Lista de obras -

2,6,10-Tris(dialkylamino)trioxatriangulenium salts: a new promising fluorophore. Ion-pair formation and aggregation in non-polar solvents.

artículo científico publicado en 2005

3-Amino-thieno[2,3-b]pyridines as microtubule-destabilising agents: Molecular modelling and biological evaluation in the sea urchin embryo and human cancer cells.

artículo científico publicado en 2016

A Novel Class of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Contains the Octahydro-2-chromen-4-ol Scaffold

artículo científico publicado en 2018

Acetyl-CoA-mediated activation of Mycobacterium tuberculosis isocitrate lyase 2

artículo científico publicado en 2019

Aminoadamantanes containing monoterpene-derived fragments as potent tyrosyl-DNA phosphodiesterase 1 inhibitors.

artículo científico publicado en 2017

Anti-influenza activity of diazaadamantanes combined with monoterpene moieties

artículo científico publicado en 2017

Bond stability of the "undesirable" heteroatom-heteroatom molecular moieties for high-throughput screening libraries

artículo científico publicado en 2011

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-5

scientific article published on 30 June 2019

Characterisation of radicals formed by the triazine 1,4-dioxide hypoxia-activated prodrug, SN30000.

artículo científico publicado en 2014

Coumarin Antifungal Lead Compounds from Millettia thonningii and Their Predicted Mechanism of Action

artículo científico publicado en 2016

DFT calculations on the deprotonation site of the one-electron oxidised guanine-cytosine base pair

artículo científico publicado en 2010

Design, Synthesis, and Biological Investigation of Novel Classes of 3-Carene-Derived Potent Inhibitors of TDP1

artículo científico publicado en 2020

Development of NMR and thermal shift assays for the evaluation of isocitrate lyase inhibitors

artículo científico publicado en 2017

Discovery and Characterisation of Dual Inhibitors of Tryptophan 2,3-Dioxygenase (TDO2) and Indoleamine 2,3-Dioxygenase 1 (IDO1) Using Virtual Screening

artículo científico publicado en 2019

Evidence that phospholipase C is involved in the antitumour action of NSC768313, a new thieno[2,3-b]pyridine derivative

artículo científico publicado en 2016

Ferrocenyl Paclitaxel and Docetaxel Derivatives: Impact of an Organometallic Moiety on the Mode of Action of Taxanes.

artículo científico publicado en 2016

GPCR Modulation of Thieno[2,3-b]pyridine Anti-Proliferative Agents.

artículo científico publicado en 2017

Generation of Quality Hit Matter for Successful Drug Discovery Projects

artículo científico publicado en 2019

Glycophenotype of breast and prostate cancer stem cells treated with thieno[2,3-b]pyridine anticancer compound

artículo científico publicado en 2017

Half-sandwich ruthenium(II) biotin conjugates as biological vectors to cancer cells

artículo científico publicado en 2015

Hit generation and exploration: imidazo[4,5-b]pyridine derivatives as inhibitors of Aurora kinases

artículo científico publicado en 2007

Hydrogen bonding between histidine and lignin model compounds or redox mediators as calculated with the DFT method. Effects on the ease of oxidation

artículo científico publicado en 2004

Identification of Isoform-Selective Ligands for the Middle Domain of Heat Shock Protein 90 (Hsp90)

artículo científico publicado en 2019

Identification of anticancer agents based on the thieno[2,3-b]pyridine and 1H-pyrazole molecular scaffolds

artículo científico publicado en 2016

Imidazo[4,5-b]pyridine derivatives as inhibitors of Aurora kinases: lead optimization studies toward the identification of an orally bioavailable preclinical development candidate

artículo científico publicado en 2010

Intercalation of trioxatriangulenium ion in DNA: binding, electron transfer, x-ray crystallography, and electronic structure.

artículo científico publicado en 2003

Investigation into Improving the Aqueous Solubility of the Thieno[2,3-b]pyridine Anti-Proliferative Agents.

artículo científico publicado en 2018

Investigation of the incidence of "undesirable" molecular moieties for high-throughput screening compound libraries in marketed drug compounds

artículo científico publicado en 2008

Molecular mechanism of base pairing infidelity during DNA duplication upon one-electron oxidation ⬇️

artículo científico publicado el 10 de noviembre de 2010

Mutagenic potential of nitrenium ions of nitrobenzanthrones: correlation between theory and experiment

artículo científico publicado en 2008

Mutagenicity and DNA adduct formation by the urban air pollutant 2-nitrobenzanthrone

artículo científico publicado en 2007

New Anti-Seizure (Arylalkyl)azole Derivatives: Synthesis, In Vivo and In Silico Studies.

artículo científico publicado en 2017

New Iminodiacetate-Thiosemicarbazone Hybrids and Their Copper(II) Complexes Are Potential Ribonucleotide Reductase R2 Inhibitors with High Antiproliferative Activity

artículo científico publicado en 2017

New inhibitors of tyrosyl-DNA phosphodiesterase I (Tdp 1) combining 7-hydroxycoumarin and monoterpenoid moieties

artículo científico publicado en 2016

Novel Semisynthetic Derivatives of Bile Acids as Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibitors.

