Lista de obras -

A CREB-C/EBPbeta cascade induces M2 macrophage-specific gene expression and promotes muscle injury repair

artículo científico publicado en 2009

A dynamic niche provides Kit ligand in a stage-specific manner to the earliest thymocyte progenitors.

artículo científico publicado en 2016

A transit-amplifying population underpins the efficient regenerative capacity of the testis.

artículo científico publicado en 2017

Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block

artículo científico publicado en 2006

Acute multiple organ failure in adult mice deleted for the developmental regulator Wt1

artículo científico publicado en 2011

Bi-directional signaling by membrane-bound KitL induces proliferation and coordinates thymic endothelial cell and thymocyte expansion

scientific article published in Nature Communications

C/EBPalpha and beta couple interfollicular keratinocyte proliferation arrest to commitment and terminal differentiation

artículo científico publicado en 2009

C/EBPα and GATA-2 Mutations Induce Bilineage Acute Erythroid Leukemia through Transformation of a Neomorphic Neutrophil-Erythroid Progenitor

artículo científico publicado en 2020

CEBPA-mutated leukemia is sensitive to genetic and pharmacological targeting of the MLL1 complex

scientific article published on 24 January 2019

Canonical Notch signaling is dispensible for adult steady-state and stress myelo-erythropoiesis

artículo científico publicado en 2018

Cdk6 blocks myeloid differentiation by interfering with Runx1 DNA binding and Runx1-C/EBPalpha interaction

artículo científico publicado en 2007

Cell-intrinsic depletion of Aml1-ETO-expressing pre-leukemic hematopoietic stem cells by K-Ras activating mutation

scientific article published on 11 April 2019

Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal

artículo científico publicado en 2016

DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction.

artículo científico publicado en 2009

DNMT1 Deficiency Impacts on Plasmacytoid Dendritic Cells in Homeostasis and Autoimmune Disease

artículo científico publicado en 2021

Dependence on Myb expression is attenuated in myeloid leukaemia with N-terminal CEBPA mutations

artículo científico publicado en 2019

Dicer is selectively important for the earliest stages of erythroid development

artículo científico publicado en 2012

Direct role of FLT3 in regulation of early lymphoid progenitors.

artículo científico publicado en 2018

Disease evolution and outcomes in familial AML with germline CEBPA mutations

artículo científico publicado en 2015

Distinct C/EBPalpha motifs regulate lipogenic and gluconeogenic gene expression in vivo

scientific journal article

Distinct myeloid progenitor-differentiation pathways identified through single-cell RNA sequencing.

scientific article published on 04 April 2016

E2F repression by C/EBPalpha is required for adipogenesis and granulopoiesis in vivo

scientific journal article

Early myeloid lineage choice is not initiated by random PU.1 to GATA1 protein ratios.

artículo científico publicado en 2016

Ectopic expression of PAX5 promotes maintenance of biphenotypic myeloid progenitors coexpressing myeloid and B-cell lineage-associated genes

artículo científico publicado en 2007

Erratum: Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia

scholarly article by Florian Grebien et al published October 2015 in Nature Chemical Biology

Erythropoietin guides multipotent hematopoietic progenitor cells toward an erythroid fate

artículo científico publicado en 2014

FLT3-ITDs instruct a myeloid differentiation and transformation bias in lymphomyeloid multipotent progenitors

artículo científico publicado en 2013

FOG-1 and GATA-1 act sequentially to specify definitive megakaryocytic and erythroid progenitors

artículo científico publicado en 2011

Haematopoiesis in the era of advanced single-cell technologies

artículo científico publicado en 2019

Hematopoietic Lineage Diversification, Simplified

artículo científico publicado en 2016

Hematopoietic stem cell expansion precedes the generation of committed myeloid leukemia-initiating cells in C/EBPalpha mutant AML.

artículo científico publicado en 2009

Hierarchically related lineage-restricted fates of multipotent haematopoietic stem cells

artículo científico publicado en 2018

Human adult HSCs can be discriminated from lineage-committed HPCs by the expression of endomucin

artículo científico publicado en 2018

Identification of two distinct pathways of human myelopoiesis

artículo científico publicado en 2019

Impact of gene dosage, loss of wild-type allele, and FLT3 ligand on Flt3-ITD-induced myeloproliferation

scientific journal article

Inflammatory signals directly instruct PU.1 in HSCs via TNF

artículo científico publicado en 2018

Initial seeding of the embryonic thymus by immune-restricted lympho-myeloid progenitors

artículo científico publicado en 2016

Insights into specificity, redundancy and new cellular functions of C/EBPa and C/EBPb transcription factors through interactome network analysis

artículo científico

Kit ligand has a critical role in mouse yolk sac and aorta-gonad-mesonephros hematopoiesis

scientific article published on 30 August 2018

Liver haploinsufficiency of RuvBL1 causes hepatic insulin resistance and enhances hepatocellular carcinoma progression

