Lista de obras -

A Single Glycan at the 99-Loop of Human Kallikrein-related Peptidase 2 Regulates Activation and Enzymatic Activity

artículo científico publicado en 2015

A bioengineered 3D ovarian cancer model for the assessment of peptidase-mediated enhancement of spheroid growth and intraperitoneal spread

artículo científico publicado en 2013

Advanced high-grade serous ovarian cancer: inverse association of KLK13 and KLK14 mRNA levels in tumor tissue and patients' prognosis

artículo científico publicado en 2018

Assessment of Urokinase-Type Plasminogen Activator and Its Inhibitor PAI-1 in Breast Cancer Tissue: Historical Aspects and Future Prospects ⬇️

artículo científico publicado el 15 de octubre de 2008

Assessment of kallikrein-related peptidase 5 (KLK5) protein expression in tumor tissue of advanced ovarian cancer patients by immunohistochemistry and ELISA: correlation with clinical outcome

artículo científico publicado en 2015

Association of tissue mRNA and serum antigen levels of members of the urokinase-type plasminogen activator system with clinical and prognostic parameters in prostate cancer.

artículo científico publicado en 2014

Characteristics of the level-of-evidence-1 disease forecast cancer biomarkers uPA and its inhibitor PAI-1.

artículo científico publicado en 2010

Characterization of kallikrein-related peptidase 4 (KLK4) mRNA expression in tumor tissue of advanced high-grade serous ovarian cancer patients

artículo científico publicado en 2019

Chymotryptic specificity determinants in the 1.0 A structure of the zinc-inhibited human tissue kallikrein 7

artículo científico publicado en 2007

Clinical relevance of kallikrein-related peptidase 9, 10, 11, and 15 mRNA expression in advanced high-grade serous ovarian cancer.

artículo científico publicado en 2017

Clinical utility of level-of-evidence-1 disease forecast cancer biomarkers uPA and its inhibitor PAI-1.

artículo científico publicado en 2010

Combined expression of KLK4, KLK5, KLK6, and KLK7 by ovarian cancer cells leads to decreased adhesion and paclitaxel-induced chemoresistance

artículo científico publicado en 2012

Combined mRNA expression levels of members of the urokinase plasminogen activator (uPA) system correlate with disease-associated survival of soft-tissue sarcoma patients

artículo científico publicado en 2011

Downregulation of serine protease HTRA1 is associated with poor survival in breast cancer

artículo científico publicado en 2013

Emerging clinical importance of the cancer biomarkers kallikrein-related peptidases (KLK) in female and male reproductive organ malignancies

artículo científico publicado en 2013

Function and clinical relevance of kallikrein-related peptidases and other serine proteases in gynecological cancers

artículo científico publicado en 2014

Gene expression analysis of HUVEC in response to TF-binding ⬇️

artículo científico publicado el 24 de diciembre de 2010

Impact of expression of the uPA system in sarcomas

artículo científico publicado en 2013

In vitro evidence that KLK14 regulates the components of the HGF/Met axis, pro-HGF and HGF-activator inhibitor 1A and 1B.

artículo científico publicado en 2016

Inhibition of the tumor-associated urokinase-type plasminogen activation system: effects of high-level synthesis of soluble urokinase receptor in ovarian and breast cancer cells in vitro and in vivo

artículo científico publicado en 2003

KLK4 Induces Anti-Tumor Effects in Human Xenograft Mouse Models of Orthotopic and Metastatic Prostate Cancer

artículo científico publicado en 2020

Kallikrein-related peptidase 4: a new activator of the aberrantly expressed protease-activated receptor 1 in colon cancer cells

artículo científico publicado en 2010

Molecular and functional interdependence of the urokinase-type plasminogen activator system with integrins

artículo científico publicado en 2003

Natural and synthetic inhibitors of kallikrein-related peptidases (KLKs).

artículo científico publicado en 2010

Non-muscle alpha-actinin-4 interacts with plasminogen activator inhibitor type-1 (PAI-1).

artículo científico publicado en 2004

Overexpression of the urokinase receptor splice variant uPAR-del4/5 in breast cancer cells affects cell adhesion and invasion in a dose-dependent manner and modulates transcription of tumor-associated genes ⬇️

artículo científico publicado el 1 de diciembre de 2012

Phosphoserine aminotransferase 1 is associated to poor outcome on tamoxifen therapy in recurrent breast cancer

artículo científico publicado en 2017

Plasmin(ogen) serves as a favorable biomarker for prediction of survival in advanced high-grade serous ovarian cancer.

artículo científico publicado en 2016

Preclinical evaluation of [111 In]MICA-401, an activity-based probe for SPECT imaging of in vivo uPA activity

artículo científico publicado en 2016

Prognostic impact of urokinase-type plasminogen activator system components in clear cell renal cell carcinoma patients without distant metastasis

artículo científico publicado en 2014

Prognostic relevance of uPAR-del4/5 and TIMP-3 mRNA expression levels in breast cancer.

