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A Multi-Omics Perspective of Quantitative Trait Loci in Precision Medicine

scientific article published on 24 February 2020

A Pan-cancer Analysis of the Expression and Clinical Relevance of Small Nucleolar RNAs in Human Cancer.

artículo científico publicado en 2017

A Patient-Derived, Pan-Cancer EMT Signature Identifies Global Molecular Alterations and Immune Target Enrichment Following Epithelial-to-Mesenchymal Transition

artículo científico publicado en 2015

A YAP/FOXM1 axis mediates EMT-associated EGFR inhibitor resistance and increased expression of spindle assembly checkpoint components

scientific article published on 01 September 2020

A comprehensive evaluation of biomarkers predictive of response to PI3K inhibitors and of resistance mechanisms in head and neck squamous cell carcinoma

artículo científico publicado en 2014

A murine preclinical syngeneic transplantation model for breast cancer precision medicine.

artículo científico publicado en 2017

A pan-cancer proteomic perspective on The Cancer Genome Atlas.

artículo científico publicado en 2014

A two-gene signature, SKI and SLAMF1, predicts time-to-treatment in previously untreated patients with chronic lymphocytic leukemia

artículo científico publicado en 2011

APAatlas: decoding alternative polyadenylation across human tissues

artículo científico publicado en 2020

AXL Inhibition Suppresses the DNA Damage Response and Sensitizes Cells to PARP Inhibition in Multiple Cancers.

artículo científico publicado en 2016

AXL inhibition induces DNA damage and replication stress in non-small cell lung cancer cells and promotes sensitivity to ATR inhibitors

artículo científico publicado en 2020

Aberrant expression of proteins involved in signal transduction and DNA repair pathways in lung cancer and their association with clinical parameters

artículo científico publicado en 2012

Abstract 3772: Inter- and intra-tumoral variations in ASCL1, NEUROD1, and POU2F3 transcriptional programs underlie three distinct molecular subtypes of small cell lung cancers

scholarly article

Abstract LB-148: Combination treatment of the CHK1 inhibitor, SRA737, and low dose gemcitabine demonstrates profound synergy with anti-PDL1 inducing durable tumor regressions and modulating the immune microenvironment in small cell lung cancer

scholarly article

Activating NOTCH1 Mutations Define a Distinct Subgroup of Patients With Adenoid Cystic Carcinoma Who Have Poor Prognosis, Propensity to Bone and Liver Metastasis, and Potential Responsiveness to Notch1 Inhibitors

artículo científico publicado en 2016

Activation of the PI3K/mTOR Pathway following PARP Inhibition in Small Cell Lung Cancer

artículo científico publicado en 2016

Activation of β-catenin signaling in androgen receptor-negative prostate cancer cells

artículo científico publicado en 2012

Adverse events associated with potential drugs for COVID-19: a case study from real-world data

artículo científico publicado en 2020

Altered regulation of HIF-1α in naïve- and drug-resistant EGFR mutant NSCLC: implications for a VEGF-dependent phenotype

scientific article published on 09 December 2020

An Integrated Molecular Analysis of Lung Adenocarcinomas Identifies Potential Therapeutic Targets among TTF1-Negative Tumors, Including DNA Repair Proteins and Nrf2.

artículo científico publicado en 2015

An epithelial-mesenchymal transition gene signature predicts resistance to EGFR and PI3K inhibitors and identifies Axl as a therapeutic target for overcoming EGFR inhibitor resistance

artículo científico publicado en 2012

An integrin β₃-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition.

artículo científico publicado en 2014

Assessing the clinical utility of cancer genomic and proteomic data across tumor types.

artículo científico publicado en 2014

Biomarker-Integrated Neoadjuvant Dasatinib Trial in Resectable Malignant Pleural Mesothelioma

artículo científico publicado en 2017

Bisphosphorylated PEA-15 sensitizes ovarian cancer cells to paclitaxel by impairing the microtubule-destabilizing effect of SCLIP.

