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Activation of DAF-16/FOXO by reactive oxygen species contributes to longevity in long-lived mitochondrial mutants in Caenorhabditis elegans. ⬇️

artículo científico publicado en 2018

Activation of the mitochondrial unfolded protein response promotes longevity and dopamine neuron survival in Parkinson's disease models

artículo científico publicado en 2017

Body weight is modulated by levels of full-length huntingtin

artículo científico publicado en 2006

Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease.

artículo científico publicado en 2002

Cystamine treatment is neuroprotective in the YAC128 mouse model of Huntington disease.

artículo científico publicado en 2005

Ethyl-EPA treatment improves motor dysfunction, but not neurodegeneration in the YAC128 mouse model of Huntington disease.

artículo científico publicado en 2005

Huntingtin inhibits caspase-3 activation

scientific journal article

Loss of wild-type huntingtin influences motor dysfunction and survival in the YAC128 mouse model of Huntington disease

artículo científico publicado en 2005

Mitochondrial unfolded protein response transcription factor ATFS-1 promotes longevity in a long-lived mitochondrial mutant through activation of stress response pathways

artículo científico publicado en 2018

Phenotypic abnormalities in the YAC128 mouse model of Huntington disease are penetrant on multiple genetic backgrounds and modulated by strain

artículo científico publicado en 2006

Selective degeneration and nuclear localization of mutant huntingtin in the YAC128 mouse model of Huntington disease

artículo científico publicado en 2005

Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease

artículo científico publicado en 2003

Testicular degeneration in Huntington disease.

artículo científico publicado en 2007

Treatment of YAC128 mice and their wild-type littermates with cystamine does not lead to its accumulation in plasma or brain: implications for the treatment of Huntington disease

artículo científico publicado en 2005

Wild-type huntingtin ameliorates striatal neuronal atrophy but does not prevent other abnormalities in the YAC128 mouse model of Huntington disease

artículo científico publicado en 2006

Wild-type huntingtin protects neurons from excitotoxicity

artículo científico publicado en 2006

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