Lista de obras -

6-Azido-7-nitro-1,4-dihydroquinoxaline-2,3-dione (ANQX) Forms an Irreversible Bond To the Active Site of the GluR2 AMPA Receptor †

artículo científico publicado en 2008

A gene-expression screen identifies a non-toxic sumoylation inhibitor that mimics SUMO-less human LRH-1 in liver

artículo científico publicado en 2015

A high-throughput screening method to identify small molecule inhibitors of thyroid hormone receptor coactivator binding

artículo científico publicado en 2006

A surface on the androgen receptor that allosterically regulates coactivator binding

artículo científico publicado en 2007

Advances in our structural understanding of orphan nuclear receptors.

artículo científico publicado en 2014

An atomic model of the thin filament in the relaxed and Ca2+-activated states.

artículo científico

Conformational adaptation of nuclear receptor ligand binding domains to agonists: potential for novel approaches to ligand design

artículo científico publicado en 2005

Coordination between motor domains in processive kinesins

artículo científico publicado en 2004

Covalent Modification and Regulation of the Nuclear Receptor Nurr1 by a Dopamine Metabolite

artículo científico publicado en 2019

Crystal structure of kinesin regulated by Ca(2+)-calmodulin

artículo científico publicado en 2004

Design of thyroid hormone receptor antagonists from first principles

artículo científico publicado en 2002

Development of 5N-Bicalutamide, a High-Affinity Reversible Covalent Antiandrogen

artículo científico publicado en 2017

Discovery of small molecule inhibitors of the interaction of the thyroid hormone receptor with transcriptional coregulators

artículo científico publicado en 2005

Disulfide-Trapping Identifies a New, Effective Chemical Probe for Activating the Nuclear Receptor Human LRH-1 (NR5A2)

artículo científico publicado en 2016

Dlx5 Homeodomain:DNA Complex: Structure, Binding and Effect of Mutations Related to Split Hand and Foot Malformation Syndrome

artículo científico publicado en 2016

Histone demethylase KDM5A is regulated by its reader domain through a positive-feedback mechanism

artículo científico publicado en 2015

How does ATP hydrolysis control actin's associations?

artículo científico publicado en 2002

Inhibitors of the interaction of a thyroid hormone receptor and coactivators: preliminary structure-activity relationships.

artículo científico publicado en 2007

Interaction between the androgen receptor and a segment of its corepressor SHP

artículo científico publicado en 2007

LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival

artículo científico publicado en 2018

Ligand selectivity by seeking hydrophobicity in thyroid hormone receptor

artículo científico publicado en 2003

Molecular basis for dimer formation of TRβ variant D355R ⬇️

artículo científico publicado en 2009

NR5A2 discovering compounds that block tumor growth in PDAC.

artículo científico publicado en 2017

Nuclear receptor liver receptor homologue 1 (LRH-1) regulates pancreatic cancer cell growth and proliferation

artículo científico publicado en 2011

Perspectives on designs of antiandrogens for prostate cancer.

artículo científico publicado en 2007

Phosphorylation and intramolecular stabilization of the ligand binding domain in the nuclear receptor steroidogenic factor 1.

artículo científico publicado en 2002

Rearrangements in thyroid hormone receptor charge clusters that stabilize bound 3,5',5-triiodo-L-thyronine and inhibit homodimer formation

artículo científico publicado en 2005

Silencing LRH-1 in colon cancer cell lines impairs proliferation and alters gene expression programs

artículo científico publicado en 2015

Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1.

artículo científico publicado en 2005

Structural and functional insight into TAF1-TAF7, a subcomplex of transcription factor II D

artículo científico publicado en 2014

Structural basis for ligand-independent activation of the orphan nuclear receptor LRH-1

artículo científico publicado en 2003

Structural basis of coactivation of liver receptor homolog-1 by -catenin

artículo científico publicado en 2012

Structural insight into the mode of action of a direct inhibitor of coregulator binding to the thyroid hormone receptor

artículo científico publicado en 2007

Structure of Liver Receptor Homolog-1 (NR5A2) with PIP3 hormone bound in the ligand binding pocket

artículo científico publicado en 2015

Structure of SF-1 Bound by Different Phospholipids: Evidence for Regulatory Ligands

artículo científico publicado en 2009

Structure of a Novel Winged-Helix Like Domain from Human NFRKB Protein

artículo científico publicado en 2012

Structure of an F-actin trimer disrupted by gelsolin and implications for the mechanism of severing

artículo científico publicado en 2003

Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells

artículo científico publicado en 2015

Structure-based discovery of antagonists of nuclear receptor LRH-1.

artículo científico publicado en 2013

TR surfaces and conformations required to bind nuclear receptor corepressor

artículo científico publicado en 2002

Targeting the regulation of androgen receptor signaling by the heat shock protein 90 cochaperone FKBP52 in prostate cancer cells

artículo científico publicado en 2011

The FKBP52 Cochaperone Acts in Synergy with β-Catenin to Potentiate Androgen Receptor Signaling.

