Lista de obras - Graziano Pinna - Dominio Público Uruguay

5α-reductase type I expression is downregulated in the prefrontal cortex/Brodmann's area 9 (BA9) of depressed patients.

artículo científico publicado en 2014

Allopregnanolone (1938-2019): A trajectory of 80 years of outstanding scientific achievements

scientific article published on 05 August 2020

Allopregnanolone mediates the exacerbation of Tourette-like responses by acute stress in mouse models

artículo científico publicado en 2017

Allopregnanolone, the Neuromodulator Turned Therapeutic Agent: Thank You, Next?

artículo científico publicado en 2020

Allopregnanolone: From molecular pathophysiology to therapeutics. A historical perspective

scientific article published on 14 March 2020

Animal Models of PTSD: The Socially Isolated Mouse and the Biomarker Role of Allopregnanolone.

artículo científico publicado en 2019

Animal models of post-traumatic stress disorder and novel treatment targets

artículo científico publicado en 2019

Are the effects of T3 on resting metabolic rate in euthyroid rats entirely caused by T3 itself?

artículo científico publicado en 2002

Associations between PTSD-Related extinction retention deficits in women and plasma steroids that modulate brain GABAA and NMDA receptor activity

artículo científico publicado en 2020

Biomarkers for PTSD at the Interface of the Endocannabinoid and Neurosteroid Axis

Brain neurosteroids in gender-related aggression induced by social isolation

artículo científico publicado en 2004

Changes in brain testosterone and allopregnanolone biosynthesis elicit aggressive behavior

artículo científico publicado en 2005

Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis

artículo científico publicado en 2006

Chronic intermittent ethanol (CIE) administration in rats decreases levels of neurosteroids in hippocampus, accompanied by altered behavioral responses to neurosteroids and memory function

artículo científico publicado en 2004

Composite contributions of cerebrospinal fluid GABAergic neurosteroids, neuropeptide Y and interleukin-6 to PTSD symptom severity in men with PTSD

scientific article published on 18 April 2020

Concentrations of seven iodothyronine metabolites in brain regions and the liver of the adult rat.

artículo científico publicado en 2002

Corrigendum: Allopregnanolone, the Neuromodulator Turned Therapeutic Agent: Thank You, Next?

artículo científico publicado en 2020

Could a blood test for PTSD and depression be on the horizon?

scientific article published on 20 November 2018

Current understanding of fear learning and memory in humans and animal models and the value of a linguistic approach for analyzing fear learning and memory in humans

scientific article published on 07 April 2019

Decreased cerebrospinal fluid allopregnanolone levels in women with posttraumatic stress disorder

artículo científico publicado en 2006

Decreased corticolimbic allopregnanolone expression during social isolation enhances contextual fear: A model relevant for posttraumatic stress disorder

artículo científico publicado en 2008

Down-regulation of neurosteroid biosynthesis in corticolimbic circuits mediates social isolation-induced behavior in mice

artículo científico publicado en 2007

Effects of pyrethroids on the concentrations of thyroid hormones in the rat serum and brain

artículo científico publicado en 2002

Elevated 3,5-Diiodothyronine Concentrations in the Sera of Patients with Nonthyroidal Illnesses and Brain Tumors

Emerging Therapeutic Role of PPAR-α in Cognition and Emotions

scholarly article by Khalin E Nisbett & Graziano Pinna published 2018 in Frontiers in Pharmacology

Enhanced fear responses in mice treated with anabolic androgenic steroids.

artículo científico publicado en 2009

Epigenetic regulation of GABAergic neurotransmission and neurosteroid biosynthesis in alcohol use disorder

scientific article published on 24 September 2020

Fast-acting antidepressant-like effects of Reelin evaluated in the repeated-corticosterone chronic stress paradigm

scientific article published on 11 January 2020

Fluoxetine and norfluoxetine stereospecifically and selectively increase brain neurosteroid content at doses that are inactive on 5-HT reuptake

artículo científico publicado en 2006

Fluoxetine and norfluoxetine stereospecifically facilitate pentobarbital sedation by increasing neurosteroids

scholarly article

GABA(A) receptor neurotransmission dysfunction in a mouse model of social isolation-induced stress: possible insights into a non-serotonergic mechanism of action of SSRIs in mood and anxiety disorders

artículo científico publicado en 2007

Ganaxolone improves behavioral deficits in a mouse model of post-traumatic stress disorder

artículo científico publicado en 2014

Higher Circulating Cortisol in the Follicular vs. Luteal Phase of the Menstrual Cycle: A Meta-Analysis

artículo científico publicado en 2020

Imidazenil and diazepam increase locomotor activity in mice exposed to protracted social isolation.