artículo científico publicado en 2013

CD38-Mediated Immunosuppression as a Mechanism of Tumor Cell Escape from PD-1/PD-L1 Blockade

artículo científico publicado en 2018

CD73 expression defines immune, molecular, and clinicopathological subgroups of lung adenocarcinoma

artículo científico publicado en 2021

Characterization of Hypoxia-associated Molecular Features to Aid Hypoxia-Targeted Therapy

artículo científico publicado en 2019

Characterization of the dual functional effects of heat shock proteins (HSPs) in cancer hallmarks to aid development of HSP inhibitors

artículo científico publicado en 2020

Characterization of the immune landscape of EGFR-mutant NSCLC identifies CD73/adenosine pathway as a potential therapeutic target

artículo científico publicado en 2020

CircView: a visualization and exploration tool for circular RNAs.

artículo científico publicado en 2017

Circulating microRNAs in Pancreatic Juice as Candidate Biomarkers of Pancreatic Cancer

artículo científico publicado en 2014

Co-occurring genomic alterations define major subsets of KRAS-mutant lung adenocarcinoma with distinct biology, immune profiles, and therapeutic vulnerabilities

artículo científico publicado en 2015

Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8+ T cell exhaustion

scientific article published on 09 September 2020

Combination Treatment of the Oral CHK1 Inhibitor, SRA737, and Low-Dose Gemcitabine Enhances the Effect of Programmed Death Ligand 1 Blockade by Modulating the Immune Microenvironment in SCLC

artículo científico publicado en 2019

Comprehensive Characterization of Alternative Polyadenylation in Human Cancer

artículo científico publicado en 2017

Comprehensive biomarker analysis and final efficacy results of sorafenib in the BATTLE trial

artículo científico publicado en 2013

Comprehensive characterization of circular RNAs in ~ 1000 human cancer cell lines

artículo científico publicado en 2019

Concomitant targeting of the mTOR/MAPK pathways: novel therapeutic strategy in subsets of -altered non-small cell lung cancer

Corrigendum: A pan-cancer proteomic perspective on The Cancer Genome Atlas

scientific article published on 28 January 2015

Dasatinib induces DNA damage and activates DNA repair pathways leading to senescence in non-small cell lung cancer cell lines with kinase-inactivating BRAF mutations

artículo científico publicado en 2015

DeMix: deconvolution for mixed cancer transcriptomes using raw measured data

artículo científico publicado en 2013

Decreased expression of microRNA-26b in locally advanced and inflammatory breast cancer.

artículo científico publicado en 2018

Dual inhibition of MEK and AXL targets tumor cell heterogeneity and prevents resistant outgrowth mediated by the epithelial-to-mesenchymal transition in NSCLC

artículo científico publicado en 2021

Effect of KRAS oncogene substitutions on protein behavior: implications for signaling and clinical outcome

artículo científico publicado en 2012

Epithelial-Mesenchymal Transition Is Associated with a Distinct Tumor Microenvironment Including Elevation of Inflammatory Signals and Multiple Immune Checkpoints in Lung Adenocarcinoma

artículo científico publicado en 2016

Epithelial-Mesenchymal Transition Predicts Polo-Like Kinase 1 Inhibitor-Mediated Apoptosis in Non-Small Cell Lung Cancer.

artículo científico publicado en 2015

Focal adhesion kinase: an alternative focus for anti-angiogenesis therapy in ovarian cancer.

artículo científico publicado en 2014

Genes suppressed by DNA methylation in non-small cell lung cancer reveal the epigenetics of epithelial-mesenchymal transition

artículo científico publicado en 2014

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas.

artículo científico publicado en 2018

Genotype-specific differences in circulating tumor DNA levels in advanced NSCLC

artículo científico publicado en 2020

Global analysis of tRNA and translation factor expression reveals a dynamic landscape of translational regulation in human cancers

artículo científico publicado en 2018

Growth and metastasis of lung adenocarcinoma is potentiated by BMP4-mediated immunosuppression

artículo científico publicado en 2016

HeRA: an atlas of enhancer RNAs across human tissues

scientific article published on 29 October 2020

High OX-40 expression in the tumor immune infiltrate is a favorable prognostic factor of overall survival in non-small cell lung cancer

