined by Mössbauer spectroscopy

artículo científico publicado en 2002

Experimental Correlation of Substrate Position with Reaction Outcome in the Aliphatic Halogenase, SyrB2.

artículo científico publicado en 2015

Facile electron transfer during formation of cluster X and kinetic competence of X for tyrosyl radical production in protein R2 of ribonucleotide reductase from mouse

artículo científico publicado en 2002

Fe-S cofactors in the SARS-CoV-2 RNA-dependent RNA polymerase are potential antiviral targets

artículo científico publicado en 2021

Flavin redox chemistry precedes substrate chlorination during the reaction of the flavin-dependent halogenase RebH.

artículo científico publicado en 2006

Formation and function of the Manganese(IV)/Iron(III) cofactor in Chlamydia trachomatis ribonucleotide reductase

scientific article published on December 2008

Four-electron oxidation of p-hydroxylaminobenzoate to p-nitrobenzoate by a peroxodiferric complex in AurF from Streptomyces thioluteus

artículo científico publicado en 2010

Freeze-quench (57)Fe-Mössbauer spectroscopy: trapping reactive intermediates

artículo científico publicado en 2009

Frontiers in enzymatic C–H-bond activation

scientific article published on 01 February 2009

Function of the diiron cluster of Escherichia coli class Ia ribonucleotide reductase in proton-coupled electron transfer

scientific article published on 31 May 2013

Geometric and electronic structure of the Mn(IV)Fe(III) cofactor in class Ic ribonucleotide reductase: correlation to the class Ia binuclear non-heme iron enzyme

artículo científico publicado en 2013

Getting the metal right

scientific article published in Nature

Heme biosynthesis depends on previously unrecognized acquisition of iron-sulfur cofactors in human amino-levulinic acid dehydratase

artículo científico publicado en 2020

High-resolution iron X-ray absorption spectroscopic and computational studies of non-heme diiron peroxo intermediates

scientific article published on 22 October 2019

Hydrogen Donation but not Abstraction by a Tyrosine (Y68) during Endoperoxide Installation by Verruculogen Synthase (FtmOx1)

artículo científico publicado en 2019

Installation of the Ether Bridge of Lolines by the Iron- and 2-Oxoglutarate-Dependent Oxygenase, LolO: Regio- and Stereochemistry of Sequential Hydroxylation and Oxacyclization Reactions.

artículo científico publicado en 2018

Interaction of C225SR1 mutant subunit of ribonucleotide reductase with R2 and nucleoside diphosphates: tales of a suicidal enzyme

artículo científico publicado el 13 de octubre de 1992

Kinetic analysis of cysteine desulfurase CD0387 from Synechocystis sp. PCC 6803: formation of the persulfide intermediate

artículo científico publicado en 2009

Kinetic and structural characterization of Slr0077/SufS, the essential cysteine desulfurase from Synechocystis sp. PCC 6803.

artículo científico publicado en 2004

Kinetic dissection of the catalytic mechanism of taurine:alpha-ketoglutarate dioxygenase (TauD) from Escherichia coli

artículo científico publicado en 2005

Kinetic mechanism of ornithine hydroxylase (PvdA) from Pseudomonas aeruginosa: substrate triggering of O2 addition but not flavin reduction

artículo científico publicado en 2009

Mechanism of Rapid Electron Transfer during Oxygen Activation in the R2 Subunit ofEscherichiacoliRibonucleotide Reductase. 1. Evidence for a Transient Tryptophan Radical

article

Mechanism of Rapid Electron Transfer during Oxygen Activation in the R2 Subunit ofEscherichiacoliRibonucleotide Reductase. 2. Evidence for and Consequences of Blocked Electron Transfer in the W48F Variant

article

Mechanism of Taurine: α-Ketoglutarate Dioxygenase (TauD) fromEscherichia coli

article

Mechanism of cysteine desulfurase Slr0387 from Synechocystis sp. PCC 6803: kinetic analysis of cleavage of the persulfide intermediate by chemical reductants

artículo científico publicado en 2004

Mechanism of the C5 Stereoinversion Reaction in the Biosynthesis of Carbapenem Antibiotics

artículo científico publicado en 2014

Mechanism-based inhibition of a mutant Escherichia coli ribonucleotide reductase (cysteine-225----serine) by its substrate CDP.

