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Carnitine palmitoyltransferases 1 and 2: biochemical, molecular and medical aspects

artículo científico publicado en 2004

Correlation between genotype, metabolic data, and clinical presentation in carnitine palmitoyltransferase 2 (CPT2) deficiency.

artículo científico publicado en 2003

Demonstration of N- and C-terminal domain intramolecular interactions in rat liver carnitine palmitoyltransferase 1 that determine its degree of malonyl-CoA sensitivity

artículo científico publicado en 2005

Enhancing enterocyte fatty acid oxidation in mice affects glycemic control depending on dietary fat

artículo científico publicado en 2018

Enhancing hepatic mitochondrial fatty acid oxidation stimulates eating in food-deprived mice

artículo científico publicado en 2014

Enhancing liver mitochondrial fatty acid oxidation capacity in obese mice improves insulin sensitivity independently of hepatic steatosis

artículo científico publicado en 2011

Functional and structural basis of carnitine palmitoyltransferase 1A deficiency.

artículo científico publicado en 2003

Glucose induces de novo lipogenesis in rat muscle satellite cells through a sterol-regulatory-element-binding-protein-1c-dependent pathway

artículo científico publicado en 2004

Impaired energy metabolism of senescent muscle satellite cells is associated with oxidative modifications of glycolytic enzymes

artículo científico publicado en 2016

Impaired metabolism of senescent muscle satellite cells is associated with oxidative modifications of glycolytic enzymes

artículo científico publicado en 2014

Increased mitochondrial fatty acid oxidation is sufficient to protect skeletal muscle cells from palmitate-induced apoptosis

artículo científico publicado en 2010

Increasing mitochondrial muscle fatty acid oxidation induces skeletal muscle remodeling toward an oxidative phenotype

scientific article published on 23 February 2015

Inhibition of hepatic carnitine palmitoyl-transferase I (CPT IA) by valproyl-CoA as a possible mechanism of valproate-induced steatosis

artículo científico publicado en 2009

Inhibition of receptor-interacting protein kinase 1 improves experimental non-alcoholic fatty liver disease

artículo científico publicado en 2019

Liver microRNA-21 is overexpressed in non-alcoholic steatohepatitis and contributes to the disease in experimental models by inhibiting PPARα expression

artículo científico publicado en 2015

Mitochondrial retrograde signaling mediated by UCP2 inhibits cancer cell proliferation and tumorigenesis

artículo científico publicado en 2014

Modulation of the hepatic malonyl-CoA-carnitine palmitoyltransferase 1A partnership creates a metabolic switch allowing oxidation of de novo fatty acids

scientific journal article

Muscle expression of a malonyl-CoA-insensitive carnitine palmitoyltransferase-1 protects mice against high-fat/high-sucrose diet-induced insulin resistance.

artículo científico publicado en 2016

Myocardial carnitine palmitoyltransferase I expression and long-chain fatty acid oxidation in fetal and newborn lambs

artículo científico publicado en 2004

N-3PUFA differentially modulate palmitate-induced lipotoxicity through alterations of its metabolism in C2C12 muscle cells.

artículo científico publicado en 2015

Novel Grb14-Mediated Cross Talk between Insulin and p62/Nrf2 Pathways Regulates Liver Lipogenesis and Selective Insulin Resistance

scientific article published on 23 May 2016

Oleate dose-dependently regulates palmitate metabolism and insulin signaling in C2C12 myotubes

artículo científico publicado en 2016

Oleate metabolism in pig enterocytes is characterized by an increased oxidation rate in the presence of a high esterification rate within two days after birth

artículo científico publicado en 2012

Organization of the human liver carnitine palmitoyltransferase 1 gene ( CPT1A) and identification of novel mutations in hypoketotic hypoglycaemia

artículo científico publicado en 2002

Oxidation of hydrogen sulfide by human liver mitochondria.

artículo científico publicado en 2014

Protective role of the ELOVL2/docosahexaenoic acid axis in glucolipotoxicity-induced apoptosis in rodent beta cells and human islets.

artículo científico publicado en 2018

Rat liver carnitine palmitoyltransferase 1 forms an oligomeric complex within the outer mitochondrial membrane

artículo científico publicado en 2007

The Ala16Val genetic dimorphism modulates the import of human manganese superoxide dismutase into rat liver mitochondria

artículo científico publicado en 2003

The N-terminal Domain of Rat Liver Carnitine Palmitoyltransferase 1 Mediates Import into the Outer Mitochondrial Membrane and Is Essential for Activity and Malonyl-CoA Sensitivity

artículo científico publicado el 6 de noviembre de 1998

The extreme C terminus of rat liver carnitine palmitoyltransferase I is not involved in malonyl-CoA sensitivity but in initial protein folding

scientific journal article

The histone demethylase Phf2 acts as a molecular checkpoint to prevent NAFLD progression during obesity.

artículo científico publicado en 2018

The role of the GrpE homologue, Mge1p, in mediating protein import and protein folding in mitochondria

artículo científico publicado el 17 de julio de 1995

The transcription factor COUP-TFII is negatively regulated by insulin and glucose via Foxo1- and ChREBP-controlled pathways

artículo científico publicado en 2008

Topological and functional analysis of the rat liver carnitine palmitoyltransferase 1 expressed in Saccharomyces cerevisiae

artículo científico publicado el 12 de junio de 1998

UCP2 Deficiency Increases Colon Tumorigenesis by Promoting Lipid Synthesis and Depleting NADPH for Antioxidant Defenses

scientific article published on 01 August 2019