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A DNA-Encoded Library of Chemical Compounds Based on Common Scaffolding Structures Reveals the Impact of Ligand Geometry on Protein Recognition

scientific article published on 01 June 2018

A Focused DNA-Encoded Chemical Library for the Discovery of Inhibitors of NAD+-Dependent Enzymes

scientific article published on 19 March 2019

Achievements, Challenges, and Opportunities in DNA-Encoded Library Research: An Academic Point of View

artículo científico publicado en 2016

Automated screening for small organic ligands using DNA-encoded chemical libraries.

artículo científico publicado en 2016

Bioorthogonal Removal of 3-Isocyanopropyl Groups Enables the Controlled Release of Fluorophores and Drugs in Vivo

artículo científico publicado en 2018

DNA-encoded chemical libraries: advancing beyond conventional small-molecule libraries

artículo científico publicado en 2014

Dissociative Bioorthogonal Reactions

artículo científico publicado en 2019

Dissociative reactions of benzonorbornadienes with tetrazines: scope of leaving groups and mechanistic insights.

artículo científico publicado en 2017

Dual-display of small molecules enables the discovery of ligand pairs and facilitates affinity maturation.

artículo científico publicado en 2015

Identification of structure-activity relationships from screening a structurally compact DNA-encoded chemical library

artículo científico publicado en 2015

Interrogating target-specificity by parallel screening of a DNA-encoded chemical library against closely related proteins

artículo científico publicado en 2015

Isonitrile-responsive and bioorthogonally removable tetrazine protecting groups

artículo científico publicado en 2019

Mechanisms and Substituent Effects of Metal-Free Bioorthogonal Reactions

scientific article published on 05 January 2021

Rapid and efficient tetrazine-induced drug release from highly stable benzonorbornadiene derivatives

artículo científico publicado en 2017

Stability of Oligonucleotide-Small Molecule Conjugates to DNA-Deprotection Conditions

artículo científico publicado en 2017

Stable, Reactive, and Orthogonal Tetrazines: Dispersion Forces Promote the Cycloaddition with Isonitriles

scientific article published on 06 June 2019

Systematic evaluation and optimization of modification reactions of oligonucleotides with amines and carboxylic acids for the synthesis of DNA-encoded chemical libraries

artículo científico publicado en 2014

Tankyrase 1 Inhibitors with Drug-like Properties Identified by Screening a DNA-Encoded Chemical Library

artículo científico publicado en 2015

The Unique Bioorthogonal Chemistry of Isonitriles

artículo científico publicado en 2020

Tuning Isonitrile/Tetrazine Chemistry for Accelerated Deprotection and Formation of Stable Conjugates

artículo científico publicado en 2019

“Cap-and-Catch” Purification for Enhancing the Quality of Libraries of DNA Conjugates