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A SNP in G6PC2 predicts insulin secretion in type 1 diabetes ⬇️

artículo científico publicado el 22 de marzo de 2012

A comparison of the baseline metabolic profiles between Diabetes Prevention Trial-Type 1 and TrialNet Natural History Study participants

artículo científico publicado en 2011

A new approach for diagnosing type 1 diabetes in autoantibody-positive individuals based on prediction and natural history

artículo científico publicado en 2014

A risk score for type 1 diabetes derived from autoantibody-positive participants in the diabetes prevention trial-type 1.

artículo científico publicado en 2007

Abnormalities in proinsulin processing in islets from individuals with longstanding T1D

scientific article published on 09 August 2019

Acceleration of the loss of the first-phase insulin response during the progression to type 1 diabetes in diabetes prevention trial-type 1 participants

artículo científico publicado en 2013

Accumulation of(125)iodine labeled interleukin-2 in the pancreas of NOD mice

scientific article published on 01 December 2001

Acute Hyperinsulinemia Alters Bone Turnover in Women and Men With Type 1 Diabetes

artículo científico publicado en 2020

Acute hyperglycemia impairs IL-6 expression in humans

artículo científico publicado en 2016

Alefacept provides sustained clinical and immunological effects in new-onset type 1 diabetes patients.

artículo científico publicado en 2015

Altered B Cell Homeostasis Is Associated with Type I Diabetes and Carriers of the PTPN22 Allelic Variant ⬇️

artículo científico publicado el 21 de noviembre de 2011

An Anti-CD3 Antibody, Teplizumab, in Relatives at Risk for Type 1 Diabetes

artículo científico publicado en 2019

Analysis of T-Cell Assays to Measure Autoimmune Responses in Subjects With Type 1 Diabetes

article

Analysis of pancreatic beta cell specific CD4+ T cells reveals a predominance of proinsulin specific cells

scientific article published on 07 November 2018

Antigen-Specific T Cell Analysis Reveals That Active Immune Responses to β Cell Antigens Are Focused on a Unique Set of Epitopes.

artículo científico publicado en 2017

Antigen-based therapy with glutamic acid decarboxylase (GAD) vaccine in patients with recent-onset type 1 diabetes: a randomised double-blind trial ⬇️

artículo científico publicado el 27 de junio de 2011

Assessment of Beta Cell Mass and Function by AIRmax and IVGTT in High Risk Subjects for Type 1 Diabetes

artículo científico publicado en 2017

Assessment of CD4+ T cell responses to glutamic acid decarboxylase 65 using DQ8 tetramers reveals a pathogenic role of GAD65 121-140 and GAD65 250-266 in T1D development

artículo científico publicado en 2014

Attenuated IL-2R signaling in CD4 memory T cells of T1D subjects is intrinsic and dependent on activation state.

artículo científico publicado en 2017

Autoantibodies Directed Toward a Novel IA-2 Variant Protein Enhance Prediction of Type 1 Diabetes

artículo científico publicado en 2019

Autoantibody Reversion: Changing Risk Categories in Multiple-Autoantibody-Positive Individuals

scientific article published on 04 February 2020

Autoimmunity and clinical course in children with type 1, type 2, and type 1.5 diabetes

artículo científico publicado en 2005

Autoimmunity to islet proteins in children diagnosed with new-onset diabetes

artículo científico publicado en 2004

Autoreactive CD8+ T cell exhaustion distinguishes subjects with slow type 1 diabetes progression

artículo científico publicado en 2020

Autoreactive T cells specific for insulin B:11-23 recognize a low-affinity peptide register in human subjects with autoimmune diabetes

artículo científico publicado en 2014

Avidity-dependent programming of autoreactive T cells in T1D

artículo científico publicado en 2014

B lymphocyte alterations accompany abatacept resistance in new-onset type 1 diabetes

artículo científico publicado en 2019

B-lymphocyte depletion with rituximab and β-cell function: two-year results

artículo científico publicado en 2013

Biobanking, consent, and commercialization in international genetics research: the Type 1 Diabetes Genetics Consortium

artículo científico publicado en 2010

C-Peptide Levels in Subjects Followed Longitudinally Before and After Type 1 Diabetes Diagnosis in TrialNet

scientific article published on 26 May 2020

C-peptide is the appropriate outcome measure for type 1 diabetes clinical trials to preserve beta-cell function: report of an ADA workshop, 21-22 October 2001.