scientific article published on 16 December 2019

Hsp90 Inhibitor Ganetespib Sensitizes Non-Small Cell Lung Cancer to Radiation but Has Variable Effects with Chemoradiation

scientific article published on 28 June 2016

INO80 governs superenhancer-mediated oncogenic transcription and tumor growth in melanoma

artículo científico publicado en 2016

Identification and characterization of a suite of tumor targeting peptides for non-small cell lung cancer

artículo científico publicado en 2014

In Vivo Delivery of miR-34a Sensitizes Lung Tumors to Radiation Through RAD51 Regulation

artículo científico publicado en 2015

Integrated MicroRNA-mRNA Profiling Identifies Oncostatin M as a Marker of Mesenchymal-Like ER-Negative/HER2-Negative Breast Cancer

scientific article published on 19 January 2017

Integrative Molecular Characterization of Malignant Pleural Mesothelioma

artículo científico publicado en 2018

Integrative proteomic and transcriptomic analysis provides evidence for TrkB (NTRK2) as a therapeutic target in combination with tyrosine kinase inhibitors for non-small cell lung cancer.

artículo científico publicado en 2018

KDR Amplification Is Associated with VEGF-Induced Activation of the mTOR and Invasion Pathways but does not Predict Clinical Benefit to the VEGFR TKI Vandetanib

artículo científico publicado en 2015

LNCediting: a database for functional effects of RNA editing in lncRNAs

scientific article published on 19 September 2016

Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression

artículo científico publicado en 2014

MicroRNA expression profiling identifies decreased expression of miR-205 in inflammatory breast cancer.

artículo científico publicado en 2016

Multi-omics prediction of immune-related adverse events during checkpoint immunotherapy

scientific article published on 02 October 2020

Multiomics profiling of primary lung cancers and distant metastases reveals immunosuppression as a common characteristic of tumor cells with metastatic plasticity

artículo científico publicado en 2020

Multiregion gene expression profiling reveals heterogeneity in molecular subtypes and immunotherapy response signatures in lung cancer

artículo científico publicado en 2018

Myeloid loss of Beclin 1 promotes PD-L1hi precursor B cell lymphoma development

artículo científico publicado en 2019

Neoadjuvant Chemotherapy Increases Cytotoxic T cell, Tissue Resident Memory T cell and B Cell Infiltration in Resectable Non-Small Cell Lung Cancer

artículo científico publicado en 2020

Neutrophil expansion defines an immunoinhibitory peripheral and intratumoral inflammatory milieu in resected non-small cell lung cancer: a descriptive analysis of a prospectively immunoprofiled cohort

artículo científico publicado en 2020

Pan-Cancer Landscape and Analysis of ERBB2 Mutations Identifies Poziotinib as a Clinically Active Inhibitor and Enhancer of T-DM1 Activity

artículo científico publicado en 2020

Pan-Cancer Landscape and Analysis of ERBB2 Mutations Identifies Poziotinib as a Clinically Active Inhibitor and Enhancer of T-DM1 Activity

scientific article published on 03 October 2019

Pancan-meQTL: a database to systematically evaluate the effects of genetic variants on methylation in human cancer.

artículo científico publicado en 2019

PancanQTL: systematic identification of cis-eQTLs and trans-eQTLs in 33 cancer types.

artículo científico publicado en 2017

Plasma microRNA profiles for bladder cancer detection

artículo científico publicado en 2012

Poly ADP-ribose polymerase-1 as a potential therapeutic target in Merkel cell carcinoma

artículo científico publicado en 2018

Proteomic Profiling Identifies PTK2/FAK as a Driver of Radioresistance in HPV-negative Head and Neck Cancer

artículo científico publicado en 2016

Proteomic markers of DNA repair and PI3K pathway activation predict response to the PARP inhibitor BMN 673 in small cell lung cancer

artículo científico publicado en 2013

Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1.

artículo científico publicado en 2012

Proteomic profiling identifies pathways dysregulated in non-small cell lung cancer and an inverse association of AMPK and adhesion pathways with recurrence

artículo científico publicado en 2010

Randomized, Double-Blind, Phase II Study of Temozolomide in Combination With Either Veliparib or Placebo in Patients With Relapsed-Sensitive or Refractory Small-Cell Lung Cancer.