artículo científico publicado en 2006

In a mouse model relevant for post-traumatic stress disorder, selective brain steroidogenic stimulants (SBSS) improve behavioral deficits by normalizing allopregnanolone biosynthesis

artículo científico publicado en 2010

In socially isolated mice, the reversal of brain allopregnanolone down-regulation mediates the anti-aggressive action of fluoxetine

artículo científico publicado en 2003

Induction of the reelin promoter by retinoic acid is mediated by Sp1

artículo científico publicado en 2007

Intersectin 1 contributes to phenotypes in vivo: implications for Down's syndrome.

artículo científico publicado en 2011

Is There a Future for PPARs in the Treatment of Neuropsychiatric Disorders?

artículo científico publicado en 2020

MON-449 Serum Neuroactive Steroid Levels in Postmenopausal Women with Treatment-Resistant Major Depressive Disorder.

artículo científico publicado en 2019

Neuroactive Steroids and Affective Symptoms in Women Across the Weight Spectrum

artículo científico publicado en 2017

Neuroactive Steroids and PTSD Treatment

artículo científico publicado en 2017

Neurosteroid biosynthesis downregulation and changes in GABAA receptor subunit composition: A biomarker axis in stress-induced cognitive and emotional impairment.

artículo científico publicado en 2017

Neurosteroid biosynthesis regulates sexually dimorphic fear and aggressive behavior in mice.

artículo científico publicado en 2008

Neurosteroids reduce social isolation-induced behavioral deficits: a proposed link with neurosteroid-mediated upregulation of BDNF expression

artículo científico publicado en 2011

Neurosteroids regulate mouse aggression induced by anabolic androgenic steroids

artículo científico publicado en 2006

PPAR and functional foods: Rationale for natural neurosteroid-based interventions for postpartum depression

artículo científico publicado en 2020

PTSD in women is associated with a block in conversion of progesterone to the GABAergic neurosteroids allopregnanolone and pregnanolone measured in plasma

artículo científico publicado en 2018

Relationships between cerebrospinal fluid GABAergic neurosteroid levels and symptom severity in men with PTSD

scientific article published on 22 November 2018

Repeated anabolic androgenic steroid treatment causes antidepressant-reversible alterations of the hypothalamic-pituitary-adrenal axis, BDNF levels and behavior

artículo científico publicado en 2010

S-adenosyl methionine and DNA methyltransferase-1 mRNA overexpression in psychosis

artículo científico publicado en 2007

S-norfluoxetine microinfused into the basolateral amygdala increases allopregnanolone levels and reduces aggression in socially isolated mice ⬇️

artículo científico publicado el 29 de octubre de 2010

SSRIs act as selective brain steroidogenic stimulants (SBSSs) at low doses that are inactive on 5-HT reuptake

artículo científico publicado en 2009

Sex and COVID-19: A Protective Role for Reproductive Steroids

artículo científico publicado en 2020

Social Isolation in Early versus Late Adolescent Mice Is Associated with Persistent Behavioral Deficits That Can Be Improved by Neurosteroid-Based Treatment

artículo científico publicado en 2017

Social isolation as a promising animal model of PTSD comorbid suicide: neurosteroids and cannabinoids as possible treatment options

scientific article published on 23 December 2018

Social isolation stress-induced aggression in mice: a model to study the pharmacology of neurosteroidogenesis

artículo científico publicado en 2005

Stimulation of Peroxisome Proliferator-Activated Receptor-α by N-Palmitoylethanolamine Engages Allopregnanolone Biosynthesis to Modulate Emotional Behavior

artículo científico publicado en 2019

Targeting neurosteroidogenesis as therapy for PTSD.