artículo científico publicado en 2004

CD4+ T cells from type 1 diabetic and healthy subjects exhibit different thresholds of activation to a naturally processed proinsulin epitope

artículo científico publicado en 2008

CD4+ T cells recognize diverse epitopes within GAD65: implications for repertoire development and diabetes monitoring.

artículo científico publicado en 2013

Cell type-specific immune phenotypes predict loss of insulin secretion in new-onset type 1 diabetes

artículo científico publicado en 2019

Cellular immune responses to human islet proteins in antibody-positive type 2 diabetic patients.

artículo científico publicado en 1999

Changes in autoreactive T cell avidity during type 1 diabetes development.

scientific article published on 23 May 2009

Changing the Course of Disease in Type 1 Diabetes

artículo científico publicado en 2000

Clinical evolution of beta cell function in youth with diabetes: the SEARCH for Diabetes in Youth study ⬇️

artículo científico publicado el 20 de septiembre de 2012

Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled trial ⬇️

artículo científico publicado el 28 de junio de 2011

Comment on: Atkinson. It's Time to Consider Changing the Rules: The Rationale for Rethinking Control Groups in Clinical Trials Aimed at Reversing Type 1 Diabetes. Diabetes 2011;60:361–363 ⬇️

artículo científico publicado el 1 de junio de 2011

Comparative study of GAD65-specific CD4+ T cells in healthy and type 1 diabetic subjects

artículo científico publicado en 2005

Conformation-dependent GAD65 autoantibodies in diabetes

artículo científico publicado en 2004

Costimulation modulation with abatacept in patients with recent-onset type 1 diabetes: follow-up 1 year after cessation of treatment

artículo científico publicado en 2013

DRB4*01:01 Has a Distinct Motif and Presents a Proinsulin Epitope That Is Recognized in Subjects with Type 1 Diabetes

artículo científico publicado en 2018

Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4(+)CD25(+) regulatory T-cells of type 1 diabetic subjects

artículo científico publicado en 2009

Defining pathways for development of disease-modifying therapies in children with type 1 diabetes: a consensus report

artículo científico publicado en 2015

Discriminative T cell recognition of cross-reactive islet-antigens is associated with HLA-DQ8 transdimer-mediated autoimmune diabetes

scientific article published on 21 August 2019

Disease modifying therapies in type 1 diabetes: Where have we been, and where are we going?

artículo científico publicado en 2015

Disease progression among 446 children with newly diagnosed type 1 diabetes located in Scandinavia, Europe, and North America during the last 27 yr

artículo científico publicado en 2013

Disease-Modifying Therapies in Type 1 Diabetes: A Look into the Future of Diabetes Practice

artículo científico publicado en 2019

Dissecting heterogeneity in paediatric Type 1 diabetes: association of TCF7L2 rs7903146 TT and low-risk human leukocyte antigen (HLA) genotypes.

artículo científico publicado en 2016

Dynamic Immune Phenotypes of B and T Helper Cells Mark Distinct Stages of T1D Progression

scientific article published on 20 March 2019

Dynamic perifusion to maintain and assess isolated pancreatic islets

artículo científico publicado en 2002

Editorial: The role of glucagon in postprandial hyperglycemia--the jury's still out

artículo científico publicado en 2007

Effect of Oral Insulin on Prevention of Diabetes in Relatives of Patients With Type 1 Diabetes: A Randomized Clinical Trial

artículo científico publicado en 2017

Effect of rituximab on human in vivo antibody immune responses ⬇️

artículo científico publicado el 9 de septiembre de 2011

Effects of an anti-CD5 immunoconjugate (CD5-plus) in recent onset type I diabetes mellitus: a preliminary investigation. The CD5 Diabetes Project Team

artículo científico publicado en 1993

Effects of oral insulin in relatives of patients with type 1 diabetes: The Diabetes Prevention Trial--Type 1.