artículo científico publicado en 2015

The human orphan nuclear receptor tailless (TLX, NR2E1) is druggable

artículo científico publicado en 2014

The molecular mechanisms of coactivator utilization in ligand-dependent transactivation by the androgen receptor

artículo científico publicado en 2005

The signaling phospholipid PIP3 creates a new interaction surface on the nuclear receptor SF-1.

artículo científico publicado en 2014

The structure of corepressor Dax-1 bound to its target nuclear receptor LRH-1

artículo científico publicado en 2008

Thyroid hormone receptor-beta mutations conferring hormone resistance and reduced corepressor release exhibit decreased stability in the N-terminal ligand-binding domain

artículo científico publicado en 2003

Thyroxine-thyroid hormone receptor interactions

artículo científico publicado en 2004

Lista de obras de

6-Azido-7-nitro-1,4-dihydroquinoxaline-2,3-dione (ANQX) Forms an Irreversible Bond To the Active Site of the GluR2 AMPA Receptor †

A gene-expression screen identifies a non-toxic sumoylation inhibitor that mimics SUMO-less human LRH-1 in liver

A high-throughput screening method to identify small molecule inhibitors of thyroid hormone receptor coactivator binding

A surface on the androgen receptor that allosterically regulates coactivator binding

Advances in our structural understanding of orphan nuclear receptors.

An atomic model of the thin filament in the relaxed and Ca2+-activated states.

Conformational adaptation of nuclear receptor ligand binding domains to agonists: potential for novel approaches to ligand design

Coordination between motor domains in processive kinesins

Covalent Modification and Regulation of the Nuclear Receptor Nurr1 by a Dopamine Metabolite

Crystal structure of kinesin regulated by Ca(2+)-calmodulin

Design of thyroid hormone receptor antagonists from first principles

Development of 5N-Bicalutamide, a High-Affinity Reversible Covalent Antiandrogen

Discovery of small molecule inhibitors of the interaction of the thyroid hormone receptor with transcriptional coregulators

Disulfide-Trapping Identifies a New, Effective Chemical Probe for Activating the Nuclear Receptor Human LRH-1 (NR5A2)

Dlx5 Homeodomain:DNA Complex: Structure, Binding and Effect of Mutations Related to Split Hand and Foot Malformation Syndrome

Histone demethylase KDM5A is regulated by its reader domain through a positive-feedback mechanism

How does ATP hydrolysis control actin's associations?

Inhibitors of the interaction of a thyroid hormone receptor and coactivators: preliminary structure-activity relationships.

Interaction between the androgen receptor and a segment of its corepressor SHP

LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival

Ligand selectivity by seeking hydrophobicity in thyroid hormone receptor

Molecular basis for dimer formation of TRβ variant D355R ⬇️

NR5A2 discovering compounds that block tumor growth in PDAC.

Nuclear receptor liver receptor homologue 1 (LRH-1) regulates pancreatic cancer cell growth and proliferation

Perspectives on designs of antiandrogens for prostate cancer.

Phosphorylation and intramolecular stabilization of the ligand binding domain in the nuclear receptor steroidogenic factor 1.

Rearrangements in thyroid hormone receptor charge clusters that stabilize bound 3,5',5-triiodo-L-thyronine and inhibit homodimer formation

Silencing LRH-1 in colon cancer cell lines impairs proliferation and alters gene expression programs

Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1.

Structural and functional insight into TAF1-TAF7, a subcomplex of transcription factor II D

Structural basis for ligand-independent activation of the orphan nuclear receptor LRH-1

Structural basis of coactivation of liver receptor homolog-1 by -catenin

Structural insight into the mode of action of a direct inhibitor of coregulator binding to the thyroid hormone receptor

Structure of Liver Receptor Homolog-1 (NR5A2) with PIP3 hormone bound in the ligand binding pocket

Structure of SF-1 Bound by Different Phospholipids: Evidence for Regulatory Ligands

Structure of a Novel Winged-Helix Like Domain from Human NFRKB Protein

Structure of an F-actin trimer disrupted by gelsolin and implications for the mechanism of severing

Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells

Structure-based discovery of antagonists of nuclear receptor LRH-1.

TR surfaces and conformations required to bind nuclear receptor corepressor

Targeting the regulation of androgen receptor signaling by the heat shock protein 90 cochaperone FKBP52 in prostate cancer cells

The FKBP52 Cochaperone Acts in Synergy with β-Catenin to Potentiate Androgen Receptor Signaling.

The human orphan nuclear receptor tailless (TLX, NR2E1) is druggable

The molecular mechanisms of coactivator utilization in ligand-dependent transactivation by the androgen receptor

The signaling phospholipid PIP3 creates a new interaction surface on the nuclear receptor SF-1.

The structure of corepressor Dax-1 bound to its target nuclear receptor LRH-1

Thyroid hormone receptor-beta mutations conferring hormone resistance and reduced corepressor release exhibit decreased stability in the N-terminal ligand-binding domain

Thyroxine-thyroid hormone receptor interactions