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ALK2 inhibitors display beneficial effects in preclinical models of mutant diffuse intrinsic pontine glioma

article

BTB domain mutations perturbing KCTD15 oligomerisation cause a distinctive frontonasal dysplasia syndrome

artículo científico publicado en 2024

CIS is a potent checkpoint in NK cell-mediated tumor immunity

artículo científico publicado en 2016

Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors

scientific article published on 29 August 2016

Development of Macrocycle Kinase Inhibitors for ALK2 Using Fibrodysplasia Ossificans Progressiva-Derived Endothelial Cells

scientific article published on 07 October 2019

Fostering open collaboration in drug development for paediatric brain tumours

scientific article published on 01 October 2019

Lessons from LIMK1 enzymology and their impact on inhibitor design

artículo científico publicado en 2019

Still in Search for an EAAT Activator: GT949 Does Not Activate EAAT2, nor EAAT3 in Impedance and Radioligand Uptake Assays

artículo científico publicado en 2024

Structural Basis for Recruitment of DAPK1 to the KLHL20 E3 Ligase

artículo científico publicado en 2019

Structural basis for the potent and selective binding of LDN-212854 to the BMP receptor kinase ALK2.

artículo científico publicado en 2017

Targeted protein degradation: expanding the toolbox

scientific article published on 30 October 2019

The DUF1669 domain of FAM83 family proteins anchor casein kinase 1 isoforms.

artículo científico publicado en 2018

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