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"Lineage addiction" in human cancer: lessons from integrated genomics

artículo científico publicado en 2005

A Mathematical Methodology for Determining the Temporal Order of Pathway Alterations Arising during Gliomagenesis ⬇️

artículo científico publicado el 5 de enero de 2012

A Multicenter, Phase II, Randomized, Noncomparative Clinical Trial of Radiation and Temozolomide with or without Vandetanib in Newly Diagnosed Glioblastoma Patients

artículo científico publicado en 2015

A mathematical framework to determine the temporal sequence of somatic genetic events in cancer

artículo científico publicado en 2010

A prognostic cytogenetic scoring system to guide the adjuvant management of patients with atypical meningioma

artículo científico publicado en 2015

ACTR-93. A PHASE I STUDY OF MLN0128 (TAK-228) AND BEVACIZUMAB IN PATIENTS WITH ADVANCED SOLID TUMORS INCLUDING GLIOBLASTOMA

ARID1A and TERT promoter mutations in dedifferentiated meningioma

artículo científico publicado en 2015

AT-36PANOBINOSTAT IN COMBINATION WITH BEVACIZUMAB FOR RECURRENT GLIOBLASTOMA AND ANAPLASTIC GLIOMA

ATARiS: computational quantification of gene suppression phenotypes from multisample RNAi screens

artículo científico publicado en 2012

ATNT-18A PHASE I STUDY OF MLN0128 AND BEVACIZUMAB IN PATIENTS WITH RECURRENT GLIOBLASTOMA AND OTHER SOLID TUMORS.

artículo científico publicado en 2015

Absolute quantification of somatic DNA alterations in human cancer

artículo científico publicado en 2012

Abstracts

article by L. Bie et al published 1 April 2013 in Neuro-Oncology

Adjuvant radiation therapy, local recurrence, and the need for salvage therapy in atypical meningioma

artículo científico publicado en 2014

Allele-specific amplification in cancer revealed by SNP array analysis

artículo científico publicado en 2005

Amplification and overexpression of prosaposin in prostate cancer

artículo científico publicado en 2005

Amplification of chromosomal segment 4q12 in non-small cell lung cancer

artículo científico publicado en 2009

Amplification of phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis.

artículo científico publicado en 2012

An in-tumor genetic screen reveals that the BET bromodomain protein, BRD4, is a potential therapeutic target in ovarian carcinoma

artículo científico publicado en 2014

An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaB

artículo científico publicado en 2010

Analyses of non-coding somatic drivers in 2,658 cancer whole genomes

artículo científico publicado en 2020

Ancestry-specific predisposing germline variants in cancer

artículo científico publicado en 2020

Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer

scientific article published on July 2009

Aneuploidy renders cancer cells vulnerable to mitotic checkpoint inhibition

artículo científico publicado en 2021

Angiomatous meningiomas have a distinct genetic profile with multiple chromosomal polysomies including polysomy of chromosome 5.

artículo científico publicado en 2014

Assessing the significance of chromosomal aberrations in cancer: methodology and application to glioma

artículo científico publicado en 2007

Author Correction: Cas9 activates the p53 pathway and selects for p53-inactivating mutations

artículo científico publicado en 2020

Author Correction: Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes

article

BET bromodomain inhibition of MYC-amplified medulloblastoma.

artículo científico publicado en 2013

BIOL-04. INTEGRATED COPY-NUMBER AND CANCER DEPENDENCY ANALYSIS REVEALS ALTERED SPLICEOSOME STOICHIOMETRY AS A NOVEL VULNERABILITY IN GENOMICALLY DISRUPTED CANCERS.

artículo científico publicado en 2017

BM-07GENOMIC CHARACTERIZATION OF BRAIN METASTASES REVEALS BRANCHED EVOLUTION AND METASTASIS-SPECIFIC MUTATIONS

Bead-based profiling of tyrosine kinase phosphorylation identifies SRC as a potential target for glioblastoma therapy

artículo científico publicado en 2008

Beating the odds: extreme long-term survival with glioblastoma

artículo científico publicado en 2014

Buparlisib in Patients With Recurrent Glioblastoma Harboring Phosphatidylinositol 3-Kinase Pathway Activation: An Open-Label, Multicenter, Multi-Arm, Phase II Trial