artículo científico publicado en 2018

One-electron reduction of 2-aminopurine in the aqueous phase. A DFT and pulse radiolysis study

artículo científico publicado en 2005

Photoionization versus photoheterolysis of all-trans-retinol. The effects of solvent and laser radiation intensity

artículo científico publicado en 2006

Photophysics of trioxatriangulenium ion. electrophilic reactivity in the ground state and excited singlet state.

artículo científico publicado en 2002

Radical Chemistry and Cytotoxicity of Bioreductive 3-Substituted Quinoxaline Di-N-Oxides

artículo científico publicado en 2016

Serendipity in anticancer drug discovery ⬇️

artículo científico publicado el 10 de enero de 2012

Size estimation of chemical space: how big is it?

artículo científico publicado en 2011

Structure-based design of imidazo[1,2-a]pyrazine derivatives as selective inhibitors of Aurora-A kinase in cells

artículo científico publicado en 2010

Synthesis and antiproliferative activity of 2-chlorophenyl carboxamide thienopyridines

artículo científico publicado en 2016

Synthesis and biological evaluation of novel tyrosyl-DNA phosphodiesterase 1 inhibitors with a benzopentathiepine moiety

artículo científico

Synthesis and cytotoxicity of thieno[2,3-b]pyridine and furo[2,3-b]pyridine derivatives

artículo científico publicado en 2014

Synthesis and cytotoxicity of thieno[2,3-b]quinoline-2-carboxamide and cycloalkyl[b]thieno[3,2-e]pyridine-2-carboxamide derivatives.

artículo científico publicado en 2016

Synthesis and in vitro Biological Evaluation of Ferrocenyl Side-Chain-Functionalized Paclitaxel Derivatives.

artículo científico publicado en 2017

Target profiling of an antimetastatic RAPTA agent by chemical proteomics: relevance to the mode of action

artículo científico publicado en 2015

Target profiling of an antimetastatic RAPTA agent by chemical proteomics: relevance to the mode of action† †Electronic supplementary information (ESI) available: Experimental, crystallographic, biological and mass spectrometric data, full list of pr

artículo científico publicado en 2015

The Development of a Weighted Index to Optimise Compound Libraries for High Throughput Screening

article

The First Berberine-Based Inhibitors of Tyrosyl-DNA Phosphodiesterase 1 (Tdp1), an Important DNA Repair Enzyme

scientific article published on 28 September 2020

The cytotoxic potential of cationic triangulenes against tumour cells

artículo científico publicado en 2019

The effect of PLC-γ2 inhibitors on the growth of human tumour cells

artículo científico publicado en 2012

The identification of novel PLC-gamma inhibitors using virtual high throughput screening

artículo científico publicado en 2009

The physicochemical properties of a new class of anticancer fungal polysaccharides: a comparative study

artículo científico publicado en 2013

Tuning of hydrogen bond strength using substituents on phenol and aniline: a possible ligand design strategy

artículo científico publicado en 2004

Validating TDP1 as an Inhibition Target for the Development of Chemosensitizers for Camptothecin-Based Chemotherapy Drugs

artículo científico publicado en 2021

Virtual screening and biophysical studies lead to HSP90 inhibitors.

artículo científico publicado en 2016

Wine Compounds as a Source for HTS Screening Collections. A Feasibility Study

artículo científico publicado en 2012

Lista de obras de

2,6,10-Tris(dialkylamino)trioxatriangulenium salts: a new promising fluorophore. Ion-pair formation and aggregation in non-polar solvents.

3-Amino-thieno[2,3-b]pyridines as microtubule-destabilising agents: Molecular modelling and biological evaluation in the sea urchin embryo and human cancer cells.

A Novel Class of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Contains the Octahydro-2-chromen-4-ol Scaffold

Acetyl-CoA-mediated activation of Mycobacterium tuberculosis isocitrate lyase 2

Aminoadamantanes containing monoterpene-derived fragments as potent tyrosyl-DNA phosphodiesterase 1 inhibitors.

Anti-influenza activity of diazaadamantanes combined with monoterpene moieties

Bond stability of the "undesirable" heteroatom-heteroatom molecular moieties for high-throughput screening libraries

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-5

Characterisation of radicals formed by the triazine 1,4-dioxide hypoxia-activated prodrug, SN30000.

Coumarin Antifungal Lead Compounds from Millettia thonningii and Their Predicted Mechanism of Action

DFT calculations on the deprotonation site of the one-electron oxidised guanine-cytosine base pair

Design, Synthesis, and Biological Investigation of Novel Classes of 3-Carene-Derived Potent Inhibitors of TDP1

Development of NMR and thermal shift assays for the evaluation of isocitrate lyase inhibitors

Discovery and Characterisation of Dual Inhibitors of Tryptophan 2,3-Dioxygenase (TDO2) and Indoleamine 2,3-Dioxygenase 1 (IDO1) Using Virtual Screening

Evidence that phospholipase C is involved in the antitumour action of NSC768313, a new thieno[2,3-b]pyridine derivative

Ferrocenyl Paclitaxel and Docetaxel Derivatives: Impact of an Organometallic Moiety on the Mode of Action of Taxanes.

