Lista de obras -

A Systematic Protein Turnover Map for Decoding Protein Degradation

artículo científico publicado en 2020

A lipid E-MAP identifies Ubx2 as a critical regulator of lipid saturation and lipid bilayer stress

scientific article published on 25 July 2013

A neurodegenerative disease mutation that accelerates the clearance of apoptotic cells

artículo científico publicado en 2011

A new way to look at fat

artículo científico publicado en 2011

ACAT2 deficiency limits cholesterol absorption in the cholesterol-fed mouse: impact on hepatic cholesterol homeostasis

artículo científico publicado en 2004

Activation of protein kinase C-zeta by insulin and phosphatidylinositol-3,4,5-(PO4)3 is defective in muscle in type 2 diabetes and impaired glucose tolerance: amelioration by rosiglitazone and exercise

artículo científico publicado en 2003

Activation of the ERK pathway and atypical protein kinase C isoforms in exercise- and aminoimidazole-4-carboxamide-1-beta-D-riboside (AICAR)-stimulated glucose transport

artículo científico publicado en 2002

An 8-week, open-label, dose-finding study of nimodipine for the treatment of progranulin insufficiency from GRN gene mutations

artículo científico publicado en 2017

An open-access volume electron microscopy atlas of whole cells and tissues

artículo científico publicado en 2021

Analysis of energy expenditure at different ambient temperatures in mice lacking DGAT1.

artículo científico publicado en 2002

Angiopoietin-like 4 (ANGPTL4, fasting-induced adipose factor) is a direct glucocorticoid receptor target and participates in glucocorticoid-regulated triglyceride metabolism

artículo científico publicado en 2009

Arf1/COPI machinery acts directly on lipid droplets and enables their connection to the ER for protein targeting.

scientific article published on 04 February 2014

Atypical PKC, PKCλ/ι, activates β-secretase and increases Aβ1-40/42 and phospho-tau in mouse brain and isolated neuronal cells, and may link hyperinsulinemia and other aPKC activators to development of pathological and memory abnormalities in Alzhei

artículo científico publicado en 2017

Atypical PKC: therapeutic target for Alzheimer's?

Balancing the fat: lipid droplets and human disease ⬇️

artículo científico publicado el 6 de junio de 2013

Cbl PYXXM motifs activate the P85 subunit of phosphatidylinositol 3-kinase, Crk, atypical protein kinase C, and glucose transport during thiazolidinedione action in 3T3/L1 and human adipocytes

artículo científico publicado en 2003

Cbl, IRS-1, and IRS-2 mediate effects of rosiglitazone on PI3K, PKC-lambda, and glucose transport in 3T3/L1 adipocytes

artículo científico publicado en 2002

Cryo-electron microscopy structure of the lipid droplet-formation protein seipin

artículo científico publicado en 2018

DGAT1 is not essential for intestinal triacylglycerol absorption or chylomicron synthesis

artículo científico publicado en 2002

Defective Activation of Protein Kinase C-z in Muscle by Insulin and Phosphatidylinositol-3,4,5,-(PO(4))(3) in Obesity and Polycystic Ovary Syndrome

artículo científico publicado en 2004

Defective activation of atypical protein kinase C zeta and lambda by insulin and phosphatidylinositol-3,4,5-(PO4)(3) in skeletal muscle of rats following high-fat feeding and streptozotocin-induced diabetes

artículo científico publicado en 2003

Deficiency of acyl CoA:cholesterol acyltransferase 2 prevents atherosclerosis in apolipoprotein E-deficient mice

artículo científico publicado en 2003

Deficiency of acyl coenzyme a:diacylglycerol acyltransferase 1 increases leptin sensitivity in murine obesity models

artículo científico publicado en 2002

Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice ⬇️

artículo científico publicado el 1 de enero de 2012

Deletion of Protein Kinase C λ in POMC Neurons Predisposes to Diet-Induced Obesity

artículo científico publicado en 2017

Determinants of Endoplasmic Reticulum-to-Lipid Droplet Protein Targeting

artículo científico publicado en 2020

Determination of adipocyte size by computer image analysis.