scientific article published on 04 February 2019

CANCER. The oncogene makes its escape

artículo científico publicado en 2016

CELL BIOLOGY AND SIGNALING

article

Cancer vulnerabilities unveiled by genomic loss

artículo científico publicado en 2012

Cas9 activates the p53 pathway and selects for p53-inactivating mutations

scientific article published on 18 May 2020

Case Report: Next generation sequencing identifies a NAB2-STAT6 fusion in Glioblastoma

artículo científico publicado en 2016

Characterizing genomic alterations in cancer by complementary functional associations

artículo científico publicado en 2016

Characterizing the cancer genome in lung adenocarcinoma

artículo científico publicado en 2007

Chemical Genomics Identifies Small-Molecule MCL1 Repressors and BCL-xL as a Predictor of MCL1 Dependency ⬇️

artículo científico publicado el 17 de abril de 2012

Clinical identification of oncogenic drivers and copy number alterations in pituitary tumors.

artículo científico publicado en 2017

Clinical implementation of integrated whole-genome copy number and mutation profiling for glioblastoma

artículo científico publicado en 2015

Clinical multiplexed exome sequencing distinguishes adult oligodendroglial neoplasms from astrocytic and mixed lineage gliomas

artículo científico publicado en 2014

Clinical targeted exome-based sequencing in combination with genome-wide copy number profiling: precision medicine analysis of 203 pediatric brain tumors.

artículo científico publicado en 2017

CloneSifter: enrichment of rare clones from heterogeneous cell populations

artículo científico publicado en 2020

Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients

artículo científico

Comprehensive Analysis of Genetic Ancestry and Its Molecular Correlates in Cancer

scientific article published on 01 May 2020

Comprehensive Characterization of Cancer Driver Genes and Mutations

article

Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma

artículo científico publicado en 2015

Comprehensive Pan-Genomic Characterization of Adrenocortical Carcinoma

article

Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas

artículo científico publicado en 2015

Coordinate activation of Shh and PI3K signaling in PTEN-deficient glioblastoma: new therapeutic opportunities

artículo científico publicado en 2013

Copy number alterations unmasked as enhancer hijackers

artículo científico publicado en 2016

Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability.

artículo científico publicado en 2017

Correction: Inferring Loss-of-Heterozygosity from Unpaired Tumors Using High-Density Oligonucleotide SNP Arrays.

artículo científico publicado en 2007

Corrigendum: Recurrent hormone-binding domain truncated ESR1 amplifications in primary endometrial cancers suggest their implication in hormone independent growth

artículo científico publicado en 2017

Corrigendum: Recurrent hormone-binding domain truncated ESR1 amplifications in primary endometrial cancers suggest their implication in hormone independent growth

artículo científico publicado en 2016

DIPG-02. TRANSLATIONAL MR IMAGING CORRELATES FOR MOLECULAR ANALYSES IN DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG)

artículo científico publicado en 2019

DIPG-12. CHARACTERIZING THE ROLE OF PPM1D MUTATIONS IN THE PATHOGENESIS OF DIFFUSE INTRINSIC PONTINE GLIOMAS (DIPGs)

artículo científico publicado en 2019

DIPG-29. GENOMIC LANDSCAPE OF DIFFUSE INTRINSIC PONTINE GLIOMA: AN ANALYSIS OF THE DIPG-BATS COHORT.

artículo científico publicado en 2017

DRES-05. MOLECULAR EVOLUTION OF DIFFUSE GLIOMAS AND THE GLIOMA LONGITUDINAL ANALYSIS CONSORTIUM

artículo científico publicado en 2018

Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq

artículo científico publicado en 2018

Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer

artículo científico publicado en 2020

Disseminated glioneuronal tumors occurring in childhood: treatment outcomes and BRAF alterations including V600E mutation.

artículo científico publicado en 2016

Distinct Classes of Complex Structural Variation Uncovered across Thousands of Cancer Genome Graphs

scientific article published on 01 October 2020

Distinct genomic aberrations associated with ERG rearranged prostate cancer

artículo científico publicado en 2009

EPIGENETIC TARGETING OF HEDGEHOG PATHWAY TRANSCRIPTIONAL OUTPUT.

artículo científico publicado en 2014

EPT-20CLINICAL TARGETED EXOME-BASED SEQUENCING IN COMBINATION WITH GENOME WIDE COPY NUMBER PROFILING: A CLIA CERTIFIED APPROACH FOR PRECISION MEDICINE IN 203 PEDIATRIC BRAIN TUMOR PATIENTS.

