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(15)N{(31)P} REDOR NMR studies of the binding of phosphonate reaction intermediate analogues to Saccharomyces cerevisiae lumazine synthase

artículo científico publicado en 2008

13C Isotopologue editing of FMN bound to phototropin domains

artículo científico publicado en 2007

2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate synthases of fungi and archaea

scientific journal article

A high-throughput screen utilizing the fluorescence of riboflavin for identification of lumazine synthase inhibitors

artículo científico publicado en 2005

A metastable prerequisite for the growth of lumazine synthase crystals

artículo científico publicado en 2005

A novel lumazine synthase inhibitor derived from oxidation of 1,3,6,8-tetrahydroxy-2,7-naphthyridine to a tetraazaperylenehexaone derivative

artículo científico publicado en 2007

A structure-based model of the reaction catalyzed by lumazine synthase from Aquifex aeolicus

artículo científico publicado en 2003

Antibody Cross-Reactivity between Proteins of Chia Seed ( Salvia hispanica L.) and Other Food Allergens

scientific article published on 19 June 2019

Aryl Bis-Sulfonamide Inhibitors of IspF fromArabidopsis thalianaandPlasmodium falciparum

scholarly article by Jonas Thelemann et al published 5 October 2015 in ChemMedChem

Assessment of Mixtures by Spectral Superposition. An Approach in the Field of Metabolomics

scientific article published on 13 May 2019

Binding modes of reverse fosmidomycin analogs toward the antimalarial target IspC

artículo científico publicado en 2014

Biosynthesis of flavocoenzymes

artículo científico publicado en 2005

Biosynthesis of pteridines. Reaction mechanism of GTP cyclohydrolase I

artículo científico publicado en 2003

Biosynthesis of riboflavin in archaea studies on the mechanism of 3,4-dihydroxy-2-butanone-4-phosphate synthase of Methanococcus jannaschii

artículo científico publicado en 2002

Biosynthesis of riboflavin in archaea. 6,7-dimethyl-8-ribityllumazine synthase of Methanococcus jannaschii

artículo científico publicado en 2003

Biosynthesis of riboflavin. Single turnover kinetic analysis of 6,7-dimethyl-8-ribityllumazine synthase

artículo científico publicado en 2003

Biosynthesis of riboflavin: 6,7-dimethyl-8-ribityllumazine synthase of Schizosaccharomyces pombe

artículo científico publicado en 2002

Biosynthesis of riboflavin: structure and properties of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase of Methanocaldococcus jannaschii

artículo científico publicado en 2006

Biosynthesis of tetrahydrofolate in plants: crystal structure of 7,8-dihydroneopterin aldolase from Arabidopsis thaliana reveals a novel adolase class

artículo científico publicado en 2004

Biosynthesis of tetrahydrofolate. Stereochemistry of dihydroneopterin aldolase

artículo científico publicado en 2002

Biosynthesis of vitamin B2: Structure and mechanism of riboflavin synthase

artículo científico publicado en 2008

Biosynthesis of vitamin B2: a unique way to assemble a xylene ring

scientific article published on March 2011

Biosynthesis of vitamin B2: diastereomeric reaction intermediates of archaeal and non-archaeal riboflavin synthases

artículo científico publicado en 2005

Blue light perception in plants. Detection and characterization of a light-induced neutral flavin radical in a C450A mutant of phototropin

artículo científico publicado en 2003

Catalysis of an Essential Step in Vitamin B2 Biosynthesis by a Consortium of Broad Spectrum Hydrolases.