artículo científico publicado en 2005

Elevated T cell levels in peripheral blood predict poor clinical response following rituximab treatment in new-onset type 1 diabetes

artículo científico publicado en 2018

Emerging Concepts on Disease-Modifying Therapies in Type 1 Diabetes

artículo científico publicado en 2017

Enhanced T cell responses to IL-6 in type 1 diabetes are associated with early clinical disease and increased IL-6 receptor expression

artículo científico publicado en 2016

Erratum to: Understanding and preventing type 1 diabetes through the unique working model of TrialNet.

artículo científico publicado en 2017

Erratum. Genetics coming of age in type 1 diabetes. Diabetes Care 2019;42:189-191

article

Erratum. Validation of the Diabetes Prevention Trial-Type 1 Risk Score in the TrialNet Natural History Study. Diabetes Care 2011;34:1785-1787.

artículo científico publicado en 2018

Erratum. Who Is Enrolling? The Path to Monitoring in Type 1 Diabetes TrialNet's Pathway to Prevention. Diabetes Care 2019;42:2228-2236

artículo científico publicado en 2020

Evaluation of in vivo T cell kinetics: use of heavy isotope labelling in type 1 diabetes

artículo científico publicado en 2013

Evaluation of leptin levels in subjects at risk for type 1 diabetes

scientific article published on 27 December 2005

Failure to preserve beta-cell function with mycophenolate mofetil and daclizumab combined therapy in patients with new- onset type 1 diabetes

artículo científico publicado en 2010

Fall in C-Peptide During First 4 Years From Diagnosis of Type 1 Diabetes: Variable Relation to Age, HbA1c, and Insulin Dose

artículo científico publicado en 2016

Fall in C-peptide during first 2 years from diagnosis: evidence of at least two distinct phases from composite Type 1 Diabetes TrialNet data

artículo científico publicado en 2012

Fifth International Serum Exchange Workshop for Insulin Autoantibody (IAA) Standardization. The Immunology and Diabetes Workshops and participating laboratories

artículo científico publicado el 1 de agosto de 1992

Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes

artículo científico publicado en 2021

First Genome-Wide Association Study of Latent Autoimmune Diabetes in Adults Reveals Novel Insights Linking Immune and Metabolic Diabetes

artículo científico publicado en 2018

Functional islet-specific Treg can be generated from CD4+CD25- T cells of healthy and type 1 diabetic subjects

artículo científico publicado en 2009

Future intervention trials in type 1 diabetes

artículo científico publicado en 2004

GAD65-specific CD4+ T-cells with high antigen avidity are prevalent in peripheral blood of patients with type 1 diabetes

artículo científico publicado en 2004

Genetic Discrimination Between LADA and Childhood-Onset Type 1 Diabetes Within the MHC

scientific article published on 16 December 2019

Genetic variation in PTPN22 corresponds to altered function of T and B lymphocytes

artículo científico publicado en 2007

Genetics Coming of Age in Type 1 Diabetes

artículo científico publicado en 2019

Glucose excursions between states of glycemia with progression to type 1 diabetes in the diabetes prevention trial-type 1 (DPT-1).

artículo científico publicado en 2010

Guidelines for Intervention Trials in Subjects With Newly Diagnosed Type 1 Diabetes ⬇️

artículo científico publicado el 1 de mayo de 2003

HLA-DRB1*15:01-DQA1*01:02-DQB1*06:02 Haplotype Protects Autoantibody-Positive Relatives From Type 1 Diabetes Throughout the Stages of Disease Progression

artículo científico publicado en 2016

Heterogeneity in recent-onset type 1 diabetes - a clinical trial perspective

artículo científico publicado en 2015

High Concentration of Medium-Sized HDL Particles and Enrichment in HDL Paraoxonase 1 Associate With Protection From Vascular Complications in People With Long-standing Type 1 Diabetes

scientific article published on 09 October 2019

High frequency of abnormal glucose tolerance in DQA1*0102/DQB1*0602 relatives identified as part of the Diabetes Prevention Trial--Type 1 Diabetes

artículo científico publicado en 2004

High residual C-peptide likely contributes to glycemic control in type 1 diabetes

artículo científico publicado en 2020

Hyaluronan deposition in islets may precede and direct the location of islet immune-cell infiltrates

artículo científico publicado en 2020

Hybrid Insulin Peptides are Recognized by Human T Cells in the Context of DRB1*04:01

