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1,4,5-Trisubstituted Imidazole-Based p53-MDM2/MDMX Antagonists with Aliphatic Linkers for Conjugation with Biological Carriers.

artículo científico publicado en 2017

A therapeutic patent overview of MDM2/X-targeted therapies (2014-2018)

scientific article published on 01 March 2019

Biphenyl Ether Analogs Containing Pomalidomide as Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction

artículo científico publicado en 2022

Competition NMR for Detection of Hit/Lead Inhibitors of Protein-Protein Interactions

artículo científico publicado en 2020

Design of indole- and MCR-based macrocycles as p53-MDM2 antagonists

scientific article published on 20 February 2019

Development of the Inhibitors that Target the PD-1/PD-L1 Interaction-A Brief Look at Progress on Small Molecules, Peptides and Macrocycles

artículo científico publicado en 2019

Molecular basis for the inhibition of p53 by Mdmx

artículo científico publicado en 2007

Optimized Inhibitors of MDM2 via an Attempted Protein-Templated Reductive Amination

artículo científico publicado en 2019

PD-L1 Inhibitors: Different Classes, Activities, and Mechanisms of Action

artículo científico publicado en 2021

Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) Interaction via Transiently Induced Protein States and Dimerization of PD-L1.

artículo científico publicado en 2017

Structural Characterization of a Macrocyclic Peptide Modulator of the PD-1/PD-L1 Immune Checkpoint Axis

artículo científico publicado en 2021

Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain

artículo científico publicado en 2008

Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery.

artículo científico publicado en 2010

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