Lista de obras -

4-Acyl pyrroles: mimicking acetylated lysines in histone code reading

artículo científico publicado en 2013

4-Biphenylalanine- and 3-Phenyltyrosine-Derived Hydroxamic Acids as Inhibitors of the JumonjiC-Domain-Containing Histone Demethylase KDM4A.

artículo científico publicado en 2016

A Chemical Probe For Tudor Domain Protein Spindlin1 to Investigate Chromatin Functions

A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function

artículo científico publicado en 2019

A novel arginine methyltransferase inhibitor with cellular activity

artículo científico publicado en 2007

A novel inducible transactivation domain in the androgen receptor: implications for PRK in prostate cancer

artículo científico publicado en 2003

A novel murine model of myeloproliferative disorders generated by overexpression of the transcription factor NF-E2.

artículo científico publicado en 2012

Acyl derivatives of p-aminosulfonamides and dapsone as new inhibitors of the arginine methyltransferase hPRMT1.

artículo científico publicado en 2011

Androgen receptor coactivators lysine-specific histone demethylase 1 and four and a half LIM domain protein 2 predict risk of prostate cancer recurrence

artículo científico publicado en 2006

Assembly of methylated KDM1A and CHD1 drives androgen receptor-dependent transcription and translocation

artículo científico publicado en 2016

Cell type specific gene expression analysis of prostate needle biopsies resolves tumor tissue heterogeneity.

artículo científico publicado en 2015

Cell type-specific functions of the lysosomal protease cathepsin L in the heart

artículo científico publicado en 2007

Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression

artículo científico publicado en 2007

Correction: LSD1 inhibition by tranylcypromine derivatives interferes with GFI1-mediated repression of PU.1 target genes and induces differentiation in AML

artículo científico publicado en 2019

CtBP and associated LSD1 are required for transcriptional activation by NeuroD1 in gastrointestinal endocrine cells

artículo científico publicado en 2014

Deficiency in the LIM-only protein Fhl2 impairs skin wound healing

artículo científico publicado en 2007

Depletion of histone methyltransferase KMT9 inhibits lung cancer cell proliferation by inducing non-apoptotic cell death

artículo científico publicado en 2020

Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1 (SPIN1)

scientific article published on 24 July 2019

Enhanced FHL2 and TGF-β1 Expression Is Associated With Invasive Growth and Poor Survival in Malignant Melanomas

artículo científico publicado en 2015

Epigenetic regulation of cancer growth by histone demethylases

artículo científico publicado en 2010

Epigenetics meets GPCR: inhibition of histone H3 methyltransferase (G9a) and histamine H3 receptor for Prader-Willi Syndrome

artículo científico publicado en 2020

Extracellular signal-regulated kinase 2 interacts with and is negatively regulated by the LIM-only protein FHL2 in cardiomyocytes

artículo científico publicado en 2004

FHL2 expression in peritumoural fibroblasts correlates with lymphatic metastasis in sporadic but not in HNPCC-associated colon cancer

artículo científico publicado en 2011

FHL2 mediates dexamethasone-induced mesenchymal cell differentiation into osteoblasts by activating Wnt/beta-catenin signaling-dependent Runx2 expression.

artículo científico publicado en 2008

FHL2 silencing reduces Wnt signaling and osteosarcoma tumorigenesis in vitro and in vivo

artículo científico publicado en 2013

Fat or bone? A non-canonical decision

artículo científico publicado en 2007

Fhl2 deficiency results in osteopenia due to decreased activity of osteoblasts

artículo científico publicado en 2005

Focal adhesion kinase interacts with the transcriptional coactivator FHL2 and both are overexpressed in epithelial ovarian cancer.

artículo científico publicado en 2004

Four-and-a-half LIM domains protein 2 (FHL2) is associated with the development of craniofacial musculature in the teleost fish Sparus aurata

artículo científico publicado en 2011

Generation and characterization of an Nse-CreERT2 transgenic line suitable for inducible gene manipulation in cerebellar granule cells.