artículo científico publicado en 2016

ERG rearrangement is specific to prostate cancer and does not occur in any other common tumor

artículo científico publicado en 2010

Early TP53 alterations engage environmental exposures to promote gastric premalignancy in an integrative mouse model

artículo científico publicado en 2020

Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain

artículo científico publicado en 2006

Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition

artículo científico publicado en 2014

Erratum: Corrigendum: High-throughput oncogene mutation profiling in human cancer

article

Erratum: Genomic landscape of high-grade meningiomas.

artículo científico publicado en 2017

Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity

artículo científico publicado en 2013

Exome sequencing of lymphomas from three dog breeds reveals somatic mutation patterns reflecting genetic background

artículo científico publicado en 2015

Expression profiles of 151 pediatric low-grade gliomas reveal molecular differences associated with location and histological subtype

artículo científico publicado en 2015

Extent of resection and overall survival for patients with atypical and malignant meningioma

artículo científico publicado en 2015

Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer.

artículo científico publicado en 2010

GENE-07. LIQUID BIOPSY DETECTION OF GENOMIC ALTERATIONS IN PEDIATRIC BRAIN TUMORS FROM CELL-FREE DNA IN PERIPHERAL BLOOD, CSF, AND URINE

artículo científico publicado en 2019

GENE-09. PRECISION MEDICINE ANALYSIS OF 203 PEDIATRIC BRAIN TUMORS REVEALS CLINICALLY RELEVANT GENOMIC ALTERATIONS.

artículo científico publicado en 2017

GENO-09LANDSCAPE OF GENOMIC ALTERATIONS IN PITUITARY ADENOMAS.

artículo científico publicado en 2015

GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers

artículo científico publicado en 2011

Gastrointestinal adenocarcinomas of the esophagus, stomach, and colon exhibit distinct patterns of genome instability and oncogenesis

artículo científico publicado en 2012

Genetic and Functional Studies Implicate HIF1α as a 14q Kidney Cancer Suppressor Gene ⬇️

artículo científico publicado el 7 de junio de 2011

Genetic and transcriptional evolution alters cancer cell line drug response

artículo científico publicado en 2018

Genome coverage and sequence fidelity of phi29 polymerase-based multiple strand displacement whole genome amplification

artículo científico publicado en 2004

Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition

artículo científico publicado en 2014

Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets

artículo científico publicado en 2015

Genomic Heterogeneity and Exceptional Response to Dual Pathway Inhibition in Anaplastic Thyroid Cancer

artículo científico publicado en 2016

Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1

artículo científico publicado en 2013

Genomic and Epigenomic Landscape in Meningioma

artículo científico publicado en 2016

Genomic and Functional Approaches to Understanding Cancer Aneuploidy

artículo científico publicado en 2018

Genomic evolution and chemoresistance in germ-cell tumours.

artículo científico publicado en 2016

Genomic evolution of cancer models: perils and opportunities

scientific article published on 01 February 2019

Genomic landscape of high-grade meningiomas.

artículo científico

Genomic landscape of intracranial meningiomas

artículo científico publicado en 2016

Genomic profile of human meningioma cell lines.

artículo científico publicado en 2017

Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations

artículo científico publicado en 2013

Germline and somatic BAP1 mutations in high-grade rhabdoid meningiomas

artículo científico publicado en 2016

HER-2/neu expression is associated with high tumor cell proliferation and aggressive phenotype in a population based patient series of endometrial carcinomas

scientific article published on 01 February 2008

HG-73SAFETY AND FEASIBILITY OF A MULTI-INSTITUTIONAL PHASE II TRIAL INCOPORATING BIOPSY AND MOLECULARLY DETERMINED TREATMENT OF CHILDREN AND YOUNG ADULTS WITH NEWLY DIAGNOSED DIFFUSE INTRINSIC PONTINE GLIOMAS (DIPG).

artículo científico publicado en 2016

High-resolution genomic and expression analyses of copy number alterations in breast tumors

artículo científico publicado en 2008

High-throughput oncogene mutation profiling in human cancer

article

Highly parallel identification of essential genes in cancer cells

scholarly article

Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis

artículo científico publicado en 2020

Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate

artículo científico publicado en 2019

Homozygous deletions and chromosome amplifications in human lung carcinomas revealed by single nucleotide polymorphism array analysis

artículo científico publicado en 2005

INNV-22. LIQUID BIOPSY DETECTION OF GENOMIC ALTERATIONS IN PEDIATRIC BRAIN TUMORS FROM CELL FREE DNA IN PERIPHERAL BLOOD, CSF, AND URINE

Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer

artículo científico publicado en 2009

In vivo multiplexed interrogation of amplified genes identifies GAB2 as an ovarian cancer oncogene

artículo científico publicado en 2014

Incidence, risk factors, and reasons for hospitalization among glioblastoma patients receiving chemoradiation

artículo científico publicado en 2015

Inferring loss-of-heterozygosity from unpaired tumors using high-density oligonucleotide SNP arrays

artículo científico publicado en 2006

Integrated genome-wide DNA copy number and expression analysis identifies distinct mechanisms of primary chemoresistance in ovarian carcinomas

scientific article published on 03 February 2009

Integrated genomic analysis of the 8q24 amplification in endometrial cancers identifies ATAD2 as essential to MYC-dependent cancers

artículo científico publicado en 2013

Integrated genomic profiling of endometrial carcinoma associates aggressive tumors with indicators of PI3 kinase activation

scholarly article

Integrative analysis reveals 53BP1 copy loss and decreased expression in a subset of human diffuse large B-cell lymphomas

artículo científico

Integrative analysis reveals an outcome-associated and targetable pattern of p53 and cell cycle deregulation in diffuse large B cell lymphoma.

artículo científico publicado en 2012

Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma

artículo científico publicado en 2005

Integrative molecular analysis of intrahepatic cholangiocarcinoma reveals 2 classes that have different outcomes

artículo científico publicado en 2013

Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins

scientific journal article

LAB-OMICS AND PROGNOSTIC MARKERS

article

LG-02MYB-QKI REARRANGEMENTS IN ANGIOCENTRIC GLIOMA DRIVE TUMORIGENICITY THROUGH A TRIPARTITE MECHANISM.

artículo científico publicado en 2016

LG-47TYPE II RAF INHIBITORS INHIBIT BRAF MUTATIONS AND TRUNCATED FUSIONS IN PEDIATRIC LOW-GRADE GLIOMAS.

artículo científico publicado en 2016

LGG-04. CLINICO-HISTO-MOLECULAR LANDSCAPE OF EIGHTY-TWO PEDIATRIC AND YOUNG ADULT DYSEMBRYOPLASTIC NEUROEPITHELIAL TUMORS

LGG-05. SINGLE CELL RNA SEQUENCING REVEALS MITOGENIC AND PROGENITOR GENE PROGRAMS IN BRAF-REARRANGED PILOCYTIC ASTROCYTOMAS

artículo científico publicado en 2019

LGG-05. SINGLE-CELL RNA SEQUENCING OF PEDIATRIC LOW-GRADE GLIOMAS REVEALS INTRATUMORAL HETEROGENEITY.

artículo científico publicado en 2017

LGG-06. FUNCTIONAL AND THERAPEUTIC RELEVANCE OF MYB-QKI-INDUCED TRANSCRIPTIONAL EVENTS TO GLIOMAGENESIS.

artículo científico publicado en 2017

LGG-13. RESOLVING TRANSCRIPTIONAL PROFILES IN BRAF-REARRANGED PILOCYTIC ASTROCYTOMA USING SINGLE CELL RNA SEQUENCING

artículo científico publicado en 2018

LOW GRADE GLIOMAS

Landscape of Genomic Alterations in Pituitary Adenomas.

artículo científico publicado en 2016

Leveraging molecular datasets for biomarker-based clinical trial design in glioblastoma.

artículo científico publicado en 2017

Lin28 promotes transformation and is associated with advanced human malignancies

scientific article published on 31 May 2009

Long-term outcome of 4,040 children diagnosed with pediatric low-grade gliomas: an analysis of the Surveillance Epidemiology and End Results (SEER) database

artículo científico publicado en 2014

Longitudinal molecular trajectories of diffuse glioma in adults

scientific article published on 20 November 2019

Loss of heterozygosity of essential genes represents a widespread class of potential cancer vulnerabilities

scientific article published on 20 May 2020

Low BMI-1 expression is associated with an activated BMI-1-driven signature, vascular invasion, and hormone receptor loss in endometrial carcinoma

artículo científico publicado en 2008

MAPK activation and HRAS mutation identified in pituitary spindle cell oncocytoma

artículo científico publicado en 2016

MCL1 and DEDD Promote Urothelial Carcinoma Progression

scientific article published on 18 February 2019

MECP2 Is a Frequently Amplified Oncogene with a Novel Epigenetic Mechanism That Mimics the Role of Activated RAS in Malignancy