artículo científico publicado en 2002

Development of the mammary gland requires DGAT1 expression in stromal and epithelial tissues

artículo científico publicado en 2004

Differential effect of bicycling exercise intensity on activity and phosphorylation of atypical protein kinase C and extracellular signal-regulated protein kinase in skeletal muscle

article

Dissociation of frontotemporal dementia-related deficits and neuroinflammation in progranulin haploinsufficient mice

artículo científico publicado en 2013

Dissociation of obesity and impaired glucose disposal in mice overexpressing acyl coenzyme a:diacylglycerol acyltransferase 1 in white adipose tissue

artículo científico publicado en 2002

Downregulation of microRNA-9 in iPSC-derived neurons of FTD/ALS patients with TDP-43 mutations.

artículo científico publicado en 2013

Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD

artículo científico publicado en 2014

Exercise improves phosphatidylinositol-3,4,5-trisphosphate responsiveness of atypical protein kinase C and interacts with insulin signalling to peptide elongation in human skeletal muscle

article

FIT2 is an acyl-coenzyme A diphosphatase crucial for endoplasmic reticulum homeostasis

scientific article published on 01 October 2020

Fat breakdown: a function for CGI-58 (ABHD5) provides a new piece of the puzzle

artículo científico publicado en 2006

FoxO1 regulates multiple metabolic pathways in the liver: effects on gluconeogenic, glycolytic, and lipogenic gene expression

artículo científico publicado en 2006

Frontotemporal degeneration, the next therapeutic frontier: molecules and animal models for frontotemporal degeneration drug development

artículo científico

Functional Contribution of the Spastic Paraplegia-Related Triglyceride Hydrolase DDHD2 to the Formation and Content of Lipid Droplets.

artículo científico publicado en 2017

Functional genomic analyses identify pathways dysregulated by progranulin deficiency, implicating Wnt signaling

artículo científico publicado en 2011

Global Analyses of Selective Insulin Resistance in Hepatocytes due to Palmitate Lipotoxicity

artículo científico publicado en 2018

Hepatocyte Deletion of Triglyceride-Synthesis Enzyme Acyl CoA: Diacylglycerol Acyltransferase 2 Reduces Steatosis Without Increasing Inflammation or Fibrosis in Mice

scientific article published on 26 June 2019

High confidence proteomic analysis of yeast LDs identifies additional droplet proteins and reveals connections to dolichol synthesis and sterol acetylation.

artículo científico publicado en 2014

Identification and characterization of a novel DGAT1 missense mutation associated with congenital diarrhea

artículo científico publicado en 2017

Identification of a gene encoding MGAT1, a monoacylglycerol acyltransferase

artículo científico publicado en 2002

Increased atypical PKC activity in endurance-trained human skeletal muscle

article

Increased insulin and leptin sensitivity in mice lacking acyl CoA:diacylglycerol acyltransferase 1.

artículo científico publicado en 2002

Induced Pluripotent Stem Cell Models of Progranulin-Deficient Frontotemporal Dementia Uncover Specific Reversible Neuronal Defects ⬇️

artículo científico publicado el 11 de octubre de 2012

Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models

artículo científico publicado en 2012

Inhibition of sphingolipid synthesis improves outcomes and survival in GARP mutant wobbler mice, a model of motor neuron degeneration

scientific article published on 28 April 2020

Insulin-induced activation of atypical protein kinase C, but not protein kinase B, is maintained in diabetic (ob/ob and Goto-Kakazaki) liver. Contrasting insulin signaling patterns in liver versus muscle define phenotypes of type 2 diabetic and high

artículo científico publicado en 2004

LDAF1 and Seipin Form a Lipid Droplet Assembly Complex

scientific article published on 07 November 2019

Leptin modulates the effects of acyl CoA:diacylglycerol acyltransferase deficiency on murine fur and sebaceous glands

artículo científico publicado en 2002

Lipid Droplet Biogenesis.