artículo científico publicado en 1989

Mediation by indole analogues of electron transfer during oxygen activation in variants of Escherichia coli ribonucleotide reductase R2 lacking the electron-shuttling tryptophan 48.

artículo científico publicado en 2004

Metal-free class Ie ribonucleotide reductase from pathogens initiates catalysis with a tyrosine-derived dihydroxyphenylalanine radical

article published in the Proceedings of the National Academy of Sciences of the United States of America

Molecular basis for enantioselective herbicide degradation imparted by aryloxyalkanoate dioxygenases in transgenic plants

artículo científico publicado en 2019

Nature of the peroxo intermediate of the W48F/D84E ribonucleotide reductase variant: implications for O2 activation by binuclear non-heme iron enzymes

artículo científico publicado en 2004

Non-heme Fe(IV)-oxo intermediates

artículo científico publicado en 2007

Novel Approaches for the Accumulation of Oxygenated Intermediates to Multi-Millimolar Concentrations

artículo científico publicado en 2013

Nuclear Resonance Vibrational Spectroscopic Definition of the Facial Triad FeIV═O Intermediate in Taurine Dioxygenase: Evaluation of Structural Contributions to Hydrogen Atom Abstraction

artículo científico publicado en 2020

O(2)-evolving chlorite dismutase as a tool for studying O(2)-utilizing enzymes.

artículo científico publicado en 2012

O-H Activation by an Unexpected Ferryl Intermediate during Catalysis by 2-Hydroxyethylphosphonate Dioxygenase

artículo científico publicado en 2017

Organophosphonate-degrading PhnZ reveals an emerging family of HD domain mixed-valent diiron oxygenases

artículo científico publicado en 2013

Oxygen activation by a mixed-valent, diiron(II/III) cluster in the glycol cleavage reaction catalyzed by myo-inositol oxygenase

artículo científico publicado en 2006

Peroxide Activation for Electrophilic Reactivity by the Binuclear Non-heme Iron Enzyme AurF.

artículo científico publicado en 2017

Radical-translocation intermediates and hurdling of pathway defects in "super-oxidized" (Mn(IV)/Fe(IV)) Chlamydia trachomatis ribonucleotide reductase.

artículo científico publicado en 2012

Rapid Reduction of the Diferric-Peroxyhemiacetal Intermediate in Aldehyde-Deformylating Oxygenase by a Cyanobacterial Ferredoxin: Evidence for a Free-Radical Mechanism

artículo científico publicado en 2015

Rapid and quantitative activation of Chlamydia trachomatis ribonucleotide reductase by hydrogen peroxide

artículo científico publicado en 2008

Rapid freeze-quench 57Fe Mössbauer spectroscopy: monitoring changes of an iron-containing active site during a biochemical reaction

artículo científico publicado en 2005

Rapid-freeze-quench magnetic circular dichroism of intermediate X in ribonucleotide reductase: new structural insight

artículo científico publicado en 2003

Rational reprogramming of the R2 subunit of Escherichia coli ribonucleotide reductase into a self-hydroxylating monooxygenase.

artículo científico publicado en 2001

Spectroscopic Evidence for the Two C-H-Cleaving Intermediates of Aspergillus nidulans Isopenicillin N Synthase

artículo científico publicado en 2016

Spectroscopic and computational evaluation of the structure of the high-spin Fe(IV)-oxo intermediates in taurine: alpha-ketoglutarate dioxygenase from Escherichia coli and its His99Ala ligand variant

artículo científico publicado en 2007

Spectroscopic and electronic structure studies of intermediate X in ribonucleotide reductase R2 and two variants: a description of the FeIV-oxo bond in the FeIII-O-FeIV dimer

artículo científico publicado en 2007

Spectroscopic evidence for a high-spin Br-Fe(IV)-oxo intermediate in the alpha-ketoglutarate-dependent halogenase CytC3 from Streptomyces

artículo científico publicado en 2007

Stalking intermediates in oxygen activation by iron enzymes: motivation and method

artículo científico publicado en 2006

Steric Enforcement of cis-Epoxide Formation in the Radical C-O-Coupling Reaction by Which (S)-2-Hydroxypropylphosphonate Epoxidase (HppE) Produces Fosfomycin

scientific article published on 11 December 2019

Structural Basis for Assembly of the Mn IV /Fe III Cofactor in the Class Ic Ribonucleotide Reductase from Chlamydia trachomatis

artículo científico publicado en 2013

Structural Basis for Superoxide Activation of Flavobacterium johnsoniae Class I Ribonucleotide Reductase and for Radical Initiation by its Dimanganese Cofactor.