artículo científico publicado en 2018

Reciprocal regulation of c-Src and STAT3 in non-small cell lung cancer

artículo científico publicado en 2009

Reply to F. Liang

artículo científico publicado en 2018

Reproducibility of SELDI Spectra Across Time and Laboratories

artículo científico publicado en 2011

SARS-CoV-2 infection induces EMT-like molecular changes, including ZEB1-mediated repression of the viral receptor ACE2, in lung cancer models

artículo científico publicado en 2020

STING Pathway Expression Identifies NSCLC With an Immune-Responsive Phenotype

scientific article published on 15 February 2020

STK11/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment.

artículo científico publicado en 2016

Selecting Reliable mRNA Expression Measurements Across Platforms Improves Downstream Analysis

artículo científico publicado en 2016

Sex specific function of epithelial STAT3 signaling in pathogenesis of K-ras mutant lung cancer

scientific article published in Nature Communications

Sex-associated molecular differences for cancer immunotherapy

artículo científico publicado en 2020

Single-cell reconstruction of differentiation trajectory reveals a critical role of ETS1 in human cardiac lineage commitment

artículo científico publicado en 2019

Stress hormones promote EGFR inhibitor resistance in NSCLC: Implications for combinations with β-blockers

artículo científico publicado en 2017

Structure-based classification predicts drug response in EGFR-mutant NSCLC

artículo científico publicado en 2021

Survivin is highly expressed in CD34(+)38(-) leukemic stem/progenitor cells and predicts poor clinical outcomes in AML

artículo científico publicado en 2012

TANRIC: An Interactive Open Platform to Explore the Function of lncRNAs in Cancer

artículo científico publicado en 2015

THO Complex-Dependent Posttranscriptional Control Contributes to Vascular Smooth Muscle Cell Fate Decision

artículo científico publicado en 2018

Targeting AXL and mTOR Pathway Overcomes Primary and Acquired Resistance to WEE1 Inhibition in Small-Cell Lung Cancer

artículo científico publicado en 2017

Targeting DNA Damage Response Promotes Antitumor Immunity through STING-Mediated T-cell Activation in Small Cell Lung Cancer

scientific article published on 18 February 2019

The BATTLE-2 Study: A Biomarker-Integrated Targeted Therapy Study in Previously Treated Patients With Advanced Non-Small-Cell Lung Cancer

artículo científico publicado en 2016

The EMT activator ZEB1 accelerates endosomal trafficking to establish a polarity axis in lung adenocarcinoma cells

artículo científico publicado en 2021

The Genomic Landscape and Clinical Relevance of A-to-I RNA Editing in Human Cancers

artículo científico publicado en 2015

The Genomic Landscape and Pharmacogenomic Interactions of Clock Genes in Cancer Chronotherapy.

artículo científico publicado en 2018

The Pan-Cancer analysis of pseudogene expression reveals biologically and clinically relevant tumour subtypes

artículo científico publicado en 2014

The epithelial-to-mesenchymal transition activator ZEB1 initiates a prometastatic competing endogenous RNA network

artículo científico publicado en 2018

The epithelial-to-mesenchymal transition activator ZEB1 initiates a prometastatic competing endogenous RNA network.

artículo científico publicado en 2018

The genetic and pharmacogenomic landscape of snoRNAs in human cancer

artículo científico publicado en 2020

Three-dimensional mRNA measurements reveal minimal regional heterogeneity in esophageal squamous cell carcinoma

artículo científico publicado en 2012

Transcriptional landscape and clinical utility of enhancer RNAs for eRNA-targeted therapy in cancer

scientific article published on 08 October 2019

Tumor- and circulating-free DNA methylation identifies clinically relevant small cell lung cancer subtypes

scholarly article

ZEB1 suppression sensitizes KRAS mutant cancers to MEK inhibition by an IL17RD-dependent mechanism

artículo científico publicado en 2019

drexplorer: A tool to explore dose-response relationships and drug-drug interactions

artículo científico publicado en 2015

tRic: a user-friendly data portal to explore the expression landscape of tRNAs in human cancers

scientific article published on 25 August 2019