Lista de obras -

A human antibody that inhibits factor IX/IXa function potently inhibits arterial thrombosis without increasing bleeding

artículo científico publicado en 2002

A phase 1 study to evaluate the safety and LDL cholesterol-lowering effects of RG7652, a fully human monoclonal antibody against proprotein convertase subtilisin/kexin type 9.

artículo científico publicado en 2017

A selective, slow binding inhibitor of factor VIIa binds to a nonstandard active site conformation and attenuates thrombus formation in vivo

artículo científico publicado en 2005

Albumin binding as a general strategy for improving the pharmacokinetics of proteins

artículo científico publicado en 2002

Allosteric Peptide Activators of Pro-Hepatocyte Growth Factor Stimulate Met Signaling ⬇️

artículo científico publicado el 11 de octubre de 2010

Alternatively spliced tissue factor contributes to tumor spread and activation of coagulation in pancreatic ductal adenocarcinoma.

artículo científico publicado en 2013

An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma

artículo científico publicado en 2019

An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma

scientific article published on 01 January 2020

An allosteric anti-hepsin antibody derived from a constrained phage display library

artículo científico publicado en 2012

An ancient mechanism of arginine-specific substrate cleavage: What's 'up' with NSP4?

artículo científico publicado en 2019

Bivalent antibody pliers inhibit β-tryptase by an allosteric mechanism dependent on the IgG hinge

artículo científico publicado en 2020

Calcium-Independent Inhibition of PCSK9 by Affinity-Improved Variants of the LDL Receptor EGF(A) Domain ⬇️

artículo científico publicado el 21 de junio de 2012

Conformational lability in serine protease active sites: structures of hepatocyte growth factor activator (HGFA) alone and with the inhibitory domain from HGFA inhibitor-1B

artículo científico publicado en 2005

Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor

artículo científico publicado en 2004

Design of Organo-Peptides As Bipartite PCSK9 Antagonists

scientific article published on 30 January 2020

Design of a Selective Substrate and Activity Based Probe for Human Neutrophil Serine Protease 4

artículo científico publicado en 2015

Design of selective phenylglycine amide tissue factor/factor VIIa inhibitors

artículo científico publicado en 2005

Development of a therapeutic anti-HtrA1 antibody and the identification of DKK3 as a pharmacodynamic biomarker in geographic atrophy

scientific article published on 28 April 2020

Discovery of a cryptic peptide-binding site on PCSK9 and design of antagonists.

artículo científico publicado en 2017

Domain-Specific Antibodies Reveal Differences in the Membrane Topologies of Apolipoprotein L1 in Serum and Podocytes

artículo científico publicado en 2020

Excess of heme induces tissue factor-dependent activation of coagulation in mice

artículo científico publicado en 2015

Functional impairments caused by chiasma syndromes prior to and following transsphenoidal pituitary adenoma surgery

artículo científico publicado en 2010

Furin-cleaved Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Is Active and Modulates Low Density Lipoprotein Receptor and Serum Cholesterol Levels ⬇️

artículo científico publicado el 7 de noviembre de 2012

Fusion of two distinct peptide exosite inhibitors of Factor VIIa

artículo científico publicado en 2002

Hepatocyte growth factor activator (HGFA): molecular structure and interactions with HGFA inhibitor-1 (HAI-1).

artículo científico publicado en 2010

Hepatocyte growth factor activator inhibitor-1 (HAI-1) is essential for the integrity of basement membranes in the developing placental labyrinth

scientific journal article

Hepsin activates pro-hepatocyte growth factor and is inhibited by hepatocyte growth factor activator inhibitor-1B (HAI-1B) and HAI-2.

artículo científico publicado en 2005

Heterodimers of the transcriptional factors NFATc3 and FosB mediate tissue factor expression for 15(S)-hydroxyeicosatetraenoic acid-induced monocyte trafficking.

artículo científico publicado en 2017

Identification of a Small Peptide That Inhibits PCSK9 Protein Binding to the Low Density Lipoprotein Receptor

artículo científico publicado en 2014

Identification of hepatocyte growth factor activator inhibitor-1B as a potential physiological inhibitor of prostasin

artículo científico publicado en 2005

Inflammasome Activation Triggers Blood Clotting and Host Death through Pyroptosis

artículo científico publicado en 2019

Inflammation drives thrombosis after Salmonella infection via CLEC-2 on platelets

artículo científico publicado en 2015

Inhibiting Alternative Pathway Complement Activation by Targeting the Factor D Exosite

artículo científico publicado en 2012

Inhibition of Angiopoietin-2 Production by Myofibrocytes Inhibits Neointimal Hyperplasia After Endoluminal Injury in Mice

artículo científico publicado en 2018

Inhibitors of Tissue Factor. Factor VIIa for anticoagulant therapy

artículo científico publicado en 2004

Interferon-gamma–mediated tissue factor expression contributes to T-cell-mediated hepatitis through induction of hypercoagulation in mice ⬇️

artículo científico publicado el 1 de enero de 2013

Laminin-332 cleavage by matriptase alters motility parameters of prostate cancer cells.

