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3,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands

artículo científico publicado en 2011

A series of potent CREBBP bromodomain ligands reveals an induced-fit pocket stabilized by a cation-π interaction

artículo científico publicado en 2014

Bromodomain-peptide displacement assays for interactome mapping and inhibitor discovery

artículo científico publicado en 2011

Click JAHAs: conformationally restricted ferrocene-based histone deacetylase inhibitors

Discovery of a Potent Nonpeptidomimetic, Small-Molecule Antagonist of Cellular Inhibitor of Apoptosis Protein 1 (cIAP1) and X-Linked Inhibitor of Apoptosis Protein (XIAP).

artículo científico publicado en 2017

Enabling synthesis in fragment-based drug discovery by reactivity mapping: photoredox-mediated cross-dehydrogenative heteroarylation of cyclic amines

artículo científico publicado en 2018

Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2

artículo científico publicado en 2018

Highly Potent Clickable Probe for Cellular Imaging of MDM2 and Assessing Dynamic Responses to MDM2-p53 Inhibition

scientific article published on 12 June 2018

Quantitation of ERK1/2 inhibitor cellular target occupancies with a reversible slow off-rate probe

scientific article published on 17 September 2018

Selective inhibition of BET bromodomains

artículo científico publicado en 2010

Structure-Activity and Structure-Conformation Relationships of Aryl Propionic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1/Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1/NRF2) Protein-Protein Interaction

artículo científico publicado en 2019

Synthesis and Biological Evaluation of JAHAs: Ferrocene-Based Histone Deacetylase Inhibitors

artículo científico publicado en 2011

The design and synthesis of 5- and 6-isoxazolylbenzimidazoles as selective inhibitors of the BET bromodomains

artículo científico publicado en 2013

Visualization of Endogenous ERK1/2 in Cells with a Bioorthogonal Covalent Probe.

artículo científico publicado en 2017

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