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An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function.

artículo científico publicado en 2017

Asymmetry of fibrillar plaque burden in amyloid mouse models

scientific article published on 15 May 2020

Early and Longitudinal Microglial Activation but Not Amyloid Accumulation Predicts Cognitive Outcome in PS2APP Mice

scientific article published on 27 September 2018

Early increase of CSF sTREM2 in Alzheimer's disease is associated with tau related-neurodegeneration but not with amyloid-β pathology

artículo científico publicado en 2019

Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region

artículo científico publicado en 2020

Higher CSF sTREM2 and microglia activation are associated with slower rates of beta-amyloid accumulation

artículo científico publicado en 2020

Higher CSF sTREM2 attenuates ApoE4-related risk for cognitive decline and neurodegeneration

artículo científico publicado en 2020

Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer's disease

scientific article published on 01 August 2019

Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE

scientific article published on 07 January 2019

Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism.

artículo científico publicado en 2019

TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury.

artículo científico publicado en 2017

The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism.

artículo científico publicado en 2017

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