artículo científico publicado en 2011

Laminin-332 is a substrate for hepsin, a protease associated with prostate cancer progression

artículo científico publicado en 2008

Local protease signaling contributes to neural tube closure in the mouse embryo

artículo científico publicado en 2010

Matriptase activation connects tissue factor-dependent coagulation initiation to epithelial proteolysis and signaling

artículo científico publicado en 2016

Mechanisms of enhanced thrombus formation in cerebral microvessels of mice expressing hemoglobin-S ⬇️

artículo científico publicado el 8 de febrero de 2011

Monocyte tissue factor-dependent activation of coagulation in hypercholesterolemic mice and monkeys is inhibited by simvastatin

artículo científico publicado en 2012

Mouse venous thrombosis upon silencing of anticoagulants depends on tissue factor and platelets, not FXII or neutrophils

scientific article published on 21 March 2019

Mutational tail loss is an evolutionary mechanism for liberating marapsins and other type I serine proteases from transmembrane anchors

artículo científico publicado en 2013

Myeloid cell tissue factor does not contribute to venous thrombogenesis in an electrolytic injury model.

artículo científico publicado en 2011

Neutrophil serine protease 4 is required for mast cell-dependent vascular leakage

artículo científico publicado en 2020

New insight into how tissue factor allosterically regulates factor VIIa

artículo científico publicado en 2002

Noncompetitive inhibition of hepatocyte growth factor-dependent Met signaling by a phage-derived peptide

artículo científico publicado en 2008

PAR-1 contributes to the innate immune response during viral infection.

artículo científico publicado en 2013

Pegylated kunitz domain inhibitor suppresses hepsin-mediated invasive tumor growth and metastasis

artículo científico publicado en 2009

Pre-existing chiasma syndromes do not entirely remit following transsphenoidal surgery for pituitary adenomas ⬇️

artículo científico publicado el 18 de septiembre de 2010

Pro-urokinase-type plasminogen activator is a substrate for hepsin

artículo científico publicado en 2006

Proprotein convertase 7 (PCSK7) reduces apoA-V levels

scientific article published on 16 January 2020

Protease activity of MALT1: a mystery unravelled ⬇️

artículo científico publicado el 1 de junio de 2012

Protective and detrimental effects of neuroectodermal cell–derived tissue factor in mouse models of stroke

artículo científico publicado en 2016

Proteolysis-induced N-terminal ectodomain shedding of the integral membrane glycoprotein CUB domain-containing protein 1 (CDCP1) is accompanied by tyrosine phosphorylation of its C-terminal domain and recruitment of Src and PKCdelta.

artículo científico publicado en 2010

Proteolytic activation of pro-macrophage-stimulating protein by hepsin.

artículo científico publicado en 2011

Pseudo-active sites of protease domains: HGF/Met and Sonic hedgehog signaling in cancer

scientific article published on August 2010

Reactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes.

artículo científico publicado en 2018

Regions of conformational flexibility in the proprotein convertase PCSK9 and design of antagonists for LDL cholesterol lowering

artículo científico publicado en 2020

Role of coagulation factors in cerebral venous sinus and cerebral microvascular thrombosis

artículo científico publicado en 2010

Similar molecular interactions of factor VII and factor VIIa with the tissue factor region that allosterically regulates enzyme activity

artículo científico publicado en 2004

Structural and Functional Analysis of HtrA1 and Its Subdomains ⬇️

artículo científico publicado el 10 de mayo de 2012

Structural and functional basis of the serine protease-like hepatocyte growth factor beta-chain in Met binding and signaling

artículo científico publicado en 2004

Structural and mechanistic insight into how antibodies inhibit serine proteases.

scientific article published on September 2010

Structural insight into distinct mechanisms of protease inhibition by antibodies

artículo científico publicado en 2007

Structural insight into how an anti-idiotypic antibody against D3H44 (anti-tissue factor antibody) restores normal coagulation

artículo científico publicado en 2003

Structures of neutrophil serine protease 4 reveal an unusual mechanism of substrate recognition by a trypsin-fold protease

artículo científico publicado en 2014

Structures of the ApoL1 and ApoL2 N-terminal domains reveal a non-classical four-helix bundle motif

artículo científico publicado en 2021

Targeting STUB1-tissue factor axis normalizes hyperthrombotic uremic phenotype without increasing bleeding risk.