artículo científico publicado en 2015

Crystal structure of Schizosaccharomyces pombe riboflavin kinase reveals a novel ATP and riboflavin-binding fold

artículo científico publicado en 2003

Crystal structure of an archaeal pentameric riboflavin synthase in complex with a substrate analog inhibitor: stereochemical implications

artículo científico publicado en 2005

Crystal structure of lumazine synthase from Mycobacterium tuberculosis as a target for rational drug design: binding mode of a new class of purinetrione inhibitors

artículo científico publicado en 2005

Deorphaning pyrrolopyrazines as potent multi-target antimalarial agents

artículo científico publicado en 2014

Design, synthesis, and biochemical evaluation of 1,5,6,7-tetrahydro-6,7-dioxo-9-D-ribitylaminolumazines bearing alkyl phosphate substituents as inhibitors of lumazine synthase and riboflavin synthase

artículo científico publicado en 2005

Design, synthesis, and evaluation of 6-carboxyalkyl and 6-phosphonoxyalkyl derivatives of 7-oxo-8-ribitylaminolumazines as inhibitors of riboflavin synthase and lumazine synthase

artículo científico publicado en 2002

Design, synthesis, and evaluation of 9-D-ribitylamino-1,3,7,9-tetrahydro-2,6,8-purinetriones bearing alkyl phosphate and alpha,alpha-difluorophosphonate substituents as inhibitors of tiboflavin synthase and lumazine synthase

artículo científico publicado en 2004

Design, synthesis, and evaluation of acyclic C-nucleoside and N-methylated derivatives of the ribitylaminopyrimidine substrate of lumazine synthase as potential enzyme inhibitors and mechanistic probes

artículo científico publicado en 2004

Detecting a new source for photochemically induced dynamic nuclear polarization in the LOV2 domain of phototropin by magnetic-field dependent (13)C NMR spectroscopy

artículo científico publicado en 2014

Determination of the Geographical Origin of Asparagus officinalis L. by 1H NMR Spectroscopy

artículo científico publicado en 2020

Development of a Multiplex Real-Time PCR for Determination of Apricot in Marzipan Using the Plexor System.

artículo científico publicado en 2016

Discovery and development of a small molecule library with lumazine synthase inhibitory activity

artículo científico publicado en 2009

Enzyme catalysis via control of activation entropy: site-directed mutagenesis of 6,7-dimethyl-8-ribityllumazine synthase

artículo científico publicado en 2003

Enzymes from the haloacid dehalogenase (HAD) superfamily catalyse the elusive dephosphorylation step of riboflavin biosynthesis.

artículo científico publicado en 2013

Evolution of vitamin B2 biosynthesis. A novel class of riboflavin synthase in Archaea

artículo científico publicado en 2004

Evolution of vitamin B2 biosynthesis: riboflavin synthase of Arabidopsis thaliana and its inhibition by riboflavin

artículo científico publicado en 2005

Evolution of vitamin B2 biosynthesis: structural and functional similarity between pyrimidine deaminases of eubacterial and plant origin

artículo científico publicado en 2004

Femtosecond to Millisecond Dynamics of Light Induced Allostery in the Avena sativa LOV Domain

artículo científico publicado en 2017

Folate biosynthesis in higher plants. cDNA cloning, heterologous expression, and characterization of dihydroneopterin aldolases

artículo científico publicado en 2004

Folate synthesis in plants: the first step of the pterin branch is mediated by a unique bimodular GTP cyclohydrolase I

artículo científico publicado en 2002

Food Authentication: Small-Molecule Profiling as a Tool for the Geographic Discrimination of German White Asparagus

scientific article published on 04 December 2018

Food Profiling: Determination of the Geographical Origin of Walnuts by H-1 NMR Spectroscopy Using the Polar Extract

artículo científico publicado en 2020

Food Targeting: Geographical Origin Determination of Hazelnuts (Corylus avellana) by LC-QqQ-MS/MS-Based Targeted Metabolomics Application.

artículo científico publicado en 2017

Food authentication in real-life: How to link non-targeted approaches with routine analytics?