artículo científico publicado en 2005

Prognostic value of kallikrein-related peptidase 12 (KLK12) mRNA expression in triple-negative breast cancer patients

artículo científico publicado en 2020

Prognostic value of kallikrein-related peptidase 7 (KLK7) mRNA expression in advanced high-grade serous ovarian cancer

artículo científico publicado en 2020

Proteolytic regulation of the urokinase receptor/CD87 on monocytic cells by neutrophil elastase and cathepsin G

artículo científico publicado en 2004

Quantitative assessment and clinical relevance of kallikrein-related peptidase 5 mRNA expression in advanced high-grade serous ovarian cancer

scientific article published on 15 July 2019

Quantitative reverse transcription-PCR assay for detection of mRNA encoding full-length human tissue kallikrein 7: prognostic relevance of KLK7 mRNA expression in breast cancer

artículo científico publicado en 2006

Rab31 expression levels modulate tumor-relevant characteristics of breast cancer cells ⬇️

artículo científico publicado el 24 de agosto de 2012

STIM1/ORAI1-mediated Ca2+ Influx Regulates Enolase-1 Exteriorization.

artículo científico publicado en 2015

Secreted uPAR isoform 2 (uPAR7b) is a novel direct target of miR-221.

artículo científico publicado en 2015

Secretome and degradome profiling shows that Kallikrein-related peptidases 4, 5, 6, and 7 induce TGFβ-1 signaling in ovarian cancer cells

artículo científico publicado en 2013

Specificity profiling of seven human tissue kallikreins reveals individual subsite preferences

artículo científico publicado en 2006

Structural basis for the Zn2+ inhibition of the zymogen-like kallikrein-related peptidase 10

artículo científico publicado en 2016

Structural basis of the zinc inhibition of human tissue kallikrein 5

artículo científico publicado en 2007

Structure-function analyses of human kallikrein-related peptidase 2 establish the 99-loop as master regulator of activity.

artículo científico publicado en 2014

Structures and specificity of the human kallikrein-related peptidases KLK 4, 5, 6, and 7.

artículo científico publicado en 2008

Sweetened kallikrein-related peptidases (KLKs): glycan trees as potential regulators of activation and activity.

artículo científico publicado en 2014

The alpha and beta subunits of the metalloprotease meprin are expressed in separate layers of human epidermis, revealing different functions in keratinocyte proliferation and differentiation

artículo científico publicado en 2007

The human fibrinolytic system is a target for the staphylococcal metalloprotease aureolysin

artículo científico

The solution structure of the kallikrein-related peptidases inhibitor SPINK6

artículo científico publicado en 2016

The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10.

artículo científico publicado en 2012

The urokinase receptor (uPAR, CD87) as a target for tumor therapy: uPA-silica particles (SP-uPA) as a new tool for assessing synthetic peptides to interfere with uPA/uPA-receptor interaction.

artículo científico publicado en 2003

Tissue kallikrein-related peptidase 4 (KLK4), a novel biomarker in triple-negative breast cancer

artículo científico publicado en 2017

Urokinase-type plasminogen activator (uPA) and its receptor (uPAR): development of antagonists of uPA/uPAR interaction and their effects in vitro and in vivo

artículo científico publicado en 2003

Lista de obras de

A Single Glycan at the 99-Loop of Human Kallikrein-related Peptidase 2 Regulates Activation and Enzymatic Activity

A bioengineered 3D ovarian cancer model for the assessment of peptidase-mediated enhancement of spheroid growth and intraperitoneal spread

Advanced high-grade serous ovarian cancer: inverse association of KLK13 and KLK14 mRNA levels in tumor tissue and patients' prognosis

Assessment of Urokinase-Type Plasminogen Activator and Its Inhibitor PAI-1 in Breast Cancer Tissue: Historical Aspects and Future Prospects ⬇️

Assessment of kallikrein-related peptidase 5 (KLK5) protein expression in tumor tissue of advanced ovarian cancer patients by immunohistochemistry and ELISA: correlation with clinical outcome

Association of tissue mRNA and serum antigen levels of members of the urokinase-type plasminogen activator system with clinical and prognostic parameters in prostate cancer.

Characteristics of the level-of-evidence-1 disease forecast cancer biomarkers uPA and its inhibitor PAI-1.

Characterization of kallikrein-related peptidase 4 (KLK4) mRNA expression in tumor tissue of advanced high-grade serous ovarian cancer patients

Chymotryptic specificity determinants in the 1.0 A structure of the zinc-inhibited human tissue kallikrein 7

Clinical relevance of kallikrein-related peptidase 9, 10, 11, and 15 mRNA expression in advanced high-grade serous ovarian cancer.

Clinical utility of level-of-evidence-1 disease forecast cancer biomarkers uPA and its inhibitor PAI-1.