artículo científico publicado en 2017

Lipid Droplets in Brown Adipose Tissue Are Dispensable for Cold-Induced Thermogenesis

artículo científico publicado en 2020

Lipid droplets and liver disease: from basic biology to clinical implications.

artículo científico publicado en 2017

Lipid droplets at a glance

artículo científico publicado en 2009

Lipid droplets finally get a little R-E-S-P-E-C-T.

artículo científico publicado en 2009

Lipid droplets go nuclear

artículo científico publicado en 2016

Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment

scientific article published on 04 December 2018

Mechanism and Determinants of Amphipathic Helix-Containing Protein Targeting to Lipid Droplets

artículo científico publicado en 2018

Membrane topology and identification of key functional amino acid residues of murine acyl-CoA:diacylglycerol acyltransferase-2.

artículo científico publicado en 2006

Mice lacking lipid droplet-associated hydrolase, a gene linked to human prostate cancer, have normal cholesterol ester metabolism

artículo científico publicado en 2016

MicroRNA-29b regulates the expression level of human progranulin, a secreted glycoprotein implicated in frontotemporal dementia

artículo científico publicado en 2010

Mogat1 deletion does not ameliorate hepatic steatosis in lipodystrophic (Agpat2-/-) or obese (ob/ob) mice

artículo científico publicado en 2016

Murine knockin model for progranulin-deficient frontotemporal dementia with nonsense-mediated mRNA decay

artículo científico publicado en 2018

Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency

scientific article published on 31 August 2020

Obesity resistance and enhanced glucose metabolism in mice transplanted with white adipose tissue lacking acyl CoA:diacylglycerol acyltransferase 1

artículo científico publicado en 2003

Partitioning of MLX-Family Transcription Factors to Lipid Droplets Regulates Metabolic Gene Expression

artículo científico publicado en 2020

Phosphatidylcholine Synthesis for Lipid Droplet Expansion Is Mediated by Localized Activation of CTP:Phosphocholine Cytidylyltransferase ⬇️

artículo científico publicado el 5 de octubre de 2011

Plasma cholesteryl esters provided by lecithin:cholesterol acyltransferase and acyl-coenzyme a:cholesterol acyltransferase 2 have opposite atherosclerotic potential

artículo científico publicado en 2004

Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids

artículo científico publicado en 2019

Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation

artículo científico publicado en 2016

Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury

artículo científico publicado en 2012

Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells

artículo científico publicado en 2013

Progranulin in the hematopoietic compartment protects mice from atherosclerosis

scientific article published on 30 August 2018

Protein Correlation Profiles Identify Lipid Droplet Proteins with High Confidence ⬇️

artículo científico publicado el 14 de enero de 2013

Protein Crowding Is a Determinant of Lipid Droplet Protein Composition

artículo científico publicado en 2015

Protein Kinase C-λ Knockout in Embryonic Stem Cells and Adipocytes Impairs Insulin-Stimulated Glucose Transport ⬇️

artículo científico publicado el 13 de noviembre de 2003

Proteomic and phosphoproteomic analyses of yeast reveal the global cellular response to sphingolipid depletion.

artículo científico

Rab18 is not necessary for lipid droplet biogenesis or turnover in human mammary carcinoma cells

artículo científico publicado en 2018

Repletion of atypical protein kinase C following RNA interference-mediated depletion restores insulin-stimulated glucose transport

artículo científico publicado en 2006

Retinol Esterification by DGAT1 Is Essential for Retinoid Homeostasis in Murine Skin

artículo científico publicado en 2008

Role of adipocyte-derived factors in enhancing insulin signaling in skeletal muscle and white adipose tissue of mice lacking Acyl CoA:diacylglycerol acyltransferase 1.