artículo científico publicado en 2017

The serine protease marapsin is expressed in stratified squamous epithelia and is up-regulated in the hyperproliferative epidermis of psoriasis and regenerating wounds

artículo científico publicado en 2008

The trimeric serine protease HtrA1 forms a cage-like inhibition complex with an anti-HtrA1 antibody

artículo científico publicado en 2015

Tissue expression, protease specificity, and Kunitz domain functions of hepatocyte growth factor activator inhibitor-1B (HAI-1B), a new splice variant of HAI-1

artículo científico publicado en 2003

Tissue factor promotes activation of coagulation and inflammation in a mouse model of sickle cell disease

artículo científico publicado en 2012

Tissue factor-dependent coagulation contributes to alpha-naphthylisothiocyanate-induced cholestatic liver injury in mice

artículo científico publicado en 2009

Tissue factor: a link between C5a and neutrophil activation in antiphospholipid antibody induced fetal injury

artículo científico publicado en 2007

Tissue factor: a mediator of inflammatory cell recruitment, tissue injury, and thrombus formation in experimental colitis

artículo científico publicado en 2007

Tumor-derived tissue factor activates coagulation and enhances thrombosis in a mouse xenograft model of human pancreatic cancer ⬇️

artículo científico publicado el 30 de abril de 2012

Unraveling the allosteric mechanism of serine protease inhibition by an antibody

artículo científico publicado en 2009

Unusual proteolytic activation of pro-hepatocyte growth factor by plasma kallikrein and coagulation factor XIa

artículo científico publicado en 2002

Utilizing the activation mechanism of serine proteases to engineer hepatocyte growth factor into a Met antagonist

artículo científico publicado en 2007

Lista de obras de

A human antibody that inhibits factor IX/IXa function potently inhibits arterial thrombosis without increasing bleeding

A phase 1 study to evaluate the safety and LDL cholesterol-lowering effects of RG7652, a fully human monoclonal antibody against proprotein convertase subtilisin/kexin type 9.

A selective, slow binding inhibitor of factor VIIa binds to a nonstandard active site conformation and attenuates thrombus formation in vivo

Albumin binding as a general strategy for improving the pharmacokinetics of proteins

Allosteric Peptide Activators of Pro-Hepatocyte Growth Factor Stimulate Met Signaling ⬇️

Alternatively spliced tissue factor contributes to tumor spread and activation of coagulation in pancreatic ductal adenocarcinoma.

An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma

An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma

An allosteric anti-hepsin antibody derived from a constrained phage display library

An ancient mechanism of arginine-specific substrate cleavage: What's 'up' with NSP4?

Bivalent antibody pliers inhibit β-tryptase by an allosteric mechanism dependent on the IgG hinge

Calcium-Independent Inhibition of PCSK9 by Affinity-Improved Variants of the LDL Receptor EGF(A) Domain ⬇️

Conformational lability in serine protease active sites: structures of hepatocyte growth factor activator (HGFA) alone and with the inhibitory domain from HGFA inhibitor-1B

Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor

Design of Organo-Peptides As Bipartite PCSK9 Antagonists

Design of a Selective Substrate and Activity Based Probe for Human Neutrophil Serine Protease 4

Design of selective phenylglycine amide tissue factor/factor VIIa inhibitors

Development of a therapeutic anti-HtrA1 antibody and the identification of DKK3 as a pharmacodynamic biomarker in geographic atrophy

Discovery of a cryptic peptide-binding site on PCSK9 and design of antagonists.

Domain-Specific Antibodies Reveal Differences in the Membrane Topologies of Apolipoprotein L1 in Serum and Podocytes

Excess of heme induces tissue factor-dependent activation of coagulation in mice

Functional impairments caused by chiasma syndromes prior to and following transsphenoidal pituitary adenoma surgery

Furin-cleaved Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Is Active and Modulates Low Density Lipoprotein Receptor and Serum Cholesterol Levels ⬇️

Fusion of two distinct peptide exosite inhibitors of Factor VIIa

Hepatocyte growth factor activator (HGFA): molecular structure and interactions with HGFA inhibitor-1 (HAI-1).

Hepatocyte growth factor activator inhibitor-1 (HAI-1) is essential for the integrity of basement membranes in the developing placental labyrinth

Hepsin activates pro-hepatocyte growth factor and is inhibited by hepatocyte growth factor activator inhibitor-1B (HAI-1B) and HAI-2.

Heterodimers of the transcriptional factors NFATc3 and FosB mediate tissue factor expression for 15(S)-hydroxyeicosatetraenoic acid-induced monocyte trafficking.