artículo científico publicado en 2014

The allopregnanolone to progesterone ratio across the menstrual cycle and in menopause

scientific article published on 14 November 2019

The combination of huperzine A and imidazenil is an effective strategy to prevent diisopropyl fluorophosphate toxicity in mice

artículo científico publicado en 2008

Thyroid hormones in the rat amygdala as common targets for antidepressant drugs, mood stabilizers, and sleep deprivation

artículo científico publicado en 2003

Tolerance to and Dependence on Alprazolam are Due to Changes in GABAa Receptor Function and Are Independent of Exposure to Experimental Set-up.

artículo científico publicado en 1998

Up‐Regulation of Neurosteroid Biosynthesis as a Pharmacological Strategy to Improve Behavioural Deficits in a Putative Mouse Model of Post‐Traumatic Stress Disorder ⬇️

artículo científico publicado el 1 de enero de 2012

Valproate corrects the schizophrenia-like epigenetic behavioral modifications induced by methionine in mice

artículo científico publicado en 2005

Lista de obras de Graziano Pinna

5α-reductase type I expression is downregulated in the prefrontal cortex/Brodmann's area 9 (BA9) of depressed patients.

Allopregnanolone (1938-2019): A trajectory of 80 years of outstanding scientific achievements

Allopregnanolone mediates the exacerbation of Tourette-like responses by acute stress in mouse models

Allopregnanolone, the Neuromodulator Turned Therapeutic Agent: Thank You, Next?

Allopregnanolone: From molecular pathophysiology to therapeutics. A historical perspective

Animal Models of PTSD: The Socially Isolated Mouse and the Biomarker Role of Allopregnanolone.

Animal models of post-traumatic stress disorder and novel treatment targets

Are the effects of T3 on resting metabolic rate in euthyroid rats entirely caused by T3 itself?

Associations between PTSD-Related extinction retention deficits in women and plasma steroids that modulate brain GABAA and NMDA receptor activity

Biomarkers for PTSD at the Interface of the Endocannabinoid and Neurosteroid Axis

Brain neurosteroids in gender-related aggression induced by social isolation

Changes in brain testosterone and allopregnanolone biosynthesis elicit aggressive behavior

Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis

Chronic intermittent ethanol (CIE) administration in rats decreases levels of neurosteroids in hippocampus, accompanied by altered behavioral responses to neurosteroids and memory function

Composite contributions of cerebrospinal fluid GABAergic neurosteroids, neuropeptide Y and interleukin-6 to PTSD symptom severity in men with PTSD

Concentrations of seven iodothyronine metabolites in brain regions and the liver of the adult rat.

Corrigendum: Allopregnanolone, the Neuromodulator Turned Therapeutic Agent: Thank You, Next?

Could a blood test for PTSD and depression be on the horizon?

Current understanding of fear learning and memory in humans and animal models and the value of a linguistic approach for analyzing fear learning and memory in humans

Decreased cerebrospinal fluid allopregnanolone levels in women with posttraumatic stress disorder

Decreased corticolimbic allopregnanolone expression during social isolation enhances contextual fear: A model relevant for posttraumatic stress disorder

Down-regulation of neurosteroid biosynthesis in corticolimbic circuits mediates social isolation-induced behavior in mice

Effects of pyrethroids on the concentrations of thyroid hormones in the rat serum and brain

Elevated 3,5-Diiodothyronine Concentrations in the Sera of Patients with Nonthyroidal Illnesses and Brain Tumors

Emerging Therapeutic Role of PPAR-α in Cognition and Emotions

Enhanced fear responses in mice treated with anabolic androgenic steroids.