scientific article published on 12 November 2019

Loss of C/EBP alpha cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineage

artículo científico publicado en 2005

Micro-environmental sensing by bone marrow stroma identifies IL-6 and TGFβ1 as regulators of hematopoietic ageing

artículo científico publicado en 2020

Modeling of C/EBPα Mutant Acute Myeloid Leukemia Reveals a Common Expression Signature of Committed Myeloid Leukemia-Initiating Cells

article

Molecular and cellular effects of oncogene cooperation in a genetically accurate AML mouse model

artículo científico publicado en 2012

Mutation of C/EBPalpha predisposes to the development of myeloid leukemia in a retroviral insertional mutagenesis screen

artículo científico publicado en 2008

Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo

Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo

artículo científico publicado en 2014

Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusion

artículo científico publicado en 2008

Myeloid lineage enhancers drive oncogene synergy in CEBPA/CSF3R mutant acute myeloid leukemia

scientific article published on 29 November 2019

NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements

artículo científico

Neurotrophin/Trk receptor signaling mediates C/EBPalpha, -beta and NeuroD recruitment to immediate-early gene promoters in neuronal cells and requires C/EBPs to induce immediate-early gene transcription.

artículo científico publicado en 2007

Niche-mediated depletion of the normal hematopoietic stem cell reservoir by Flt3-ITD-induced myeloproliferation.

artículo científico publicado en 2017

Ontogenic Changes in Hematopoietic Hierarchy Determine Pediatric Specificity and Disease Phenotype in Fusion Oncogene-Driven Myeloid Leukemia

scientific article published on 29 October 2019

Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia

artículo científico publicado en 2015

Phosphorylation of serine 248 of C/EBPα is dispensable for myelopoiesis but its disruption leads to a low penetrant myeloid disorder with long latency.

artículo científico publicado en 2012

Platelet-biased stem cells reside at the apex of the haematopoietic stem-cell hierarchy.

artículo científico publicado en 2013

Pontin is essential for murine hematopoietic stem cell survival

artículo científico publicado en 2012

Sensitized phenotypic screening identifies gene dosage sensitive region on chromosome 11 that predisposes to disease in mice

artículo científico publicado en 2011

Single-cell RNA sequencing reveals molecular and functional platelet bias of aged haematopoietic stem cells

artículo científico publicado en 2016

Single-cell analysis of bone marrow-derived CD34+ cells from children with sickle cell disease and thalassemia

scientific article published on 01 December 2019

Sox4 is a key oncogenic target in C/EBPα mutant acute myeloid leukemia

artículo científico publicado en 2013

The amino terminal and E2F interaction domains are critical for C/EBP alpha-mediated induction of granulopoietic development of hematopoietic cells

artículo científico publicado en 2003

The earliest thymic T cell progenitors sustain B cell and myeloid lineage potential

artículo científico publicado en 2012

The molecular signature of MDS stem cells supports a stem-cell origin of 5q myelodysplastic syndromes

artículo científico publicado en 2007

The proline-histidine-rich CDK2/CDK4 interaction region of C/EBPalpha is dispensable for C/EBPalpha-mediated growth regulation in vivo

artículo científico publicado en 2006

Wnt/β-Catenin Signaling Induces Integrin α4β1 in T Cells and Promotes a Progressive Neuroinflammatory Disease in Mice.

artículo científico publicado en 2017

β-Catenin activation synergizes with Pten loss and Myc overexpression in Notch-independent T-ALL ⬇️

artículo científico publicado el 25 de junio de 2013

Lista de obras de

A CREB-C/EBPbeta cascade induces M2 macrophage-specific gene expression and promotes muscle injury repair

A dynamic niche provides Kit ligand in a stage-specific manner to the earliest thymocyte progenitors.

A transit-amplifying population underpins the efficient regenerative capacity of the testis.

Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block

Acute multiple organ failure in adult mice deleted for the developmental regulator Wt1

Bi-directional signaling by membrane-bound KitL induces proliferation and coordinates thymic endothelial cell and thymocyte expansion

C/EBPalpha and beta couple interfollicular keratinocyte proliferation arrest to commitment and terminal differentiation

C/EBPα and GATA-2 Mutations Induce Bilineage Acute Erythroid Leukemia through Transformation of a Neomorphic Neutrophil-Erythroid Progenitor

CEBPA-mutated leukemia is sensitive to genetic and pharmacological targeting of the MLL1 complex

Canonical Notch signaling is dispensible for adult steady-state and stress myelo-erythropoiesis

Cdk6 blocks myeloid differentiation by interfering with Runx1 DNA binding and Runx1-C/EBPalpha interaction

Cell-intrinsic depletion of Aml1-ETO-expressing pre-leukemic hematopoietic stem cells by K-Ras activating mutation

Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal

DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction.