scientific article published on 06 April 2020

Formation of metal nanoclusters on specific surface sites of protein molecules

artículo científico publicado en 2002

H NMR Spectroscopy for Determination of the Geographical Origin of Hazelnuts

article

Hindered rotation of a cofactor methyl group as a probe for protein-cofactor interaction

artículo científico publicado en 2010

Improvement of the quality of lumazine synthase crystals by protein engineering

artículo científico publicado en 2008

Incorporation of an amide into 5-phosphonoalkyl-6-D-ribitylaminopyrimidinedione lumazine synthase inhibitors results in an unexpected reversal of selectivity for riboflavin synthase vs lumazine synthase

artículo científico publicado en 2002

Inhibition of methyl-CoM Reductase from Methanobrevibacter ruminantium by 2-bromoethanesulfonate

Inhibitors of the Herbicidal Target IspD: Allosteric Site Binding

artículo científico publicado el 18 de julio de 2011

IspC as target for antiinfective drug discovery: synthesis, enantiomeric separation, and structural biology of fosmidomycin thia isosters

artículo científico publicado en 2013

Ligand binding properties of the N-terminal domain of riboflavin synthase from Escherichia coli.

artículo científico publicado en 2007

Localization of two enzymes of the tetrahydrobiopterin biosynthetic pathway in embryonic chick retina

artículo científico publicado en 2002

Lumazine proteins from photobacteria: localization of the single ligand binding site to the N-terminal domain

artículo científico publicado en 2007

Lumazine synthase from Candida albicans as an anti-fungal target enzyme: structural and biochemical basis for drug design

artículo científico publicado en 2007

Mass-Spectrometry-Based Food Metabolomics in Routine Applications: A Basic Standardization Approach Using Housekeeping Metabolites for the Authentication of Asparagus

scientific article published on 04 April 2020

Mechanism of Allosteric Inhibition of the Enzyme IspD by Three Different Classes of Ligands

artículo científico publicado en 2017

Mechanistic insights on riboflavin synthase inspired by selective binding of the 6,7-dimethyl-8-ribityllumazine exomethylene anion

artículo científico publicado en 2010

Metal sites in 3,4-dihydroxy-2-butanone 4-phosphate synthase from Methanococcus jannaschii in complex with the substrate ribulose 5-phosphate

artículo científico publicado en 2004

Methyl groups matter: Photo-CIDNP characterizations of the semiquinone radicals of FMN and demethylated FMN analogs

scientific article published on 01 December 2019

Natural abundance solution 13C NMR studies of a phototropin with photoinduced polarization

artículo científico publicado en 2008

Nonmevalonate terpene biosynthesis enzymes as antiinfective drug targets: substrate synthesis and high-throughput screening methods

artículo científico publicado en 2006

Nonradioactive Cell Assay for the Evaluation of Modular Prostate-Specific Membrane Antigen Targeting Ligands via Inductively Coupled Plasma Mass Spectrometry

artículo científico publicado en 2019

O-Nucleoside, S-Nucleoside, and N-Nucleoside Probes of Lumazine Synthase and Riboflavin Synthase

artículo científico publicado el 10 de julio de 2012

Omics-approaches for food authentication.

artículo científico publicado en 2018

On the reaction mechanism of adduct formation in LOV domains of the plant blue-light receptor phototropin

artículo científico publicado en 2004

Photochemically induced dynamic nuclear polarization in a C450A mutant of the LOV2 domain of the Avena sativa blue-light receptor phototropin

artículo científico publicado en 2005

Plant Metabolomics: Evaluation of different Extraction Parameters for Nontargeted UPLC-ESI-QTOF-Mass Spectrometry at the Example of white Asparagus officinalis

article

Plant Metabolomics: Maximizing Metabolome Coverage by Optimizing Mobile Phase Additives for Nontargeted Mass Spectrometry in Positive and Negative Electrospray Ionization Mode.