scientific article published on 14 April 2020

IL-2 therapy in type 1 diabetes: "Trials" and tribulations

artículo científico

ISPAD Clinical Practice Consensus Guidelines 2018: Stages of type 1 diabetes in children and adolescents

artículo científico publicado en 2018

Identification of Novel HLA-A*0201-restricted epitopes in recent-onset type 1 diabetic subjects and antibody-positive relatives

artículo científico publicado en 2006

Identification of tissue-specific cell death using methylation patterns of circulating DNA

artículo científico publicado en 2016

Immunomodulation in type 1 diabetes by NBI-6024, an altered peptide ligand of the insulin B epitope

scientific article published on 01 January 2006

Impaired beta-cell function, incretin effect, and glucagon suppression in patients with type 1 diabetes who have normal fasting glucose

artículo científico publicado en 2002

Improved specificity of ICA assays in the Fourth International Immunology of Diabetes Serum Exchange Workshop

artículo científico publicado el 1 de diciembre de 1992

Improvement in outcomes of clinical islet transplantation: 1999-2010.

artículo científico publicado en 2012

In-vivo assessment of T cell kinetics in individuals at risk for type 1 diabetes

artículo científico publicado en 2019

Incident dysglycemia and progression to type 1 diabetes among participants in the Diabetes Prevention Trial-Type 1

artículo científico publicado en 2009

Increased specificity and sensitivity of insulin antibody measurements in autoimmune thyroid disease and type I diabetes

artículo científico publicado en 1992

Increasing the accuracy of oral glucose tolerance testing and extending its application to individuals with normal glucose tolerance for the prediction of type 1 diabetes: the Diabetes Prevention Trial-Type 1.

artículo científico publicado en 2007

Innate immune activity as a predictor of persistent insulin secretion and association with responsiveness to CTLA4-Ig treatment in recent-onset type 1 diabetes

article

Innate immune stimulation of whole blood reveals IFN-1 hyper-responsiveness in type 1 diabetes

scientific article published on 05 June 2020

Insulin Antibodies and Insulin Autoantibodies ⬇️

artículo científico publicado el 1 de febrero de 1991

Insulin autoantibodies measured by radioimmunoassay methodology are more related to insulin-dependent diabetes mellitus than those measured by enzyme-linked immunosorbent assay: results of the Fourth International Workshop on the Standardization of

artículo científico publicado en 1992

Insulin is necessary but not sufficient: changing the therapeutic paradigm in type 1 diabetes

artículo científico publicado en 2020

Insulin resistance in type 1 diabetes

artículo científico publicado en 2002

Interaction of Onset and Duration of Diabetes on the Percent of GAD and IA-2 Antibody–Positive Subjects in the Type 1 Diabetes Genetics Consortium Database ⬇️

artículo científico publicado el 17 de febrero de 2011

Interleukin-1 antagonism in type 1 diabetes of recent onset: two multicentre, randomised, double-blind, placebo-controlled trials

artículo científico publicado en 2013

Interleukin-1 antagonism moderates the inflammatory state associated with Type 1 diabetes during clinical trials conducted at disease onset

artículo científico publicado en 2015

Intermolecular antigen spreading occurs during the preclinical period of human type 1 diabetes

artículo científico publicado en 2001

International comparison of C-peptide measurements

artículo científico publicado en 2007

Intra-islet insulin permits glucose to directly suppress pancreatic A cell function ⬇️

artículo científico publicado el 1 de septiembre de 1991

Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes

artículo científico publicado en 2019

Islet cell antibodies and glutamic acid decarboxylase antibodies, but not the clinical phenotype, help to identify type 1(1/2) diabetes in patients presenting with type 2 diabetes

artículo científico publicado en 2001

Islet cell antibody-positive relatives with human leukocyte antigen DQA1*0102, DQB1*0602: identification by the Diabetes Prevention Trial-type 1

artículo científico publicado en 2000

Islet-specific glucose-6-phosphatase catalytic subunit-related protein-reactive CD4+ T cells in human subjects.