Combined expression of KLK4, KLK5, KLK6, and KLK7 by ovarian cancer cells leads to decreased adhesion and paclitaxel-induced chemoresistance

Combined mRNA expression levels of members of the urokinase plasminogen activator (uPA) system correlate with disease-associated survival of soft-tissue sarcoma patients

Downregulation of serine protease HTRA1 is associated with poor survival in breast cancer

Emerging clinical importance of the cancer biomarkers kallikrein-related peptidases (KLK) in female and male reproductive organ malignancies

Function and clinical relevance of kallikrein-related peptidases and other serine proteases in gynecological cancers

Gene expression analysis of HUVEC in response to TF-binding ⬇️

Impact of expression of the uPA system in sarcomas

In vitro evidence that KLK14 regulates the components of the HGF/Met axis, pro-HGF and HGF-activator inhibitor 1A and 1B.

Inhibition of the tumor-associated urokinase-type plasminogen activation system: effects of high-level synthesis of soluble urokinase receptor in ovarian and breast cancer cells in vitro and in vivo

KLK4 Induces Anti-Tumor Effects in Human Xenograft Mouse Models of Orthotopic and Metastatic Prostate Cancer

Kallikrein-related peptidase 4: a new activator of the aberrantly expressed protease-activated receptor 1 in colon cancer cells

Molecular and functional interdependence of the urokinase-type plasminogen activator system with integrins

Natural and synthetic inhibitors of kallikrein-related peptidases (KLKs).

Non-muscle alpha-actinin-4 interacts with plasminogen activator inhibitor type-1 (PAI-1).

Overexpression of the urokinase receptor splice variant uPAR-del4/5 in breast cancer cells affects cell adhesion and invasion in a dose-dependent manner and modulates transcription of tumor-associated genes ⬇️

Phosphoserine aminotransferase 1 is associated to poor outcome on tamoxifen therapy in recurrent breast cancer

Plasmin(ogen) serves as a favorable biomarker for prediction of survival in advanced high-grade serous ovarian cancer.

Preclinical evaluation of [111 In]MICA-401, an activity-based probe for SPECT imaging of in vivo uPA activity

Prognostic impact of urokinase-type plasminogen activator system components in clear cell renal cell carcinoma patients without distant metastasis

Prognostic relevance of uPAR-del4/5 and TIMP-3 mRNA expression levels in breast cancer.

Prognostic value of kallikrein-related peptidase 12 (KLK12) mRNA expression in triple-negative breast cancer patients

Prognostic value of kallikrein-related peptidase 7 (KLK7) mRNA expression in advanced high-grade serous ovarian cancer

Proteolytic regulation of the urokinase receptor/CD87 on monocytic cells by neutrophil elastase and cathepsin G

Quantitative assessment and clinical relevance of kallikrein-related peptidase 5 mRNA expression in advanced high-grade serous ovarian cancer

Quantitative reverse transcription-PCR assay for detection of mRNA encoding full-length human tissue kallikrein 7: prognostic relevance of KLK7 mRNA expression in breast cancer

Rab31 expression levels modulate tumor-relevant characteristics of breast cancer cells ⬇️

STIM1/ORAI1-mediated Ca2+ Influx Regulates Enolase-1 Exteriorization.

Secreted uPAR isoform 2 (uPAR7b) is a novel direct target of miR-221.

Secretome and degradome profiling shows that Kallikrein-related peptidases 4, 5, 6, and 7 induce TGFβ-1 signaling in ovarian cancer cells

Specificity profiling of seven human tissue kallikreins reveals individual subsite preferences

Structural basis for the Zn2+ inhibition of the zymogen-like kallikrein-related peptidase 10

Structural basis of the zinc inhibition of human tissue kallikrein 5

Structure-function analyses of human kallikrein-related peptidase 2 establish the 99-loop as master regulator of activity.

Structures and specificity of the human kallikrein-related peptidases KLK 4, 5, 6, and 7.

Sweetened kallikrein-related peptidases (KLKs): glycan trees as potential regulators of activation and activity.

The alpha and beta subunits of the metalloprotease meprin are expressed in separate layers of human epidermis, revealing different functions in keratinocyte proliferation and differentiation

The human fibrinolytic system is a target for the staphylococcal metalloprotease aureolysin

The solution structure of the kallikrein-related peptidases inhibitor SPINK6

The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10.

The urokinase receptor (uPAR, CD87) as a target for tumor therapy: uPA-silica particles (SP-uPA) as a new tool for assessing synthetic peptides to interfere with uPA/uPA-receptor interaction.

Tissue kallikrein-related peptidase 4 (KLK4), a novel biomarker in triple-negative breast cancer

Urokinase-type plasminogen activator (uPA) and its receptor (uPAR): development of antagonists of uPA/uPAR interaction and their effects in vitro and in vivo