artículo científico publicado en 2018

Structural analysis of the Mn(IV)/Fe(III) cofactor of Chlamydia trachomatis ribonucleotide reductase by extended X-ray absorption fine structure spectroscopy and density functional theory calculations

artículo científico publicado en 2008

Structural characterization of the peroxodiiron(III) intermediate generated during oxygen activation by the W48A/D84E variant of ribonucleotide reductase protein R2 from Escherichia coli

artículo científico publicado en 2003

Structure of Escherichia coli ribonucleotide reductase R2 in space group P6122.

artículo científico publicado en 2005

Structure of a Ferryl Mimic in the Archetypal Iron(II)- and 2-(Oxo)-glutarate-Dependent Dioxygenase, TauD

artículo científico publicado en 2019

Substrate activation by iron superoxo intermediates

artículo científico publicado en 2010

Substrate positioning controls the partition between halogenation and hydroxylation in the aliphatic halogenase, SyrB2.

artículo científico publicado en 2009

Substrate-Triggered Formation of a Peroxo-Fe2(III/III) Intermediate during Fatty Acid Decarboxylation by UndA

scientific article published on 10 September 2019

Substrate-triggered addition of dioxygen to the diferrous cofactor of aldehyde-deformylating oxygenase to form a diferric-peroxide intermediate

artículo científico publicado en 2013

Substrate-triggered formation and remarkable stability of the C-H bond-cleaving chloroferryl intermediate in the aliphatic halogenase, SyrB2

artículo científico publicado en 2009

The active form of Chlamydia trachomatis ribonucleotide reductase R2 protein contains a heterodinuclear Mn(IV)/Fe(III) cluster with S = 1 ground state

scientific article published on 27 May 2007

The biosynthesis of methanobactin.

artículo científico publicado en 2018

The first direct characterization of a high-valent iron intermediate in the reaction of an alpha-ketoglutarate-dependent dioxygenase: a high-spin FeIV complex in taurine/alpha-ketoglutarate dioxygenase (TauD) from Escherichia coli

artículo científico publicado en 2003

The manganese(IV)/iron(III) cofactor of Chlamydia trachomatis ribonucleotide reductase: structure, assembly, radical initiation, and evolution

artículo científico publicado en 2008

The nonribosomal peptide synthetase enzyme DdaD tethers N(β)-fumaramoyl-l-2,3-diaminopropionate for Fe(II)/α-ketoglutarate-dependent epoxidation by DdaC during dapdiamide antibiotic biosynthesis.

artículo científico publicado en 2010

Two Distinct Mechanisms for C-C Desaturation by Iron(II)- and 2-(Oxo)glutarate-Dependent Oxygenases: Importance of α-Heteroatom Assistance

scientific article published on 04 June 2018

Two distinct mechanisms of inactivation of the class Ic ribonucleotide reductase from Chlamydia trachomatis by hydroxyurea: implications for the protein gating of intersubunit electron transfer

artículo científico publicado en 2010

Two interconverting Fe(IV) intermediates in aliphatic chlorination by the halogenase CytC3

Two-Color Valence-to-Core X-ray Emission Spectroscopy Tracks Cofactor Protonation State in a Class I Ribonucleotide Reductase

artículo científico publicado en 2018

Use of a chemical trigger for electron transfer to characterize a precursor to cluster X in assembly of the iron-radical cofactor of Escherichia coli ribonucleotide reductase

artículo científico publicado en 2004

Vanadyl as a Stable Structural Mimic of Reactive Ferryl Intermediates in Mononuclear Nonheme-Iron Enzymes.

artículo científico publicado en 2017

Variable coordination geometries at the diiron(II) active site of ribonucleotide reductase R2

artículo científico publicado en 2003

Visualizing the Reaction Cycle in an Iron(II)- and 2-(Oxo)-glutarate-Dependent Hydroxylase

artículo científico publicado en 2017

myo-Inositol oxygenase: a radical new pathway for O(2) and C-H activation at a nonheme diiron cluster

artículo científico publicado en 2009

α-Amine Desaturation of d-Arginine by the Iron(II)- and 2-(Oxo)glutarate-Dependent l-Arginine 3-Hydroxylase, VioC

artículo científico publicado en 2018

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