GPCR Modulation of Thieno[2,3-b]pyridine Anti-Proliferative Agents.

Generation of Quality Hit Matter for Successful Drug Discovery Projects

Glycophenotype of breast and prostate cancer stem cells treated with thieno[2,3-b]pyridine anticancer compound

Half-sandwich ruthenium(II) biotin conjugates as biological vectors to cancer cells

Hit generation and exploration: imidazo[4,5-b]pyridine derivatives as inhibitors of Aurora kinases

Hydrogen bonding between histidine and lignin model compounds or redox mediators as calculated with the DFT method. Effects on the ease of oxidation

Identification of Isoform-Selective Ligands for the Middle Domain of Heat Shock Protein 90 (Hsp90)

Identification of anticancer agents based on the thieno[2,3-b]pyridine and 1H-pyrazole molecular scaffolds

Imidazo[4,5-b]pyridine derivatives as inhibitors of Aurora kinases: lead optimization studies toward the identification of an orally bioavailable preclinical development candidate

Intercalation of trioxatriangulenium ion in DNA: binding, electron transfer, x-ray crystallography, and electronic structure.

Investigation into Improving the Aqueous Solubility of the Thieno[2,3-b]pyridine Anti-Proliferative Agents.

Investigation of the incidence of "undesirable" molecular moieties for high-throughput screening compound libraries in marketed drug compounds

Molecular mechanism of base pairing infidelity during DNA duplication upon one-electron oxidation ⬇️

Mutagenic potential of nitrenium ions of nitrobenzanthrones: correlation between theory and experiment

Mutagenicity and DNA adduct formation by the urban air pollutant 2-nitrobenzanthrone

New Anti-Seizure (Arylalkyl)azole Derivatives: Synthesis, In Vivo and In Silico Studies.

New Iminodiacetate-Thiosemicarbazone Hybrids and Their Copper(II) Complexes Are Potential Ribonucleotide Reductase R2 Inhibitors with High Antiproliferative Activity

New inhibitors of tyrosyl-DNA phosphodiesterase I (Tdp 1) combining 7-hydroxycoumarin and monoterpenoid moieties

Novel Semisynthetic Derivatives of Bile Acids as Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibitors.

One-electron reduction of 2-aminopurine in the aqueous phase. A DFT and pulse radiolysis study

Photoionization versus photoheterolysis of all-trans-retinol. The effects of solvent and laser radiation intensity

Photophysics of trioxatriangulenium ion. electrophilic reactivity in the ground state and excited singlet state.

Radical Chemistry and Cytotoxicity of Bioreductive 3-Substituted Quinoxaline Di-N-Oxides

Serendipity in anticancer drug discovery ⬇️

Size estimation of chemical space: how big is it?

Structure-based design of imidazo[1,2-a]pyrazine derivatives as selective inhibitors of Aurora-A kinase in cells

Synthesis and antiproliferative activity of 2-chlorophenyl carboxamide thienopyridines

Synthesis and biological evaluation of novel tyrosyl-DNA phosphodiesterase 1 inhibitors with a benzopentathiepine moiety

Synthesis and cytotoxicity of thieno[2,3-b]pyridine and furo[2,3-b]pyridine derivatives

Synthesis and cytotoxicity of thieno[2,3-b]quinoline-2-carboxamide and cycloalkyl[b]thieno[3,2-e]pyridine-2-carboxamide derivatives.

Synthesis and in vitro Biological Evaluation of Ferrocenyl Side-Chain-Functionalized Paclitaxel Derivatives.

Target profiling of an antimetastatic RAPTA agent by chemical proteomics: relevance to the mode of action

Target profiling of an antimetastatic RAPTA agent by chemical proteomics: relevance to the mode of action† †Electronic supplementary information (ESI) available: Experimental, crystallographic, biological and mass spectrometric data, full list of pr

The Development of a Weighted Index to Optimise Compound Libraries for High Throughput Screening

The First Berberine-Based Inhibitors of Tyrosyl-DNA Phosphodiesterase 1 (Tdp1), an Important DNA Repair Enzyme

The cytotoxic potential of cationic triangulenes against tumour cells

The effect of PLC-γ2 inhibitors on the growth of human tumour cells

The identification of novel PLC-gamma inhibitors using virtual high throughput screening

The physicochemical properties of a new class of anticancer fungal polysaccharides: a comparative study

Tuning of hydrogen bond strength using substituents on phenol and aniline: a possible ligand design strategy

Validating TDP1 as an Inhibition Target for the Development of Chemosensitizers for Camptothecin-Based Chemotherapy Drugs

Virtual screening and biophysical studies lead to HSP90 inhibitors.

Wine Compounds as a Source for HTS Screening Collections. A Feasibility Study