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A Long-Range Acting Dehydratase Domain as the Missing Link for C17-Dehydration in Iso-Migrastatin Biosynthesis.

artículo científico

Biochemical and Structural Characterization of TtnD, a Prenylated FMN-Dependent Decarboxylase from the Tautomycetin Biosynthetic Pathway

scientific article published on 10 September 2018

Biomimetic Stereoselective Sulfa-Michael Addition Leads to Platensimycin and Platencin Sulfur Analogues against Methicillin-Resistant Staphylococcus aureus

artículo científico publicado en 2018

Biosynthesis of thiocarboxylic acid-containing natural products. ⬇️

artículo científico publicado en 2018

Biosynthetic Origin of the Ether Ring in Platensimycin.

artículo científico publicado en 2016

Challenges and opportunities for natural product discovery, production, and engineering in native producers versus heterologous hosts

scientific article published on 13 November 2018

Characterization and Crystal Structure of a Nonheme Diiron Monooxygenase Involved in Platensimycin and Platencin Biosynthesis

scientific article published on 23 July 2019

Comparative Studies of the Biosynthetic Gene Clusters for Anthraquinone-Fused Enediynes Shedding Light into the Tailoring Steps of Tiancimycin Biosynthesis

artículo científico publicado en 2018

Correction: The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research

artículo científico publicado en 2018

Cryptic Sulfur Incorporation in Thioangucycline Biosynthesis

artículo científico publicado en 2021

Cryptic and Stereospecific Hydroxylation, Oxidation, and Reduction in Platensimycin and Platencin Biosynthesis.

artículo científico publicado en 2019

Cytochrome P450-Catalyzed Hydroxylation Initiating Ether Formation in Platensimycin Biosynthesis

artículo científico publicado en 2018

Discovery and Characterization of 1-Aminocyclopropane-1-carboxylic Acid Synthase of Bacterial Origin

scientific article published on 28 November 2018

Discovery of Alternative Producers of the Enediyne Antitumor Antibiotic C-1027 with High Titers.

artículo científico publicado en 2018

Discovery of Kirromycins with Anti- Wolbachia Activity from Streptomyces sp. CB00686

scientific article published on 10 May 2019

Discovery of ammosesters by mining the Streptomyces uncialis DCA2648 genome revealing new insight into ammosamide biosynthesis ⬇️

artículo científico publicado en 2021

Discovery of the Tiancilactone Antibiotics by Genome Mining of Atypical Bacterial Type II Diterpene Synthases ⬇️

scientific article published on 27 May 2018

Discovery of the leinamycin family of natural products by mining actinobacterial genomes ⬇️

artículo científico publicado en 2017

Divergent synthesis of complex diterpenes through a hybrid oxidative approach

artículo científico publicado en 2020

Evaluation of Platensimycin and Platensimycin-Inspired Thioether Analogues against Methicillin-Resistant Staphylococcus aureus in Topical and Systemic Infection Mouse Models

artículo científico publicado en 2019

Genome Mining of Micromonospora yangpuensis DSM 45577 as a Producer of an Anthraquinone-Fused Enediyne. ⬇️

artículo científico publicado en 2017

Genome Mining of Streptomyces mobaraensis DSM40847 as a Bleomycin Producer Providing a Biotechnology Platform To Engineer Designer Bleomycin Analogues.

artículo científico publicado en 2017

Herbicidins from Streptomyces sp. CB01388 Showing Anti- Cryptosporidium Activity.

artículo científico publicado en 2018

Late-Stage Functionalization of Platensimycin Leading to Multiple Analogues with Improved Antibacterial Activity in Vitro and in Vivo

scientific article published on 02 July 2019

Natural separation of the acyl-CoA ligase reaction results in a non-adenylating enzyme

artículo científico publicado en 2018

P450-Catalyzed Tailoring Steps in Leinamycin Biosynthesis Featuring Regio- and Stereoselective Hydroxylations and Substrate Promiscuities

artículo científico publicado en 2018

Platensimycin-Encapsulated Liposomes or Micelles as Biosafe Nanoantibiotics Exhibited Strong Antibacterial Activities against Methicillin-Resistant Staphylococcus aureus Infection in Mice

artículo científico publicado en 2020

Platensimycin-Encapsulated Poly(lactic-co-glycolic acid) and Poly(amidoamine) Dendrimers Nanoparticles with Enhanced Anti-Staphylococcal Activity in Vivo

scientific article published on 14 April 2020

PokMT1 from the Polyketomycin Biosynthetic Machinery of Streptomyces diastatochromogenes Tü6028 Belongs to the Emerging Family of C-Methyltransferases That Act on CoA-Activated Aromatic Substrates

artículo científico publicado en 2018

PtmC Catalyzes the Final Step of Thioplatensimycin, Thioplatencin, and Thioplatensilin Biosynthesis and Expands the Scope of Arylamine <i>N</i>-Acetyltransferases

scientific article published on 14 December 2020

Semisynthesis of Platensimycin Derivatives with Antibiotic Activities in Mice via Suzuki-Miyaura Cross-Coupling Reactions

scientific article published on 05 December 2018

Structural Insights into the Free-Standing Condensation Enzyme SgcC5 Catalyzing Ester-Bond Formation in the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027.

artículo científico publicado en 2018

The Isolation of Pyrroloformamide Congeners and Characterization of Their Biosynthetic Gene Cluster

artículo científico publicado en 2020

The LnmK Bifunctional Acyltransferase/Decarboxylase Specifying (2R)-Methylmalonyl-CoA and Employing Substrate-Assisted Catalysis for Polyketide Biosynthesis

artículo científico publicado en 2020

The semi-synthesis, biological evaluation and docking analysis of the oxime, hydrazine and hydrazide derivatives of platensimycin

scientific article published on 06 March 2018

Yangpumicins F and G, Enediyne Congeners from Micromonospora yangpuensis DSM 45577 ⬇️

artículo científico publicado en 2019

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