Epigenetic regulation of GABAergic neurotransmission and neurosteroid biosynthesis in alcohol use disorder

Fast-acting antidepressant-like effects of Reelin evaluated in the repeated-corticosterone chronic stress paradigm

Fluoxetine and norfluoxetine stereospecifically and selectively increase brain neurosteroid content at doses that are inactive on 5-HT reuptake

Fluoxetine and norfluoxetine stereospecifically facilitate pentobarbital sedation by increasing neurosteroids

GABA(A) receptor neurotransmission dysfunction in a mouse model of social isolation-induced stress: possible insights into a non-serotonergic mechanism of action of SSRIs in mood and anxiety disorders

Ganaxolone improves behavioral deficits in a mouse model of post-traumatic stress disorder

Higher Circulating Cortisol in the Follicular vs. Luteal Phase of the Menstrual Cycle: A Meta-Analysis

Imidazenil and diazepam increase locomotor activity in mice exposed to protracted social isolation.

In a mouse model relevant for post-traumatic stress disorder, selective brain steroidogenic stimulants (SBSS) improve behavioral deficits by normalizing allopregnanolone biosynthesis

In socially isolated mice, the reversal of brain allopregnanolone down-regulation mediates the anti-aggressive action of fluoxetine

Induction of the reelin promoter by retinoic acid is mediated by Sp1

Intersectin 1 contributes to phenotypes in vivo: implications for Down's syndrome.

Is There a Future for PPARs in the Treatment of Neuropsychiatric Disorders?

MON-449 Serum Neuroactive Steroid Levels in Postmenopausal Women with Treatment-Resistant Major Depressive Disorder.

Neuroactive Steroids and Affective Symptoms in Women Across the Weight Spectrum

Neuroactive Steroids and PTSD Treatment

Neurosteroid biosynthesis downregulation and changes in GABAA receptor subunit composition: A biomarker axis in stress-induced cognitive and emotional impairment.

Neurosteroid biosynthesis regulates sexually dimorphic fear and aggressive behavior in mice.

Neurosteroids reduce social isolation-induced behavioral deficits: a proposed link with neurosteroid-mediated upregulation of BDNF expression

Neurosteroids regulate mouse aggression induced by anabolic androgenic steroids

PPAR and functional foods: Rationale for natural neurosteroid-based interventions for postpartum depression

PTSD in women is associated with a block in conversion of progesterone to the GABAergic neurosteroids allopregnanolone and pregnanolone measured in plasma

Relationships between cerebrospinal fluid GABAergic neurosteroid levels and symptom severity in men with PTSD

Repeated anabolic androgenic steroid treatment causes antidepressant-reversible alterations of the hypothalamic-pituitary-adrenal axis, BDNF levels and behavior

S-adenosyl methionine and DNA methyltransferase-1 mRNA overexpression in psychosis

S-norfluoxetine microinfused into the basolateral amygdala increases allopregnanolone levels and reduces aggression in socially isolated mice ⬇️

SSRIs act as selective brain steroidogenic stimulants (SBSSs) at low doses that are inactive on 5-HT reuptake

Sex and COVID-19: A Protective Role for Reproductive Steroids

Social Isolation in Early versus Late Adolescent Mice Is Associated with Persistent Behavioral Deficits That Can Be Improved by Neurosteroid-Based Treatment

Social isolation as a promising animal model of PTSD comorbid suicide: neurosteroids and cannabinoids as possible treatment options

Social isolation stress-induced aggression in mice: a model to study the pharmacology of neurosteroidogenesis

Stimulation of Peroxisome Proliferator-Activated Receptor-α by N-Palmitoylethanolamine Engages Allopregnanolone Biosynthesis to Modulate Emotional Behavior

Targeting neurosteroidogenesis as therapy for PTSD.

The allopregnanolone to progesterone ratio across the menstrual cycle and in menopause

The combination of huperzine A and imidazenil is an effective strategy to prevent diisopropyl fluorophosphate toxicity in mice

Thyroid hormones in the rat amygdala as common targets for antidepressant drugs, mood stabilizers, and sleep deprivation

Tolerance to and Dependence on Alprazolam are Due to Changes in GABAa Receptor Function and Are Independent of Exposure to Experimental Set-up.

Up‐Regulation of Neurosteroid Biosynthesis as a Pharmacological Strategy to Improve Behavioural Deficits in a Putative Mouse Model of Post‐Traumatic Stress Disorder ⬇️

Valproate corrects the schizophrenia-like epigenetic behavioral modifications induced by methionine in mice