artículo científico publicado en 2015

MEDU-36. BCL2 FAMILY MEMBERS ATTENUATE RESPONSE OF MYC-DRIVEN MEDULLOBLASTOMAS TO BET-BROMODOMAIN INHIBITION

artículo científico publicado en 2019

MEDU-37. NEURONAL DIFFERENTIATION AND CELL-CYCLE PROGRAMS MEDIATE RESPONSE AND RESISTANCE TO BET-BROMODOMAIN INHIBITION IN MYC-DRIVEN MEDULLOBLASTOMA

MEDULLOBLASTOMA

MNGO-01A PROGNOSTIC CYTOGENETIC SCORING SYSTEM TO GUIDE THE ADJUVANT MANAGEMENT OF PATIENTS WITH ATYPICAL MENINGIOMA.

artículo científico publicado en 2015

MR Imaging Correlates for Molecular and Mutational Analyses in Children with Diffuse Intrinsic Pontine Glioma

scientific article published on 07 May 2020

MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism

artículo científico publicado en 2016

Major copy proportion analysis of tumor samples using SNP arrays

artículo científico publicado en 2008

Mechanisms and therapeutic implications of hypermutation in gliomas

artículo científico publicado en 2020

Medical therapies for meningiomas ⬇️

artículo científico publicado el 4 de septiembre de 2010

MicroRNA Signatures and Molecular Subtypes of Glioblastoma: The Role of Extracellular Transfer

artículo científico publicado en 2017

Mitogenic and progenitor gene programmes in single pilocytic astrocytoma cells

artículo científico publicado en 2019

Modeling genomic diversity and tumor dependency in malignant melanoma

artículo científico publicado en 2008

Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma

artículo científico

Molecular characterization of TMPRSS2-ERG gene fusion in the NCI-H660 prostate cancer cell line: a new perspective for an old model.

artículo científico publicado en 2007

Molecular characterization of the tumor microenvironment in breast cancer

artículo científico publicado en 2004

Molecular definition of breast tumor heterogeneity

artículo científico publicado en 2007

Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors.

artículo científico publicado en 2005

Molecular profiling and targeted therapy in pediatric gliomas: review and consensus recommendations

artículo científico publicado en 2019

Molecular profiling of endometrial carcinoma precursor, primary and metastatic lesions suggests different targets for treatment in obese compared to non-obese patients

artículo científico publicado en 2015

Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes

article

Myxopapillary ependymomas in children: imaging, treatment and outcomes

artículo científico

NEURO/MEDICAL ONCOLOGY

Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma

artículo científico publicado en 2019

ONGOING CLINICAL TRIALS

article

OS08.3 Genomic landscape of meningiomas.

artículo científico publicado en 2017

OS10.1 Genomic landscape of pituitary adenomas.

artículo científico publicado en 2017

Oncogenic PI3K mutations are as common as AKT1 and SMO mutations in meningioma

artículo científico publicado en 2016

Oncogenic PIK3CA-driven mammary tumors frequently recur via PI3K pathway-dependent and PI3K pathway-independent mechanisms

artículo científico publicado en 2011

Oncosome formation in prostate cancer: association with a region of frequent chromosomal deletion in metastatic disease

artículo científico publicado en 2009

Open data: Spot data glitches before publication

artículo científico publicado en 2017

Orthotopic xenografts of RCC retain histological, immunophenotypic and genetic features of tumours in patients ⬇️

artículo científico publicado el 27 de junio de 2011

Overexpression, amplification, and androgen regulation of TPD52 in prostate cancer

artículo científico publicado en 2004

PAK1 is a breast cancer oncogene that coordinately activates MAPK and MET signaling

artículo científico publicado en 2012

PATH-16. MOLECULAR PATHOLOGY AND CLINICAL CHARACTERISTICS OF MMR DEFICIENCY (MMRd) IN DIFFUSE GLIOMAS

PATH-30. GENOMIC LANDSCAPE OF CENTRAL NERVOUS SYSTEM TUMORS

PDTM-06. ALK AMPLIFICATION AND REARRANGEMENTS ARE RECURRENT TARGETABLE EVENTS IN GLIOBLASTOMA

artículo científico publicado en 2018

PIK3CA Amplification Associates with Aggressive Phenotype but Not Markers of AKT-MTOR Signaling in Endometrial Carcinoma