artículo científico publicado en 2006

Latent autoimmune diabetes in adults (LADA) should be less latent

artículo científico publicado en 2005

Longitudinal monitoring of gene expression in ultra-low-volume blood samples self-collected at home

artículo científico publicado en 2016

Low HERV-K(C4) copy number is associated with type 1 diabetes

artículo científico publicado en 2014

Low serum conditions for in vitro generation of human macrophages with macrophage colony stimulating factor

artículo científico publicado en 2001

Low-Dose Anti-Thymocyte Globulin (ATG) Preserves β-Cell Function and Improves HbA in New-Onset Type 1 Diabetes

article

Low-Dose Anti-Thymocyte Globulin Preserves C-Peptide, Reduces HbA1c, and Increases Regulatory to Conventional T-Cell Ratios in New-Onset Type 1 Diabetes: Two-Year Clinical Trial Data

artículo científico publicado en 2019

Macrophages from high-risk HLA-DQB1*0201/*0302 type 1 diabetes mellitus patients are hypersensitive to lipopolysaccharide stimulation.

artículo científico publicado en 2002

Major histocompatibility complex class I molecule expression is normal on peripheral blood lymphocytes from patients with insulin-dependent diabetes mellitus

artículo científico publicado en 1996

Making progress: preserving beta cells in type 1 diabetes ⬇️

artículo científico publicado el 1 de diciembre de 2011

Male sex increases the risk of autoimmunity but not type 1 diabetes

artículo científico publicado en 2004

Measurement of Pro-Islet Amyloid Polypeptide (1-48) in Diabetes and Islet Transplants

artículo científico publicado en 2017

Metabolic tests to determine risk for type 1 diabetes in clinical trials ⬇️

artículo científico publicado el 1 de septiembre de 2011

Mixed-meal tolerance test versus glucagon stimulation test for the assessment of beta-cell function in therapeutic trials in type 1 diabetes

artículo científico publicado en 2008

Modifying Enzymes are Elicited by ER Stress, Generating Epitopes that are Selectively Recognized by CD4+ T Cells in Patients With Type 1 Diabetes.

artículo científico publicado en 2018

Molecular signatures differentiate immune states in type 1 diabetic families

artículo científico publicado en 2014

Multiple autoimmune-associated variants confer decreased IL-2R signaling in CD4+ CD25(hi) T cells of type 1 diabetic and multiple sclerosis patients

artículo científico publicado en 2013

Multiplexing DNA methylation markers to detect circulating cell-free DNA derived from human pancreatic beta-cells

artículo científico publicado en 2020

NETosis-associated serum biomarkers are reduced in type 1 diabetes in association with neutrophil count

artículo científico publicado en 2016

Nicotinamide's effects on glucose metabolism in subjects at risk for IDDM

artículo científico publicado en 1996

Non-invasive imaging of beta cell mass: a quantitative analysis

artículo científico publicado en 2004

Nonprogression of subclinical beta-cell dysfunction among first-degree relatives of IDDM patients. 5-yr follow-up of the Seattle Family Study

artículo científico publicado en 1990

Nonprogression of subclinical beta-cell dysfunction among first-degree relatives of IDDM patients. 5-yr follow-up of the Seattle Family Study

Parenteral insulin suppresses T cell proliferation to islet antigens

artículo científico publicado en 2011

Patterns of metabolic progression to type 1 diabetes in the Diabetes Prevention Trial-Type 1.

artículo científico publicado en 2006

Peripheral blood mononuclear cells of insulin-dependent diabetic patients respond to multiple islet cell proteins

artículo científico publicado en 1996

Persistence is the twin sister of excellence: an important lesson for attempts to prevent and reverse type 1 diabetes

artículo científico publicado en 2011

Preservation of C-peptide secretion in subjects at high risk of developing type 1 diabetes mellitus--a new surrogate measure of non-progression?