artículo científico publicado en 2014

Heterogeneous Antibody-Based Activity Assay for Lysine Specific Demethylase 1 (LSD1) on a Histone Peptide Substrate

artículo científico publicado en 2014

Histone demethylation and androgen-dependent transcription

artículo científico publicado en 2006

Identification and Structure-Activity Relationship Studies of Small-Molecule Inhibitors of the Methyllysine Reader Protein Spindlin1.

artículo científico publicado en 2016

Identification of Highly Potent Protein Kinase C-Related Kinase 1 Inhibitors by Virtual Screening, Binding Free Energy Rescoring, and in vitro Testing

artículo científico publicado en 2016

Identification of a small-molecule ligand of the epigenetic reader protein Spindlin1 via a versatile screening platform.

artículo científico publicado en 2016

Impairment of prostate cancer cell growth by a selective and reversible lysine-specific demethylase 1 inhibitor

artículo científico publicado en 2012

Inactivation of Lsd1 triggers senescence in trophoblast stem cells by induction of Sirt4.

artículo científico publicado en 2017

KDM4 inhibition targets breast cancer stem-like cells

artículo científico publicado en 2017

KMT9 monomethylates histone H4 lysine 12 and controls proliferation of prostate cancer cells

scientific article published on 06 May 2019

LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription

artículo científico publicado en 2005

LSD1 inhibition by tranylcypromine derivatives interferes with GFI1-mediated repression of PU.1 target genes and induces differentiation in AML

artículo científico publicado en 2019

LSD1 promotes oxidative metabolism of white adipose tissue

artículo científico publicado en 2014

Lestaurtinib inhibits histone phosphorylation and androgen-dependent gene expression in prostate cancer cells

artículo científico publicado en 2012

Long-range upstream and downstream enhancers control distinct subsets of the complex spatiotemporal Sox9 expression pattern

artículo científico publicado en 2006

Lsd1 Ablation Triggers Metabolic Reprogramming of Brown Adipose Tissue

artículo científico publicado en 2016

Lsd1 prevents age-programed loss of beige adipocytes

artículo científico publicado en 2017

Lsd1 regulates skeletal muscle regeneration and directs the fate of satellite cells

artículo científico publicado en 2018

Lsd1, a metabolic sensor of environment requirements that prevents adipose tissue from aging

artículo científico publicado en 2017

Lysine-specific demethylase 1 (LSD1) is highly expressed in ER-negative breast cancers and a biomarker predicting aggressive biology

artículo científico publicado en 2010

Lysine-specific demethylase 1 has dual functions as a major regulator of androgen receptor transcriptional activity.

artículo científico publicado en 2014

Lysine-specific demethylase 1 is highly expressed in solitary fibrous tumors, synovial sarcomas, rhabdomyosarcomas, desmoplastic small round cell tumors, and malignant peripheral nerve sheath tumors

artículo científico publicado en 2011

Lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma: implications for therapy

artículo científico publicado en 2009

Lysine-specific demethylase 1 regulates differentiation onset and migration of trophoblast stem cells

artículo científico publicado en 2014

Molecular cloning of the Matrix Gla Protein gene from Xenopus laevis. Functional analysis of the promoter identifies a calcium sensitive region required for basal activity

artículo científico publicado en 2002

Molecular cloning of the Matrix Gla Protein gene from Xenopus laevis. Functional analysis of the promoter identifies a calcium sensitive region required for basal activity

article

NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.

artículo científico publicado en 2005

NIR, an inhibitor of histone acetyltransferases, regulates transcription factor TAp63 and is controlled by the cell cycle

artículo científico publicado en 2010

Next-generation sequencing reveals a novel role of lysine-specific demethylase 1 in adhesion of rhabdomyosarcoma cells

scientific article published on 21 November 2019

Nitroreductase-Mediated Release of Inhibitors of Lysine-Specific Demethylase 1 (LSD1) from Prodrugs in Transfected Acute Myeloid Leukaemia Cells

article published in 2019

Nitroreductase-mediated release of inhibitors of Lysine-Specific Demethylase 1 (LSD1) from prodrugs in transfected acute myeloid leukaemia cells

scientific article published on 30 March 2020

Nonpeptidic propargylamines as inhibitors of lysine specific demethylase 1 (LSD1) with cellular activity