scientific article published on 15 November 2018

PPM1D mutations are oncogenic drivers of de novo diffuse midline glioma formation

artículo científico publicado en 2022

Pan-Cancer Analysis Links PARK2 to BCL-XL-Dependent Control of Apoptosis

artículo científico publicado en 2016

Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition

artículo científico publicado en 2020

Pan-cancer genetic analysis identifies PARK2 as a master regulator of G1/S cyclins

artículo científico publicado en 2014

Pan-cancer patterns of somatic copy number alteration

artículo científico publicado en 2013

Patient-derived xenografts undergo mouse-specific tumor evolution.

artículo científico publicado en 2017

Patterns of gene expression and copy-number alterations in von-hippel lindau disease-associated and sporadic clear cell carcinoma of the kidney

artículo científico publicado en 2009

Patterns of somatic structural variation in human cancer genomes

artículo científico publicado en 2020

Pediatric low-grade gliomas: how modern biology reshapes the clinical field

artículo científico publicado en 2014

Phase 2 study of dose-intense temozolomide in recurrent glioblastoma

artículo científico publicado en 2013

Phase II study of monthly pasireotide LAR (SOM230C) for recurrent or progressive meningioma

artículo científico publicado en 2014

Phase II study of panobinostat in combination with bevacizumab for recurrent glioblastoma and anaplastic glioma

artículo científico publicado en 2015

Phase II trial of ponatinib in patients with bevacizumab-refractory glioblastoma

scientific article published on 24 August 2019

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

artículo científico publicado en 2011

Portraits of genetic intra-tumour heterogeneity and subclonal selection across cancer types

Predicting clinical response to anticancer drugs using an ex vivo platform that captures tumour heterogeneity

artículo científico publicado en 2015

Predicting drug susceptibility of non-small cell lung cancers based on genetic lesions

scientific article published on 18 May 2009

Prioritizing causal disease genes using unbiased genomic features

artículo científico publicado en 2014

Proteasomal and genetic inactivation of the NF1 tumor suppressor in gliomagenesis

artículo científico publicado en 2009

Publisher Correction: Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes

article

Quantification of aneuploidy in targeted sequencing data using ASCETS

scientific article published on 28 November 2020

Radiographic prediction of meningioma grade by semantic and radiomic features

artículo científico publicado en 2017

Recurrent hemizygous deletions in cancers may optimize proliferative potential

artículo científico publicado en 2012

Recurrent hormone-binding domain truncated ESR1 amplifications in primary endometrial cancers suggest their implication in hormone independent growth

artículo científico publicado en 2016

Renal medullary carcinomas depend upon loss and are sensitive to proteasome inhibition

scientific article published on 12 March 2019

Reply to Parsons: Many tumor types follow the monoclonal model of tumor initiation

artículo científico publicado en 2011

Resistance to Epigenetic-Targeted Therapy Engenders Tumor Cell Vulnerabilities Associated with Enhancer Remodeling

artículo científico publicado en 2018

Retrospective study of carmustine or lomustine with bevacizumab in recurrent glioblastoma patients who have failed prior bevacizumab

artículo científico publicado en 2014

SNP panel identification assay (SPIA): a genetic-based assay for the identification of cell lines

artículo científico publicado en 2008

SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas ⬇️

artículo científico publicado en 2009

SQSTM1 is a pathogenic target of 5q copy number gains in kidney cancer

scientific article published on December 2013

Safety of concurrent bevacizumab therapy and anticoagulation in glioma patients ⬇️

artículo científico publicado el 26 de junio de 2011

Selective and mechanistic sources of recurrent rearrangements across the cancer genome

SeqLib: a C ++ API for rapid BAM manipulation, sequence alignment and sequence assembly

artículo científico publicado en 2016

Sequence analysis of mutations and translocations across breast cancer subtypes

artículo científico publicado en 2012

Single nucleotide polymorphism array analysis of cancer.