artículo científico publicado en 2004

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

artículo científico publicado en 2010

Secreted progranulin is a homodimer and is not a component of high density lipoproteins (HDL)

artículo científico publicado en 2013

Seipin is required for converting nascent to mature lipid droplets

artículo científico publicado en 2016

Seipin transmembrane segments critically function in triglyceride nucleation and lipid droplet budding from the membrane

artículo científico publicado en 2022

Short-term overexpression of DGAT1 or DGAT2 increases hepatic triglyceride but not VLDL triglyceride or apoB production

artículo científico publicado en 2006

Skeletal muscle insulin resistance in obesity-associated type 2 diabetes in monkeys is linked to a defect in insulin activation of protein kinase C-zeta/lambda/iota

artículo científico publicado en 2002

SnapShot: Lipid Droplets

artículo científico publicado en 2009

Structure and catalytic mechanism of a human triacylglycerol-synthesis enzyme

scientific article published on 13 May 2020

Suberoylanilide hydroxamic acid (vorinostat) up-regulates progranulin transcription: rational therapeutic approach to frontotemporal dementia

artículo científico publicado en 2011

Targeting Fat: Mechanisms of Protein Localization to Lipid Droplets

artículo científico publicado en 2016

The GARP complex is required for cellular sphingolipid homeostasis

artículo científico publicado en 2015

The Lipid Droplet Knowledge Portal: A resource for systematic analyses of lipid droplet biology

artículo científico publicado en 2022

The advantages of frontotemporal degeneration drug development (part 2 of frontotemporal degeneration: the next therapeutic frontier)

artículo científico publicado en 2013

The critical role of atypical protein kinase C in activating hepatic SREBP-1c and NFkappaB in obesity

artículo científico publicado en 2009

The life of lipid droplets

artículo científico publicado en 2009

The triacylglycerol synthesis enzyme DGAT1 also catalyzes the synthesis of diacylglycerols, waxes, and retinyl esters

artículo científico publicado en 2005

The triglyceride synthesis enzymes DGAT1 and DGAT2 have distinct and overlapping functions in adipocytes

scientific article published on 01 April 2019

Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis

artículo científico publicado en 2008

Tissue-specific differences in activation of atypical protein kinase C and protein kinase B in muscle, liver, and adipocytes of insulin receptor substrate-1 knockout mice

artículo científico publicado en 2004

Tissue-specific knockouts of ACAT2 reveal that intestinal depletion is sufficient to prevent diet-induced cholesterol accumulation in the liver and blood ⬇️

artículo científico publicado el 29 de marzo de 2012

Triacylglycerol synthesis enzymes mediate lipid droplet growth by relocalizing from the ER to lipid droplets.

artículo científico publicado en 2013

Triglyceride Synthesis by DGAT1 Protects Adipocytes from Lipid-Induced ER Stress during Lipolysis.

artículo científico publicado en 2017

Triglyceride accumulation protects against fatty acid-induced lipotoxicity

artículo científico publicado en 2003

Un-phased: Lipid Droplets Modulate the Bioavailability of Antibiotics

artículo científico publicado en 2019

Lista de obras de

A Systematic Protein Turnover Map for Decoding Protein Degradation

A lipid E-MAP identifies Ubx2 as a critical regulator of lipid saturation and lipid bilayer stress

A neurodegenerative disease mutation that accelerates the clearance of apoptotic cells

A new way to look at fat

ACAT2 deficiency limits cholesterol absorption in the cholesterol-fed mouse: impact on hepatic cholesterol homeostasis

Activation of protein kinase C-zeta by insulin and phosphatidylinositol-3,4,5-(PO4)3 is defective in muscle in type 2 diabetes and impaired glucose tolerance: amelioration by rosiglitazone and exercise

Activation of the ERK pathway and atypical protein kinase C isoforms in exercise- and aminoimidazole-4-carboxamide-1-beta-D-riboside (AICAR)-stimulated glucose transport

An 8-week, open-label, dose-finding study of nimodipine for the treatment of progranulin insufficiency from GRN gene mutations

An open-access volume electron microscopy atlas of whole cells and tissues

Analysis of energy expenditure at different ambient temperatures in mice lacking DGAT1.