artículo científico publicado en 2013

Overexpression of histone demethylase Fbxl10 leads to enhanced migration in mouse embryonic fibroblasts

artículo científico publicado en 2016

PELP1 is a reader of histone H3 methylation that facilitates oestrogen receptor-alpha target gene activation by regulating lysine demethylase 1 specificity

artículo científico publicado en 2010

PRK1/PKN1 controls migration and metastasis of androgen-independent prostate cancer cells

artículo científico publicado en 2014

Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation

artículo científico publicado en 2008

Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4

artículo científico publicado en 2010

Preparation data of the bromodomains BRD3(1), BRD3(2), BRD4(1), and BRPF1B and crystallization of BRD4(1)-inhibitor complexes.

artículo científico publicado en 2016

Proline-, glutamic acid-, and leucine-rich protein-1/modulator of nongenomic activity of estrogen receptor enhances androgen receptor functions through LIM-only coactivator, four-and-a-half LIM-only protein 2

artículo científico publicado en 2007

SNAIL1 combines competitive displacement of ASCL2 and epigenetic mechanisms to rapidly silence the EPHB3 tumor suppressor in colorectal cancer

artículo científico publicado en 2014

Screening assays for epigenetic targets using native histones as substrates

scientific article published on 30 September 2011

Selective targeting of epigenetic reader domains

artículo científico publicado en 2017

Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance.

artículo científico publicado en 2015

Structure-activity studies on N-Substituted tranylcypromine derivatives lead to selective inhibitors of lysine specific demethylase 1 (LSD1) and potent inducers of leukemic cell differentiation

artículo científico publicado en 2017

Studies of intestinal morphology and cathepsin B expression in a transgenic mouse aiming at intestine-specific expression of Cath B-EGFP.

artículo científico publicado en 2011

Substituted 2-(2-aminopyrimidin-4-yl)pyridine-4-carboxylates as potent inhibitors of JumonjiC domain-containing histone demethylases

artículo científico publicado en 2016

TGF-β1-dependent induction and nuclear translocation of FHL2 promotes keratin expression in pilomatricoma

artículo científico publicado en 2014

Target-based approach to inhibitors of histone arginine methyltransferases

artículo científico publicado en 2007

Tetrazolylhydrazides as Selective Fragment-Like Inhibitors of the JumonjiC-Domain-Containing Histone Demethylase KDM4A.

artículo científico publicado en 2015

The Clinically Used Iron Chelator Deferasirox Is an Inhibitor of Epigenetic JumonjiC Domain-Containing Histone Demethylases

scientific article published on 19 July 2019

The Clinically Used Iron Chelator Deferasirox is an Inhibitor of Epigenetic JumonjiC Domain-Containing Histone Demethylases

artículo científico publicado en 2019

The LIM-only coactivator FHL2 modulates WT1 transcriptional activity during gonadal differentiation

scientific journal article

The expanding world of histone lysine demethylases

artículo científico publicado en 2007

The histone acetyltransferase inhibitor Nir regulates epidermis development.

artículo científico publicado en 2018

The histone code reader SPIN1 controls RET signaling in liposarcoma

artículo científico publicado en 2015

The histone code reader Spin1 controls skeletal muscle development.

artículo científico publicado en 2017

The human cysteine protease cathepsin V can compensate for murine cathepsin L in mouse epidermis and hair follicles.

artículo científico publicado en 2004

The transcriptional coactivator FHL2 transmits Rho signals from the cell membrane into the nucleus

artículo científico publicado en 2002

Tofacitinib and analogs as inhibitors of the histone kinase PRK1 (PKN1).

artículo científico publicado en 2016

Transcriptional repressor NIR interacts with the p53-inhibiting ubiquitin ligase MDM2.

artículo científico

Tumoral expression of nuclear cofactor FHL2 is associated with lymphatic metastasis in sporadic but not in HNPCC-associated colorectal cancer

artículo científico publicado en 2014

Virtual screening of PRK1 inhibitors: ensemble docking, rescoring using binding free energy calculation and QSAR model development

artículo científico publicado en 2014

Lista de obras de

4-Acyl pyrroles: mimicking acetylated lysines in histone code reading

4-Biphenylalanine- and 3-Phenyltyrosine-Derived Hydroxamic Acids as Inhibitors of the JumonjiC-Domain-Containing Histone Demethylase KDM4A.