artículo científico publicado en 2017

Potential anti-infective targets in pathogenic yeasts: structure and properties of 3,4-dihydroxy-2-butanone 4-phosphate synthase of Candida albicans

artículo científico publicado en 2004

Pre-steady-state kinetic analysis of riboflavin synthase using a pentacyclic reaction intermediate as substrate

artículo científico publicado en 2005

Presteady State Kinetic Analysis of Riboflavin Synthase

artículo científico publicado el 22 de septiembre de 2003

Prodrugs of reverse fosmidomycin analogues

artículo científico publicado en 2015

Pseudilins: halogenated, allosteric inhibitors of the non-mevalonate pathway enzyme IspD

artículo científico publicado en 2014

Random isotopolog libraries for protein perturbation studies. 13C NMR studies on lumazine protein of Photobacterium leiognathi

artículo científico publicado en 2005

Rapid preparation of isotopolog libraries by in vivo transformation of 1)C-glucose. Studies on 6,7-dimethyl-8-ribityllumazine, a biosynthetic precursor of vitamin B2.

artículo científico publicado en 2004

Reaction mechanism of GTP cyclohydrolase I: single turnover experiments using a kinetically competent reaction intermediate

artículo científico publicado en 2002

Recent advances in riboflavin biosynthesis

artículo científico

Reverse fosmidomycin derivatives against the antimalarial drug target IspC (Dxr)

artículo científico publicado en 2011

Riboflavin synthase of Schizosaccharomyces pombe. Protein dynamics revealed by 19F NMR protein perturbation experiments

artículo científico publicado en 2003

Strategy for Enhancement of (13)C-Photo-CIDNP NMR Spectra by Exploiting Fractional (13)C-Labeling of Tryptophan

artículo científico publicado en 2015

Structural basis of charge transfer complex formation by riboflavin bound to 6,7-dimethyl-8-ribityllumazine synthase

artículo científico publicado en 2004

Structural study and thermodynamic characterization of inhibitor binding to lumazine synthase fromBacillus anthracis

artículo científico publicado en 2010

Structure and Properties of an Engineered Transketolase from Maize

artículo científico publicado en 2003

Structure of 3,4-dihydroxy-2-butanone 4-phosphate synthase from Methanococcus jannaschii in complex with divalent metal ions and the substrate ribulose 5-phosphate: implications for the catalytic mechanism

artículo científico publicado en 2003

Structure of lumazine protein, an optical transponder of luminescent bacteria

artículo científico publicado en 2008

Structure of the molybdenum-cofactor biosynthesis protein MoaB of Escherichia coli

artículo científico publicado en 2004

Structures and reaction mechanisms of GTP cyclohydrolases

artículo científico publicado el 4 de marzo de 2013

Synthesis and antiplasmodial activity of highly active reverse analogues of the antimalarial drug candidate fosmidomycin

artículo científico publicado en 2010

Synthesis and enzyme inhibitory activity of the s-nucleoside analogue of the ribitylaminopyrimidine substrate of lumazine synthase and product of riboflavin synthase.

artículo científico publicado en 2007

Temperature-dependent presteady state kinetics of lumazine synthase from the hyperthermophilic eubacterium Aquifex aeolicus

artículo científico publicado en 2003

The lumazine synthase/riboflavin synthase complex: shapes and functions of a highly variable enzyme system

artículo científico publicado el 24 de abril de 2013

The structural basis of riboflavin binding to Schizosaccharomyces pombe 6,7-dimethyl-8-ribityllumazine synthase

artículo científico publicado en 2002

Thiazolopyrimidine inhibitors of 2-methylerythritol 2,4-cyclodiphosphate synthase (IspF) from Mycobacterium tuberculosis and Plasmodium falciparum

scientific journal article

Tryptophan 13C nuclear-spin polarization generated by intraprotein electron transfer in a LOV2 domain of the blue-light receptor phototropin

artículo científico publicado en 2009

Ultrafast infrared spectroscopy of an isotope-labeled photoactivatable flavoprotein

artículo científico publicado en 2011

Variation in LOV Photoreceptor Activation Dynamics Probed by Time-Resolved Infrared Spectroscopy.

artículo científico publicado en 2017

Vibrational assignment of the ultrafast infrared spectrum of the photoactivatable flavoprotein AppA.

artículo científico publicado en 2012

Virtual screening, selection and development of a benzindolone structural scaffold for inhibition of lumazine synthase

artículo científico publicado en 2010