Angiopoietin-like 4 (ANGPTL4, fasting-induced adipose factor) is a direct glucocorticoid receptor target and participates in glucocorticoid-regulated triglyceride metabolism

Arf1/COPI machinery acts directly on lipid droplets and enables their connection to the ER for protein targeting.

Atypical PKC, PKCλ/ι, activates β-secretase and increases Aβ1-40/42 and phospho-tau in mouse brain and isolated neuronal cells, and may link hyperinsulinemia and other aPKC activators to development of pathological and memory abnormalities in Alzhei

Atypical PKC: therapeutic target for Alzheimer's?

Balancing the fat: lipid droplets and human disease ⬇️

Cbl PYXXM motifs activate the P85 subunit of phosphatidylinositol 3-kinase, Crk, atypical protein kinase C, and glucose transport during thiazolidinedione action in 3T3/L1 and human adipocytes

Cbl, IRS-1, and IRS-2 mediate effects of rosiglitazone on PI3K, PKC-lambda, and glucose transport in 3T3/L1 adipocytes

Cryo-electron microscopy structure of the lipid droplet-formation protein seipin

DGAT1 is not essential for intestinal triacylglycerol absorption or chylomicron synthesis

Defective Activation of Protein Kinase C-z in Muscle by Insulin and Phosphatidylinositol-3,4,5,-(PO(4))(3) in Obesity and Polycystic Ovary Syndrome

Defective activation of atypical protein kinase C zeta and lambda by insulin and phosphatidylinositol-3,4,5-(PO4)(3) in skeletal muscle of rats following high-fat feeding and streptozotocin-induced diabetes

Deficiency of acyl CoA:cholesterol acyltransferase 2 prevents atherosclerosis in apolipoprotein E-deficient mice

Deficiency of acyl coenzyme a:diacylglycerol acyltransferase 1 increases leptin sensitivity in murine obesity models

Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice ⬇️

Deletion of Protein Kinase C λ in POMC Neurons Predisposes to Diet-Induced Obesity

Determinants of Endoplasmic Reticulum-to-Lipid Droplet Protein Targeting

Determination of adipocyte size by computer image analysis.

Development of the mammary gland requires DGAT1 expression in stromal and epithelial tissues

Differential effect of bicycling exercise intensity on activity and phosphorylation of atypical protein kinase C and extracellular signal-regulated protein kinase in skeletal muscle

Dissociation of frontotemporal dementia-related deficits and neuroinflammation in progranulin haploinsufficient mice

Dissociation of obesity and impaired glucose disposal in mice overexpressing acyl coenzyme a:diacylglycerol acyltransferase 1 in white adipose tissue

Downregulation of microRNA-9 in iPSC-derived neurons of FTD/ALS patients with TDP-43 mutations.

Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD

Exercise improves phosphatidylinositol-3,4,5-trisphosphate responsiveness of atypical protein kinase C and interacts with insulin signalling to peptide elongation in human skeletal muscle

FIT2 is an acyl-coenzyme A diphosphatase crucial for endoplasmic reticulum homeostasis

Fat breakdown: a function for CGI-58 (ABHD5) provides a new piece of the puzzle

FoxO1 regulates multiple metabolic pathways in the liver: effects on gluconeogenic, glycolytic, and lipogenic gene expression

Frontotemporal degeneration, the next therapeutic frontier: molecules and animal models for frontotemporal degeneration drug development

Functional Contribution of the Spastic Paraplegia-Related Triglyceride Hydrolase DDHD2 to the Formation and Content of Lipid Droplets.