A Chemical Probe For Tudor Domain Protein Spindlin1 to Investigate Chromatin Functions

A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function

A novel arginine methyltransferase inhibitor with cellular activity

A novel inducible transactivation domain in the androgen receptor: implications for PRK in prostate cancer

A novel murine model of myeloproliferative disorders generated by overexpression of the transcription factor NF-E2.

Acyl derivatives of p-aminosulfonamides and dapsone as new inhibitors of the arginine methyltransferase hPRMT1.

Androgen receptor coactivators lysine-specific histone demethylase 1 and four and a half LIM domain protein 2 predict risk of prostate cancer recurrence

Assembly of methylated KDM1A and CHD1 drives androgen receptor-dependent transcription and translocation

Cell type specific gene expression analysis of prostate needle biopsies resolves tumor tissue heterogeneity.

Cell type-specific functions of the lysosomal protease cathepsin L in the heart

Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression

Correction: LSD1 inhibition by tranylcypromine derivatives interferes with GFI1-mediated repression of PU.1 target genes and induces differentiation in AML

CtBP and associated LSD1 are required for transcriptional activation by NeuroD1 in gastrointestinal endocrine cells

Deficiency in the LIM-only protein Fhl2 impairs skin wound healing

Depletion of histone methyltransferase KMT9 inhibits lung cancer cell proliferation by inducing non-apoptotic cell death

Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1 (SPIN1)

Enhanced FHL2 and TGF-β1 Expression Is Associated With Invasive Growth and Poor Survival in Malignant Melanomas

Epigenetic regulation of cancer growth by histone demethylases

Epigenetics meets GPCR: inhibition of histone H3 methyltransferase (G9a) and histamine H3 receptor for Prader-Willi Syndrome

Extracellular signal-regulated kinase 2 interacts with and is negatively regulated by the LIM-only protein FHL2 in cardiomyocytes

FHL2 expression in peritumoural fibroblasts correlates with lymphatic metastasis in sporadic but not in HNPCC-associated colon cancer

FHL2 mediates dexamethasone-induced mesenchymal cell differentiation into osteoblasts by activating Wnt/beta-catenin signaling-dependent Runx2 expression.

FHL2 silencing reduces Wnt signaling and osteosarcoma tumorigenesis in vitro and in vivo

Fat or bone? A non-canonical decision

Fhl2 deficiency results in osteopenia due to decreased activity of osteoblasts

Focal adhesion kinase interacts with the transcriptional coactivator FHL2 and both are overexpressed in epithelial ovarian cancer.

Four-and-a-half LIM domains protein 2 (FHL2) is associated with the development of craniofacial musculature in the teleost fish Sparus aurata

Generation and characterization of an Nse-CreERT2 transgenic line suitable for inducible gene manipulation in cerebellar granule cells.

Heterogeneous Antibody-Based Activity Assay for Lysine Specific Demethylase 1 (LSD1) on a Histone Peptide Substrate

Histone demethylation and androgen-dependent transcription

Identification and Structure-Activity Relationship Studies of Small-Molecule Inhibitors of the Methyllysine Reader Protein Spindlin1.

Identification of Highly Potent Protein Kinase C-Related Kinase 1 Inhibitors by Virtual Screening, Binding Free Energy Rescoring, and in vitro Testing

Identification of a small-molecule ligand of the epigenetic reader protein Spindlin1 via a versatile screening platform.

Impairment of prostate cancer cell growth by a selective and reversible lysine-specific demethylase 1 inhibitor

Inactivation of Lsd1 triggers senescence in trophoblast stem cells by induction of Sirt4.