Identification of a Small Peptide That Inhibits PCSK9 Protein Binding to the Low Density Lipoprotein Receptor

Identification of hepatocyte growth factor activator inhibitor-1B as a potential physiological inhibitor of prostasin

Inflammasome Activation Triggers Blood Clotting and Host Death through Pyroptosis

Inflammation drives thrombosis after Salmonella infection via CLEC-2 on platelets

Inhibiting Alternative Pathway Complement Activation by Targeting the Factor D Exosite

Inhibition of Angiopoietin-2 Production by Myofibrocytes Inhibits Neointimal Hyperplasia After Endoluminal Injury in Mice

Inhibitors of Tissue Factor. Factor VIIa for anticoagulant therapy

Interferon-gamma–mediated tissue factor expression contributes to T-cell-mediated hepatitis through induction of hypercoagulation in mice ⬇️

Laminin-332 cleavage by matriptase alters motility parameters of prostate cancer cells.

Laminin-332 is a substrate for hepsin, a protease associated with prostate cancer progression

Local protease signaling contributes to neural tube closure in the mouse embryo

Matriptase activation connects tissue factor-dependent coagulation initiation to epithelial proteolysis and signaling

Mechanisms of enhanced thrombus formation in cerebral microvessels of mice expressing hemoglobin-S ⬇️

Monocyte tissue factor-dependent activation of coagulation in hypercholesterolemic mice and monkeys is inhibited by simvastatin

Mouse venous thrombosis upon silencing of anticoagulants depends on tissue factor and platelets, not FXII or neutrophils

Mutational tail loss is an evolutionary mechanism for liberating marapsins and other type I serine proteases from transmembrane anchors

Myeloid cell tissue factor does not contribute to venous thrombogenesis in an electrolytic injury model.

Neutrophil serine protease 4 is required for mast cell-dependent vascular leakage

New insight into how tissue factor allosterically regulates factor VIIa

Noncompetitive inhibition of hepatocyte growth factor-dependent Met signaling by a phage-derived peptide

PAR-1 contributes to the innate immune response during viral infection.

Pegylated kunitz domain inhibitor suppresses hepsin-mediated invasive tumor growth and metastasis

Pre-existing chiasma syndromes do not entirely remit following transsphenoidal surgery for pituitary adenomas ⬇️

Pro-urokinase-type plasminogen activator is a substrate for hepsin

Proprotein convertase 7 (PCSK7) reduces apoA-V levels

Protease activity of MALT1: a mystery unravelled ⬇️

Protective and detrimental effects of neuroectodermal cell–derived tissue factor in mouse models of stroke

Proteolysis-induced N-terminal ectodomain shedding of the integral membrane glycoprotein CUB domain-containing protein 1 (CDCP1) is accompanied by tyrosine phosphorylation of its C-terminal domain and recruitment of Src and PKCdelta.

Proteolytic activation of pro-macrophage-stimulating protein by hepsin.

Pseudo-active sites of protease domains: HGF/Met and Sonic hedgehog signaling in cancer

Reactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes.

Regions of conformational flexibility in the proprotein convertase PCSK9 and design of antagonists for LDL cholesterol lowering

Role of coagulation factors in cerebral venous sinus and cerebral microvascular thrombosis

Similar molecular interactions of factor VII and factor VIIa with the tissue factor region that allosterically regulates enzyme activity

Structural and Functional Analysis of HtrA1 and Its Subdomains ⬇️

Structural and functional basis of the serine protease-like hepatocyte growth factor beta-chain in Met binding and signaling

Structural and mechanistic insight into how antibodies inhibit serine proteases.

Structural insight into distinct mechanisms of protease inhibition by antibodies

Structural insight into how an anti-idiotypic antibody against D3H44 (anti-tissue factor antibody) restores normal coagulation

Structures of neutrophil serine protease 4 reveal an unusual mechanism of substrate recognition by a trypsin-fold protease

Structures of the ApoL1 and ApoL2 N-terminal domains reveal a non-classical four-helix bundle motif

Targeting STUB1-tissue factor axis normalizes hyperthrombotic uremic phenotype without increasing bleeding risk.

The serine protease marapsin is expressed in stratified squamous epithelia and is up-regulated in the hyperproliferative epidermis of psoriasis and regenerating wounds

The trimeric serine protease HtrA1 forms a cage-like inhibition complex with an anti-HtrA1 antibody

Tissue expression, protease specificity, and Kunitz domain functions of hepatocyte growth factor activator inhibitor-1B (HAI-1B), a new splice variant of HAI-1

Tissue factor promotes activation of coagulation and inflammation in a mouse model of sickle cell disease

Tissue factor-dependent coagulation contributes to alpha-naphthylisothiocyanate-induced cholestatic liver injury in mice

Tissue factor: a link between C5a and neutrophil activation in antiphospholipid antibody induced fetal injury

Tissue factor: a mediator of inflammatory cell recruitment, tissue injury, and thrombus formation in experimental colitis

Tumor-derived tissue factor activates coagulation and enhances thrombosis in a mouse xenograft model of human pancreatic cancer ⬇️

Unraveling the allosteric mechanism of serine protease inhibition by an antibody