DNMT1 Deficiency Impacts on Plasmacytoid Dendritic Cells in Homeostasis and Autoimmune Disease

Dependence on Myb expression is attenuated in myeloid leukaemia with N-terminal CEBPA mutations

Dicer is selectively important for the earliest stages of erythroid development

Direct role of FLT3 in regulation of early lymphoid progenitors.

Disease evolution and outcomes in familial AML with germline CEBPA mutations

Distinct C/EBPalpha motifs regulate lipogenic and gluconeogenic gene expression in vivo

Distinct myeloid progenitor-differentiation pathways identified through single-cell RNA sequencing.

E2F repression by C/EBPalpha is required for adipogenesis and granulopoiesis in vivo

Early myeloid lineage choice is not initiated by random PU.1 to GATA1 protein ratios.

Ectopic expression of PAX5 promotes maintenance of biphenotypic myeloid progenitors coexpressing myeloid and B-cell lineage-associated genes

Erratum: Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia

Erythropoietin guides multipotent hematopoietic progenitor cells toward an erythroid fate

FLT3-ITDs instruct a myeloid differentiation and transformation bias in lymphomyeloid multipotent progenitors

FOG-1 and GATA-1 act sequentially to specify definitive megakaryocytic and erythroid progenitors

Haematopoiesis in the era of advanced single-cell technologies

Hematopoietic Lineage Diversification, Simplified

Hematopoietic stem cell expansion precedes the generation of committed myeloid leukemia-initiating cells in C/EBPalpha mutant AML.

Hierarchically related lineage-restricted fates of multipotent haematopoietic stem cells

Human adult HSCs can be discriminated from lineage-committed HPCs by the expression of endomucin

Identification of two distinct pathways of human myelopoiesis

Impact of gene dosage, loss of wild-type allele, and FLT3 ligand on Flt3-ITD-induced myeloproliferation

Inflammatory signals directly instruct PU.1 in HSCs via TNF

Initial seeding of the embryonic thymus by immune-restricted lympho-myeloid progenitors

Insights into specificity, redundancy and new cellular functions of C/EBPa and C/EBPb transcription factors through interactome network analysis

Kit ligand has a critical role in mouse yolk sac and aorta-gonad-mesonephros hematopoiesis

Liver haploinsufficiency of RuvBL1 causes hepatic insulin resistance and enhances hepatocellular carcinoma progression

Loss of C/EBP alpha cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineage

Micro-environmental sensing by bone marrow stroma identifies IL-6 and TGFβ1 as regulators of hematopoietic ageing

Modeling of C/EBPα Mutant Acute Myeloid Leukemia Reveals a Common Expression Signature of Committed Myeloid Leukemia-Initiating Cells

Molecular and cellular effects of oncogene cooperation in a genetically accurate AML mouse model

Mutation of C/EBPalpha predisposes to the development of myeloid leukemia in a retroviral insertional mutagenesis screen

Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo

Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo

Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo

Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusion

Myeloid lineage enhancers drive oncogene synergy in CEBPA/CSF3R mutant acute myeloid leukemia

NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements

Neurotrophin/Trk receptor signaling mediates C/EBPalpha, -beta and NeuroD recruitment to immediate-early gene promoters in neuronal cells and requires C/EBPs to induce immediate-early gene transcription.

Niche-mediated depletion of the normal hematopoietic stem cell reservoir by Flt3-ITD-induced myeloproliferation.

Ontogenic Changes in Hematopoietic Hierarchy Determine Pediatric Specificity and Disease Phenotype in Fusion Oncogene-Driven Myeloid Leukemia

Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia

Phosphorylation of serine 248 of C/EBPα is dispensable for myelopoiesis but its disruption leads to a low penetrant myeloid disorder with long latency.

Platelet-biased stem cells reside at the apex of the haematopoietic stem-cell hierarchy.

Pontin is essential for murine hematopoietic stem cell survival

Sensitized phenotypic screening identifies gene dosage sensitive region on chromosome 11 that predisposes to disease in mice

Single-cell RNA sequencing reveals molecular and functional platelet bias of aged haematopoietic stem cells

Single-cell analysis of bone marrow-derived CD34+ cells from children with sickle cell disease and thalassemia

Sox4 is a key oncogenic target in C/EBPα mutant acute myeloid leukemia

The amino terminal and E2F interaction domains are critical for C/EBP alpha-mediated induction of granulopoietic development of hematopoietic cells

The earliest thymic T cell progenitors sustain B cell and myeloid lineage potential

The molecular signature of MDS stem cells supports a stem-cell origin of 5q myelodysplastic syndromes

The proline-histidine-rich CDK2/CDK4 interaction region of C/EBPalpha is dispensable for C/EBPalpha-mediated growth regulation in vivo

Wnt/β-Catenin Signaling Induces Integrin α4β1 in T Cells and Promotes a Progressive Neuroinflammatory Disease in Mice.

β-Catenin activation synergizes with Pten loss and Myc overexpression in Notch-independent T-ALL ⬇️