artículo científico publicado en 2007

Somatic copy number alterations in gastric adenocarcinomas among Asian and Western patients

artículo científico publicado en 2017

Somatic mutations are present in all members of the AKT family in endometrial carcinoma

artículo científico publicado en 2009

Somatic rearrangements across cancer reveal classes of samples with distinct patterns of DNA breakage and rearrangement-induced hypermutability

artículo científico publicado en 2012

Stathmin is superior to AKT and phospho‐AKT staining for the detection of phosphoinositide 3‐kinase activation and aggressive endometrial cancer ⬇️

artículo científico publicado el 1 de octubre de 2010

Structural Alterations Driving Castration-Resistant Prostate Cancer Revealed by Linked-Read Genome Sequencing

artículo científico publicado en 2018

Structure and mechanism of activity-based inhibition of the EGF receptor by Mig6

artículo científico publicado en 2015

Subgroup-specific structural variation across 1,000 medulloblastoma genomes

artículo científico publicado en 2012

Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy

artículo científico publicado en 2010

SvABA: genome-wide detection of structural variants and indels by local assembly.

artículo científico publicado en 2018

Systematic interrogation of 3q26 identifies TLOC1 and SKIL as cancer drivers.

artículo científico publicado en 2013

Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage

artículo científico publicado en 2014

TBIO-18. LIQUID BIOPSY DETECTION OF GENOMIC ALTERATIONS IN PEDIATRIC BRAIN TUMORS FROM CELL FREE DNA IN PERIPHERAL BLOOD, CSF, AND URINE

THER-22. BROMODOMAIN INHIBITORS INDUCE DOWNREGULATION OF DNA DAMAGE REPAIR PATHWAYS AND OFFER NOVEL SYNERGISTIC COMBINATIONS WITH ENHANCED SAFETY PROFILES FOR THE TREATMENT OF MEDULLOBLASTOMA AND GLIOBLASTOMA

TMOD-14. A PATIENT-DERIVED CANCER CELL LINE ATLAS OF PRIMARY AND METASTATIC CENTRAL NERVOUS SYSTEM TUMORS

TMPRSS2:ERG fusion-associated deletions provide insight into the heterogeneity of prostate cancer

artículo científico publicado en 2006

TRAF2 is an NF-κB-activating oncogene in epithelial cancers.

artículo científico publicado en 2013

TRTH-15. RESISTANCE MECHANISMS TO BET-BROMODOMAIN INHIBITION IN MYC-AMPLIFIED MEDULLOBLASTOMA.

artículo científico publicado en 2017

Targeting Cancer Gene Dependencies with Anthrax-Mediated Delivery of Peptide Nucleic Acids

scientific article published on 29 April 2020

The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma

artículo científico publicado en 2018

The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma

article

The RasGAP gene, RASAL2, is a tumor and metastasis suppressor

artículo científico publicado en 2013

The Somatic Genomic Landscape of Glioblastoma

article

The UTX Tumor Suppressor Directly Senses Oxygen to Control Chromatin and Cell Fate

The evolutionary history of 2,658 cancers

The evolutionary history of 2,658 cancers

artículo científico publicado en 2020

The genomic landscape and evolution of endometrial carcinoma progression and abdominopelvic metastasis

artículo científico publicado en 2016

The genomic landscape of schwannoma

artículo científico publicado en 2016

The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset

artículo científico publicado en 2011

The landscape of somatic copy-number alteration across human cancers

artículo científico publicado en 2010

The somatic genomic landscape of glioblastoma

artículo científico publicado en 2013

The whole-genome landscape of medulloblastoma subtypes

artículo científico publicado en 2017

Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway

artículo científico publicado en 2020

Tumor Interferon Signaling Is Regulated by a lncRNA INCR1 Transcribed from the PD-L1 Locus

artículo científico publicado en 2020

Tumor associated seizures in glioblastomas are influenced by survival gene expression in a region-specific manner: a gene expression imaging study

artículo científico publicado en 2014

Tumor-suppressor genes that escape from X-inactivation contribute to cancer sex bias

artículo científico publicado en 2016

Tyrosine receptor kinase B is a drug target in astrocytomas

artículo científico publicado en 2016

Update on bevacizumab and other angiogenesis inhibitors for brain cancer ⬇️

artículo científico publicado el 14 de mayo de 2013

VRK1 as a synthetic lethal target in VRK2-methylated cancers of the nervous system

artículo científico publicado en 2022

Vandetanib plus sirolimus in adults with recurrent glioblastoma: results of a phase I and dose expansion cohort study

artículo científico publicado en 2014

VariantBam: filtering and profiling of next-generational sequencing data using region-specific rules

artículo científico publicado en 2016

miR-4516 predicts poor prognosis and functions as a novel oncogene via targeting PTPN14 in human glioblastoma

scientific article published on 17 December 2018

β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis

artículo científico publicado en 2012

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