KDM4 inhibition targets breast cancer stem-like cells

KMT9 monomethylates histone H4 lysine 12 and controls proliferation of prostate cancer cells

LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription

LSD1 inhibition by tranylcypromine derivatives interferes with GFI1-mediated repression of PU.1 target genes and induces differentiation in AML

LSD1 promotes oxidative metabolism of white adipose tissue

Lestaurtinib inhibits histone phosphorylation and androgen-dependent gene expression in prostate cancer cells

Long-range upstream and downstream enhancers control distinct subsets of the complex spatiotemporal Sox9 expression pattern

Lsd1 Ablation Triggers Metabolic Reprogramming of Brown Adipose Tissue

Lsd1 prevents age-programed loss of beige adipocytes

Lsd1 regulates skeletal muscle regeneration and directs the fate of satellite cells

Lsd1, a metabolic sensor of environment requirements that prevents adipose tissue from aging

Lysine-specific demethylase 1 (LSD1) is highly expressed in ER-negative breast cancers and a biomarker predicting aggressive biology

Lysine-specific demethylase 1 has dual functions as a major regulator of androgen receptor transcriptional activity.

Lysine-specific demethylase 1 is highly expressed in solitary fibrous tumors, synovial sarcomas, rhabdomyosarcomas, desmoplastic small round cell tumors, and malignant peripheral nerve sheath tumors

Lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma: implications for therapy

Lysine-specific demethylase 1 regulates differentiation onset and migration of trophoblast stem cells

Molecular cloning of the Matrix Gla Protein gene from Xenopus laevis. Functional analysis of the promoter identifies a calcium sensitive region required for basal activity

Molecular cloning of the Matrix Gla Protein gene from Xenopus laevis. Functional analysis of the promoter identifies a calcium sensitive region required for basal activity

NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.

NIR, an inhibitor of histone acetyltransferases, regulates transcription factor TAp63 and is controlled by the cell cycle

Next-generation sequencing reveals a novel role of lysine-specific demethylase 1 in adhesion of rhabdomyosarcoma cells

Nitroreductase-Mediated Release of Inhibitors of Lysine-Specific Demethylase 1 (LSD1) from Prodrugs in Transfected Acute Myeloid Leukaemia Cells

Nitroreductase-mediated release of inhibitors of Lysine-Specific Demethylase 1 (LSD1) from prodrugs in transfected acute myeloid leukaemia cells

Nonpeptidic propargylamines as inhibitors of lysine specific demethylase 1 (LSD1) with cellular activity

Overexpression of histone demethylase Fbxl10 leads to enhanced migration in mouse embryonic fibroblasts

PELP1 is a reader of histone H3 methylation that facilitates oestrogen receptor-alpha target gene activation by regulating lysine demethylase 1 specificity

PRK1/PKN1 controls migration and metastasis of androgen-independent prostate cancer cells

Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation

Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4

Preparation data of the bromodomains BRD3(1), BRD3(2), BRD4(1), and BRPF1B and crystallization of BRD4(1)-inhibitor complexes.

Proline-, glutamic acid-, and leucine-rich protein-1/modulator of nongenomic activity of estrogen receptor enhances androgen receptor functions through LIM-only coactivator, four-and-a-half LIM-only protein 2

SNAIL1 combines competitive displacement of ASCL2 and epigenetic mechanisms to rapidly silence the EPHB3 tumor suppressor in colorectal cancer

Screening assays for epigenetic targets using native histones as substrates

Selective targeting of epigenetic reader domains

Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance.

Structure-activity studies on N-Substituted tranylcypromine derivatives lead to selective inhibitors of lysine specific demethylase 1 (LSD1) and potent inducers of leukemic cell differentiation

Studies of intestinal morphology and cathepsin B expression in a transgenic mouse aiming at intestine-specific expression of Cath B-EGFP.

Substituted 2-(2-aminopyrimidin-4-yl)pyridine-4-carboxylates as potent inhibitors of JumonjiC domain-containing histone demethylases

TGF-β1-dependent induction and nuclear translocation of FHL2 promotes keratin expression in pilomatricoma

Target-based approach to inhibitors of histone arginine methyltransferases

Tetrazolylhydrazides as Selective Fragment-Like Inhibitors of the JumonjiC-Domain-Containing Histone Demethylase KDM4A.

The Clinically Used Iron Chelator Deferasirox Is an Inhibitor of Epigenetic JumonjiC Domain-Containing Histone Demethylases