artículo científico publicado en 2004

Preservation of beta-cell function in autoantibody-positive youth with diabetes

artículo científico publicado en 2009

Prevalence of detectable C-Peptide according to age at diagnosis and duration of type 1 diabetes

artículo científico publicado en 2014

Prevalence, characteristics and clinical diagnosis of maturity onset diabetes of the young due to mutations in HNF1A, HNF4A, and glucokinase: results from the SEARCH for Diabetes in Youth

artículo científico publicado en 2013

Progress, but not yet ready for clinical use: interrupting immune-mediated destruction of pancreatic beta cells in type 1 diabetes

artículo científico publicado en 2006

Proinsulin Secretion Is a Persistent Feature of Type 1 Diabetes

scientific article published on 10 December 2018

Prospective evaluation of β-cell function in insulin antoantibody-positive relatives of insulin-dependent diabetic patients

artículo científico publicado en 1993

Rapamycin/IL-2 Combination Therapy in Patients With Type 1 Diabetes Augments Tregs yet Transiently Impairs β-Cell Function ⬇️

artículo científico publicado el 20 de junio de 2012

Recognition of posttranslationally modified GAD65 epitopes in subjects with type 1 diabetes.

artículo científico publicado en 2014

Reduced CD11b Integrin Expression with Short-term Administration of an IL-1R Antagonist in Type 1 Diabetes Patients

Relationship of beta-cell function and autoantibodies to progression and nonprogression of subclinical type 1 diabetes: follow-up of the Seattle Family Study

scientific article published on 01 January 1999

Residual C-peptide in type 1 diabetes: what do we really know?

artículo científico

Response to Comment on Sims et al. Proinsulin Secretion Is a Persistent Feature of Type 1 Diabetes. Diabetes Care 2019;42:258-264

artículo científico publicado en 2019

Response to Comment on So et al. Autoantibody Reversion: Changing Risk Categories in Multiple-Autoantibody-Positive Individuals. Diabetes Care 2020;43:913-917

artículo científico publicado en 2020

Response to Comment on: Greenbaum et al. Fall in C-peptide during first 2 years from diagnosis: evidence of at least two distinct phases from composite type 1 diabetes TrialNet data. Diabetes 2012;61:2066-2073.

artículo científico publicado en 2013

Response to Comment on: Greenbaum et al. Through the Fog: Recent Clinical Trials to Preserve β-Cell Function in Type 1 Diabetes. Diabetes 2012;61:1323–1330.

artículo científico publicado en 2012

Rituximab, B-Lymphocyte Depletion, and Preservation of Beta-Cell Function

article

Role of insulin resistance in predicting progression to type 1 diabetes

scientific article published on 29 May 2007

Sample size requirements for studies of treatment effects on beta-cell function in newly diagnosed type 1 diabetes

artículo científico publicado en 2011

Sensitive detection of multiple islet autoantibodies in type 1 diabetes using small sample volumes by agglutination-PCR

artículo científico publicado en 2020

Short-term IL-1β blockade reduces monocyte CD11b integrin expression in an IL-8 dependent fashion in patients with type 1 diabetes

artículo científico publicado en 2010

Short-term responses to periodontal therapy in insulin-dependent diabetic patients

artículo científico publicado en 1996

Single-Cell RNA Sequencing Reveals Expanded Clones of Islet Antigen-Reactive CD4+ T Cells in Peripheral Blood of Subjects with Type 1 Diabetes.

artículo científico publicado en 2017

Specific human leukocyte antigen DQ influence on expression of antiislet autoantibodies and progression to type 1 diabetes

scientific article published on 07 February 2006

Stacking the Deck: Studies of Patients with Multiple Autoimmune Diseases Propelled Our Understanding of Type 1 Diabetes as an Autoimmune Disease.

artículo científico publicado en 2017

Staging presymptomatic type 1 diabetes: a scientific statement of JDRF, the Endocrine Society, and the American Diabetes Association

scientific article published on October 2015

Standardization of C-peptide measurements

artículo científico publicado en 2008

Strength in Numbers: Opportunities for Enhancing the Development of Effective Treatments for Type 1 Diabetes-The TrialNet Experience

scientific article published on 16 May 2018

Stress Testing of an Artificial Pancreas System With Pizza and Exercise Leads to Improvements in the System's Fuzzy Logic Controller

artículo científico publicado en 2015

Systematic Assessment of Immune Marker Variation in Type 1 Diabetes: A Prospective Longitudinal Study

artículo científico publicado en 2019

Systematic screening of potential beta-cell imaging agents

artículo científico publicado en 2004

T.128. Short-term Administration of Anakinra does not Appear to Affect Stimulated C-peptide Responses Acutely in Patients with Type 1 Diabetes

article

Targeting of memory T cells with alefacept in new-onset type 1 diabetes (T1DAL study): 12 month results of a randomised, double-blind, placebo-controlled phase 2 trial