Functional genomic analyses identify pathways dysregulated by progranulin deficiency, implicating Wnt signaling

Global Analyses of Selective Insulin Resistance in Hepatocytes due to Palmitate Lipotoxicity

Hepatocyte Deletion of Triglyceride-Synthesis Enzyme Acyl CoA: Diacylglycerol Acyltransferase 2 Reduces Steatosis Without Increasing Inflammation or Fibrosis in Mice

High confidence proteomic analysis of yeast LDs identifies additional droplet proteins and reveals connections to dolichol synthesis and sterol acetylation.

Identification and characterization of a novel DGAT1 missense mutation associated with congenital diarrhea

Identification of a gene encoding MGAT1, a monoacylglycerol acyltransferase

Increased atypical PKC activity in endurance-trained human skeletal muscle

Increased insulin and leptin sensitivity in mice lacking acyl CoA:diacylglycerol acyltransferase 1.

Induced Pluripotent Stem Cell Models of Progranulin-Deficient Frontotemporal Dementia Uncover Specific Reversible Neuronal Defects ⬇️

Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models

Inhibition of sphingolipid synthesis improves outcomes and survival in GARP mutant wobbler mice, a model of motor neuron degeneration

Insulin-induced activation of atypical protein kinase C, but not protein kinase B, is maintained in diabetic (ob/ob and Goto-Kakazaki) liver. Contrasting insulin signaling patterns in liver versus muscle define phenotypes of type 2 diabetic and high

LDAF1 and Seipin Form a Lipid Droplet Assembly Complex

Leptin modulates the effects of acyl CoA:diacylglycerol acyltransferase deficiency on murine fur and sebaceous glands

Lipid Droplet Biogenesis.

Lipid Droplets in Brown Adipose Tissue Are Dispensable for Cold-Induced Thermogenesis

Lipid droplets and liver disease: from basic biology to clinical implications.

Lipid droplets at a glance

Lipid droplets finally get a little R-E-S-P-E-C-T.

Lipid droplets go nuclear

Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment

Mechanism and Determinants of Amphipathic Helix-Containing Protein Targeting to Lipid Droplets

Membrane topology and identification of key functional amino acid residues of murine acyl-CoA:diacylglycerol acyltransferase-2.

Mice lacking lipid droplet-associated hydrolase, a gene linked to human prostate cancer, have normal cholesterol ester metabolism

MicroRNA-29b regulates the expression level of human progranulin, a secreted glycoprotein implicated in frontotemporal dementia

Mogat1 deletion does not ameliorate hepatic steatosis in lipodystrophic (Agpat2-/-) or obese (ob/ob) mice

Murine knockin model for progranulin-deficient frontotemporal dementia with nonsense-mediated mRNA decay

Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency

Obesity resistance and enhanced glucose metabolism in mice transplanted with white adipose tissue lacking acyl CoA:diacylglycerol acyltransferase 1

Partitioning of MLX-Family Transcription Factors to Lipid Droplets Regulates Metabolic Gene Expression

Phosphatidylcholine Synthesis for Lipid Droplet Expansion Is Mediated by Localized Activation of CTP:Phosphocholine Cytidylyltransferase ⬇️

Plasma cholesteryl esters provided by lecithin:cholesterol acyltransferase and acyl-coenzyme a:cholesterol acyltransferase 2 have opposite atherosclerotic potential

Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids

Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation

Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury

Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells

Progranulin in the hematopoietic compartment protects mice from atherosclerosis

Protein Correlation Profiles Identify Lipid Droplet Proteins with High Confidence ⬇️

Protein Crowding Is a Determinant of Lipid Droplet Protein Composition

Protein Kinase C-λ Knockout in Embryonic Stem Cells and Adipocytes Impairs Insulin-Stimulated Glucose Transport ⬇️