artículo científico publicado en 2013

Teplizumab (anti-CD3 mAb) treatment preserves C-peptide responses in patients with new-onset type 1 diabetes in a randomized controlled trial: metabolic and immunologic features at baseline identify a subgroup of responders

artículo científico publicado en 2013

The Effect of DPT-1 Intravenous Insulin Infusion and Daily Subcutaneous Insulin on Endogenous Insulin Secretion and Postprandial Glucose Tolerance

artículo científico publicado en 2015

The Fourth International Workshop on the Standardisation of Insulin Autoantibody Workshop.

artículo científico publicado en 1990

The antibody response to bacteriophage is linked to the lymphopenia gene in congenic BioBreeding rats

scientific journal article

The application of the diabetes prevention trial-type 1 risk score for identifying a preclinical state of type 1 diabetes

artículo científico publicado en 2012

The case for intravenous arginine stimulation in lieu of mixed-meal tolerance tests as outcome measure for intervention studies in recent-onset type 1 diabetes

artículo científico publicado en 2004

The development and utility of a novel scale that quantifies the glycemic progression toward type 1 diabetes over 6 months

artículo científico publicado en 2015

The effect of age on insulin sensitivity and insulin secretion in first-degree relatives of type 1 diabetic patients: a population analysis

scientific article published on 28 April 2009

The effector T cells of diabetic subjects are resistant to regulation via CD4+ FOXP3+ regulatory T cells

artículo científico publicado en 2008

The influence of exposure to maternal diabetes in utero on the rate of decline in β-cell function among youth with diabetes

artículo científico publicado en 2013

The relationship between BMI and insulin resistance and progression from single to multiple autoantibody positivity and type 1 diabetes among TrialNet Pathway to Prevention participants

artículo científico publicado en 2016

Through the fog: recent clinical trials to preserve β-cell function in type 1 diabetes

artículo científico

Treatment of patients with new onset Type 1 diabetes with a single course of anti-CD3 mAb Teplizumab preserves insulin production for up to 5 years

scientific article published on 14 May 2009

Treatment of type 1 diabetes with teplizumab: clinical and immunological follow-up after 7 years from diagnosis

artículo científico publicado en 2018

Trends of earlier and later responses of C-peptide to oral glucose challenges with progression to type 1 diabetes in diabetes prevention trial-type 1 participants

artículo científico publicado en 2009

Type 1 Diabetes TrialNet--an international collaborative clinical trials network

artículo científico publicado en 2008

Type 1 Diabetes TrialNet: A Multifaceted Approach to Bringing Disease-Modifying Therapy to Clinical Use in Type 1 Diabetes

artículo científico publicado en 2018

Type 1 diabetes intervention trials: what have we learned? A critical review of selected intervention trials

artículo científico publicado en 2002

Type 1 diabetes mellitus: primary, secondary, and tertiary prevention

scientific article published on August 2008

Type I diabetes manifested solely by 2-h oral glucose tolerance test criteria

artículo científico publicado en 2001

Understanding and preventing type 1 diabetes through the unique working model of TrialNet

artículo científico publicado en 2017

Urinary excretion of RAS, BMP, and WNT pathway components in diabetic kidney disease

artículo científico publicado en 2014

Use of a "fuzzy logic" controller in a closed-loop artificial pancreas

artículo científico publicado en 2013

Use of oral glucose minimal model-derived index of insulin sensitivity in subjects with early type 1 diabetes mellitus

artículo científico publicado en 2008

Use of the Diabetes Prevention Trial-Type 1 Risk Score (DPTRS) for improving the accuracy of the risk classification of type 1 diabetes

artículo científico publicado en 2014

Validation of the Diabetes Prevention Trial-Type 1 Risk Score in the TrialNet Natural History Study

artículo científico publicado en 2011

Who Is Enrolling? The Path to Monitoring in Type 1 Diabetes TrialNet's Pathway to Prevention

artículo científico publicado en 2019

Zinc Transporter-8 Autoantibodies Improve Prediction of Type 1 Diabetes in Relatives Positive for the Standard Biochemical Autoantibodies ⬇️

artículo científico publicado el 23 de marzo de 2012

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